Analysis of HIV-1 the cervicovaginal secretions and blood of pregnant and nonpregnant women

Journal of Human Virology

Volumn 2, Issue 3, 1999, Pages 154-166

  Shaheen, Farida ^a,b   Sison, Antonio V ^c,d   McIntosh, LaShauna ^c,d   Mukhtar, Muhammad ^a,b   Pomerantz, Roger J ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d ROBERT WOOD JOHNSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Cervicovaginal secretions; Cervix; Genotype; HIV 1; Pregnancy; Transmission

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENVELOPE GENE; FEMALE; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; PREGNANCY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; UTERINE CERVIX CYTOLOGY; VIRION; VIRUS TRANSMISSION;

ADULT; AMINO ACID SEQUENCE; CD4 LYMPHOCYTE COUNT; CERVIX UTERI; COHORT STUDIES; FEMALE; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RNA, VIRAL; SEQUENCE HOMOLOGY, AMINO ACID; VAGINA; VARIATION (GENETICS); VIRAL LOAD;

EID: 0033509562     PISSN: 10909508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Alexander NJ. Sexual transmission of human immunodeficiency virus: virus entry into the male and female genital tract. Fertil Steril 1990;54:1-18.
2. Royce RA, Sena A, Cates W, Cohen MS. Sexual transmission of HIV-1. N Engl J Med 1997;336:1072-1078.
3. Gillet JY, Bongain A, Monpoux F, Mariani R. Maternal-fetal transmission of HIV-1. Arch Pediatr 1995;2:169-172.
4. Vogt MW, Craven DE, Crawford DF, et al. Isolation of HTLV-III/LAV from cervical secretions of women risk for AIDS. Lancet 1986;1:525-527.
5. Wofsy CB, Haver LB, Michaelis BA. Isolation of AIDS-associated retrovirus from genital secretions of women with antibodies to the virus. Lancet 1986;1:527-529.
6. Goulston C, McFarland W, Katzenstein D. Human immunodeficiency virus type 1 RNA shedding in the female genital tract. J Infect Dis 1998;177:1100-1103.
7. Henin Y, Mandelbrot L, Pradinaud R, Couland JP, Montagnier L. Virus excretion in the cervicovaginal secretions of pregnant and non-pregnant HIV infected women. J Acquir Immune Defic Syndr 1993;6:72-75.
8. Mostad SB, Kreiss JK. Shedding of HIV-1 in the genital tract. AIDS 1996;10:1305-1315.
9. Pomerantz RJ, de la Monte AM, Donegan SP, et al. Human immunodeficiency virus (HIV) infection of the uterine cervix. Ann Intern Med 1988;108:321-327.
10. Clemetson DBA, Moss GB, Willerford D, et al. Detection of HIV-1 DNA in cervical and vaginal secretions: prevalence and correlates among women in Nairobi, Kenya. JAMA 1993;269:2860-2864.
11. Rasheed R, Zhiliang L, Xu D, Kovacs A. Presence of cell-free human immunodeficiency virus in cervicovaginal secretions is independent of viral load in the blood of human immunodeficiency virus-infected women. Am J Obstet Gynecol 1996;175:122-130.
12. Uvin SC, Caliendo AM. Cervicovaginal human immunodeficiency virus secretion and plasma viral load in human immunodeficiency virus-seropositive women. Obstet Gynecol 1997;90:739-743.
13. Connor EM, Sperling RS, Gelber R. Reduction of maternal-infant transmission of human immunodeficiency virus type-1 with zidovudine treatment. N Engl J Med 1994; 331:1173-1180.
14. Mellors JW, Kingsley LA, Rinaldo CR Jr, et al. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995;122:573-579.
15. Sei S, Kleiner DE, Kopp JB, et al. Quantitative analysis of viral burden in tissues from adults and children with symptomatic human immunodeficiency virus type 1 infection assessed by polymerase chain reaction. J Infect Dis 1994;170:325-333.
16. Chesebro B, Wehrly K, Nishio J, Perryman S. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell tropic isolates: definition of critical amino acids involved in cell tropism. J Virol 1992;66:6547-6554.
17. Fouchier RAM, Groeninl M, Kootstra NA, et al. Phenotype associated sequence variation in the third variable region of the human immunodeficiency virus type 1 gp120 molecule. J Virol 1992;66:3183-3187.
18. Hwang SS, Boyle TJ, Lyerly HK, Cullen BR. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 1991;253:71-74.
19. Shioda T, Levy JA, Cheng-Mayer C. Small amino acid changes in the V3 hypervariable region of gp120 can affect on T-cell-line and macrophage tropism of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1992;89;9434-9438.
20. York-Higgins D, Cheng-Mayer C, Bauer D, Levy JA, Dina D. Human immunodeficiency virus type 1 cellular host range, replication, and cytopathicity are linked to the envelope region of the viral genome. J Virol 1990;64:4016-4020.
21. Wolfs TF, Zwart G, Bakker M, Goudsmit J. HIV-1 genomic RNA diversification following sexual and parenteral virus transmission. Virology 1992;189:103-110.
22. Cheng-Mayer C, Weiss C, Seto D, Levy JA. Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus. Proc Natl Acad Sci USA 1989;86:8575-8579.
23. Korber BM, Kunstman KJ, Patterson BK, et al. Genetic differences between blood-and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J Virol 1994;68:7467-7487.
24. Power C, McArthur JC, Johnson RT, et al. Demented and non-demented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelop sequences. J Virol 1994;68:4643-4649.
25. Epstein LG, Kuiken C, Blumberg BM, et al. HIV-1 V3 domain variation in brain and spleen of children with AIDS: tissue-specific evolution within host determined quasispecies. Virology 1991;180:583-590.
26. Westervelt P, Trowbridge DB, Epstein LG, et al. Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol 1992;66:2577-2582.
27. De Jong JJ, Ronde AD, Keulen W, Tersmette M, Goudsmit J. Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: An analysis by single amino acid substitution. J Virol 1992;66:6777-6780.
28. Abbott MA, Poiesz BJ, Kwok S, Sninsky JJ, Ehrlich GD. Enzymatic gene amplification: qualitative and quantitative methods for detecting viral DNA amplified in vitro. J Infect Dis 1988;158:1158-1168.
29. Myers TW, Gelfand DH. Reverse transcription and DNA amplification by a Thermus thermophilus DNA polymerase. Biochemistry 1991;30:7661-7666.
30. Zhang H, Zhang Y, Spicer TP, Abbott LZ, Abbott M, Poisez BJ. Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance. AIDS Res Hum Retroviruses 1993;9:1287-1296.
31. Wolinsky SM, Wike CM, Korber B, et al. Selective transmission of human immunodeficiency virus type-1 variants from mother to infants. Science 1992;255:1134-1137.
32. Corpet F. Multiple sequence alignment with hierarchical clustering. Nucleic Acid Res 1988;16:10881-10890.
33. Zhang H, Dornadula G, Beumont M, et al. HIV-1 in the semen of men receiving highly active anti-retroviral therapy. N Engl J Med 1998;339:1803-1809.
34. Iversen AKN, Larsen AR, Jensen T, et al. Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions. J Infect Dis 1998;177:1214-1220.
35. Grace CJ, Nduati RW, Mbori-Ngacha D, et al. Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency. J Infect Dis 1997;175:57-62.
36. Loussert-Ajaka I, Mandelbrot L, Delmas MC, et al. HIV-1 detection in cervicovaginal secretions during pregnancy. AIDS 1997;11:1575-1581.
37. Ghys PD, Fransen K, Diallo MO, et al. The association between cervicovaginal HIV-1 shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d'Ivoire. AIDS 1997;11:F85-F93.
38. Kreiss J, Willerford DM, Hensel M, et al. Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA. J Infect Dis 1994;170: 1597-1601.
39. Fang G, Burger H, Grimson R. Maternal plasma human immunodeficiency virus type-1 RNA level: a determinant and projected threshold for mother-to-child transmission. Proc Natl Acad Sci USA 1995;92:12100-12104.
40. Uvin SC, Caliendo AM, Reinert SE, Mayer KH, Flanigan TP, Carpenter CCJ. HIV-1 in the female genital tract and the effect of antiretroviral therapy. AIDS 1998;12:826-827.
41. Albert L, Abrahamsson B, Nagy K, et al. Rapid development of isolation specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera. AIDS 1990;4:107-112.
42. Palker TJ, Clark ME, Langlosis AJ, et al. Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides. Proc Natl Acad Sci USA 1988;85:1932-1936.
43. Alkhatib G, Combadiere C, Broder CC, et al. CC-CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996;272:1955-1958.
44. Connor R, Sheriden I, Kristine E, Ceradini D, Choe S, Landua NR. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J Exp Med 1997;85:621-628.
45. Deng HK, Choe SC, Ellmerier W, et al. Identification of C-C chemokine receptor 5 as the major coreceptor for entry of macrophage-tropic human immunodeficiency virus type-1. Nature (London) 1996;381:661-666.
46. Wong JK, Ignacio CC, Torriani F, Havlir D, Fitch NJS, Richman DD. In vivo compartmentalization of human immunodeficiency virus: Evidence from the examination of pol sequences from autopsy tissues. J Virol 1997;71: 2059-2071.
47. Overbaugh J, Anderson RJ, Ndinja-Achola JO, Kreiss JK. Distinct but related human immunodeficiency virus type 1 variant populations in genital tract secretions and blood. AIDS Res Hum Retroviruses 1996;12:107-115.
48. Poss M, Martin HL, Kreiss JK, et al. Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1. J Virol 1995;69:8118-8122.
49. Van't Wout AB, Kootstra NA, Mulder-Kampinga GA, et al. Macrophage-tropic variants initiate HIV-1 infection after sexual, parenteral, and vertical transmission. J Clin Invest 1994;94:2060-2067.
50. Zhu T, Mo H, Wang N, et al. Genotype and phenotype characterization of HIV-1 in patients with primary infections. Science 1993;261:1179-1181.
51. Scarlatti G, Leitner T, Halapi E, et al. Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers. Proc Natl Acad Sci USA 1993;90:1721-1725.
52. Scarlatti G, Hodara V, Rossi P, et al. Transmission of human immunodeficiency virus type-1 (HIV-1) from mother-to-child correlated with viral phenotype. Virology 1993;197:624-629.
53. Yoshimura K, Matsushita S, Hayashi A, Takatsuki K. Relationship of HIV-1 envelope V2 and V3 sequences of the primary isolates to the viral phenotype. Microbiol Immunol 1996;40:277-287.
54. Tan X, Phillips DM. Cell-mediated infection of cervix derived epithelial cells with primary isolates of human immunodeficiency virus. Arch Virol 1996;141:1177-1189.