Signal sequence recognition in cotranslational translocation by protein components of the endoplasmic reticulum membrane

Journal of Cell Biology

Volumn 142, Issue 2, 1998, Pages 355-364

  Mothes, Walther ^a   Jungnickel, Berit ^a,c   Brunner, Josef ^b   Rapoport, Tom A ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cross linking; Endoplasmic reticulum; Sec61p; Signal sequence; Translocation

Indexed keywords

MEMBRANE PROTEIN; SIGNAL PEPTIDE;

ARTICLE; BINDING SITE; ENDOPLASMIC RETICULUM; LIPID ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CROSS-LINKING REAGENTS; DETERGENTS; DOGS; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; INTRACELLULAR MEMBRANES; MEMBRANE LIPIDS; MEMBRANE PROTEINS; PROLACTIN; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; RIBOSOMES; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL RECOGNITION PARTICLE; SOLUTIONS;

EID: 0032572529     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.142.2.355     Document Type: Article

References (41)

1. Beckmann, R., D. Bubeck, R. Grassuci, P. Penczek, A. Verschoor, G. Blobel, and J. Frank. 1997. Alignment of conduits for the nascent polypeptide chain in the ribosome-sec61 complex. Science. 278:2123-2130.
2. Belokon, Y.N., V.I. Bakhmutov, N.I. Chernoglazova, K.A. Kochetkov, S.V. Vitt, N.S. Garbalinkaya, and V.M. Belikov. 1988. General method for the asymmetric synthesis of α-amino acids via alkylation of the chiral nickel(II) Schiff base complexes of glycine and alanine. J. Chem. Soc. Perkin Trans. I: 305-312.
3. Bernstein, H., M. Poritz, K. Strub, P. Hoben, S. Brenner, and P. Walter. 1989. Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature. 340:482-486.
4. Blobel, G., and B. Dobberstein. 1975. Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J. Cell Biol. 67:852-862.
5. Briggs, M.S., L.M. Gierasch, A. Zlotnick, J.D. Lear, and W.F. DeGrado. 1985. In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides. Science. 228:1096-1099.
6. Connolly, T., P. Collins, and R. Gilmore. 1989. Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes. J. Cell Biol. 108:299-307.
7. Crowley, K.S., S. Liao, V.E. Worrell, G.D. Reinhart, and A.E. Johnson. 1994. Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore. Cell. 78:461-471.
8. Deshaies, R.J., and R. Schekman. 1987. A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum. J. Cell Biol. 105:633-645.
9. Dorman, G., and G.D. Prestwich. 1994. Benzophenone photophores in biochemistry. Biochemistry. 33:5661-5673.
10. Gilmore, R., P. Walter, and G. Blobel. 1982. Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J. Cell Biol. 95:470-477.
11. Görlich, D., and T.A. Rapoport. 1993. Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell. 75:615-630.
12. Görlich, D., E. Hartmann, S. Prehn, and T.A. Rapoport. 1992a. A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature. 357:47-52.
13. Görlich, D., S. Prehn, E. Hartmann, K.U. Kalies, and T.A. Rapoport. 1992b. A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell. 71:489-503.
14. Hanein, D., K.E.S. Matlack, B. Jungnickel, K. Plath, K.U. Kalies, K.R. Miller, T.A. Rapoport, and C.W. Akey. 1996. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation. Cell. 87:721-732.
15. Higgins, C.F., and M.M. Gottesman. 1992. Is the multidrug transporter a flip-pase? Trends Biochem. Sci. 17:18-21.
16. High, S., B. Martoglio, D. Görlich, S.S.L. Andersen, A.J. Ashford, A. Giner, E. Hartmann, S. Prehn, T.A. Rapoport, B. Dobberstein, and J. Brunner. 1993. Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J. Biol. Chem. 268: 26745-26751.
17. Jungnickel, B., and T.A. Rapoport. 1995. A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane. Cell. 82:261-270.
18. Kalies, K.U., D. Görlich, and T.A. Rapoport. 1994. Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p complex. J. Cell Biol. 126:925-934.
19. Kanamori, T., S.I. Nishikawa, I. Shin, P.G. Schultz, and T. Endo. 1997. Probing the environment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking. Proc. Natl. Acad. Sci. USA. 94:485-490.
20. Kutay, U., G. Ahnert-Hilger, E. Hartmann, B. Wiedenmann, and T.A. Rapoport. 1995. Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. EMBO (Eur. Mol. Biol. Organ.) J. 14:217-223.
21. Lauring, B., G. Kreibich, and M. Wiedmann. 1995. The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-assoeiated complex. Proc. Natl. Acad. Sci. USA. 92:9435-9439.
22. Martoglio, B., M.W. Hofmann, J. Brunner, and B. Dobberstein. 1995. The prolein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer. Cell. 81:207-214.
23. Matlack, K.E.S., K. Plath, B. Misselwitz, and T.A. Rapoport. 1997. Protein transport by purified yeast s complex and Kar2p without membranes. Science. 277:938-941.
24. Meyer, D.I., E. Krause, and B. Dobberstein. 1982. Secretory protein translocation across membranes - the role of the docking protein. Nature. 297:647-650.
25. Moroder, L., A. Hallett, E. Wünsch, O. Keller, and G. Wersin. 1976. Di-tert.-butyldicarbonat - ein vorteilhaftes Reagenz zur Einführung der tert.-Butyloxycarbonyl-Schutzgruppe. Hoppe-Seyler's Z. Physiol. Chem. 357:1651-1653.
26. Mothes, W., S. Prehn, and T.A. Rapoport. 1994. Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane. EMBO (Eur. Mol. Biol. Organ.) J. 13:3937-3982.
27. Mothes, W., S.U. Heinrich, R. Graf, I. Nilsson, G. von Heijne, J. Brunner, and T.A. Rapoport. 1997. Molecular mechanism of membrane protein integration into the endoplasmic reticulum. Cell. 89:523-533.
28. Neuhof, A., M.M. Rolls, B. Jungnickel, K.U. Kalies, and T.A. Rapoport. 1998. Binding of signal recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction. Mol. Biol. Cell. 9:103-115.
29. Nicchitta, C.V., and T. Zheng. 1997. Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. J. Cell Biol. 139:1697-1708.
30. Nicchitta, C.V., G. Migliaccio, and G. Blobel. 1991. Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. Cell. 65:587-598.
31. Osborne, R.S., and T.J. Silhavy. 1993. PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains. EMBO (Eur. Mol. Biol. Organ.) J. 12:3391-3398.
32. Prehn, S., A. Tsamaloukas, and T.A. Rapoport. 1980. Demonstration of specific receptors of the rough endoplasmic membrane for the signal sequence of carp preproinsulin. Eur. J. Biochem. 107:185-195.
33. Raden, D., and R. Gilmore. 1998. Signal recognition particle-dependent targeting of ribosomes to the rough endoplasmic reticulum in the absence and presence of the nascent polypeptide-associated complex. Mol. Biol. Cell. 9:117-130.
34. Rapoport, T.A., B. Jungnickel, and U. Kutay. 1996. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes. Annu. Rev. Biochem. 65:271-303.
35. Robertson, S.A., J.A. Ellman, and P.G. Schultz, 1991. A general and efficient route for chemical aminoacylation of transfer RNAs. J. Am. Chem. Soc. 113: 2722-2729.
36. Robinson, A., M.A. Kaderbhai, and B.M. Austen. 1987. Identification of signal sequence binding proteins integrated into the rough endoplasmic reticulum membrane. Biochem. J. 242:767-777.
37. Simon, S.M., and G. Blobel. 1992. Signal peptides open protein-conducting channels in E-coli. Cell. 69:677-684.
38. Voigt, S., B. Jungnickel, E. Hartmann, and T.A. Rapoport. 1996. Signal-sequence-dependent function of the TRAM protein during early phases of protein transport across the ER membrane. J. Cell Biol. 134:25-35.
39. Walter, P., and A.E. Johnson. 1994. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu. Rev. Cell Biol. 10: 87-119.
40. Walter, P., I. Ibrahimi, and G. Blobel. 1981. Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in vitro assembled polysomes synthesizing secretory protein. J. Cell Biol. 91:545-550.
41. Wiedmann, M., T.V. Kurzchalia, H. Bielka, and T.A. Rapoport. 1987. Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking. J. Cell Biol. 104:201-208.