Editorial: Is leptin a secretion of the brain?

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 7, 1999, Pages 2267-2269

  Reichlin, Seymour ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA; PROTEIN;

EDITORIAL; HORMONE RELEASE; HUMAN; NEUROENDOCRINE SYSTEM; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; ANIMAL; BRAIN; FEMALE; MALE; NOTE; SECRETION;

ANIMALS; BRAIN; FEMALE; HUMANS; LEPTIN; MALE; OBESITY; PROTEINS;

EID: 0033161458     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.7.5900     Document Type: Editorial

References (43)

1. Neural control of the pituitary gland
2. Functions of the median eminence gland
3. Leptin is released from the human brain; Influence of adiposity and gender
4. Leptin and the regulation of body weight in mammals
5. Removal of endogenous leptin from the circulation by the kidney
6. Positional cloning of the mouse obese gene and its human homologue
7. cDNA cloning and tissue-specific gene expression of ovine leptin, NPY-Y1 receptor, and NPY-Y2 receptor
8. Distributions of leptin receptor mRNA isoforms in the rat brain
9. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
10. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus - Relationship with NPY neurones
11. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
12. Cerebro-spinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
13. Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid
14. Cerebrospinal fluid leptin in anorexia nervosa: Correlation with nutritional status and potential role in resistance to weight gain
15. Phenotype of the obese Koletsky (f) rat due to Tyr763 stop mutation in the extracellular domain of the leptin receptor (Lepr): Evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat
16. Leptin enters the brain by a saturable system independent of insulin
17. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
18. Expression of leptin receptor isoforms in rat brain microvessels
19. Fate of leptin after intracerebroventicular injection into the mouse brain
20. The stomach is a source of leptin
21. Leptin expression in human mammary epithelial cells and breast milk
22. A nutrient sensing pathway regulates leptin gene expression in muscle and fat
23. Transdifferentiation of rat hepatic stellate cells results in leptin expression
24. Synthesis of leptin in human placenta
25. A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth
26. Leptin accelerates the onset of puberty in normal female mice
27. Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucles
28. Direct determination of homovanillic acid release from the human brain, an indicator of central dopaminergic activity
29. Brain is the major site of estrogen synthesis in a male songbird
30. Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage
31. Neuroendocrinology of infection, and the innate immune system
32. Alternative pathways of neural control of the immune process
33. Increased circulating interleukin-1 and interleukin-6 after intracerebroventricular injection of lipopolysaccharide
34. Modulation of systemic interleukin-6 induction by central interleukin-1
35. Interleukin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1β in rats
36. Cytokines and metabolic dysfunction after severe head injury
37. Persistent inflammatory response in stroke survivors
38. Blood-brain barrier damage in patients with bacterial meningitis: Association with tumor necrosis factor-alpha but not interleukin-1 beta
39. Blood levels of cytokines in brain dead patients. Relationship with circulating hormones and acute phase reactants
40. Pathways and mechanisms for cytokine signaling of the central nervous system
41. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit