Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions

Journal of Infectious Diseases

Volumn 177, Issue 5, 1998, Pages 1214-1220

  Iversen, Astrid K N ^a   Larsen, Anders R ^b   Jensen, Trine ^b   Fugger, Lars ^b   Balslev, Ulla ^b   Wahl, Susanne ^b   Gerstoft, Jan ^b   Mullins, James I ^b   Skinhøj, Peter ^b  

^a University of Copenhagen   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DIDANOSINE; LAMIVUDINE; LOVIRIDE; VIRUS DNA; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; UTERINE CERVIX CYTOLOGY; VAGINA SECRETION; VIRUS DETECTION; VIRUS TRANSMISSION; VIRUS TYPING;

EID: 0031899820     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515266     Document Type: Article

References (15)

1. Quinn TC. Global burden of the HIV pandemic. Lancet 1996;348:99-106.
2. Clemetson DBA, Moss GB, Willerford DM, et al. Detection of HIV DNA in cervical and vaginal secretions. JAMA 1993;269:2860-4.
3. Goulston C, Stevens E, Gallo D, Mullins JI, Hanson CV, Katzenstein D. HIV in plasma and genital secretions during the menstrual cycle. J Infect Dis 1996;174:858-61.
4. Hénin Y, Mandelbrot L, Henrion R, Pradinaud R, Coulaud JP, Montagnier L. Virus excretion in the cervicovaginal secretions of pregnant and nonpregnant HIV-infected women. J Acquir Immune Defic Syndr 1993; 6:72-5.
5. Poss M, Martin HL, Kreiss JK, et al. Diversity in virus populations from genital secretions and peripheral blood from women recently infected with human immunodeficiency virus type 1. J Virol 1996; 69:8118-26.
6. Vogt MW, Witt DJ, Craven DE, et al. Isolation patterns of the human immunodeficiency virus from cervical secretions during the menstrual cycle of women at risk for the acquired immunodeficiency syndrome. Ann Intern Med 1987;106:380-2.
7. Vogt MW, Witt DJ, Craven DE, et al. Isolation of HTLV-III/LAV from cervical secretions of women at risk for AIDS. Lancet 1986;1:525.
8. Wofsy CB, Cohen JB, Hauer LB, et al. Isolation of AIDS-associated retrovirus from genital secretions of women with antibodies to the virus. Lancet 1986;1:527-9.
9. Jackson R B, Drew JB, Lin HJ, Wolinsky SM, Yen-Lieberman B. Qualitative HIV-1 DNA polymerase chain reaction (PCR) assay. In: Hollinger FB, ed. ACTG virology manual for HIV laboratories. Vol 2.1. Bethesda, MD: National Institutes of Health, 1993.
10. Saiki RK, Gelfand DH, Stoffel S, et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988; 239:487-91.
11. Simmonds P, Balfe P, Peutherer JF, Ludlam CA, Bishop JO, Leigh-Brown AJ. Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers. J Virol 1990;64:864-72.
12. Holmes EC, Zhang LQ, Robertson P, et al. The molecular epidemiology of human immunodeficiency virus type 1 in Edinburgh. J Infect Dis 1995;171:45-53.
13. Usala SJ, Schumacher GFB. Volumetric self-sampling of cervicovaginal fluid: a new approach to ovulation timing. Fertil Steril 1983;39:304-9.
14. Kreiss J, Willerford DM, Hensel M, et al. Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA. J Infect Dis 1994;170:1597-601.
15. Rasheed S, Li Z, Xu D, Kovacs A. Presence of cell-free human immunodeficiency virus in cervicovaginal secretions is independent of viral load in the blood of human immunodeficiency virus-infected women. Am J Obstet Gynecol 1996;175:122-30.