High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 10, 1998, Pages 1221-1224

  Berg, Thorsten ^a   Vandersteen, Anthony M ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; METAL COMPLEX; ORGANOMETALLIC COMPOUND;

ARTICLE; CATALYSIS; CELL TRANSFORMATION; CHEMICAL REACTION KINETICS; CRYSTAL STRUCTURE; HYDROLYSIS; METAL BINDING; STRUCTURE ANALYSIS; SYNTHESIS; X RAY ANALYSIS;

CARBOXYLIC ESTER HYDROLASES; CATALYSIS; KINETICS; METALS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOMETALLIC COMPOUNDS;

EID: 0032546499     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00199-1     Document Type: Article

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27. 9Br. 13. 20 μL of ligand 1 or 3a-c (10mM in MeOH) and 20 μL of metal salt (10 mM in MeOH) were mixed in the microtiter plate. After heating at 60 °C for 1h and evaporation of the solvent, metal complexes 4 were redissolved in 40 μL DMSO. 100 μL HEPES buffer (100 mM, pH 7.4) and 40 μL water were added subsequently. Solutions of the substrates in DMSO (p-nitrophenyl acetate 5: 0.2; 0.4; 0.8; 1.2; 1.6; 2 mM; N-methoxycarbonyl-L-phenylalanine-p-nitrophenylester 6: 0.2; 0.4; 0.8; 1.2 mM) were added. The absorption at 405nm was followed over 30 min.
28. w= 0.2187.
29. 15. Attempts to obtain crystals suitable for X-ray analysis of any of the metal complexes 4a-h remained unsuccesful.