Multifactorial basis of the syndrome of diabetic embryopathy

Teratology

Volumn 54, Issue 4, 1996, Pages 171-182

  Reece, E Albert ^a   Homko, Carol J ^a   Wu, Ying King ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ARACHIDIC ACID; INOSITOL; MEMBRANE LIPID; OXYGEN RADICAL; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONGENITAL MALFORMATION; DIET SUPPLEMENTATION; EMBRYOPATHY; ESSENTIAL FATTY ACID DEFICIENCY; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; MATERNAL DIABETES MELLITUS; METABOLISM; NONHUMAN; ORGANOGENESIS; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; RAT; TERATOGENESIS; YOLK SAC;

ABNORMALITIES; ANIMALS; CAUSALITY; DIABETES COMPLICATIONS; DIABETES, GESTATIONAL; FEMALE; FETAL DISEASES; HUMANS; HYPERGLYCEMIA; PREGNANCY; PREGNANCY IN DIABETICS; RATS; SYNDROME; YOLK SAC;

ANIMALIA;

EID: 0030452974     PISSN: 00403709     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9926(199610)54:4<171::AID-TERA1>3.0.CO;2-4     Document Type: Conference Paper

References (62)

1. Anonymous (1991) Gestation and Diabetes in France Study Group Multicenter survey of diabetic pregnancy in France. Diabetes Care, 14:994-100.
2. Baker, L., and R. Piddington (1993) Diabetic embryopathy: A selective review of recent trends. J. Diab. Comp., 7:204-12.
3. Becerra, J.E., M.J. Khoury, J.F. Cordero, and J.D. Erickson (1990) Diabetes mellitus during pregnancy and the risks for specific birth defects: A population-based case-control study. Pediatrics, 84:1-9.
4. Brent, R.L., A.J. Johnson, and M. Jensen (1971) The production of congenital malformations using tissue antisera. VII. Yolk-sac antiserum. Teratology, 4:255-75.
5. Buchanan, T.A., J.K. Schemmer, and N. Freinkel (1986) Embryotoxic effects of brief maternal insulinhypoglycemic serum during organogenesis in rat embryo culture. J. Clin. Invest., 78:643-49.
6. Chung, O.S., and N.C. Myrianthopoulos (1975) Factors affecting risks of congenital malformations, II. Effect of maternal diabetes on congenital malformations. Birth Defects, 11:23.
7. Cockroft, D.L. (1984) Abnormalities induced in cultured rat embryos by hyperglycemia. Br. J. Exp. Pathol., 65:625-36.
8. Cockroft, D.L., and P.T. Coppola (1977) Teratogenic effects of excess glucose on head-fold rat embryos in culture. Teratology, 16:141-46.
9. Comess, L.J., P.H. Bennett, T.A. Burch, and M. Miller (1969) Congenital anomalies and diabetes in the Pima Indians of Arizona. Diabetes, 18:471.
10. Cziezel, A.E., and I. Dudas (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med., 327:1832-35.
11. Drury, M.I., A.T. Green, and J.M. Strong (1977) Pregnancy complicated by clinical diabetes mellitus: A study of 600 pregnancies. Am. J. Obstet. Gynecol., 49:519.
12. Ellington, S.K. (1987) Development of rat embryos cultured in glucose-deficient medium. Diabetes, 36:1372-78.
13. Engstrom, E., A. Haglund, and U.J. Eriksson (1991) Effects of maternal diabetes or in vitro hyperglycemia on uptake of plamitic and arachidonic acid by rat embryos. Pediat. Res., 30:150-53.
14. Eriksson, U.J., and L.A.H. Borg (1993) Diabetes and embryonic malformations: Role of substrate-induced free oxygen radical production for dysmorphogenesis in cultured rat embryos. Diabetes, 42: 411-19.
15. Eriksson, U.J., V.E. Dahlstrome, and H.O. Lithell (1986) Diabetes in pregnancy: Influence of genetic background and maternal diabetic state on the incidence of skeletal malformations in the fetal rate. Acta Endocrinol., 277:66-73.
16. Eriksson, U.J., S.E. Brolin, and P. Naeser (1989) Influence of sorbitol accumulation on growth and development of embryos cultured in elevated levels of glucose and fructose. Diabetes Res., 17:27-32.
17. Eriksson, U.J., L.A. Hakan-Borg, H. Forsberg, and J. Styrud (1991) Diabetic embryopathy: Studies with animal and in vitro models. Diabetes, 40(Suppl 2):94-98.
18. Finley, B.E., and S. Norton (1991) Effects of hyperglycemia on mitochondrial morphology in the region of the anterior neuropore in the explanted rat embryo model: Evidence for a modified Reid hypothesis as a mechanism for diabetic teratogenesis. Am. J. Obstet. Gynecol., 165:1661-66.
19. Freeman, S.J., F. Beck, and J.B. Lloyd (1981) The role of the visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro. J. Embryol. Exp. Morphol., 66:223.
20. Fuhrmann, K., H. Reiher, K. Semmler, et al. (1983) Prevention of congenital malformations in infants of insulin-dependent diabetic mothers. Diab. Care, 6:219.
21. Goldman, A.S., L. Baker, R. Piddington, et al. (1985) Hyperglycemiainduced teratogenesis is mediated by a functional deficiency of arachidonic acid. Proc. Natl. Acad. Sci. U.S.A., 2:8227-31.
22. Goldman, J.A., D. Dicker, D. Feldberg, et al. (1986) Pregnancy outcome in patients with insulin-dependent diabetes mellitus with preconceptional diabetic control: A comparative study. Am. J. Obstet. Gynecol., 155:293-97.
23. Greene, M.F., J.W. Hare, J.P. Cloherty, B.R. Benacerraf, and J.S. Soeldner (1984) First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Br. Med. J., 289:345-46.
24. Hagay, Z.J., I. Weiss, I. Zusman, D. Kidron, U.J. Eriksson, E.A. Reece, and Y. Groner (1995) Prevention of diabetic embryopathy by over expression of the free radical scavenging enzyme superoxide disinutase in transgenic mouse embryos. Am. J. Obstet. Gynecol., 173: 1036-41.
25. Hanson, U., and B. Persson (1993) Outcome of pregnancy complicated by Type 1 insulin dependent diabetes in Sweden: Acute pregnancy complications, neonatal mortality and morbidity. Am. J. Perinat., 10:330-33.
26. Hod, M., S. Star, J.V. Passonnequ, et al. (1986) Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: Failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis. Biochem. Biophys. Res. Commun., 140: 974.
27. Horton, W.E., and T.W. Sadler (1983) Effects of maternal diabetes on early embryogenesis. Alterations in morphogenesis produced by the ketone body, β-hydroxybutyrate. Diabetes, 32:610-16.
28. Hunter, E.S., III, and T. W. Sadler (1992) The role of the visceral yolk sac in hyperglycemia-induced embryopathies in mouse embryos in vitro. Teratology, 45:195-203.
29. Katase, T., M. Tetsuo, T. Hamada, and M. Yakushiji (1992) The effects of glucose concentration on early embryogenesis using the whole embryo culture system on rats. Asia-Ocean J. Obstet. Gynecol., 18: 363-69.
30. Key, T.C., R. Giuffrida, and T.R. Moore (1987) Predictive value of early pregnancy glycohemoglobin in the insulin-treated diabetic patient. Am. J. Obstet. Gynecol., 156:1096-2000.
31. Khandelwal, M., Y.-K. Wu, M. Borenstein, and E.A. Reece (1995) Dietary phospholipid therapy, hyperglycemia-induced membrane changes and associated diabetic embryopathy. Am. J. Obstet. Gynecol., 172:265 (abstr.).
32. Kitzmiller, J.L., L.A. Gavin, and G.D. Gin, et al. (1991) Preconception management of diabetes continued through early pregnancy prevents the excess frequency of major congenital anomalies in infants of diabetic mothers. J.A.M.A., 265:731-36.
33. Kubow, S. (1993) Protection by acetylsalicyclic acid against hyperglycemia induced glycation and neural tube defects in cultured early somite mouse embryos. Diabetes Res., 22:145-188.
34. LeCorche, E. (1885) Du Diabetic dans ses rapports avec la vie uterine menstruation et al grusesse. Ann. Gynecol., 24:257.
35. Lewis, N.J., S. Akazawa, and N. Freinkel (1983) Teratogenesis from β-hydroxybutyrate during organogenesis in rat embryo organ culture and enhancement by subteratogenic glucose. Diabetes, 32(Suppl.):11A.
36. Lucas, M.J., K.J. Leveno, and L. Williams, et al. (1989) Early pregnancy glycosylated hemoglobin, severity of diabetes, and fetal malformations. Am. J. Obstet. Gynecol., 161:426-31.
37. 1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. N. Engl. J. Med., 304: 1331-33.
38. Mills, J.L., L. Baker, and A.S. Goldman (1979) Malformations in infants of diabetic mothers occur before the seventh gestational week: Implications for treatment. Diabetes, 25:292.
39. Mills, J.L., R.H. Knopp, and J.L. Simpson, et al. (1988) The NICHD-Diabetes in Early Pregnancy Study: Lack of relation of increased malformation rates in infants of diabetic mothers to glycemic control during organogenesis. N. Engl. J. Med., 318:671.
40. Otani, H. Tanakao, R. Tatewaki, H. Naora, and T. Yoneyama (1991) Diabetic environment and genetic predisposition as causes of congenital malformations in NOD mouse embryos. Diabetes, 40:1245-50.
41. Pedersen, J. (1977) The Pregnant Diabetic and Her Newborn: Problems and Management. 2nd ed. Williams & Wilkins, Baltimore.
42. Pinter, E., E.A. Reece, C.Z. Leranth, M.K. Sanyal, J.C. Hobbins, M.J. Mahoney, and F. Naftolin (1986) Yolk sac failure in embryopathy due to hyperglycemia: Ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions. Teratology, 33:73-84.
43. Pinter, E., E.A. Reece, and P.L. Ogburn Jr., et al. (1988) Fatty acid content of yolk sac and embryo in hyperglycemia-induced embryopathy and effect of arachidonic acid supplementation. Am. J. Obstet. Gynecol., 159:1484-90.
44. Reece, E.A., E. Pinter, and C.Z. Leranth, et al. (1985) Ultrastructural analysis of malformations of the embryonic neural axis induced by in vitro hyperglycemia conditions. Teratology, 32:363-73.
45. Reece, E.A., E. Pinter, and C.Z. Leranth (1989) Yolk sac failure in embryopathy due to hyperglycemia: Horseradish peroxidase uptake in the assessment of yolk sac function. Obstet. Gynecol., 74:755.
46. Reece, E.A., Y.-K. Wu, A. Wiznitzer, J. Yao, C.J. Homko, and M. Borenstein (1996a) Dietary polyunsaturated fatty acids prevent malformations in offspring of diabetic rats. Am. J. Obstet. Gynecol., 775:818-23.
47. Reece, E.A., A. Wiznitzer, C.J. Homko, Z. Hagay, and Y.-K. Wu (1996b) Synchronization of the factors critical for diabetic teratogenesis: An in vitro model. Am. J. Obstet. Gynecol., 174:1281-84.
48. Reece, E.A., M. Khandelwal, Y.-K. Wu, and M. Borenstein Dietary intake of myo-inositol reduces the incidence of embryopathy in offspring of diabetic rats. Obstet. Gynecol. (in press a).
49. Reece, E.A. Y.-K. Wu, C.J. Homko, and Z. Hagay Diabetes-induced neural tube defects: Is folate therapy the answer? Obstet. Gynecol. (in press b).
50. Rose, B.I., S. Graff, and R. Spencer, et al. (1988) Major congenital anomalies in infants and glycosylated hemoglobin levels in insulin-requiring diabetic mothers. J. Perinatol., 8.309-11.
51. Sadler, T. W. (1980) Effects of maternal diabetes on early embryogenesis: II. Hyperglycemiainduced exencephaly. Teratology, 27:349-56.
52. Sadler, T.W., and E.S. Hunter (1987) Hypoglycemia: How little is too much for the embryos? Am. J. Obstet. Gynecol., 157:190-93.
53. Sadler, T.W., L.S. Phillips, and W. Balkan, et al. (1986) Somatomedin inhibitors from diabetic rat serum alter growth and development of mouse embryos in culture. Diabetes, 35:861.
54. Sadler, T.W., E.S. Hunter, W. Balkan, and W.E. Horton, Jr. (1988) Effects of maternal diabetes on embryogenesis. Am. J. Perinatol., 5:319-26.
55. Sadler, T.W., E.S. Hunter, R-E. Wynn, and L.S. Phillips (1989) Evidence for multifactorial origin of diabetes-induced embryopathies. Diabetes, 35:70-74.
56. Shafrir, E. (1990) Polyol pathway and fetal malformations: A search for the right mode of prevention. Isr. J. Med. Sci., 25:573-74.
57. Smoak, A.W., and T.W. Sadler (1990) Embryopathic effects of short-term exposure of hypoglycemia in mouse embryos in vitro. Am. J. Obstet. Gynecol., 163:619-24.
58. Soler, N.G., C.H. Walsh, and J.M. Malins (1976) Congenital malformations in infants of diabetic mothers. Q. J. Med., 45:303.
59. Steel, J.M., F.D. Johnstone, and A.F. Smith (1982) Five years experience of a "pregnancy" clinic for insulin-dependent diabetics. Br. Med. J., 285-353.
60. Steel, J.M., F.D. Johnstone, D.A. Hepburn, and A.F. Smith (1991) Can prepregnancy care of diabetic women reduce the risk of abnormal babies? Br. Med. J., 301:1070-73.
61. Werler, M.M., S. Shapiro, and A.A. Mitchell (1993) Periconceptional folic acid exposure and risk of occurrent neural tube defects. J.A.M.A., 269:1257-61.
62. 1c values in early pregnancy. Br. Med. J. 289:345.