Clostridium spiroforme toxin genes are related to C. Perfringens iota toxin genes but have a different genomic localization

Systematic and Applied Microbiology

Volumn 20, Issue 3, 1997, Pages 337-347

  Gibert, Maryse ^a   Perelle, Sylvie ^a   Daube, George ^b   Popoff, Michel R ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

ADP ribosylation; Clostridium difficile; Clostridium perfringens; Clostridium spiroforme; Iota toxin

Indexed keywords

BACTERIAL TOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ARTICLE; BACTERIAL GENE; CLOSTRIDIUM; GENE LOCATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM PERFRINGENS; CLOSTRIDIUM SPIROFORME;

EID: 0030832145     PISSN: 07232020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0723-2020(97)80001-X     Document Type: Article

References (37)

1. AKTORIES, K., BÄRMANN, M., OHISHI, I., TSUYAMA, S., JAKOBS, K. H. and HABERMANN, E.: Botulinum C2 toxin ADP-ribosylates actin. Nature 322, 390-392 (1986).
2. BREFORT, G., MAGOT, M., IONESCO, H. and SEBSALD, M.: Characterization and transferability of Clostridium perfringens plasmids. Plasmid 1, 52-66 (1977).
3. BRYNESTAD, S., IWANEKO, L. A., STEWART, S. A. B. and GRANUM, P. E.: A complex array of Hpr consensus DNA recognition sequences proximal to the enterotoxin gene in Clostridium perfringens type A. Microbiol. 140, 97-104 (1994).
4. CANARD, B., SAINT-JOANIS, B. and COLE, S. T.: Genomic diversity and organization of virulence genes in the pathogenic anaerobe Clostridium perfringens. Mol. Microbiol. 6, 1421-1429 (1992).
5. CONSIDINE, R. V. and SIMPSON, L. L.: Cellular and molecular actions of binary toxins possessing ADP-ribosyltransferase activity. Toxicon 29, 913-936 (1991).
6. CORNILLOT, E., SAINT-JOANIS, B., DAUBE, G., GRANUM, P. E., CANARD, B. and COLE, S. T.: The enterotoxin gene (cpe) of Clostridium perfringens can be chromosomal or plasmid-borne. Mol. Microbiol. 15, 639-647 (1995).
7. CZECZULIN, J. R., HANNA, P. C. and MCCLANE, B. A.: Cloning, nucleotide sequencing, and expression of the Clostridium perfringens enterotoxin gene in Escherichia coli. Infect. Immun. 61, 3429-3439 (1993).
8. DAUBE, G., SIMON, P. and KAECKENBEECK, A.: IS1151, an IS-like element of Clostridium perfringens. Nucl. Acids Res. 21, 352 (1993).
9. DOMENIGHINI, M. and RAPPUOLI, R.: Three conserved consensus sequences identify the NAD-binding site of ADP-ribosylating enzymes, expressed by eukaryotes, bacteria and T-even bacteriophages. Mol. Microbiol. 21, 667-674 (1996).
10. EKLUND, M. W. and DOWELL, V. R.: Avian botulism. Springfield, III., Charles C. Thomas (1987).
11. FUJII, N., KUBOTA, T., SHIRAKAWA, S., KIMURA, K., OHISHI, I., MORIISHI, K., ISOGAI, E. and ISOGAI, H.: Characterization of component-I gene of botulinum C2 toxin and PCR detection of its gene in clostridial species. Biochem. Biophys. Res. Commun. 220, 353-359 (1996).
12. HUANG, S. H., WU, C. H., CAI, B. and HOLCENBERG, J.: cDNA cloning by inverse polymerase chain reaction, pp. 349-356. In PCR Protocols. (WHITE, B. A., eds.), Totowa, Humana Press 1993.
13. HUNTER, S. E., CLARKE, I. N., KELLY, D. C. and TITBALL, R. W.: Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli. Infect. Immun. 60, 102-110 (1992).
14. JUST, I., SELZER, J., HOFMANN, F., GREEN, G. A. and AKTORIES, K.: Inactivation of ras by Clostridium sordellii lethal toxin-catalyzed glucosylation. J. Biol. Chem. 271, 10149-10153 (1996).
15. JUST, I., SELZER, J., WILM, M., VON EICHEL-STREIBER, C., MANN, M. and AKTORIES, K.: Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature (London) 375, 500-503 (1995).
16. JUST, I., WILM, M., SELZER, J., REX, G., VON EICHEL-STREIBER, C., MANN, M. and AKTORIES, K.: The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins. J. Biol. Chem. 270, 13932-13936 (1995).
17. KATAYAMA, S., DUPUY, B., DAUBE, G., CHINA, B. and COLE, S.: Genome mapping of Clostridium perfringens strains with I-CeuI shows many virulence genes to be plasmid-borne. Mol. Gen. Genet. 251, 720-726 (1996).
18. KIM, A. Y. and BLASCHEK, H. P.: Construction of an Escherichia coli-Clostridium perfringens shuttle vector and plasmid transformation of Clostridium perfringens. Appl. Environ. Microbiol. 55, 360-365 (1989).
19. PARELLE, S., DOMENIGHINI, M. and POPOFF, M. R.: Evidence that Arg-295, Glu-378 and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin. FEBS Lett. 395, 191-194 (1996).
20. PERELLE, S., GIBERT, M., BOQUET, P. and POPOFF, M. R.: Characterization of Clostridium perfringens Iota-Toxin genes and expression in Escherichia coli. Infect. Immun. 61, 5147-5156 (Author's correction, 5163: 4967, 1995) (1993).
21. PERELLE, S., GIBERT, M., BOURLIOUX, P., CORTHIER, G. and POPOFF, M. R.: production of a complete binary toxin (Actin-ADP-Ribosylating toxin) by Clostridium difficile CD196. Infect. Immun. 65, in press (1997).
22. POPOFF, M. R. and BOQUET, P.: Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin. Biochem. Biophys. Res. Commun. 152, 1361-1368 (1988).
23. POPOFF, M. R., CHAVES-OLARTE, E., LEMICHEZ, E., VON EICHEL-STREIBER, C. M., THELESTAM, M., CHARDIN, P., CUSSAC, D., ANTONNY, B., CHAVRIER, P., FLATAU, G., GIRY, M., DE GUNZBURG, J. and BOQUET, P.: Ras, Rap, and rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation. J. Biol. Chem. 271, 10217-10224 (1996).
24. POPOFF, M. R., GUILLOU, J. P. and CARLIER, J. P.: Taxonomic position of lecithinase-negative strains of Clostridium sordellii. J. Gen. Microbiol. 131, 1697-1703 (1985).
25. POPOFF, M. R., MILWARD, F. W., BANCILLON, B. and BOQUET, P.: Purification of the Clostridium spiroforme binary toxin and activity of the toxin on HEp-2 cells. Infect. Immun. 57, 2462-2469 (1989).
26. POPOFF, M. R., RUBIN, E. J., GILL, D. M. and BOQUET, P.: Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infect. Immun. 56, 2299-2306 (1988).
27. PREKERIS, R., MAYHEW, M. W., COOPER, J. B. and TERRIAN, D. M.: Identificastion and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J. Cell Biol. 132, 77-90 (1996).
28. ROKOS, E. A., ROOD, J. I. and DUNCAN, C. L.: Multiple plasmids in different toxigenic types of Clostridium perfringens. FEMS Microbiol. Let. 4, 323-326 (1978).
29. SAMBROOK, J., FRITSCH, E. F. and MANIATIS, T.: Molecular cloning: a laboratory manual. Cold Spring Harbor, N. Y., Cold Spring Harbor Laboratory Press (1987).
30. SELZER, J., JUST, I., MANN, M. and AKTORIES, K. (1995). C. novyi α-toxin modifies the GTP-binding protein Rho. Seventh European Workshop Conference on Bacterial protein Toxins, Hindsgavl, Denmark.
31. SIMPSON, L. L.: The binary toxin produced by Clostridium botulinum enters cells by receptor-mediated endocytosis to exert its pharmacologic effects. J. Pharmacol. Exp. Ther. 251, 1223-1228 (1989).
32. SIMPSON, L. L., STILES, B. G., ZEPEDA, H. H. and WILKINS, T. D.: Molecular basis for the pathological actions of Clostridium perfringens iota toxin. Infect. Immun. 55, 118-122 (1987).
33. VAN DAMME, J., JUNG, M., HOFMANN, F., JUST, I., VANDEKERCKHOVE, J. and AKTORIES, K.: Analysis of the catalytic site of the actin ADP-ribosylating Clostridium perfringens iota toxin. FEBS Lett. 380, 291-295 (1996).
34. VAN DAMME-JONGSTEIN, M., WERNARS, K. and NOTERMANS, S.: Cloning and sequencing of the Clostridium perfringens enterotoxin gene. Ant. Van Leeu. 56, 181-190 (1989).
35. VANDEKERCKHOVE, J., SCHERING, B., BÄRMANN, M and AKTORIES, K.: Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177. FEBS Lett. 255, 48-52 (1987).
36. VON HEIJNE, G. and ABRAHMSEN, L.: Species-specific protein secretion in signal peptide design. Implication for protein secretion in foreign hosts. FEBS Lett. 244, 439-446 (1989).
37. YOUNG, M., STAUDENBAUER, W. L. and MINTON, N. P.: Genetics of Clostridium, pp. 63-103. in Clostridia. (MINTON, N. P. and CLARKE, D. J., eds.). 3, New York, Plenum Press 1989.