Tyrosine 222, a member of the YXDD motif of MuLV RT, is catalytically essential and is a major component of the fidelity center

Biochemistry

Volumn 38, Issue 9, 1999, Pages 2617-2627

  Kaushik, Neerja ^a   Singh, Kamalendra ^a   Alluru, Indira ^a   Modak, Mukund J ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TYROSINE;

AMINO ACID COMPOSITION; ARTICLE; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

BASE PAIR MISMATCH; BASE SEQUENCE; CATALYTIC DOMAIN; DEOXYRIBONUCLEOSIDES; DIDEOXYNUCLEOSIDES; DNA, VIRAL; HYDROLYSIS; LEUKEMIA VIRUS, MURINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHOSPHORIC ACIDS; PLASMIDS; REVERSE TRANSCRIPTASE INHIBITORS; RNA REPLICASE; RNA, VIRAL; RNA-DIRECTED DNA POLYMERASE; SUBSTRATE SPECIFICITY; TEMPLATES, GENETIC; TYROSINE;

EID: 0033515108     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9824285     Document Type: Article

References (74)

1. Baltimore, D. (1970) Nature 226, 1209-1211.
2. Skalka, A. M., and Goff, S. P. (1993) Reverse transcriptase, CSHL Press, Plainview, NY.
3. Temin, H. M., and Mizutani, S. (1970) Nature 226, 1211-1213.
4. Collett, M. S., Dierks, P., Parsons, J. T., and Faras, A. J. (1978) Nature 272, 181-184.
5. Gilboa, E., Mitra, S. W., Goff, S., and Baltimore, D. (1979) Cell 18, 93-100.
6. Smith, J. K., Cywinski, A., and Taylor, J. M. (1984) J. Virol. 49, 200-204.
7. Varmus, H., and Swanstrom, R. (1985) in RNA Tumor Virus (Weiss, R., Teich, N., Varmus, H., and Coffin, J., Eds.) pp 75-134, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
8. Modak, M. J., and Marcus, S. L. (1977) J. Biol. Chem. 252, 11-19.
9. Verma, I. M. (1975) J. Virol. 115, 843-854.
10. Verma, I. M. (1977) Biochim. Biophvs. Acta 473, 1-38.
11. Roth, M., Tenese, N., and Goff, S. P. (1985) J. Biol. Chem. 260, 9326-9335.
12. Shirasaka, T., Kavlick, M. F., Ueno, T., Gao, W. Y., Kojima, E., Alcaide, M. L., Chokekijchai, S., Roy, B. M., Arnold, E., Yarchoan, R., and Mitsuya, H. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 2398-2424.
13. Wainberg, M. A., Drosopoulos, W. C., Salomon, H., Hsu, M., Borkow, G., Parniak, M., Gu, Z., Song, Q., Manne, J., Islam, S., Castriota, G., and Prasad, V. R. (1996) Science 271, 1282-1285.
14. Tisdale, M., Kemp, S. D., Parry, N. R., and Larder, B. A. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 5653-5656.
15. Pandey, V. N., Kaushik, N., Rege, N., Sarafianos, S. G., Yadav, P. N. S., and Modak, M. J. (1996) Biochemistry 35, 2168-2179.
16. Loeb, L. A., and Kunkel, T.(1982) Annu. Rev. Biochem. 51, 429-458.
17. Ueno, T., and Mitsuya, H. (1997) Biochemistry 36, 1092-1099.
18. Ueno, T., Shirasaka, T., and Mitsuya, H. (1995) J. Biol. Chem. 270, 23605-23611.
19. Rezende, L. F., Curr, K., Ueno, T., Mitsuya, H., and Prasad, V. R (1997) J. Virol. 72, 2890-2895.
20. LeGrice, S. F. J., Naas, T., Wohlgensinger, B., and Schatz, O. (1991) EMBO J. 10, 3905-3911.
21. Hostomsky, Z., Hostomska, Z., Fu, T. B., and Taylor, J. (1992) J. Virol. 66, 3179-3182.
22. Kaushik, N., Rege, N., Yadav, P. N. S., Sarafianos, S. G., Modak, M. J., and Pandey, V. N. (1996) Biochemistry 35, 11536-11546.
23. Larder, B. A., Purifoy, D. J. M., Powell, K. L., and Darby, G. (1987) Nature (London) 327, 716-717.
24. Larder, B. A., Kemp, S. D., and Purifoy, D. J. M (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4803-4807.
25. Lowe, D. M., Parmar, V., Kemp, S. D., and Larder, B. A. (1991) FEBS Lett. 282, 231-234.
26. Boyer, P. L., Ferris, A. L., and Hughes, S. H. (1992) J. Virol. 66, 1031-1039.
27. Delarue, M., Poch, O., Tordo, N., Moran, D., and Argos, P. (1990) Protein Eng. 3, 461-467.
28. Johnson, M. S., McClure, M. A., Feng, D. F., Gray, F. J., and Doolittle, R. F. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 7648-7652.
29. Doolittle, R. F., Feng, D. F., Johnson, M. S., and McClure, M. A. (1989) Q. Rev. Biol. 64, 1-30.
30. Poch, O., Sauvaget, I., Delarue, M., and Tordo, N. (1989) EMBO J. 8, 3867-3874.
31. Xiong, Y., and Eickbush, T. H. (1990) EMBO J. 9, 3353-3362.
32. Larder, B. A., Kemp, S. D., and Harrigan, P. R. (1995) Science 269, 696-699.
33. Gu, Z., Gao, Q., Li, X., Parniak, M. A., and Wainberg, M.A. (1992) J. Virol. 66, 7128-7135.
34. Wakefield, J. K., Jablonski, S. A., and Morrow, C. D. (1992) J. Virol. 66, 1031-1039.
35. Schinazi, R. F., Lloyed, R. M., Jr., Nguyen, M., Cannon, D. L., McMillan, A., Ilksoy, N., Chu, C. K., Liotta, D. C., Bazmi, H. Z., and Mellors, J. W. (1993) Antimicrob. Agents Chemother. 37, 875-881.
36. Drosopoulos, W. C., and Prasad, V. R. (1998) J. Virol. 72, 4224-4230.
37. Bakhanashvili, M., Orna, A., and Hizi, A. (1996) FEBS Lett. 391, 257-262.
38. Hsu, M., Inouye, P., Rezende, L., Richard, N., Li, Z., Prasad, V. R., and Wainberg, M. A. (1997) Nucleic Acids Res. 25, 4532-4536.
39. Harris, D., Yadav, P. N., and Pandey, V. N. (1998) Biochemistry 37, 9630-9640.
40. Arts, E. J., Li, X., Gu, Z., Kleiman, L., Parniak, M., and Wainberg, M. A. (1994) J. Biol. Chem. 269, 14672-14680.
41. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol 154, 367-382.
42. Chowdhury, K., Kaushik, N., Pandey, V. N., and Modak, M. J. (1996) Biochemistry 35, 16610-16620.
43. Ausubel F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. S., Smith, J. A., and Struhl, K. (1987) Current Protocols in Molecular Biology, Greene Publishing Associates and Wiley-Intersciences, John Wiley & Sons, New York.
44. Pandey, V. N., Kaushik, N., and Modak, M. J. (1994) J. Biol. Chem. 269, 13259-13265.
45. Laemmli, U. K. (1970) Nature 227, 680-685.
46. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
47. Pandey, V. N., and Modak, M. J. (1987) Prep. Biochem. 17, 359-377.
48. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467.
49. Preston, B. D., Poiesz, B. J., and Loeb, L. A. (1988) Science 242, 1168-1171.
50. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6320-6324.
51. Doublie, S., Tabor, S., Long, A. M., Richardson, C. C., and Ellenberger, T. (1998) Nature 391, 251-258.
52. Georgiadis, M. M., Jassen, S. M., Ogata, C. M., Telesnitsky, A., Goff, S. P., and Hendrickson, W. A. (1995) Structure 3, 879-892.
53. Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H., and Kraut, J. (1994) Science 264, 1891-1903.
54. Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Ghio, G., Alagona, S., Profeta, P. K., and Weiner, J. (1984) J. Am. Chem. Soc. 106, 765-775.
55. Sousa, R. (1996) Trends Biochem. Sci. 21, 186-190.
56. Joyce, C. M. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 1619-1622.
57. Gao, G., Orlova, M., Georgiadis, M. M., Hendrickson, W., and Goff, S. P. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 407-411.
58. Astatke, M., Grindley, N. D. F., and Joyce, C. (1997) Proc. Natl. Acad. Sci. U.S.A. 95, 3402-3407.
59. Tabor, S., and Richardson, C. C. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 6339-6243.
60. Sousa, R., and Padilla, R. (1995) EMBO J. 14, 4609-4621.
61. Mizrahi, V., and Huberts, P. (1996) Nucleic Acids Res. 24, 4845-4852.
62. Tabor, S., and Richardson, C. C. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4076-4080.
63. Astatke, M., Grindley, N. D., and Joyce, C. M. (1998) J. Mol. Biol. 278, 147-165.
64. Mitsuya, H., Jarrett, R. F., Matsukura, M., Di Marzo Veronese, F., DeVico, A. L., Sarngadharan, M. G., Johns, D.G., Reitz, M. S., and Broder, S. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 2033-2037.
65. Goody, R. S., Muller, B., and Restle, T. (1991) FEBS Lett. 291, 1-5.
66. Izawa, M., Sasaki, N., Watahiki, M., Ohara, E., Yoneda, Y., Muramatsu, M., Okazaki, Y., and Hayashizaki, Y. (1998) J. Biol. Chem. 273, 14242-14246
67. Martin, J. L., Wilson, J. E., Hayes, R. B., and Furman, P. A. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6135-6139.
68. Yu, H., and Goodman, M. F. (1992) J. Biol. Chem. 267, 10888-10896.
69. Roberts, J. D., Bebenek, K., and Kunkel, T. A. (1988) Science 242, 1171-1173.
70. Bakhanashvilli, M., and Hizi, A. (1992) FEBS Lett. 306, 151-156.
71. Bakhanashvilli, M., and Hizi, A. (1992) Biochemistry 31, 9393-9398.
72. Ji, J., and Loeb, L. A. (1992) Biochemistry 31, 954-958.
73. Perrino, F. W., Preston, B. D., Sandell, L. L., and Loeb, L. A. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 8343-8347.
74. Stewart, J. J. P. (1989) J. Comput. Chem. 10, 209-220.