17α-Dihydroequilenin increases hippocampal dendritic spine density of ovariectomized rats

Brain Research

Volumn 758, Issue 1-2, 1997, Pages 241-244

  Washburn, Scott A ^a   Lewis, Carole E ^b   Johnson, James E ^a   Voytko, Mary Lou ^a   Shively, Carol A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b DAVIDSON COLLEGE   (United States)

Author keywords

Animal model; Estrogen; Hormone replacement therapy; Memory; Menopause

Indexed keywords

CORN OIL; DIHYDROEQUILIN; ESTRADIOL; ESTRADIOL BENZOATE; KETAMINE; PLACEBO; SESAME SEED OIL; XYLAZINE; DRUG DERIVATIVE; EQUILIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; DENDRITIC SPINE; DRUG EFFECT; ESTROGEN DEFICIENCY; FEMALE; HIPPOCAMPUS; HORMONE SUBSTITUTION; INTRAPERITONEAL DRUG ADMINISTRATION; MENOPAUSAL SYNDROME; NONHUMAN; ORAL DRUG ADMINISTRATION; OVARIECTOMY; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; CELL COUNT; DENDRITE; SPRAGUE DAWLEY RAT;

ANIMALS; CELL COUNT; DENDRITES; EQUILIN; FEMALE; HIPPOCAMPUS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030610939     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00303-X     Document Type: Article

References (12)

1. D.M. Archer, G.E. Fahy, A. Viniegra-Sibal, F.D. Anderson, W. Snipes, R.G. Foldesy, Initial and steady-state pharmacokinetics of a vaginally administered formulation of progesterone, Am. J. Obstet. Gynecol. 173 (1995) 471-477.
2. C.A. Derby, A.L. Hume, M.M. Barbour, J.B. McPhillips, T.M. Lasater, R.A. Carleton, Correlates of postmenopausal estrogen use and trends through the 1980s in two southeastern New England communities, Am. J. Epidemiol. 137 (1993) 1125-1135.
3. B. Ettinger, G.D. Friedman, T. Bush, C.P. Quesenberry, Reduced mortality associated with long-term postmenopausal estrogen therapy, Obstet. Gynecol. 87 (1996) 6-12.
4. E. Gould, C. Woolley, M. Frankfurt, B.S. McEwen, Gonadal steroids regulate dendritic spine density in hippocampus pyramidal cells in adulthood, J. Neurosci. 10 (1990) 1286-1291.
5. D. Grady, S.M. Rubin, D.B. Petitti, C.S. Fox, D. Black, B. Ettinger, V.L. Ernster, S.R. Cummings, Hormone therapy to prevent disease and prolong life in postmenopausal women, Ann. Intern. Med. 117 (1992) 1016-1037.
6. A.A. Nabulsi, A.R. Folsom, A. White, W. Patsch, G. Heiss, K.K. Wu, M. Szklo, Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women, New Engl. J. Med. 328 (1993) 1069-1075.
7. A. Paganini-Hill, Oestrogen replacement therapy and Alzheimer's disease, Br. J. Obstet. Gynaecol. 103 (Suppl. 13) (1996) 80-86.
8. S.M. Phillips, B.B. Sherwin, Effects of estrogen on memory function in surgically menopausal women, Psychoneuroendocrinology 17 (1992) 485-495.
9. M.J. Stampfer, G.A. Colditz, S.E. Hankinson, D.J. Humler, The use of estrogens and progestins and the risk of breast cancer in post-menopausal women, New Engl. J. Med. 332 (1995) 1589-1593.
10. S.A. Washburn, M.R. Adams, T.B. Clarkson, S.J. Adelman, A conjugated equine estrogen with differential effects on uterine weight and plasma cholesterol in the rat, Am. J. Obstet. Gynecol. 169 (1993) 251-256.
11. S.A. Washburn, E.K. Honoré, J.M. Cline, M. Helman, J.D. Wagner, S.J. Adelman, T.B. Clarkson, Effects of 17α-dihydroequilenin sulfate on atherosclerotic male and female rhesus monkeys, Am. J. Obstet. Gynecol. 175 (1996) 341-349.
12. C. Woolley, B.S. McEwen, Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat, J. Comp. Neurol. 326 (1993) 293-306.