Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells

Infection and Immunity

Volumn 66, Issue 11, 1998, Pages 5125-5131

  Gerhard, Ralf ^a   Schmidt, Gudula ^a   Hofmann, Fred ^a   Aktories, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN B; GUANOSINE TRIPHOSPHATASE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENZYME ACTIVATION; ESCHERICHIA COLI; INTESTINE MUCOSA PERMEABILITY; NONHUMAN; PRIORITY JOURNAL;

CLOSTRIDIUM DIFFICILE; ESCHERICHIA COLI;

EID: 0032412385     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.11.5125-5131.1998     Document Type: Article

References (6)

1. Aktories, K., U. Braun, S. Rösener, I. Just, and A. Hall. 1989. The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. Biochem. Biophys. Res. Commun. 158:209-213.
2. Aktories, K. 1997. Bacterial toxins that target Rho proteins. J. Clin. Invest. 99:827-829.
3. Braga, V. M., L. M. Machesky, A. Hall, and N. A. Hotchin. 1997. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137:1421-1431.
4. Braun, U., B. Habermann, I. Just, K. Aktories, and J. Vandekerckhove. 1989. Purification of the 22 kDa protein substrate of botulinum ADP-ribosyltransferase C3 from porcine brain cytosol and its characterization as a GTP-binding protein highly homologous to the rho gene product. FEBS Lett. 243:70-76.
5. Chardin, P., P. Boquet, P. Madaule, M. R. Popoff, E. J. Rubin, and D. M. Gill. 1989. The mammalian G protein rho C is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilament in Vero cells. EMBO J. 8:1087-1092.
6. de Rycke, J., P. Mazars, J.-P. Nougayrede, C. Tasca, M. Boury, F. Herault, A. Valette, and E. Oswald. 1996. Mitotic block and delayed lethality in HeLa epithelial cells exposed to Escherichia coli BM2-1 producing cytotoxic necrotizing factor type 1. Infect. Immun. 64:1694-1705.