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Volumn 5, Issue 6, 1999, Pages 553-560

Transgenic plants expressing human glutamic acid decarboxylase (GAD65), a major autoantigen in insulin-dependent diabetes mellitus

Author keywords

Autoimmunity; Carrot; Diabetes mellitus; Oral tolerance; Tobacco; Transgenic plants

Indexed keywords

ANTIGEN PRODUCTION; AUTOANTIGEN; CARROT; CHLOROPLAST; DISEASE MODEL; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME SYNTHESIS; GLUTAMATE DECARBOXYLASE; IMMUNIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MITOCHONDRION; PROTEIN FOLDING; PROTEIN TARGETING; RECOMBINANT PROTEIN; THYLAKOID; TOBACCO; TRANSGENIC PLANT;

EID: 0033452018     PISSN: 13803743     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009605729268     Document Type: Article
Times cited : (33)

References (49)
  • 1
    • 0031762753 scopus 로고    scopus 로고
    • A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes
    • Arakawa T, Yu J, Chong DKX, Hough J, Engen PC, Langridge WHR: A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nature Biotechnol 16: 934-938 (1998).
    • (1998) Nature Biotechnol , vol.16 , pp. 934-938
    • Arakawa, T.1    Yu, J.2    Chong, D.K.X.3    Hough, J.4    Engen, P.C.5    Langridge, W.H.R.6
  • 2
    • 0027363484 scopus 로고
    • Islet cell autoantigens in insulin-dependent diabetes
    • Atkinson MA, Maclaren NK: Islet cell autoantigens in insulin-dependent diabetes. J Clin Invest 92: 1608-1616 (1993).
    • (1993) J Clin Invest , vol.92 , pp. 1608-1616
    • Atkinson, M.A.1    Maclaren, N.K.2
  • 3
    • 0028007192 scopus 로고
    • Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
    • Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129 (1994).
    • (1994) J Clin Invest , vol.94 , pp. 2125-2129
    • Atkinson, M.A.1    Bowman, M.A.2    Campbell, L.3    Darrow, B.L.4    Kaufman, D.L.5    Maclaren, N.K.6
  • 5
    • 0027203970 scopus 로고
    • A plant glutamate decarboxylase containing a calmodulin binding domain. Cloning, sequence, and functional analysis
    • Baum G, Chen Y, Arazi T, Takatsuji H, Fromm H: A plant glutamate decarboxylase containing a calmodulin binding domain. Cloning, sequence, and functional analysis. J Biol Chem 268: 19610-19617 (1993).
    • (1993) J Biol Chem , vol.268 , pp. 19610-19617
    • Baum, G.1    Chen, Y.2    Arazi, T.3    Takatsuji, H.4    Fromm, H.5
  • 6
    • 0030014203 scopus 로고    scopus 로고
    • Calmodulin binding to glutamate decarboxylase is required for regulation of glutamate and GABA metabolism and normal development in plants
    • Baum G, Lev-Yadun S, Fridmann Y, Arazi T, Katsnelson H, Zik M, Fromm H: Calmodulin binding to glutamate decarboxylase is required for regulation of glutamate and GABA metabolism and normal development in plants. EMBO J 15: 2988-2996 (1996).
    • (1996) EMBO J , vol.15 , pp. 2988-2996
    • Baum, G.1    Lev-Yadun, S.2    Fridmann, Y.3    Arazi, T.4    Katsnelson, H.5    Zik, M.6    Fromm, H.7
  • 8
    • 0029959955 scopus 로고    scopus 로고
    • Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance
    • Chen YH, Weiner HL: Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Ann NY Acad Sci 778: 111-121 (1996).
    • (1996) Ann NY Acad Sci , vol.778 , pp. 111-121
    • Chen, Y.H.1    Weiner, H.L.2
  • 13
    • 0029793724 scopus 로고    scopus 로고
    • Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM
    • Falorni A, Ackefors M, Carlberg C, Daniels T, Persson B, Robertson J, Lernmark Å: Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. Diabetologia 39: 1091-1098 (1996).
    • (1996) Diabetologia , vol.39 , pp. 1091-1098
    • Falorni, A.1    Ackefors, M.2    Carlberg, C.3    Daniels, T.4    Persson, B.5    Robertson, J.6    Lernmark, Å.7
  • 17
    • 0028882673 scopus 로고
    • Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E
    • Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL: Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol 147: 1193-1199 (1995).
    • (1995) Am J Pathol , vol.147 , pp. 1193-1199
    • Hancock, W.W.1    Polanski, M.2    Zhang, J.3    Blogg, N.4    Weiner, H.L.5
  • 21
    • 0027480065 scopus 로고
    • Insulin prophylaxis in individuals at high risk of type I diabetes
    • Keller RJ, Jackson RA, Eisenbarth GS: Insulin prophylaxis in individuals at high risk of type I diabetes. Lancet 341: 927-928 (1993).
    • (1993) Lancet , vol.341 , pp. 927-928
    • Keller, R.J.1    Jackson, R.A.2    Eisenbarth, G.S.3
  • 22
    • 0001131263 scopus 로고    scopus 로고
    • Immunology of insulin-dependent diabetes mellitus
    • Pickup J, Williams G (eds) Blackwell Science, London
    • Lernmark A, Falorni A: Immunology of insulin-dependent diabetes mellitus. In: Pickup J, Williams G (eds) Textbook of Diabetes, pp. 15.1-15.23. Blackwell Science, London (1997).
    • (1997) Textbook of Diabetes , pp. 151-1523
    • Lernmark, A.1    Falorni, A.2
  • 23
    • 0028855244 scopus 로고
    • Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies
    • Li L, Jiang J, Hagopian WA, Karlsen AE, Skelly M, Baskin DG, Lernmark A: Differential detection of rat islet and brain glutamic acid decarboxylase (GAD) isoforms with sequence-specific peptide antibodies. J Histochem Cytochem 43: 53-59 (1995).
    • (1995) J Histochem Cytochem , vol.43 , pp. 53-59
    • Li, L.1    Jiang, J.2    Hagopian, W.A.3    Karlsen, A.E.4    Skelly, M.5    Baskin, D.G.6    Lernmark, A.7
  • 24
    • 0029187853 scopus 로고
    • Immunogold localization of arabinogalactan proteins, unesterified and esterified pectin in pollen grains and pollen tubes of Nicotiana tabacum L
    • Li YQ, Faleri C, Geitmann A, Zhang HQ, Cresti M: Immunogold localization of arabinogalactan proteins, unesterified and esterified pectin in pollen grains and pollen tubes of Nicotiana tabacum L. Protoplasma 189: 26-36 (1995).
    • (1995) Protoplasma , vol.189 , pp. 26-36
    • Li, Y.Q.1    Faleri, C.2    Geitmann, A.3    Zhang, H.Q.4    Cresti, M.5
  • 25
    • 0030175881 scopus 로고    scopus 로고
    • T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes
    • Lohmann T, Leslie RD, Londei M: T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes. J Autoimmun 9: 385-389 (1996).
    • (1996) J Autoimmun , vol.9 , pp. 385-389
    • Lohmann, T.1    Leslie, R.D.2    Londei, M.3
  • 26
    • 0028333066 scopus 로고
    • Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus
    • Lohmann T, Leslie RD, Hawa M, Geysen M, Rodda S, Londei M: Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet 343: 1607-1608 (1994).
    • (1994) Lancet , vol.343 , pp. 1607-1608
    • Lohmann, T.1    Leslie, R.D.2    Hawa, M.3    Geysen, M.4    Rodda, S.5    Londei, M.6
  • 28
    • 0029891823 scopus 로고    scopus 로고
    • Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice
    • Mason HS, Ball JM, Shi J-J, Jiang X, Estes MK, Arntzen CJ: Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA 93: 5335-5340 (1996).
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5335-5340
    • Mason, H.S.1    Ball, J.M.2    Shi, J.-J.3    Jiang, X.4    Estes, M.K.5    Arntzen, C.J.6
  • 29
    • 0031038166 scopus 로고    scopus 로고
    • Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha
    • Namchuk M, Lindsay L, Turck CW, Kanaani J, Baekkeskov S: Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha. J Biol Chem 272: 1548-1557 (1997).
    • (1997) J Biol Chem , vol.272 , pp. 1548-1557
    • Namchuk, M.1    Lindsay, L.2    Turck, C.W.3    Kanaani, J.4    Baekkeskov, S.5
  • 32
    • 0029806942 scopus 로고    scopus 로고
    • Glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus
    • Sanjeevi CB, Falorni A, Robertson J, Lernmark A: Glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus. Diabet Nutr Metab 9: 167-182 (1996).
    • (1996) Diabet Nutr Metab , vol.9 , pp. 167-182
    • Sanjeevi, C.B.1    Falorni, A.2    Robertson, J.3    Lernmark, A.4
  • 33
    • 0031019620 scopus 로고    scopus 로고
    • T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects
    • Schloot NC, Roep BO, Wegmann DR, Yu L, Wang TB, Eisenbarth GS: T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects. Diabetologia 40: 332-338 (1997).
    • (1997) Diabetologia , vol.40 , pp. 332-338
    • Schloot, N.C.1    Roep, B.O.2    Wegmann, D.R.3    Yu, L.4    Wang, T.B.5    Eisenbarth, G.S.6
  • 35
    • 0028216264 scopus 로고
    • Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65
    • Shi Y, Veit B, Baekkeskov S: Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. J Cell Biol 124: 927-934 (1994).
    • (1994) J Cell Biol , vol.124 , pp. 927-934
    • Shi, Y.1    Veit, B.2    Baekkeskov, S.3
  • 36
    • 0027409043 scopus 로고
    • Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region
    • Solimena M, Aggujaro D, Muntzel C, Dirkx R, Butler M, De Camilli P, Hayday A: Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region. Proc Natl Acad Sci USA 90: 3073-3077 (1993).
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3073-3077
    • Solimena, M.1    Aggujaro, D.2    Muntzel, C.3    Dirkx, R.4    Butler, M.5    De Camilli, P.6    Hayday, A.7
  • 37
    • 0028200659 scopus 로고
    • A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region
    • Solimena M, Dirkx R, Radzynski M, Mundigl O, De Camilli P: A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region. J Cell Biol 126: 331-341 (1994).
    • (1994) J Cell Biol , vol.126 , pp. 331-341
    • Solimena, M.1    Dirkx, R.2    Radzynski, M.3    Mundigl, O.4    De Camilli, P.5
  • 40
    • 0031891218 scopus 로고    scopus 로고
    • Expression of human alpha-lactalbumin in transgenic tobacco
    • Tokyo
    • Takase K, Hagiwara K: Expression of human alpha-lactalbumin in transgenic tobacco. J Biochem (Tokyo) 123: 440-444 (1998).
    • (1998) J Biochem , vol.123 , pp. 440-444
    • Takase, K.1    Hagiwara, K.2
  • 41
    • 0010386986 scopus 로고
    • Carrot (Daucus carota) hypocotyl transformation using Agrobacterium tumefaciens
    • Thomas JC, Guiltinan MJ, Bustos S, Thomas T, Nessler C: Carrot (Daucus carota) hypocotyl transformation using Agrobacterium tumefaciens. Plant Cell Rep 8: 354-357 (1989).
    • (1989) Plant Cell Rep , vol.8 , pp. 354-357
    • Thomas, J.C.1    Guiltinan, M.J.2    Bustos, S.3    Thomas, T.4    Nessler, C.5
  • 42
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptide induces Th2 responses and prevents murine insulin-dependent diabetes
    • Tian J, Atkinson MA, Clare-Salzler M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL: Nasal administration of glutamate decarboxylase (GAD65) peptide induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183: 1561-1567 (1996).
    • (1996) J Exp Med , vol.183 , pp. 1561-1567
    • Tian, J.1    Atkinson, M.A.2    Clare-Salzler, M.3    Herschenfeld, A.4    Forsthuber, T.5    Lehmann, P.V.6    Kaufman, D.L.7
  • 43
    • 0029122425 scopus 로고
    • Confocal imaging and immunogold electron microscopy of changes in distribution of myosin during pollen hydration, germination and pollen tube growth in Nicotiana tabacum L
    • Tirlapur KU, Cai G, Faleri C, Moscatelli A, Scali M, Del Casino C, Tiezzi A, Cresti M: Confocal imaging and immunogold electron microscopy of changes in distribution of myosin during pollen hydration, germination and pollen tube growth in Nicotiana tabacum L. Eur J Cell Biol 67: 209-217 (1995).
    • (1995) Eur J Cell Biol , vol.67 , pp. 209-217
    • Tirlapur, K.U.1    Cai, G.2    Faleri, C.3    Moscatelli, A.4    Scali, M.5    Del Casino, C.6    Tiezzi, A.7    Cresti, M.8
  • 44
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75 (1993).
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 45
    • 0023099393 scopus 로고
    • Nicotinamide may extend remission phase in insulin-dependent diabetes
    • Vague P, Viallettes B, Lassman-Vague V, Vallo JJ: Nicotinamide may extend remission phase in insulin-dependent diabetes. Lancet 1: 619-620 (1987).
    • (1987) Lancet , vol.1 , pp. 619-620
    • Vague, P.1    Viallettes, B.2    Lassman-Vague, V.3    Vallo, J.J.4
  • 46
    • 0028911293 scopus 로고
    • High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years
    • The Belgian Diabetes Registry
    • Vandewalle CL, Falorni A, Svanholm S, Lernmark A, Pipeleers DG, Gorus FK, Belgian Diabetes Registry: High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry. J Clin Endocrinol Metab 80: 846-851 (1995).
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 846-851
    • Vandewalle, C.L.1    Falorni, A.2    Svanholm, S.3    Lernmark, A.4    Pipeleers, D.G.5    Gorus, F.K.6    Registry, B.D.7
  • 48
    • 0025837184 scopus 로고
    • Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
    • Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL: Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 88: 10252-10256 (1991).
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10252-10256
    • Zhang, Z.J.1    Davidson, L.2    Eisenbarth, G.3    Weiner, H.L.4
  • 49
    • 0032146950 scopus 로고    scopus 로고
    • Two isoforms of glutamate decarboxylase in Arabidopsis are regulated by calcium/calmodulin and differ in organ distribution
    • Zik M, Arazi T, Snedden WA, Fromm H: Two isoforms of glutamate decarboxylase in Arabidopsis are regulated by calcium/calmodulin and differ in organ distribution. Plant Mol Biol 37: 967-975 (1998).
    • (1998) Plant Mol Biol , vol.37 , pp. 967-975
    • Zik, M.1    Arazi, T.2    Snedden, W.A.3    Fromm, H.4


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