Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry

Tetrahedron Letters

Volumn 39, Issue 20, 1998, Pages 3111-3114

  Patterson, Steven ^a   Smith, Bradley D ^a   Taylor, Richard E ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR; SIALIC ACID;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME BINDING; ENZYME SPECIFICITY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION;

EID: 0032516325     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00514-0     Document Type: Article

References (17)

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2. 1. For reviews of combinatorial methods in supramolecular chemistry see: Still, W.C. Acc. Chem. Res. 1996, 29, 155. Brady, P. A.; Sanders, J. K. Chem. Soc. Rev. 1997, 26, 327-336.
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14. 2O/DMF). Note, if the PAA-1 conjugates are not purified, then their ability to bind carbohydrates is lost after 3 days even when stored frozen. Dialysis does not solve this problem, but if the polymers are filtered through Sephadex G-15, then they retain their activity for a period of about 3 weeks.
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