Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis

Journal of Neuroimmunology

Volumn 73, Issue 1-2, 1997, Pages 57-62

  Hurwitz, Arthur A ^a   J Sullivan, Timothy ^a   Krummel, Matthew F ^a   Sobel, Raymond A ^b   Allison, James P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

autoimmunity; costimulation; CTLA 4; experimental allergic encephalomyelitis; T lymphocytes

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ETIOLOGY; FEMALE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CRICETINAE; DISEASE PROGRESSION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED STRAINS;

EID: 0031047696     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(96)00168-3     Document Type: Article

References (29)

1. Allison, J.P. (1994) CD28-B7 interactions in T cell activation. Curr. Opin. Immunol. 6, 414-419.
2. Arima, T., Atiq, R., Hickey, W.F. and Flye, M.W. (1996) Inhibition by CTLA4Ig of Experimental Allergic Encephalomyelitis. J. Immunol. 156, 4916-4924.
3. Chambers, C.A., Krummel, M.F., Boittel, B., Hurwitz, A.A., Sullivan, T.J., Fournier, S., Cassell, D., Brunner, M. and Allison, J.P. (1996) The role of CTLA-4 in the regulation and initiation of T cell responses. Immunol. Rev. (in press).
4. Cross, A.H., Girard, T.J., Giacoletto, K.S., Evans, R.J., Keeling, R.M., Lin, R.F., Trotter, J.L. and Karr, R.W. (1995) Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 95, 2783-2789.
5. June, C.H., Bluestone, J.A., Nadler, L.M. and Thompson, C.B. (1994) The B7 and CD28 receptor families. Immunol. Today 15, 321-331.
6. Kearney, E.R., Walunas, T.L., Karr, R.W., Morton, P.A., Loh, D.Y., Blueston, J.A. and Jenkins, M.K. (1995) Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155, 1032-1036.
7. Khoury, S.J., Akalin, E., Chandraker, A., Turka, L.A., Linsley, P.S., Sayegh, M.H. and HancocK, W.W. (1995) CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J. Immunol. 155, 4521-4524.
8. Krummel, M.F. and Allison, J.P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182, 459-465.
9. Krummel, M.F. and Allison, J.P. (1996) CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. (in press).
10. Krummel, M.F., Sullivan, T.J. and Allison, J.P. (1996) Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int. Immunol. 8, 519-523.
11. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A., Weiner, H.L., Nabavi, N. and Glimcher, L.H. (1995) B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80, 707-718.
12. Leach, D.R., Krummel, M.F. and Allison, J.P. (1996) Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736.
13. Linsley, P.S., Brady, W., Urnes, M., Grosmaire, L.S., Damle, N.K. and Ledbetter, J.A. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174, 561-569.
14. Marengere, L.E., Waterhouse, P., Duncan, G., Mittrucker, H.-W., Feng, G.-S. and Mak, T.W. (1996) Regulation of T Cell receptor signalling by tyrosine phosphatase SYP association with CTLA-4. Science 272, 1170-1173.
15. Miller, J.F. and Flavell, R.A. (1994) T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance. Curr. Opin. Immunol. 6, 892-899.
16. Miller, S.D., Vanderlugt, C.L., Lenschow, D.J., Pope, J.G., Karandikar, N.J., Dal Canto, M.C. and Bluestone, J.A. (1995) Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3, 739-745.
17. Mueller, D.L. and Jenkins, M.K. (1995) Molecular mechanisms underlying functional T-cell unresponsiveness. Curr. Opin. Immunol. 7, 375-381.
18. Otten, G.R. and Germain, R.N. (1991) Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science 251, 1228-1231.
19. Perrin, P.J., Scott, D., Quigley, L., Albert, P.S., Feder, O., Gray, G.S., Abe, R., June, C.H. and Racke, M.K. (1995) Role for B7: CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154, 1481-1490.
20. Perrin, P.J., Maldonado, J.H., Davis, T.A., June, C.H. and Racke, M.K. (1996) CTLA-4 Blockade Enhances Clinical Disease and Cytokine Production During Experimental Allergic Encephalomyelitis. J. Immunol. 157, 1333-1336.
21. Raine, C.S. (1984) Biology of disease: the analysis of autoimmune demyelination: its impact on multiple sclerosis. Lab. Invest. 50, 608-635.
22. Schwartz, R.H. (1990) A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356.
23. Sobel, R.A. and Kuchroo, V.K. (1992) The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions. J. Immunol. 149, 1444-1451.
24. Sobel, R.A., Greer, J.M. and Kuchroo, V.K. (1994) Minireview: autoimmune responses to myelin proteolipid protein. Neurochem. Res. 19, 915-921.
25. Theofilopolous, A.N. (1995) The basis of autoimmunity: Part I Mechanisms of aberrant self-recognition. Immunol. Today 16, 90-98.
26. Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A. and Sharpe, A.H. (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547.
27. Tuohy, V.K., Lu, Z.J., Sobel, R.A., Laursen, R.A. and Lees, M.B. (1988) A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis. J. Immunol. 141, 1126-1130.
28. Walunas, T.L., Lenschow, D.J., Bakker, C.Y., Linsley, P.S., Freeman, G.J., Green, J.M., Thompson, C.B. and Bluestone, J.A. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413.
29. Waterhouse, P., Penninger, J.M., Timms, E., Wakeham, E., Shahinian, A., Lee, K.P., Thompson, C.B., Griesser, H. and Mak, T.W. (1995) Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 985-988.