메뉴 건너뛰기




Volumn 14, Issue 6, 1999, Pages 1049-1056

Expression of TGF-β related Smad proteins in human epithelial skin tumors

Author keywords

Skin tumors; Smad proteins; Transforming growth factor

Indexed keywords

ACTIVIN RECEPTOR 1; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; DNA BINDING PROTEIN; OSTEOGENIC PROTEIN 1; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; SMAD6 PROTEIN; SMAD6 PROTEIN, HUMAN; SMAD7 PROTEIN; SMAD7 PROTEIN, HUMAN; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR PROTEIN;

EID: 0033142116     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (40)

References (55)
  • 1
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-β (TGF-β)
    • Roberts AB and Sporn MB: Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8: 1-9, 1993.
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 2
    • 0028359376 scopus 로고
    • Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
    • Cárcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L and Massagué J: Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol 14: 3810-3821, 1994.
    • (1994) Mol Cell Biol , vol.14 , pp. 3810-3821
    • Cárcamo, J.1    Weis, F.M.2    Ventura, F.3    Wieser, R.4    Wrana, J.L.5    Attisano, L.6    Massagué, J.7
  • 3
    • 0028059199 scopus 로고
    • Homomeric interactions between type II transforming growth factor-β receptor
    • Chen R-H and Derynck R: Homomeric interactions between type II transforming growth factor-β receptor. J Biol Chem 269: 22868-22874, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 22868-22874
    • Chen, R.-H.1    Derynck, R.2
  • 5
    • 0030816043 scopus 로고    scopus 로고
    • TGF-β signalling through the Smad pathway
    • Massagué J, Hata A and Liu F: TGF-β signalling through the Smad pathway. Trends Cell Biol 7: 187-192, 1997.
    • (1997) Trends Cell Biol , vol.7 , pp. 187-192
    • Massagué, J.1    Hata, A.2    Liu, F.3
  • 7
    • 0029786212 scopus 로고    scopus 로고
    • Receptor associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang Y, Feng X-H, Wu R-Y and Derynck R: Receptor associated Mad homologues synergize as effectors of the TGF-β response. Nature 383: 168-172, 1996.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.-H.2    Wu, R.-Y.3    Derynck, R.4
  • 11
    • 0030911104 scopus 로고    scopus 로고
    • The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
    • Kretzschmar M, Liu F, Hata A, Doody J and Massagué J: The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev 11: 984-995, 1997.
    • (1997) Genes Dev , vol.11 , pp. 984-995
    • Kretzschmar, M.1    Liu, F.2    Hata, A.3    Doody, J.4    Massagué, J.5
  • 12
    • 0031939744 scopus 로고    scopus 로고
    • Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
    • Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR and Yoneda T: Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273: 1872-1879, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 1872-1879
    • Nishimura, R.1    Kato, Y.2    Chen, D.3    Harris, S.E.4    Mundy, G.R.5    Yoneda, T.6
  • 15
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna G, Hata A, Hammati-Brivanlou A and Massagué J: Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383: 832-836, 1996.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hammati-Brivanlou, A.3    Massagué, J.4
  • 16
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interactions correlate with signalling activity and functional cooperativity of Smad3 and Smad4/DPCA
    • Wu R-Y, Zhang Y, Feng X-H and Derynck R: Heteromeric and homomeric interactions correlate with signalling activity and functional cooperativity of Smad3 and Smad4/DPCA. Mol Cell Biol 17: 2521-2528, 1997.
    • (1997) Mol Cell Biol , vol.17 , pp. 2521-2528
    • Wu, R.-Y.1    Zhang, Y.2    Feng, X.-H.3    Derynck, R.4
  • 20
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
    • Hata A, Lo RS, Wotton D, Lagna G and Massagué J: Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388: 82-87, 1997.
    • (1997) Nature , vol.388 , pp. 82-87
    • Hata, A.1    Lo, R.S.2    Wotton, D.3    Lagna, G.4    Massagué, J.5
  • 21
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus via Smad proteins
    • Heldin C-H, Miyazono K and ten Dijke P: TGF-β signalling from cell membrane to nucleus via Smad proteins. Nature 390: 465-471, 1997.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 23
    • 0025373886 scopus 로고
    • Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells
    • Ichijo H, Momose F and Miyazono K: Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells. Exp Cell Res 187: 263-269, 1990.
    • (1990) Exp Cell Res , vol.187 , pp. 263-269
    • Ichijo, H.1    Momose, F.2    Miyazono, K.3
  • 24
    • 0021961480 scopus 로고
    • The characterization of two monoclonal anti-keratin antibodies and their use in the study of epithelial disorders
    • Pulford KA, Gatter KC and Mason DY: The characterization of two monoclonal anti-keratin antibodies and their use in the study of epithelial disorders. Histopathology 9: 825-844, 1985.
    • (1985) Histopathology , vol.9 , pp. 825-844
    • Pulford, K.A.1    Gatter, K.C.2    Mason, D.Y.3
  • 25
    • 0027332995 scopus 로고
    • Cloning of a TGFβ type I receptor that forms a heterodimeric complex with the TGFβ type II receptor
    • Franzén P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin C-H and Miyazono K: Cloning of a TGFβ type I receptor that forms a heterodimeric complex with the TGFβ type II receptor. Cell 75: 681-692, 1993.
    • (1993) Cell , vol.75 , pp. 681-692
    • Franzén, P.1    Ten Dijke, P.2    Ichijo, H.3    Yamashita, H.4    Schulz, P.5    Heldin, C.-H.6    Miyazono, K.7
  • 26
    • 0027393417 scopus 로고
    • Involvement of transforming growth factor-β in the formation of fibrotic lesions in carcinoid heart disease
    • Waltenberger J, Lundin L, Öberg K, Wilander E, Miyazono K, Heldin C-H and Funa K: Involvement of transforming growth factor-β in the formation of fibrotic lesions in carcinoid heart disease. Am J Pathol 142: 71-78, 1993.
    • (1993) Am J Pathol , vol.142 , pp. 71-78
    • Waltenberger, J.1    Lundin, L.2    Öberg, K.3    Wilander, E.4    Miyazono, K.5    Heldin, C.-H.6    Funa, K.7
  • 28
    • 0029879560 scopus 로고    scopus 로고
    • Expression of transforming growth factor β isoforms and their receptors during hair growth phases in mice
    • Wollina U, Lange D, Funa K and Paus R: Expression of transforming growth factor β isoforms and their receptors during hair growth phases in mice. Histol Histopathol 11: 431-436, 1996.
    • (1996) Histol Histopathol , vol.11 , pp. 431-436
    • Wollina, U.1    Lange, D.2    Funa, K.3    Paus, R.4
  • 29
    • 0030927098 scopus 로고    scopus 로고
    • Dysregulated expression of transforming growth factor β and its type-I and type-II receptors in basal-cell carcinoma
    • Furue M, Kato M, Nakamura K, Nashiro K, Kikuchi K, Okochi H, Miyazono K and Tamaki K: Dysregulated expression of transforming growth factor β and its type-I and type-II receptors in basal-cell carcinoma. Int J Cancer 71: 505-509, 1997.
    • (1997) Int J Cancer , vol.71 , pp. 505-509
    • Furue, M.1    Kato, M.2    Nakamura, K.3    Nashiro, K.4    Kikuchi, K.5    Okochi, H.6    Miyazono, K.7    Tamaki, K.8
  • 30
  • 31
    • 0032531281 scopus 로고    scopus 로고
    • TGF-β receptor expression on human keratinocytes: A 150 kDa GPI-anchored TGF-β1 binding protein forms a heteromeric complex with type I and type II receptors
    • Tam BY, Germain L and Philip A: TGF-β receptor expression on human keratinocytes: a 150 kDa GPI-anchored TGF-β1 binding protein forms a heteromeric complex with type I and type II receptors. J Cell Biochem 70: 573-586, 1998.
    • (1998) J Cell Biochem , vol.70 , pp. 573-586
    • Tam, B.Y.1    Germain, L.2    Philip, A.3
  • 32
    • 0032500010 scopus 로고    scopus 로고
    • Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
    • Amendt C, Schirmacher P, Weber H and Blessing M: Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 17: 25-34, 1998.
    • (1998) Oncogene , vol.17 , pp. 25-34
    • Amendt, C.1    Schirmacher, P.2    Weber, H.3    Blessing, M.4
  • 37
    • 0029806078 scopus 로고    scopus 로고
    • Regulation of transforming growth factor β- And activin-induced transcription by mammalian MAD proteins
    • Chen Y, Lebrun JJ and Vale W: Regulation of transforming growth factor β- and activin-induced transcription by mammalian MAD proteins. Proc Natl Acad Sci USA 93: 12992-12997, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12992-12997
    • Chen, Y.1    Lebrun, J.J.2    Vale, W.3
  • 38
    • 0031916811 scopus 로고    scopus 로고
    • Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-β
    • Woo KM, Lee G, Kook JK and Min BM: Conversion of normal human oral keratinocytes to tumorigenic cells is associated with the acquisition of resistance to TGF-β. Int J Oncol 12: 833-839, 1998.
    • (1998) Int J Oncol , vol.12 , pp. 833-839
    • Woo, K.M.1    Lee, G.2    Kook, J.K.3    Min, B.M.4
  • 39
    • 0025021804 scopus 로고
    • Induction and autocrine-receptor binding of transforming growth factor-β2 during terminal differentiation of primary mouse keratinocytes
    • Glick AB, Danielpour D, Morgan D, Sporn MB and Yuspa SH: Induction and autocrine-receptor binding of transforming growth factor-β2 during terminal differentiation of primary mouse keratinocytes. Mol Endocrinol 4: 46-52, 1990.
    • (1990) Mol Endocrinol , vol.4 , pp. 46-52
    • Glick, A.B.1    Danielpour, D.2    Morgan, D.3    Sporn, M.B.4    Yuspa, S.H.5
  • 40
    • 0026682527 scopus 로고
    • Skin distribution and differential expression of transforming growth factor β1 and β2
    • Falanga V, Gerhardt CO, Dasch JR, Takehara K and Ksander GA: Skin distribution and differential expression of transforming growth factor β1 and β2. J Dermatol Sci 3: 131-136, 1992.
    • (1992) J Dermatol Sci , vol.3 , pp. 131-136
    • Falanga, V.1    Gerhardt, C.O.2    Dasch, J.R.3    Takehara, K.4    Ksander, G.A.5
  • 41
    • 0027333290 scopus 로고
    • TGF-βs and TGF-β type-II receptor in the human epidermis: Differential expression in acute and chronic wounds
    • Schmid P, Cox D, Bilbe G, McMaster G, Morrison C, Stahelin H, Luscher N and Seiler W: TGF-βs and TGF-β type-II receptor in the human epidermis: differential expression in acute and chronic wounds. J Pathol 171: 191-197, 1993.
    • (1993) J Pathol , vol.171 , pp. 191-197
    • Schmid, P.1    Cox, D.2    Bilbe, G.3    McMaster, G.4    Morrison, C.5    Stahelin, H.6    Luscher, N.7    Seiler, W.8
  • 42
    • 0028351248 scopus 로고
    • Elevated expression of type-VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-β
    • Rudnicka L, Varga J, Christiano AM, Iozzo RV, Jimenez SA and Uitto J: Elevated expression of type-VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-β. J Clin Invest 93: 1709-1715, 1994.
    • (1994) J Clin Invest , vol.93 , pp. 1709-1715
    • Rudnicka, L.1    Varga, J.2    Christiano, A.M.3    Iozzo, R.V.4    Jimenez, S.A.5    Uitto, J.6
  • 43
    • 0029070821 scopus 로고
    • A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-β and insulin-like growth factor binding protein-6, in a calcium- and cell-densitity-dependent manner
    • Kato M, Ihizaki A, Hellmann U, Wernstedt C, Kyogoku M, Miyazano K, Heldin H-C and Funa K: A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-β and insulin-like growth factor binding protein-6, in a calcium- and cell-densitity-dependent manner. J Biol Chem 270: 12373-12379, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 12373-12379
    • Kato, M.1    Ihizaki, A.2    Hellmann, U.3    Wernstedt, C.4    Kyogoku, M.5    Miyazano, K.6    Heldin, H.-C.7    Funa, K.8
  • 44
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor β-induced phosphorylation of Samd3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA and Lodish HF: Transforming growth factor β-induced phosphorylation of Samd3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci USA 94: 10669-10674, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.N.3    Karam, E.4    Weinberg, R.A.5    Lodish, H.F.6
  • 45
    • 0031317650 scopus 로고    scopus 로고
    • Cell cycle regulation and abnormalities in epidermal tumors
    • Heenen M: Cell cycle regulation and abnormalities in epidermal tumors. Ann Dermatol Venereol 124: 452-456, 1997.
    • (1997) Ann Dermatol Venereol , vol.124 , pp. 452-456
    • Heenen, M.1
  • 46
    • 0032474586 scopus 로고    scopus 로고
    • TGF-β effects on proliferation of rat intestinal cells are due to inhibition of cyclin D1 expression
    • Ko TC, Yu W, Sakai T, Sheng H, Shao J, Beauchamp RD and Thompson EA: TGF-β effects on proliferation of rat intestinal cells are due to inhibition of cyclin D1 expression. Oncogene 16: 3445-3454, 1998.
    • (1998) Oncogene , vol.16 , pp. 3445-3454
    • Ko, T.C.1    Yu, W.2    Sakai, T.3    Sheng, H.4    Shao, J.5    Beauchamp, R.D.6    Thompson, E.A.7
  • 48
    • 0030296921 scopus 로고    scopus 로고
    • Local delivery of TGFβ2 can substitute for placode epithelium to induce mesenchymal condensation during skin appendage morphogenesis
    • Ting-Berreth SA and Chuong CM: Local delivery of TGFβ2 can substitute for placode epithelium to induce mesenchymal condensation during skin appendage morphogenesis. Dev Biol 179: 347-359, 1996.
    • (1996) Dev Biol , vol.179 , pp. 347-359
    • Ting-Berreth, S.A.1    Chuong, C.M.2
  • 49
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
    • Goodrich LV, Johnson RL, Milenkovic L, McMahon JA and Scott MP: Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev 10: 301-312, 1996.
    • (1996) Genes Dev , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 52
    • 0029841366 scopus 로고    scopus 로고
    • Mutations in the human homologue of Drosophila patched (PCTH) in basal cell carcinomas and the Gorlin syndrome: Different in vivo mechanisms of PCTH activation
    • Unden AB, Holmber E, Lundh-Rozell B, Stahle-Backdahl M, Zaphiropoulos PG, Toftgard R and Vorechovsky I: Mutations in the human homologue of Drosophila patched (PCTH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PCTH activation. Cancer Res 56: 4562-4565, 1996.
    • (1996) Cancer Res , vol.56 , pp. 4562-4565
    • Unden, A.B.1    Holmber, E.2    Lundh-Rozell, B.3    Stahle-Backdahl, M.4    Zaphiropoulos, P.G.5    Toftgard, R.6    Vorechovsky, I.7
  • 54
    • 0030297553 scopus 로고    scopus 로고
    • Dual role for patched in sequestering and transducing Hegdehog
    • Chen Y and Struhl G: Dual role for patched in sequestering and transducing Hegdehog. Cell 87: 553-563, 1996.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 55
    • 1842330252 scopus 로고    scopus 로고
    • Trichoepitheliomas contain somatic mutations in the overexpressed PTCH-gene: Support for a gatekeeper mechanism in tumorigenesis
    • Vorechovsky I, Unden AB, Sandstedt B, Toftgart R and Stahle-Bachdahl M: Trichoepitheliomas contain somatic mutations in the overexpressed PTCH-gene: support for a gatekeeper mechanism in tumorigenesis. Cancer Res 57: 4677-4681, 1997.
    • (1997) Cancer Res , vol.57 , pp. 4677-4681
    • Vorechovsky, I.1    Unden, A.B.2    Sandstedt, B.3    Toftgart, R.4    Stahle-Bachdahl, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.