Molecular and cellular mechanisms of estrogen action on the skeleton

Journal of Cellular Biochemistry

Volumn 76, Issue SUPPL. 32/33, 1999, Pages 123-132

  Rickard, D J ^a   Subramaniam, M ^a   Spelsberg, T C ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

Bone cells; Estrogen action; Estrogen analogues

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; CYTOKINE; ISOPROTEIN;

ANIMAL CELL; ARTICLE; BONE CELL; BONE DEVELOPMENT; BONE MASS; BONE REMODELING; ESTROGEN RELEASE; ESTROGEN SYNTHESIS; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; BONE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OSTEOBLAST; OSTEOCLAST; PHYSIOLOGY; REVIEW;

ANIMALIA;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; CYTOKINES; ESTROGENS; GENE EXPRESSION REGULATION; HUMANS; OSTEOBLASTS; OSTEOCLASTS; PROTEIN ISOFORMS; RECEPTORS, ESTROGEN;

EID: 0033403131     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4644(1999)75:32+<123::aid-jcb15>3.0.co;2-k     Document Type: Article

References (19)

1. Arts J, Kuiper GGJM, Janssen JMMF, Gustafsson J-A, Lowik CWGM, Pols HAP, Van Leeuwen JPTM. 1997. Differential expression of estrogen receptors α and β mRNA during differentiation of human osteoblast SVHFO cells. Endocrinology 138:5067-5070.
2. Bodine PVN, Green J, Harris HA, Bhat RA, Stein GS, Lian JB, Komm BS. 1997, Functional properties of a conditionally phenotypic, estrogen-responsive, human osteoblast cell line. J Cell Biochem 65:368-387.
3. Bodine PVN, Henderson RA, Green J, Aronow M, Owen T, Stein GS, Lian JB, Komm BS. 1998. Estrogen receptor-α is developmentally regulated during osteoblast differentiation and contributes to selective estrogen responsiveness of gene expression. Endocrinology 139:2048-2057.
4. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER. 1997. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337:91-95.
5. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL. 1988. Evidence of estrogen receptors in human osteoblast-like cells. Science 241:84-86.
6. Ernst M, Parker MG, Rodan GA. 1991. Functional estrogen receptors in osteoblastic cells demonstrated by transfection with a reporter gene containing an estrogen response element. Mol Endocrinol 5:1597-1606.
7. Greendale GA, Edelstein S, Barrett-ConnorE. 1997. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study. J Bone Miner Res 12:1833-1843.
8. Harris SA, Tau KR, Enger RJ, Toft DO, Riggs BL, Speisberg TC. 1995. Estrogen response in the hFOB1.19 human fetal osteoblast cell line stably transfected with the human estrogen receptor gene. J Cell Biochem 59:193-201.
9. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsberg TC, Riggs BL. 1999. Estrogen stimulates gene expression and protein production of osteoprotegerin by human osteoblastic cells. Endocrinology 140:4367-4370.
10. Hoyland JA, Mee AP, Baird P, Braidman IP, Mawer EB, Freemont AJ. 1997. Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction. Bone 20:87-92.
11. Lieberherr M, Grosse B, Kachkache M, Balsan S. 1993. Cell signalling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors. J Bone Miner Res 8:1365-1376.
12. Lim SK, Won YJ, Lee HC, Huh KB, Park YS. 1999. A PCR analysis of ERα and ERβ mRNA abundance in rats and the effect of ovariectomy. J Bone Miner Res 14:1189-1196.
13. Manolagas SC, Jilka RL. 1995. Bone marrow, cytokines, and bone remodeling. N Engl J Med 332:305-311.
14. Moss RL, Gu Q, Wong M. 1997. Estrogen: nontranscriptional signalling pathway. Recent Prog Horm Res 52:33-69.
15. Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC. 1991. Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci USA 88:6613-6617.
16. Oursler M J, Pederson L, Fitzpatrick L, Riggs BL, Spelsberg TC. 1994. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc Natl Acad Sci USA 91:5227-5231.
17. Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustafsson J-A, Kushner PJ, Scanlan TS. 1997. Differential ligand activation of estrogen receptors ERα and ERβ at AP-1 sites. Science 277:1508-1510.
18. Paige LA, Christensen DJ, Gron H, Norris JD, Gottlin EB, Padilla KM, Chang C-Y, Ballas LM, Hamilton PT, McDonnell DP, Fowlkes DM. 1999. Estrogen receptor (ER) modulators each induce distinct conformational changes in ERα and ERβ. Proc Natl Acad Sci USA 96:3999-4004.
19. Riggs BL, Khosla S, Melton LJ. 1998. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13:763-773.