The role of CTLA-4 in tolerance induction and T cell differentiation in experimental autoimmune encephalomyelitis: I.p. antigen administration

International Immunology

Volumn 11, Issue 12, 1999, Pages 1881-1888

  Ratts, Robert B ^a   Arredondo, LaChelle R ^a   Bittner, Patrice ^a   Perrin, Peter J ^b   Lovett Racke, Amy E ^a   Racke, Michael K ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Co stimulatory molecules; Experimental autoimmune encephalomyelitis; Neuroimmunology; Tolerance

Indexed keywords

B7 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CLONE; IMMUNE RESPONSE; LYMPH NODE; LYMPH NODE CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0033455552     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.12.1881     Document Type: Article

References (38)

1. June, C. H., Bluestone, J. A., Nadler L. M. and Thompson, C. B. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
2. Jenkins, M. K. and Johnson J. G. 1993. Molecules involved in T-cell co-stimulation. Curr. Opin. Immunol. 5:351.
3. Bretscher, P. 1992. The two-signal model of lymphocyte activation twenty-one years later. Immunol. Today 13:74.
4. Linsley, P. S., Greene, J. L., Tan, P., Bradshaw, J., Ledbetter, J. A., Anasetti, C. and Damle, N. K. 1992. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J. Exp. Med. 176:1595.
5. Green, J. M., Noel, P. J., Sperling, A. I., Walunas, T. L., Gray, G. S., Bluestone, J. A. and Thompson, C. B. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1:501.
6. Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H. and Mak, T. W. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 170:985.
7. Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A. and Sharpe, A. H. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
8. Perrin, P. J., Maldonado, J. H., Davis, T. A., June, C. H. and Racke, M. K. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333.
9. Karandikar, N. J., Vanderlugt, C. L., Walunas, T. L., Miller, S. D. and Bluestone J. A. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783.
10. Hurwitz, A. A., Sullivan, T. J., Krummel, M. F., Sobel, R. A. and Allison, J. P. 1997. Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis. J. Neuroimmunol. 73:57.
11. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Gray, G. and Nadler, L. M. 1993. Human T celi clonal anergy is induced by antigen presentation in the absence of B7 co-stimulation. Proc. Natl. Acad. Sci. USA 90:6586.
12. Perez, V., Parijs, L., Biuckians, A., Zheng, X., Strom, T. and Abbas, A. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity. 6:411.
13. Walunas, T. L. and Bluestone, J. A. 1999. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160:3855.
14. Samoliova, E. B., Horton, J. L., Zhang, H., Khoury, S. J., Weiner, H. L. and Chen, Y. 1998. CTLA-4 is required for the induction of high dose oral tolerance. Int. Immunol. 10:491.
15. Issazadeh, S., Zhang, M., Sayegh, M. H. and Khoury, S. J. 1999. Acquired thymic tolerance: role of CTLA-4 in the initiation and maintenance of tolerance in a clinically relevant autoimmune disease model. J. Immunol. 162:761.
16. Martin, R., McFarland, H. F. and McFarlin, D. E. 1992. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:153.
17. Zamvil, S. S. and Steinman, L. 1990. The lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol. 8:579.
18. Murphy, E. E., Terres, G., Macatonia, S. E., Hsieh, C. S., Mattson, J., Lanier, L., Wysocka, M., Trinchieri, G., Murphy, K. and O'Garra, A. 1994. B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 co-stimulation. J. Exp. Med. 180:223.
19. Su, X.-M. and Sriram, S. 1991. Treatment of chronic relapsing experimental allergic encephalomyelitis with the intravenous administration of splenocytes coupled to encephalitogenic peptide 91-103 of myelin basic protein. J. Neuroimmunol. 34:181.
20. Kennedy, M. K., Tan, L.-J., Dal Canto, M. C., Tuohy, V. K., Lu, Z., Trotter, J. L. and Miller, S. D. 1990. Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J. Immunol. 144:909.
21. Gaur, A., Wiers, B., Liu, A., Rothbard, J. and Fathman, G. C. 1993. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258:1491.
22. Qin, Y., Sun, D., Goto, M., Meyermann, R. and Wekerle, H. 1989. Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination vs. regulation of autoaggressive lymphocytes. Eur. J. Immnunol. 19:373.
23. h2 immunity in neonatal mice. Science 271:1728.
24. Critchfield, J. M., Racke, M. K., Zuniga-Pflucker, J. C., Cannella, B., Raine, C. S., Goverman, J. and Lenardo, M. J. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139.
25. Goverman, J., Woods, A., Larson, L., Weiner, L. P., Hood, L. and Zaller, D. M. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551.
26. α region. J. Neurosci. Res. 47:489.
27. andenbark, A. A. and Offner, H. 1998. Neonatal exposure of TCR BV8S2 transgenic mice to recombinant TCR BV8S2 results in reduced T cell proliferation and elevated antibody response to BV8S2, and increased severity of EAE. J. Neurosci. Res. 52:750.
28. Deibler, G. E., Martenson, R. E. and Kies, M. W. 1972. Large scale preparation of myelin basic protein from central nervous system tissue of several mammalian species. Prep. Biochem. 2:139.
29. Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., Thompson, C. B. and Bluestone, J. A. 1994. CTLA-4 can function as a negative regulator of T cell activation, Immunity 1:405.
30. + T cells in vivo is dependent on CD28 co-stimulation and inhibited by CTLA-4. J. Immunol. 155:1032.
31. Yoshimoto, T. and Paul, W. E. 1994. CD4 pos, NK1.1 pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
32. Racke, M. K., Bonomo, A., Scott, D. E., Cannella, B., Levine, A., Raine, C. S., Shevach, E. M. and Rocken, M. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961.
33. Linsley, P. S., Green, J. L., Brady, W., Bajorath, J., Ledbetter, J. A. and Peach, R. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1:793.
34. h2 responses. J. Immunol. 162:5784.
35. Bieganowska, K. D., Ausubel, J. L., Modabber, Y., Slovik, E., Messersmith, W. and Hafler, D. A. 1997. Direct ex vivo analysis of activated fas-sensitive autoreactive T cells in human autoimmune disease. J. Exp. Med. 185:1585.
36. + memory T cells from the spleen lack MEL-14, the lymph node homing receptor. J. Immunol. 148:324.
37. Mackay, C. R., Marston, W. L. and Dudler, L. 1990. Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 171:801.
38. Ratts, R. B., Arredondo, L. R., Bittner, P., Perrin, P. J., Lovett-Racke, A. E. and Racke, M. K. (1999) The role of CTLA-4 in tolerance induction and T cell differentiation in experimental autoimmune encephalomyelitis: i.v. antigen administration. Int. Immunol. 11:1889.