Reduced expression of Pax-3 is associated with overexpression of cdc46 in the mouse embryo

Development Genes and Evolution

Volumn 208, Issue 3, 1998, Pages 128-134

  Hill, April L ^a,b   Phelan, Shelley A ^a,c   Loeken, Mary R ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b FAIRFIELD UNIVERSITY   (United States)

^c JACKSON LABORATORY   (United States)

^d JOSLIN DIABETES CENTER   (United States)

Author keywords

cdc46; Licensing factor; Neural tube; Pax 3

Indexed keywords

CELL CYCLE PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; EMBRYO; EMBRYO DEVELOPMENT; GENE OVEREXPRESSION; IN SITU HYBRIDIZATION; MOUSE; NEURAL TUBE; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALLELES; ANIMALS; CELL CYCLE PROTEINS; DIABETES MELLITUS, TYPE 1; DNA-BINDING PROTEINS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; NEURAL TUBE DEFECTS; PAIRED BOX TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0031805136     PISSN: 0949944X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004270050163     Document Type: Article

References (44)

1. Barr FG, Galili N, Holick J, Biegel JA, Rovera G, Emanuel BS (1993) Rearrangement of the PAX3 paired box gene in the paediatric solid tumor alveolar rhabdomyosarcoma. Nature Genet 3: 113-117
2. Bernasconi M, Remppis A, Fredericks WJ, Rauscher FJ, Schafer BW (1996) Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. Proc Natl Acad Sci USA 93: 13164-13169
3. Blow JJ, Laskey RA (1988) A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 332: 546-548
4. Bopp D, Burri M, Baumgartner S, Frigerio G, Noll M (1986) Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila. Cell 47: 1033-1040
5. Chalepakis G, Goulding M, Read A, Strachan T, Gruss P (1994a) Molecular basis of splotch and Waardenburg Pax-3 mutations. Proc Natl Acad Sci USA 91: 3685-3689
6. Chalepakis G, Jones FS, Edelman GM, Gruss P (1994b) Pax-3 contains domains for transcription activation and transcription inhibition. Proc Natl Acad Sci USA 91: 12745-12749
7. Chalepakis G, Tremblay P, Gruss P (1992) Pax genes mutants and molecular function. J Cell Sci Suppl 16: 61-67
8. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
9. Chong JPJ, Mahbubani HM, Khoo CY, Blow JJ (1995) Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375: 418-421
10. Chong JPJ, Thommes P, Blow JJ (1996) The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biol Sci 21: 102-106
11. Cox RA (1968) The use of guanidiniumchloride in the isolation of nucleic acids. In: Grossmann L, Moldave E (eds) Methods in enzymology. Academic Press, Orlando, FL, pp 120-129
12. Diffley JFX (1996) Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells Genes Develop 10: 2819-2830
13. Epstein DJ, Vogan KJ, Trasler DG, Gros P (1993) A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc Natl Acad Sci USA 90: 532-536
14. Epstein J A Shapiro D N Chang J Lam P Y P and Maas R L (1996) Pax3 modulates expression of the c-Met receptor during limb muscle development Proc Natl Acad Sci USA 93: 4213-4218
15. Galili N, Davis R, Fredericks WJ, Mukhopadhyay S, Rauscher FJ III, Emanuel BS, Rovera G, Barr FG (1993) Fusion of a fork head domain gene to PAX3 in the solid tumor alveolar rhabdomyosarcoma. Nature Genet 5: 230-235
16. Goulding M, Sterrer S, Fleming J, Balling R, Nadeau J, Moore KJ, Brown SDM, Steel KP, Gruss P (1993) Analysis of the Pax-3 gene in the mouse mutant splotch. Genomics 17: 355-363
17. Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P (1991) Pax-3 a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10: 1135-1147
18. Gruss P, Walther C (1992) Pax in development. Cell 69: 719-722
19. Heald R, McLoughlin M, McKeon F (1993) Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase. Cell 74: 463-474
20. Hogan B, Costantini F, Lacy E (1986) Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
21. Kimura H, Nozaki N, Sugimoto K (1994) DNA polymerase α associated protein P1 a murine homolog of yeast MCM3 changes its intranuclear distribution during the DNA synthetic period. EMBO J 13:4311-4320
22. Kimura H, Takizawa N, Nozaki N, Sugimoto K (1995) Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Nucleic Acids Res 23: 2097-2104
23. King KL, Cidlowski JA (1995) Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem 58: 175-180
24. Kioussi C, Gross MK, Gruss P (1995) Pax3: A paired domain gene as a regulator in PNS myelination. Neuron 15: 553-562
25. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR (1995) E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 69: 2491-2500
26. Krude T, Musahl C, Laskey RA, Knippers R (1996) Human replication proteins hCdc21 hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication. J Cell Sci 109: 309-318
27. Kubota Y, Mimura S, Nishimoto S-I, Takisawa H, Nojima H (1995) Identification of the yeast MCM3-related protein as a component of K DNA replication licensing factor. Cell 81: 601-609
28. Laborda J (1991) 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nuceic Acids Res 19: 3998
29. Liang P, Pardee AB (1992) Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257: 967-971
30. Madine MA, Khoo CY, Mills AD, Laskey RA (1995) MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375: 421-424
31. Maniatis T, Fritsch EF, Sambrook J (1982) Molecular Cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
32. Maroto M, Reshef R, Munsterberg AE, Koester S, Goulding M, Lassar AB (1997) Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell 89: 139-148
33. Maulbecker CC, Gruss P (1993) The oncogenic potential of Pax genes. EMBO J 12: 2361-2367
34. Moase CE, Trasler DG (1991) N-CAM alterations in splotch neural tube defect mouse embryos. Development 113: 1049-1058
35. Phelan SA, Ito M, Loeken MR (1997) Neural tube defects in embryos of diabetic: role of the Pax-3 gene and apoptosis. Diabetes 46: 1189-1197
36. Ravnik SE, Wolgemuth DJ (1996) The developmentally restricted pattern of expression in the male germ line of a murine cyclin A, cyclin A2 suggests roles in both mitotic and meiotic cell cycles. Dev Biol 173: 69-78
37. Romanowski P, Madin MA (1996) Mechanisms restricting DNA replication to once per cell cycle: MCMs pre-replicative complexes and kinases. Trends Cell Biol 6: 184-188
38. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467
39. Shapiro DN, Sublett JE, Li B, Downing JR, Naeve CW (1993) Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res 53: 5108-5112
40. Snow MHL (1977) Gastrulation in the mouse: Growth and regionalization of the epiblast. J Embryol Exp Morphol 42: 293-303
41. Stillman B (1996) Cell cycle control of DNA replication. Science 274: 1659-1664
42. Tajbakhsh S, Rocancourt D, Cossu G, Buckingham M (1997) Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD. Cell 89: 127-138
43. Tye B-K (1994) The MCM2-3-5 proteins: Are they replication licensing factors? Trends Cell Biol 4: 160-166
44. Yang X-M, Vogan K, Gros P, Park M (1996) Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limb is absent in Splotch mice. Development 122: 2163-2171