Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains

Journal of Experimental Medicine

Volumn 186, Issue 1, 1997, Pages 17-23

  Suzuki, Harumi ^a,d   Shinkai, Yoichi ^b,e   Granger, Lawrence G ^a   Alt, Frederick W ^b   Love, Paul E ^c   Singer, Alfred ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL LINEAGE; CELL SELECTION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE;

ANIMALS; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; MICE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0030789066     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.1.17     Document Type: Article

References (34)

1. Teh, H.S., P. Kisielow, B. Scott, H. Kishi, Y. Uematsu, H. Bluthmann, and H. von Boehmer. 1988. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature (Lond.). 335:229-233.
2. Robey, E.A., B.J. Fowlkes, J.W. Gordon, D. Kioussiss, H. von Boehmer, F. Ramsdell, and R. Axel. 1991. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell. 64:99-107.
3. Chan, S.H., C.B. Benoist, and D. Mathis. 1993. A challenge to the instructive model of positive selection. Immunol. Rev. 135:119-131.
4. Chan, S.H., D. Cosgrove, C. Waltzinger, C. Benoist, and D. Mathis. 1993. Another view of the selective model of thymocyte selection. Cell. 73:225-236.
5. Davis, C.B., N. Killeen, M.E.C. Crooks, D. Raulet, and D.R. Littman. 1993. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell. 73:237-247.
6. + thymocytes: selection rather than instruction? Science (Wash. DC). 261:911-915.
7. Crump, A.L., M.J. Grusby, L.H. Glimcher, and H. Cantor. 1993. Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Prof. Natl. Acad. Sci. USA. 90: 10739-10743.
8. + T cell lineages: a new perspective on thymic commitment and selection. Immunity. 2: 413-425.
9. von Boehmer, H. 1996. CD4/CD8 lineage commitment: back to instruction? J. Exp. Med. 183:713-715.
10. Italo, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella, and E. Robey. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183:731-741.
11. Matechak, E.O., N. Killeen, S.M. Hederick, and B.J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:337-347.
12. Robey, E., D. Chang, A. Italo, D. Cado, H. Alexander, D. Lans, G. Weinmaster, and P. Salmon. 1996. An activated form of notch influences the choice between CD4 and CD8 T cell lineages. Cell. 87:483-492.
13. Benveniste, P., G. Knowles, and A. Cohen. 1996. CD8/ CD4 lineage commitment occurs by an instructional/default process followed by positive selection. Eur. J. Immunol. 26: 461-471.
14. + thymocytes to the CD4 lineage, without TCR engagement. Int. Immunol. 8:297-306.
15. + thymocytes in suspension culture. Eur. J. Immunol. 26:2081-2086.
16. Cibotti, R., J.A. Punt, K.S. Dash, S.O. Sharrow, and A. Singer. 1997. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage specific signals. Immunity. 6:245-255.
17. int thymocytes with up-regulated levels of TCR-CD3. J. Immunol. 155:3806-3814.
18. hi thymocytes. J. Exp. Med. 181:1643-1651.
19. Lucas, B., F. Vasseur, and C. Penit. 1995. Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway. J. Exp. Med. 181:1623-1633.
20. + thymocytes has selectively terminated CD4 or CD8 synthesis. J. Exp. Med. 184:2091-2099.
21. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenish, M.L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature (Lond.). 360:225-231.
22. Love, P.E., E.W. Shores, M.D. Johnson, M.L. Tremblay, E.J. Lee, A. Grinberg, S.P. Huang, A. Singer, and H. Westphal. 1993. T cell development in mice that lack the ζ chain of the T cell antigen receptor complex. Science (Wash. DC). 261: 918-921.
23. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, and F.W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
24. Shinkai, Y., A. Ma, H.-L. Cheng, and F.W. Alt. 1995. CD3ε and CD3ζ cytoplasmic domains can independently generate signals for T cell development and function. Immunity. 2: 401-411.
25. Leo, O., M. Foo, D.H. Sachs, L.E. Samuelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Prof. Natl. Acad. Sci. USA. 84:1374-1378.
26. + thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway. J. Exp. Med. 181:1187-1195.
27. -/- mice. J. Exp. Med. 180:1517-1521.
28. Levelt, C.N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proc. Natl. Acad. Sci. USA. 90:11401-11405.
29. -/- mice in the absence of TCRβ chain expression. Int. Immunol. 6:995-1001.
30. Takahama, Y., and A. Singer. 1992. Post-transcriptional regulation of early T cell development by T cell receptor signals. Science (Wash. DC). 258:1456-1462.
31. Levelt, C.N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity. 3:667-672.
32. Spruyt, L.L., M.J. Glennie, A.D. Beyers, and A.F. Williams. 1991. Signal transduction by the CD2 antigen in T cell and natural killer cells: requirement for expression of a functional T cell receptor or binding of antibody Fc to the Fc receptor, Fc gamma RIIIA (CD16). J. Exp. Med. 174:1407-1415.
33. Mohigeon, P., J.L. Lucich, D.L. MacCorkey, F. Letourneur, B. Malissen, J. Kochan, H.C. Chang, H.R. Rodewald, and E.L. Reinherz. 1992. CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc. Natl. Acad. Sci. USA. 89:1492-1496.
34. Gunter, K.C., R.N. Germain, R.A. Kroczek, T. Saito, W.M. Yokoyama, A. Weiss, and E.M. Shevach. 1987. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature (Lond.). 326:505-507.