Meiosis-activating sterols: Background, discovery, and possible use

Journal of Molecular Medicine

Volumn 76, Issue 12, 1998, Pages 818-823

  Byskov, Anne Grete ^a,b   Baltsen, Mogens ^b   Andersen, Claus Yding ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Mental Health Services CPH   (Denmark)

Author keywords

Female; Male; Mammas; Meiosis; Meiosis activating sterols

Indexed keywords

CHOLESTEROL; LANOSTEROL; MEIOSIS ACTIVATING STEROL; STEROL; UNCLASSIFIED DRUG;

CHOLESTEROL SYNTHESIS; CONTRACEPTION; FERTILITY; GAMETOGENESIS; GONAD DEVELOPMENT; HORMONAL REGULATION; HUMAN; MEIOSIS; MITOSIS; NONHUMAN; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SPERMATOGENESIS; STEROL ANALYSIS; TISSUE DISTRIBUTION;

EID: 0031774248     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050286     Document Type: Review

References (30)

1. Byskov AG (1979) Regulation of meiosis in mammals. Ann Biol Anim Biochem Biophys 19:1251-1261
2. Byskov AG, Andersen CY, Nordholm L, Thøgersen H, Guoliang X, Wassmann O, Andersen JV, Guddal E, Roed T (1995) Chemical structure of sterols that activate oocyte meiosis. Nature 374:559-562
3. Eppig JJ, Downs M (1987) The effect of hypoxanthine in mouse oocyte growth and development in vitro: maintenance of meiosis arrest and gonadotropin-induced oocyte maturation. Dev Biol 119:313-321
4. Downs SM, Daniel S, Bornslaeger EA, Hoppe PC, Eppig JJ (1988) Induction of maturation in cumulus-cell enclosed mouse oocytes by follicle stimulating hormone and epidermal growth factor: evidence for a positive stimulus of somatic cell origin. J Exp Zool 245:86-96
5. Byskov AG, Yding Andersen C, Hossaini A, Guoliang X (1997) Cumulus cells of oocyte-cumulus complexes secrete a meiosis-activating substance when stimulated with FSH. Mol Reprod Dev 46:269-305
6. Byskov AG, Høyer PE (1994) Embryology of mammalian gonads and ducts. In Knobil E, Neil J (eds) The physiology of reproduction, 2nd edn. Raven, New York, pp 447-539
7. Byskov AG (1975) The role of the rete ovarii in meiosis and follicle formation in the cat, mink and ferret. J Reprod Fertil 45:201-209
8. Byskov AG (1978) The meiosis inducing interaction between germ cells and rete cells in the fetal mouse gonad. Ann Biol Anim Biochem Biophys 18:327-334
9. McLaren A (1983) Studies on mouse germ cells inside and outside the gonad. J Exp Zool 228:167-171
10. Zamboni L, Upadhyay S (1983) Germ cell differentiation in the mouse adrenal glands. J Exp Zool 228:173-193
11. Byskov AG, Saxén L (1976) Induction of meiosis in fetal mouse testis in vitro. Dev Biol 52:193-200
12. McLaren A, Southee D (1997) Entry of mouse embryonic germ cells into meiosis. Dev Biol 187:107-113
13. Westergaard L, Byskov AG, Van Look PF A, Angell R (1985) Meiosis-inducing substances in human preovulatory follicular fluid related to time of follicle aspiration and the potential of the oocyte to fertilize and cleave in vitro. Fertil Steril 44:663-667
14. Hyttel P, Westergaard L, Byskov AG (1986) Ultrastructure of human cumulus-oocyte complexes from healthy and atretic follicles. Hum Reprod 1:153-157
15. Eppig JJ (1982) The relationship between cumulus cell oocyte coupling, oocyte maturation, and cumulus expansion. Dev Biol 89:268-272
16. Downs SM, Coleman DL, Ward Bailey PF, Eppig JJ (1985) Hypoxanthine is the principal inhibitor of murinc oocyte maturation in a low molecular weight fraction of porcine follicular fluid. Proe Natl Acad Sci USA 82:454-458
17. Yding Andersen C, Byskov AG, Grinsted J (1981) Initial purification of the meiosis-inducing substance (MIS) and the meiosis-preventing substance (MPS). Acta Endocr 97:374
18. Mercer EI (1993) Inhibitors of sterol biosynthesis and their applicaions. Prog Lipid Res 32:357-416
19. Rozman M, Str̈mstedt D, Waterman MR (1996) The three human cytochrome p450 lanosterol 14α-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family. Arch Biochem Biophys 333:466-474
20. Strömstedt M, Rozman D, Waterman MR (1996) The ubiquitously expressed human CYP51 encodes lanosterol 14γ-demethylase, a cytochrome p450 whose expression is regulated by oxysterols. Arch Biochem Biophys 329:73-81
21. Rozman D, Strömstedt M, Tsui L-C, Scherer SW, Waterman MR (1996) Structure and mapping of the human lanosterol 14α-demethylase gene (CYP51) encoding the cytochrome p450 involved in cholestrol biosynyhesis; comparison of exon/intron organization with other mammalian and fungal CYP genes. Genomics 38:371-381
22. Yoshida Y, Yamashita C, Noshiro M (1996) Sterol 14-demethylase p-450 activity expressed in rat gonads contribution to the formation of mammalian meiosis-activaling sterol. Biochem Biophys Res Commun 223:534-538
23. Baulieu E-E, Schorderet-Slatkine S (1983) Steroidal and peptidic control mechanisms in membrane of Xenopus laevis oocytes resuming meiotic division. J Steroid Biochem Mol Biol 19:139-145
24. McNatty KP, Dobson C, Gibb M, Kieboom L, Thurley DC (1981) Accumulation of luteinizing hormone, oestradiol and androstenedione by sheep ovarian follicles in vivo. J Endocrinol 91:99-109
25. Yding Andersen C (1997) Biological activity of hormones in the preovulatory follicular fluid and serum of women undergoing ovarian stimulation. Danish Med Bull 44:257-273
26. Kaji E, Bornslaeger EA, Schultz RM (1987) Inhibition of mouse oocyte c amp phosphodiesterase by steroid hormones: a possible mechanism for steroid hormone inhibition of oocyte maturation. J Exp Zool 243:489-493
27. Sirotkin A (1992) Involvement of steroid hormone in bovine oocyte maturation in vitro. J Steroid Biochem Mol Biol 41:855-858
28. Zelinski-Wooten MB, Hess DL, Wolf DP, Stouffer RL (1994) Steroid reduction during ovarian stimulation impairs oocyte fertilization, but not folliculogenesis, in rhesus monkeys. Fertil Steril 61:1147-1155
29. Mattheij JAM, Swarts JJM, vander Heijden AJH, van Helvoort ALB, Kusters IC (1993) Advancement of meiotic resumption in graafian follicles reduces fertility in the rat. Gynecol Obstet Invest 36:129-135
30. Yding Andersen C, Westergaard LG, Byskov AG, Erb K (1997) Reduced in vitro fertilization of human oocytes correlates with raised circulating FSH levels during ovarian stimulation in normogonadotrophic women downregulated with gnrh-analoges. J Assist Reprod Genet 14:581-588