Region between α-helices 3 and 4 of the Mad homology 2 domain of Smad4: Functional roles in oligomer formation and transcriptional activation

Genes to Cells

Volumn 4, Issue 12, 1999, Pages 731-741

  Tada, Keiichiro ^a   Inoue, Hirofumi ^a   Ebisawa, Takanori ^a   Makuuchi, Masatoshi ^b   Kawabata, Masahiro ^a   Imamura, Takeshi ^a   Miyazono, Kohei ^a  

^a JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; DNA; OLIGOMER; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; MONKEY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION;

ANIMALIA; MAMMALIA;

EID: 0033392499     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1999.00293.x     Document Type: Article

References (38)

1. 167 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272, 27678-27685.
2. Beckmann, H., Su, L.K. & Kadesch, T. (1990) TFE3: a helixloop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif. Genes Dev. 4, 167-179.
3. Chen, X., Rubock, M.J. & Whitman, M. (1996) A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383, 691-696.
4. Chen, X., Weisberg, E., Fridmacher, V., et al. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-89.
5. Chen, Y.G., Hata, A., Lo, R.S., et al. (1998) Determinants of specificity in TGF-β signal transduction. Genes Dev. 12, 2144-2152.
6. Chen, Y.G. & Massagué, J. (1999) Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors. J. Biol. Chem. 274, 3672-3677.
7. Dennler, S., Itoh, S., Vivien, D., et al. (1998) Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100.
8. Dennler, S., Huet, S. & Gauthier, J.M. (1999) A short aminoacid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3. Oncogene 18, 1643-1648.
9. Feng, X.-H., Zhang, Y., Wu, R.Y. & Derynck, R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes Dev. 12, 2153-2163.
10. Goldman, L.A., Cutrone, E.G., Kotenko, S.V., Krause, C.D. & Langer, J.A. (1996) Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression. Biotechniques 21, 1013-1015.
11. Hata, A., Lo, R.S., Wotton, D., Lagna, G. & Massagué, J. (1997) Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388, 82-87.
12. Hayashi, H., Abdollah, S., Qiu, Y., et al. (1997) The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89, 1165-1173.
13. Heldin, C.-H., Miyazono, K. & ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
14. Hua, X., Liu, X., Ansari, D.O. & Lodish, H.F. (1998) Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev. 12, 3084-3095.
15. Imamura, T., Takase, M., Nishihara, A., et al. (1997) Smad6 inhibits signalling by the TGF-β superfamily. Nature 389, 622-626.
16. Janknecht, R., Wells, N.J. & Hunter, T. (1998) TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300. Genes Dev. 12, 2114-2119.
17. Jonk, L.J.C., Itoh, S., Heldin, C-.H., ten Dijke, P. & Kruijer, W. (1998) Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer. J. Biol. Chem. 273, 21145-21152.
18. Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. & Miyazono, K. (1998) Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17, 4056-4065.
19. Labbé, E., Silvestri, C., Hoodless, P.A., Wrana, J.L. & Attisano, L. (1998) Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2, 109-120.
20. Lagna, G. & Hemmati-Brivanlou, A. (1999) A molecular basis for Smad specificity. Dev. Dyn. 214, 269-277.
21. Liberati, N.T., Datto, M.B., Frederick, J.P., et al. (1999) Smads bind directly to the Jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. USA 96, 4844-4849.
22. Liu, F., Pouponnot, C. & Massagué, J. (1997) Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev. 11, 3157-3167.
23. Lo, R.S., Chen, Y.-G., Shi, Y., Pavletich, N.P. & Massagué, J. (1998) The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO J. 17, 996-1005.
24. Massagué, J. (1998) TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791.
25. Nakao, A., Imamura, T., Souchelnytskyi, S., et al. (1997) TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16, 5353-5362.
26. Nakashima, K., Yanagisawa, M., Arakawa, H., et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284, 479-482.
27. Nishihara, A., Hanai, J.-i., Okamoto, N., et al. (1998) Role of p300, a transcriptional coactivator, in signalling of TGF-β. Gene Cells 3, 613-623.
28. Sano, Y, Harada, J., Tashiro, S., et al. (1999) ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β signaling. J. Biol. Chem. 274, 8949-8957.
29. Shi, Y., Hata, A., Lo, R.S., Massagué, J. & Pavletich, N.P. (1997) A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87-93.
30. Shi, Y., Wang, Y.F., Jayaraman, L., et al. (1998) Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell 94, 585-594.
31. 467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling. J. Biol. Chem. 272, 28107-28115.
32. Tsukazaki, T., Chiang, T.A., Davison, A.F, Attisano, L. & Wrana, J.L. (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 95, 779-791.
33. Wotton, D., Lo, R.S., Lee, S. & Massagué, J. (1999) A Smad transcriptional corepressor. Cell 97, 29-39.
34. Yagi, K., Goto, D., Hamamoto, T., et al. (1999) Alternatively spliced variant of Smad2 lacking exon 3: Comparison with wild-type Smad2 and Smad3. J. Biol. Chem. 274, 703-709.
35. Yanagisawa, J., Yanagi, Y., Masuhiro, Y., et al. (1999) Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators. Science 283, 1317-1321.
36. Yingling, J.M., Datto, M.B., Wong, C., et al. (1997) Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol. 17, 7019-7028.
37. Zawel, L., Dai, J.L., Buckhaults, P., et al. (1998) Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1, 611-617.
38. Zhang, Y., Feng, X.-H. & Derynck, R. (1998) Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394, 909-913.