Bacterial toxins modifying the actin cytoskeleton

International Microbiology

Volumn 2, Issue 3, 1999, Pages 185-194

  Richard, Jean François ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BACTERIAL TOXIN; BIOPOLYMER; BOTULINUM TOXIN; BOTULINUM TOXIN TYPE C; CADHERIN; CYTOTOXIC NECROTIZING FACTOR 1; CYTOTOXIC NECROTIZING FACTOR TYPE 2; CYTOTOXIN; ESCHERICHIA COLI PROTEIN; IOTA TOXIN, CLOSTRIDIUM PERFRINGENS; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; BACILLUS; BINDING SITE; CELL LINE; CLOSTRIDIUM; DOG; DRUG ANTAGONISM; DRUG EFFECT; ESCHERICHIA COLI; GLYCOSYLATION; HUMAN; METABOLISM; MICROFILAMENT; PATHOGENICITY; PHYSIOLOGY; REVIEW;

ACTINS; ADP RIBOSE TRANSFERASES; ANIMALS; BACILLUS; BACTERIAL TOXINS; BINDING SITES; BIOPOLYMERS; BOTULINUM TOXINS; CADHERINS; CELL LINE; CLOSTRIDIUM; CYTOTOXINS; DOGS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCOSYLATION; HUMANS; MICROFILAMENTS; POLY(ADP-RIBOSE) POLYMERASES; RHO GTP-BINDING PROTEINS;

EID: 0033187403     PISSN: 11396709     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Aktories K (1997) Rhô proteins: targets for bacterial toxins. Trends Microbiol 5:282-288
2. Earth H, Preiss JC, Hofmann F, Aktories K (1998) Characterization of the catalytic site of the ADP-ribosyltransferase Closlridiwn bolulinwn C2 toxin by site-directed mutagenesis. J Biol Chem 273:29506-29511
3. Braga VMM, Machesky LM, Hall A, Hotchin NA (1997) The small GTPases Rho and Rac are required for the establishment of cadherindependent cell-cell contacts. J Cell Biol 137:1421-1431
4. Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K (1998) A common motif of eukaryotic glycosyllransferase is essential for the enzymatic activity of large clostridial cytotoxins. J Biol Chem 273:19566-19572
5. Chambers FG, Koshy SS, Saidi RF, Clark DP, Moore R , Sears CL (1997) Bacteroides fragilis Toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro. Infect Immun 65:3561-3570
6. Domenighini M, Rappuoli R ( 1996) Three conserved consensus sequences identify the NAD-binding site of ADP-ribosylating enzymes, expressed by eukaryotes, bacteria and T-even bacteriophages. Mol Microbiol 21:667-674
7. Falzano L, Fiorentini C, Donelli G, Michel E, Kocks C, Cossart P, Oswald E, Boquet P (1993) Induction of phagocytic behaviour in human epithelial cells by Escherichia coli cytotoxic necrotizing factor type 1. Mol Microbiol 9:1247-1254
8. Fiorentini C, Fabbri A, Flatau G, Donelli G, Mataresse P, Lemichez E, Falzano L, Boquet P (1997) Escherichia coli cytotoxic necrotizing factor 1 (CNFI), a toxin that activates the Rho GTPase. J Biol Chem 272:19532-19537
9. Flatau G, Lemichez E, Gauthier M, Chardin P, Paris S, Fiorentini C, Boquet P (1997) Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine. Nature 387:729-733
10. Franco AA, Mundy LM, Trucksis M, Wu S, Kaper JB, Sears CL (1997) Cloning and characterization of the Bacteroidesfragilis metalloprotease toxin gene. Infect Immun 65:1007-1013
11. Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV, Somlyo AP (1997) Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol Biol Cell 8:2437-2447
12. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S (1998) Claudin-1 and -2: novel integral membrane proteins localized at tight junctions with no sequence similarity to occludin. J Cell Biol 7:1539-1550
13. Gasman S, Chaserot-Golaz S, Popoff MR, Aunis D, Bader MF (1997) Trimeric G proteins control exocytosis in chromaffin cells. J Biol Chem 272:20564-20571
14. Gerhard R, Schmidt G, 1 lofmann F, Aktories K ( 1998) Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor I increases intestinal permeability in CaCo-2 cells. Infect Immun 66:5125-5131
15. Gibert M, Perelle S, Daube G, Popoff MR (1997) Clostridium spiroforme toxin genes are related to C. pcrfringens iota toxin genes but have a different genomic localization. Syst Appl Microbiol 20:337-347
16. Gopalakrishhnan S, Raman N, AtMnson SJ, Marrs JA (1998) Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. Am J Physiol 275:C798-C809
17. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-514
18. Hauser D, Gibert M, Eklund MW, Boquet P, Popoff MR (1993) Comparative analysis of C3 and botulinal neurotoxin genes and their environment in Closlridiiim boiulininn types C and D. J Bacteriol 175:7260-7268
19. Hermann C, Ahmadian MR, Hofmann F, Just I (1998) Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35. J Biol Chem 273:16134-16139
20. Hofmann F, Busch C, Aktories K (1998) Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition. Infect Immun 66:1076-1081
21. Hofmann F, Busch C, Prepcns U, Just I, Aktories K (1997) Localization of the glucosyltransferase activity ot Clostridium difficile Toxin B to the N-terminal part of the holotoxin. J Biol Chem 272:11074-11078
22. Horiguchi Y, Inoue N, Masuda M, Kazshimoto T, Katahira J, Sugimoto N, Matsuda M (1997) BorJctclla bronchisepiica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gin-63 of the GTP-binding protein Rho. Proc Nail Acad Sei USA 94:11623-11626
23. Kling JJ, Wright RL, Moncrief JS, Wilkins TD (1997) Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroidesfragilis. FEMS Microbiol Lett 146:279-284
24. Koshi SS, Montrose MH, Sears CL (1996) Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroidesfragilis. Infect Immun 64:5022-5028
25. LamazeC, Chuang TH, Terlecky LJ, Bokoch GM, Schmid SL (1996) Regulation of receptor-mediated endocytosis by Rho and Rac. Nature 382:177-179
26. Lemichez E, Flatau G, Bruzzone M, Boquet P, Gauthier M (1998) Molecular localization of the Escherichia coli cytotoxic necrotizing factor CNF1 cell-binding and catalytic domains. Mol Microbiol 24:1061-1070
27. Ma TY, Hollander D, Tran LT, Nguyen D, Hoa N, Bhalla D (1995) Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability. J Cell Physiol 164:533-545
28. Machesky LM, Hall A (1996) Rho: a connection between membrane receptor signaling and the cytoskeleton. Trends Cell Biol 6:304-310
29. Mackay DJG, Hall A (1998) Rlio GTpases. J Biol Chem 273:20685-20688
30. Moncrief JS, Duncan AJ, Wright RL, Barroso LA, Wilkins TD (1998) Molecular characterization of the Fragilysin pathogenicity islet of enterotoxigenic Bacteroidesfragilis. Infect Immun 66:1735-1739
31. Narumiya S (1996) The small GTPase Rho: cellular functions and signal transduction. J Biochem 120:215-228
32. Nemoto Y, Namba T, Kozaki S, Narumiya S ( 1991 ) Closlridium bolulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein inEscliericliia coll. J Biol Chem 266:19312-19319
33. Nusrat A, Giry M, Turner JR, Colgan SP, Parkos ÇA, Cames D, Lemichez E, Boquet P, Madara JL (1995) Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia. Proc Natl Acad Sei USA 92:10629-10633
34. Obiso RJ, Azghani AO, Wilkins TD (1997) The Bacteroidesfragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells. Infect Immun 65:1431-1439
35. Oswald E, Sugai M, Labigne A, Wu HC, Fiorcntini C, Boquet P, O'Brien AD (1994) Cylotoxic necrotizing factor type 2 produced by virulent Esclierichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. Proc Nail Acad Sei (USA) 91:3814-3818
36. Perelle S, Domenighini M, Popoff MR (1996) Evidence that Arg-295, Glu-378 and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin. FEES Lett 395:191-194
37. Perelle S, Gibert M, Boquet P, Popoff MR (1993) Characterization of Clostridiiim perfringens Iota-toxin genes and expression in Esclierichia coli. Infect Immun 61:5147-5156 (Author's correction, 63:4967, 1995)
38. Perelle S, Gibert M, Bourlioux P, Corthier G, Popoff MR (1997) Production of a complete binary toxin (Actin-ADP-ribosylating toxin) by Clostridiiim difficile CD196. Infect Immun 65:1402-1407
39. Perelle S, Scalzo S, Kochi S, Mock M, Popoff MR (1997) Immunological and functional comparison between Clostridiiim perfringens iota toxin, C. spiroforme toxin, and anthrax toxins. FEMS Microbiol Lett 146:117-121
40. Petosa C, Collier JR, Klimpel KR, Leppla SH, Liddington RC (1997) Crystal structure of the anthrax toxin protective antigen. Nature 385:833-838
41. Popoff MR (1998) Interaction of bacterial toxins with intestinal cells. Toxicon 36:665-685
42. Popoff MR, Chaves-Olarte E, Lemichez E, Von Eichel-Streiber C, Thelestam M, Chardin P, Cussac D, Antonny B, Chavrier P, Flatau G, Giry M, de Gunzburg J, Boquet P (1996) Ras, Rap, and Rac small GTPbinding proteins are targets for Clostridiiim sordellii lethal toxin glucosylation. J Biol Chem 271:10217-10224
43. Popoff MR, Hauser D, Boquet P, Eklund MW,.Gill DM (1991) Characterization of the C3 gene of Closlridiiim boliilinnm types C and D and its expression in Esclierichia coli. Infect Immun 59:3673-3679
44. Pothoulakis C, Gibert RJ, Cladaras C, Castagliudo I, Semenza G, Hitti Y, Montcrief JS, Linevsky J, Kelly CP, Nikulasson S (1996) Rabbit sucrase isomaltase contains a functional intestinal receptor to Clostridiiim difficile toxin A. J Clin Invest 98:641-649
45. Rime H, Talbi N, Popoff MR, Suziedelis K, Fessus C, Ozon R (1998) Inhibition of small G proteins by Clostridiiim sordellii lethal toxin activates cdc2 and MAP kinase in Xcnopns oocytes. Dev Biol 204:592-602
46. Saidi RF, Jaeger K, Montrose MH, Wu S, Sears CL (1997) Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content. Cell Mot Cytoskel 37:159-165
47. Saidi RF, Sears CL (1996) Bacteroides fragilis Toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro. Infect Immun 64:5029-5034
48. Schmidt G, Sehr P, Wilm M, Selzer J, Mann M, Aktories K (1997) Gin 63 of Rho is deamidated by Eschcricliia coli cytotoxic necrotizing factor-1. Nature 387:725-729
49. Schmidt M, Rümcnapp U, Bienek C, Keller J, von Eichel-Streiber C, Jakobs KH (1996) Inhibition of receptor signaling to phospholipase D by Clostridiiim difficile Toxin B. J Biol Chem 271:2422-2426
50. Schmidt M, Rümenapp U, Nehls C, Ott S, Keller J, von Eichel-Streiber C, Jakobs KH (1996) Restoration of C/oj/ri
51. Schmidt M, Vos M.Thiel M, Bauer B, Grannas A, Tapp E, Cool RH, de Gunzburg J, von Eichel-Streiber C, Jakobs KH (1998) Specific inhibition of phorbol ester-stimulated phospholipase D by Clostridiiim sordellii lethal toxin and Clostridiiim difficile toxin B-1470 in HEK-293 cells. J Biol Chem 273:7413-7422
52. Sehr P, Gili J, Genth H, Just I, Pick E, Aklories K (1998) Glucosylation and ADP ribosylation of Rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. Biochemistry 37:5296-5304
53. Takaishi K, Sasaki T, Kotani H, Nishioka H, Takai Y ( 1997) Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells. JCellBiol 139:1047-1059
54. Tapon N, Hall A ( 1997) Rho, Rac and CDC42 GTPases regulate the organization of the actin cytoskeleton. Curr Biol 9:86-92
55. von Eichel-Streiber C, Boquet P, Sauerborn M, Thelestam M (1996) Large clostridial cytotoxins-a family of glucosyltransferases modifying small GTP-binding proteins. Trends Microbiol 4:375-382
56. Wren BW (1991) A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences. Mol Microbiol 5:797-803
57. Wu S, Urn KC, Huang J, Saidi RF, Sears CL ( 1998) Bactemidesfragilis entcrotoxin cleaves the zonula adherens protein, E-cadherin. Proc Nail Acad Sei USA 95:14979-14984
58. Zigmond SH (1996) Signal transduction and actin filament organization. CurrOpn Cell Biol 8:66-73