메뉴 건너뛰기




Volumn 2, Issue 1, 1999, Pages 43-50

Molecular Pathogenesis of Acromegaly

Author keywords

Acromegaly; Oncogenes; Pituitary adenomas; Tumor suppressor genes

Indexed keywords

HYPOTHALAMUS HORMONE;

EID: 0033139646     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009917920589     Document Type: Article
Times cited : (10)

References (84)
  • 1
    • 0025700486 scopus 로고
    • Acromegaly
    • Melmed S. Acromegaly N Engl J Med 1990;322:966-977.
    • (1990) N Engl J Med , vol.322 , pp. 966-977
    • Melmed, S.1
  • 4
    • 0031158860 scopus 로고    scopus 로고
    • Genetic basis of endocrine disease: Pituitary tumor pathogenesis
    • Shimon I, Melmed S. Genetic basis of endocrine disease: Pituitary tumor pathogenesis. J Clin Endocrinol Metab 1997;82:1675-1681.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1675-1681
    • Shimon, I.1    Melmed, S.2
  • 6
    • 0026763324 scopus 로고
    • Growth hormone-releasing hormone transcripts in human pituitary adenomas
    • Levy A, Lightman SL. Growth hormone-releasing hormone transcripts in human pituitary adenomas. J Clin Endocrinol Metab 1992;74:1474-1476.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1474-1476
    • Levy, A.1    Lightman, S.L.2
  • 7
    • 0030884406 scopus 로고    scopus 로고
    • Overexpression of the growth hormone-releasing hormone gene in acromegaly-associated pituitary tumors. An event associated with neoplastic progression and aggressive behaviour
    • Thapar K, Kovacs K, Stefaneanu L, et al. Overexpression of the growth hormone-releasing hormone gene in acromegaly-associated pituitary tumors. An event associated with neoplastic progression and aggressive behaviour. Am J Pathol 1997;151:769-784.
    • (1997) Am J Pathol , vol.151 , pp. 769-784
    • Thapar, K.1    Kovacs, K.2    Stefaneanu, L.3
  • 8
    • 0025396781 scopus 로고
    • Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone
    • Asa SL, Kovacs K, Stefaneanu L, et al. Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. Proc Soc Exp Biol Med 1990;193:232-235.
    • (1990) Proc Soc Exp Biol Med , vol.193 , pp. 232-235
    • Asa, S.L.1    Kovacs, K.2    Stefaneanu, L.3
  • 9
    • 0028849727 scopus 로고
    • Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas
    • Hasimoto K, Koga M, Motomura T, et al. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. J Clin Endocrinol Metab 1995;80:2933-2939.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2933-2939
    • Hasimoto, K.1    Koga, M.2    Motomura, T.3
  • 10
    • 0027529914 scopus 로고
    • Presence and characterization of the somatostatin precursor in normal human pituitaries and in growth hormone secreting adenomas
    • Levy L, Bourdais J, Mouhieddine OE, et al. Presence and characterization of the somatostatin precursor in normal human pituitaries and in growth hormone secreting adenomas. J Clin Endocrinol Metab 1993;76:85-90.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 85-90
    • Levy, L.1    Bourdais, J.2    Mouhieddine, O.E.3
  • 12
    • 0025313163 scopus 로고
    • Clinically non-functioning pituitary tumors are monoclonal in origin
    • Alexander JM, Biller BMK, Bikkal H, et al. Clinically non-functioning pituitary tumors are monoclonal in origin. J Clin Invest 1990;86:336-340.
    • (1990) J Clin Invest , vol.86 , pp. 336-340
    • Alexander, J.M.1    Biller, B.M.K.2    Bikkal, H.3
  • 14
    • 0023720145 scopus 로고
    • Human fetal adenohypophysis. Electron microscopic and ultrastructural immunocytochemical analysis
    • Asa SL, Kovacs K, Horvath E. et al. Human fetal adenohypophysis. Electron microscopic and ultrastructural immunocytochemical analysis. Neuroendocrinology 1988;48:423-431.
    • (1988) Neuroendocrinology , vol.48 , pp. 423-431
    • Asa, S.L.1    Kovacs, K.2    Horvath, E.3
  • 15
    • 0025941135 scopus 로고
    • Mammosomatotrophs: Presence and functions in normal and neoplastic pituitary tissue
    • Frawley LS, Boockfor FR. Mammosomatotrophs: Presence and functions in normal and neoplastic pituitary tissue. Endoer Rev 1991;12:337-355.
    • (1991) Endoer Rev , vol.12 , pp. 337-355
    • Frawley, L.S.1    Boockfor, F.R.2
  • 16
    • 0024519749 scopus 로고
    • Human growth hormone and prolactin secreting pituitary adenomas analyzed by in situ hybridization
    • Lloyd RV, Cano M, Chandler WF, Barkan AL, Horvath E, Kovacs K. Human growth hormone and prolactin secreting pituitary adenomas analyzed by in situ hybridization. Am J Pathol 1989;134:605-613.
    • (1989) Am J Pathol , vol.134 , pp. 605-613
    • Lloyd, R.V.1    Cano, M.2    Chandler, W.F.3    Barkan, A.L.4    Horvath, E.5    Kovacs, K.6
  • 17
    • 0000719018 scopus 로고
    • The adenohypophysis
    • Kovacs K, Asa SL, eds. Boston: Blackwell Scientific
    • Horvath E, Kovacs K. The adenohypophysis. In Kovacs K, Asa SL, eds. Functional Endocrine Pathology. Boston: Blackwell Scientific, 1991;245-281.
    • (1991) Functional Endocrine Pathology , pp. 245-281
    • Horvath, E.1    Kovacs, K.2
  • 19
    • 0023868530 scopus 로고
    • Detection of a potential progenitor cell in the human fetal pituitary that secretes both growth hormone and prolactin
    • Mulchahey JJ, Jaffe RB. Detection of a potential progenitor cell in the human fetal pituitary that secretes both growth hormone and prolactin. J Clin Endocrinol Metab 1988;66: 24-32.
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 24-32
    • Mulchahey, J.J.1    Jaffe, R.B.2
  • 20
    • 0019523098 scopus 로고
    • Acidophil stem cell adenoma of the human pituitary: Clinicopathologic analysis of 15 cases
    • Horvath E, Kovacs K, Singer W, et al. Acidophil stem cell adenoma of the human pituitary: Clinicopathologic analysis of 15 cases. Cancer 1981;47:761-771.
    • (1981) Cancer , vol.47 , pp. 761-771
    • Horvath, E.1    Kovacs, K.2    Singer, W.3
  • 21
    • 0027258279 scopus 로고
    • Growth hormone (GH) and prolactin (PRL) gene expression and immunoreactivity in GH- and PRL-producing human pituitary adenomas
    • Li J, Stefaneanu L, Kovacs K, Horvath E, Smyth HS. Growth hormone (GH) and prolactin (PRL) gene expression and immunoreactivity in GH- and PRL-producing human pituitary adenomas. Virchows Arch A Pathol Anat Histopathol 1993;422:193-201.
    • (1993) Virchows Arch a Pathol Anat Histopathol , vol.422 , pp. 193-201
    • Li, J.1    Stefaneanu, L.2    Kovacs, K.3    Horvath, E.4    Smyth, H.S.5
  • 22
    • 0022622050 scopus 로고
    • Endocrine, biochemical, and morphological studies of a pituitary adenoma secreting growth hormone, thyrotropin (TSH), and alpha-subunit: Evidence for secretion of TSH with increased bioavailability
    • Beck-Peccoz P, Piscitelli G, Amr S, et al. Endocrine, biochemical, and morphological studies of a pituitary adenoma secreting growth hormone, thyrotropin (TSH), and alpha-subunit: Evidence for secretion of TSH with increased bioavailability. J Clin Endocrinol Metab 1986;62:704-711.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 704-711
    • Beck-Peccoz, P.1    Piscitelli, G.2    Amr, S.3
  • 23
    • 0028244872 scopus 로고
    • Colocalization of growth hormone (GH) and glycoprotein subunit alpha in GH-producing pituitary adenomas in acromegalic patients
    • Furuhata S, Kameya T, Tsuruta T, Naritaka H, Toya S. Colocalization of growth hormone (GH) and glycoprotein subunit alpha in GH-producing pituitary adenomas in acromegalic patients. Acta Neuropathol 1994;87:568-571.
    • (1994) Acta Neuropathol , vol.87 , pp. 568-571
    • Furuhata, S.1    Kameya, T.2    Tsuruta, T.3    Naritaka, H.4    Toya, S.5
  • 24
    • 0028009054 scopus 로고
    • Recurrent plurihormonal bimorphous pituitary adenoma producing growth hormone, thyrotropin, and prolactin
    • Felix I, Asa SL, Kovacs K, Horvath E, Smyth HS. Recurrent plurihormonal bimorphous pituitary adenoma producing growth hormone, thyrotropin, and prolactin. Arch Pathol Lab Med 1994;118:66-70.
    • (1994) Arch Pathol Lab Med , vol.118 , pp. 66-70
    • Felix, I.1    Asa, S.L.2    Kovacs, K.3    Horvath, E.4    Smyth, H.S.5
  • 26
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the a chain of GS and stimulate adenylyl cyclase in human pituitary tumours
    • Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the a chain of GS and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989;340:692-696.
    • (1989) Nature , vol.340 , pp. 692-696
    • Landis, C.A.1    Masters, S.B.2    Spada, A.3    Pace, A.M.4    Bourne, H.R.5    Vallar, L.6
  • 27
    • 0025127424 scopus 로고
    • Two G protein oncogenes in human endocrine tumors
    • Lyons J, Landis CA, Harsh G, et al. Two G protein oncogenes in human endocrine tumors. Science 1990;249:655-659.
    • (1990) Science , vol.249 , pp. 655-659
    • Lyons, J.1    Landis, C.A.2    Harsh, G.3
  • 28
    • 0026969324 scopus 로고
    • G-protein oncogenes in acromegaly
    • Spada A, Vallar L. G-protein oncogenes in acromegaly. Horm Res 1992;38:90-93.
    • (1992) Horm Res , vol.38 , pp. 90-93
    • Spada, A.1    Vallar, L.2
  • 29
    • 0027519698 scopus 로고
    • sα in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues
    • sα in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues. Acta Endocrinol 1993;129: 301-306.
    • (1993) Acta Endocrinol , vol.129 , pp. 301-306
    • Hosoi, E.1    Yokogoshi, Y.2    Hosoi, E.3
  • 30
    • 0029882954 scopus 로고    scopus 로고
    • Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients
    • Yang I, Park S, Ryu M, et al. Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. Eur J Endocrinol 1996;134:720-726.
    • (1996) Eur J Endocrinol , vol.134 , pp. 720-726
    • Yang, I.1    Park, S.2    Ryu, M.3
  • 31
    • 0025695763 scopus 로고
    • Clinical, biochemical and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase
    • Spada A, Arosio M, Cochicchio D, et al. Clinical, biochemical and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 1990;71:1421-1426.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1421-1426
    • Spada, A.1    Arosio, M.2    Cochicchio, D.3
  • 32
    • 0027202237 scopus 로고
    • Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors
    • Adams EF, Brockmeier S, Friedmann E, Roth M, Buchfelder M, Fahlbusch R. Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors. Neurosurgery 1993;33:198-203.
    • (1993) Neurosurgery , vol.33 , pp. 198-203
    • Adams, E.F.1    Brockmeier, S.2    Friedmann, E.3    Roth, M.4    Buchfelder, M.5    Fahlbusch, R.6
  • 33
    • 0031724241 scopus 로고    scopus 로고
    • Prognostic and therapeutic consequences of GS alpha mutations in somatotroph adenomas
    • Barlier A, Gunz G, Zamora AJ, et al. Prognostic and therapeutic consequences of GS alpha mutations in somatotroph adenomas. J Clin Endocrinol Metab 1998;83:1604-1610.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1604-1610
    • Barlier, A.1    Gunz, G.2    Zamora, A.J.3
  • 34
    • 0031754596 scopus 로고    scopus 로고
    • Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas
    • Lania A, Persani 1, Ballare E, Mantovani S, Losa M, Spada A. Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas. J Clin Endocrinol Metab 1998;83: 1624-1628.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1624-1628
    • Lania, A.1    Persani I2    Ballare, E.3    Mantovani, S.4    Losa, M.5    Spada, A.6
  • 35
    • 0025853062 scopus 로고
    • Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant
    • Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 1991;350:622-624.
    • (1991) Nature , vol.350 , pp. 622-624
    • Struthers, R.S.1    Vale, W.W.2    Arias, C.3    Sawchenko, P.E.4    Montminy, M.R.5
  • 36
    • 0029017174 scopus 로고
    • The cyclic adenosine 3′,5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas
    • Bertherat J, Chanson P, Montminy M. The cyclic adenosine 3′,5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol 1995;9:777-783.
    • (1995) Mol Endocrinol , vol.9 , pp. 777-783
    • Bertherat, J.1    Chanson, P.2    Montminy, M.3
  • 39
    • 0030910680 scopus 로고    scopus 로고
    • Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    • Pei L, Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 1997;11:433-441.
    • (1997) Mol Endocrinol , vol.11 , pp. 433-441
    • Pei, L.1    Melmed, S.2
  • 40
    • 0032894720 scopus 로고    scopus 로고
    • Stucture, expression, and function of human pituitary tumor transforming gene (PTTG)
    • Zhang X, Horwitz GA, Prezant TR, et al. Stucture, expression, and function of human pituitary tumor transforming gene (PTTG). Mol Endocrinol 1999;13:156-166.
    • (1999) Mol Endocrinol , vol.13 , pp. 156-166
    • Zhang, X.1    Horwitz, G.A.2    Prezant, T.R.3
  • 41
    • 0030921089 scopus 로고    scopus 로고
    • New opportunities for uncovering the molecular basis of cancer
    • Strausberg RL, Dahl CA, Klausner RD. New opportunities for uncovering the molecular basis of cancer. Nature Gen 1997;15(Special No.):415-416.
    • (1997) Nature Gen , vol.15 , Issue.SPECIAL NO. , pp. 415-416
    • Strausberg, R.L.1    Dahl, C.A.2    Klausner, R.D.3
  • 42
    • 0033018670 scopus 로고    scopus 로고
    • Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas: Marker for functional tumor invasiveness
    • Zhang X, Horwitz GA, Heaney A, Prezant TR, Melmed S. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas: Marker for functional tumor invasiveness. J Clin Endocrinol Metab 1999;84:761-767.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 761-767
    • Zhang, X.1    Horwitz, G.A.2    Heaney, A.3    Prezant, T.R.4    Melmed, S.5
  • 43
    • 0024982163 scopus 로고
    • Role of surgery in management of pituitary tumors
    • Wilson CB. Role of surgery in management of pituitary tumors. Neurosurg Clin N Am 1990;1:139-159.
    • (1990) Neurosurg Clin N Am , vol.1 , pp. 139-159
    • Wilson, C.B.1
  • 44
    • 0025323366 scopus 로고
    • Role of the retinoblastoma gene in the initiation and progression of human cancer
    • Benedict WF, Xu H Hu S, Takahashi R. Role of the retinoblastoma gene in the initiation and progression of human cancer. J Clin Invest 1990;5:988-993.
    • (1990) J Clin Invest , vol.5 , pp. 988-993
    • Benedict, W.F.1    Xu, H.2    Hu, S.3    Takahashi, R.4
  • 46
    • 0028961786 scopus 로고
    • Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: Evidence for a chromosome 13 tumor suppressor gene other than RB
    • Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, and Prager D. Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: Evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res 1995;55:1613-1616.
    • (1995) Cancer Res , vol.55 , pp. 1613-1616
    • Pei, L.1    Melmed, S.2    Scheithauer, B.3    Kovacs, K.4    Benedict, W.F.5    Prager, D.6
  • 47
    • 0030057813 scopus 로고    scopus 로고
    • Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary
    • Woloschak M, Yu A, Xiao J, Post KD. Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary. Int J Cancer 1996;67:16-19.
    • (1996) Int J Cancer , vol.67 , pp. 16-19
    • Woloschak, M.1    Yu, A.2    Xiao, J.3    Post, K.D.4
  • 49
    • 84995826614 scopus 로고
    • Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus
    • Zhu J, Leon SP, Beggs AH, Busque L, Gilliland DG, Black PM. Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus. J Clin Endocrinol Metab 1994;78:922-927.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 922-927
    • Zhu, J.1    Leon, S.P.2    Beggs, A.H.3    Busque, L.4    Gilliland, D.G.5    Black, P.M.6
  • 50
    • 0028340080 scopus 로고
    • Loss of heterozygosity at the retinoblastoma gene locus in human pituitary tumors
    • Woloschak M, Roberts JL, Post KD. Loss of heterozygosity at the retinoblastoma gene locus in human pituitary tumors. Cancer 1994;74:693-696.
    • (1994) Cancer , vol.74 , pp. 693-696
    • Woloschak, M.1    Roberts, J.L.2    Post, K.D.3
  • 51
    • 0029818901 scopus 로고    scopus 로고
    • Loss of heterozygosity studies at the retinoblastoma and breast cancer susceptability (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumours
    • Pearce SH, Trump D, Wooding C, Sheppard MN, Clayton RN, Thakker RV. Loss of heterozygosity studies at the retinoblastoma and breast cancer susceptability (BRCA2) loci in pituitary, parathyroid, pancreatic and carcinoid tumours. Clin Endocrinol 1996;45:195-200.
    • (1996) Clin Endocrinol , vol.45 , pp. 195-200
    • Pearce, S.H.1    Trump, D.2    Wooding, C.3    Sheppard, M.N.4    Clayton, R.N.5    Thakker, R.V.6
  • 52
    • 0027181790 scopus 로고
    • Molecular screening of pituitary adenomas for gene mutations and rearrangements
    • Herman V, Drazin NZ, Gonsky R, Melmed S. Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab 1993;77:50-55.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 50-55
    • Herman, V.1    Drazin, N.Z.2    Gonsky, R.3    Melmed, S.4
  • 53
    • 0028592564 scopus 로고
    • p53 gene mutations in pituitary adenomas: Rare events
    • Levy A, Hall 1, Yeudall WA, Lightman SL. p53 gene mutations in pituitary adenomas: Rare events. Clin Endocrinol 1994;41:809-814.
    • (1994) Clin Endocrinol , vol.41 , pp. 809-814
    • Levy, A.1    Hall I2    Yeudall, W.A.3    Lightman, S.L.4
  • 54
    • 0031054097 scopus 로고    scopus 로고
    • Pituitary carcinoma: A clinicopathologic study of 15 cases
    • Pernicone, PJ, Scheithauer BW, Sebo TJ, et al. Pituitary carcinoma: A clinicopathologic study of 15 cases. Cancer 1997;79:804-812.
    • (1997) Cancer , vol.79 , pp. 804-812
    • Pernicone, P.J.1    Scheithauer, B.W.2    Sebo, T.J.3
  • 55
    • 0029917618 scopus 로고    scopus 로고
    • p53 expression in pituitary adenomas and carcinomas: Correlation with invasiveness and tumor growth fractions
    • Thapar K, Scheithauer BW, Kovacs K, Pernicone PJ, Laws ER Jr. p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions. Neurosurgery 1996;38:763-770.
    • (1996) Neurosurgery , vol.38 , pp. 763-770
    • Thapar, K.1    Scheithauer, B.W.2    Kovacs, K.3    Pernicone, P.J.4    Laws Jr., E.R.5
  • 56
    • 0030812331 scopus 로고    scopus 로고
    • Monoallellelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M, Bonnet H, Yang A, et al. Monoallellelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-819.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1    Bonnet, H.2    Yang, A.3
  • 57
    • 0032143910 scopus 로고    scopus 로고
    • Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions
    • Mai M, Huang H, Reed C, et al. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. Genomics 1998;51:359-363.
    • (1998) Genomics , vol.51 , pp. 359-363
    • Mai, M.1    Huang, H.2    Reed, C.3
  • 58
    • 0030785767 scopus 로고    scopus 로고
    • Localisation of a gene causing endocrine neoplasia to a 4 cM region on chromosome 1p35-p36
    • Williamson C, Pannett AA, Pang JT, et al. Localisation of a gene causing endocrine neoplasia to a 4 cM region on chromosome 1p35-p36. J Med Genet 1997;34:617-619.
    • (1997) J Med Genet , vol.34 , pp. 617-619
    • Williamson, C.1    Pannett, A.A.2    Pang, J.T.3
  • 60
    • 0030741842 scopus 로고    scopus 로고
    • Chromosome 9p deletions in invasive and non-invasive nonfunctional pituitary adenomas: The deleted region involves markers outside of the MTS1 and MTS2 genes
    • Farrell WE, Simpson DJ, Bicknell JE, Talbot AJ, Bates AS, Clayton RN. Chromosome 9p deletions in invasive and non-invasive nonfunctional pituitary adenomas: The deleted region involves markers outside of the MTS1 and MTS2 genes. Cancer Res 1997;57:2703-2909.
    • (1997) Cancer Res , vol.57 , pp. 2703-2909
    • Farrell, W.E.1    Simpson, D.J.2    Bicknell, J.E.3    Talbot, A.J.4    Bates, A.S.5    Clayton, R.N.6
  • 61
    • 0030614560 scopus 로고    scopus 로고
    • Infrequent mutations of p16INK4a and P15INK4b genes in human pituitary adenomas
    • Yoshimoto K, Tanaka C, Yamada S, et al. Infrequent mutations of p16INK4a and P15INK4b genes in human pituitary adenomas. Eur J Endocrinol 1997;136:74-80.
    • (1997) Eur J Endocrinol , vol.136 , pp. 74-80
    • Yoshimoto, K.1    Tanaka, C.2    Yamada, S.3
  • 62
    • 0030801289 scopus 로고    scopus 로고
    • Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation
    • Woloschak M, Yu A, Post KD. Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcin 1997;19:221-224.
    • (1997) Mol Carcin , vol.19 , pp. 221-224
    • Woloschak, M.1    Yu, A.2    Post, K.D.3
  • 63
    • 0030010591 scopus 로고    scopus 로고
    • Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996; 85:707-720.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nokayama, K.1    Usguda, N.2    Shirane, M.3
  • 66
    • 0030614492 scopus 로고    scopus 로고
    • Aberrant p27kip1 expression in endocrine and other tumors
    • Lloyd RV, Jin L, Qian X, Kulig E. Aberrant p27kip1 expression in endocrine and other tumors. Am J Pathol 1997; 150:401-407.
    • (1997) Am J Pathol , vol.150 , pp. 401-407
    • Lloyd, R.V.1    Jin, L.2    Qian, X.3    Kulig, E.4
  • 67
    • 15144350828 scopus 로고    scopus 로고
    • Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours
    • Dahia PL, Aguiar RC, Honegger J, et al. Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours. Oncogene 1998;16:69-76.
    • (1998) Oncogene , vol.16 , pp. 69-76
    • Dahia, P.L.1    Aguiar, R.C.2    Honegger, J.3
  • 68
    • 0030611592 scopus 로고    scopus 로고
    • Infrequent mutations of p27Kip1 gene and trisomy 12 in a subset of human pituitary adenomas
    • Tanaka C, Yoshimoto K, Yang, et al. Infrequent mutations of p27Kip1 gene and trisomy 12 in a subset of human pituitary adenomas. J Clin Endocrinol Metab 1997;82:3141-3147.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3141-3147
    • Tanaka, C.1    Yoshimoto, K.2    Yang3
  • 70
    • 0027932974 scopus 로고
    • McCune-Albright syndrome and acromegaly: Clinical studies and responses to treatment in five cases
    • Chanson P, Kib A, Visot A, Derome PJ. McCune-Albright syndrome and acromegaly: clinical studies and responses to treatment in five cases. Eur J Endocrinol 1994;131:229-234.
    • (1994) Eur J Endocrinol , vol.131 , pp. 229-234
    • Chanson, P.1    Kib, A.2    Visot, A.3    Derome, P.J.4
  • 71
    • 0023828816 scopus 로고
    • Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma
    • Larsson C, Skogseid B, Oberg K, Nakamura Y, Nordenskjold M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 1988; 322:85-87.
    • (1988) Nature , vol.322 , pp. 85-87
    • Larsson, C.1    Skogseid, B.2    Oberg, K.3    Nakamura, Y.4    Nordenskjold, M.5
  • 72
    • 0026599178 scopus 로고
    • Fine mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN1)
    • Fujimori M, Wells SA, Nakamura Y. Fine mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). Am J Hum Genet 1992;55:399-403.
    • (1992) Am J Hum Genet , vol.55 , pp. 399-403
    • Fujimori, M.1    Wells, S.A.2    Nakamura, Y.3
  • 73
    • 0030963446 scopus 로고    scopus 로고
    • Positional cloning of the gene for multiple endocrine neoplasia-type 1
    • Chandrasekharappak SC, Guru SC Manickam P, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997;276:404-406.
    • (1997) Science , vol.276 , pp. 404-406
    • Chandrasekharappak, S.C.1    Guru, S.C.2    Manickam, P.3
  • 74
    • 0032539632 scopus 로고    scopus 로고
    • Menin, the product of the MEN1 gene, is a nuclear protein
    • Guru SC, Godsmith PK, Burns AL, et al. Menin, the product of the MEN1 gene, is a nuclear protein Proc Natl Acad Sci 1998;95:1630-1634.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 1630-1634
    • Guru, S.C.1    Godsmith, P.K.2    Burns, A.L.3
  • 75
    • 15144342434 scopus 로고    scopus 로고
    • Mutations of the MEN1 tumor suppressor gene in pituitary tumors
    • Zhuang Z, Ezzat SZ, Vortmeyer AO, et al. Mutations of the MEN1 tumor suppressor gene in pituitary tumors. Cancer Res 1997;57:5446-5451.
    • (1997) Cancer Res , vol.57 , pp. 5446-5451
    • Zhuang, Z.1    Ezzat, S.Z.2    Vortmeyer, A.O.3
  • 76
    • 0031732536 scopus 로고    scopus 로고
    • Molecular characterization of the Men1 tumor suppressor gene in sporadic pituitary tumors
    • Prezant T, Levine J, Melmed S. Molecular characterization of the Men1 tumor suppressor gene in sporadic pituitary tumors. J Clin Endocrinol Metab 1998;83:1388-1391.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1388-1391
    • Prezant, T.1    Levine, J.2    Melmed, S.3
  • 77
    • 0031726519 scopus 로고    scopus 로고
    • Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of MEN1 gene in sporadic pituitary adenomas
    • Tanaka C, Kimura T, Yang P, et al. Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of MEN1 gene in sporadic pituitary adenomas. J Clin Endocrinol Metab 1998;83:2631-2634.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2631-2634
    • Tanaka, C.1    Kimura, T.2    Yang, P.3
  • 78
    • 0028886972 scopus 로고
    • Familial acromegaly: A specific clinical entity - Further evidence from the genetic study of a three-generation family
    • Benlian P, Giraud S, Lahlou N, et al. Familial acromegaly: A specific clinical entity - further evidence from the genetic study of a three-generation family. Eur J Endocrinol 1995; 133:451-456.
    • (1995) Eur J Endocrinol , vol.133 , pp. 451-456
    • Benlian, P.1    Giraud, S.2    Lahlou, N.3
  • 79
    • 0031023171 scopus 로고    scopus 로고
    • Inactivation of the tumor suppressor gene on 11q13 in brothers with familial acrogigantism without multiple endocrine neoplasia type 1
    • Yamada S, Yoshimoto K, Sano T, et al. Inactivation of the tumor suppressor gene on 11q13 in brothers with familial acrogigantism without multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 1997;82:239-242.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 239-242
    • Yamada, S.1    Yoshimoto, K.2    Sano, T.3
  • 80
    • 0031760161 scopus 로고    scopus 로고
    • Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenomia in contrast to MEN1 in Japanese
    • Tanaka C, Katsuhiko Y, Shozo Y, et al. Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenomia in contrast to MEN1 in Japanese. J Clin Endocrinol Metab 1998;83: 960-965.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 960-965
    • Tanaka, C.1    Katsuhiko, Y.2    Shozo, Y.3
  • 81
    • 14444288521 scopus 로고    scopus 로고
    • Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism
    • Teh BT, Rarnebo F, Phelan C, et al. Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism. J Clin Endocrinol Metab 1998;83:2621-2626.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2621-2626
    • Teh, B.T.1    Rarnebo, F.2    Phelan, C.3
  • 82
    • 0022446058 scopus 로고
    • Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity
    • Carney JA, Hrudka LS, Beauchamp GD, Gordon H. Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity. Mayo Clin Proc 1986; 61:165-172.
    • (1986) Mayo Clin Proc , vol.61 , pp. 165-172
    • Carney, J.A.1    Hrudka, L.S.2    Beauchamp, G.D.3    Gordon, H.4
  • 83
    • 0030049026 scopus 로고    scopus 로고
    • Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2
    • Stratakis CA, Carney JA, Lin JP, et al. Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J Clin Invest 1996;97:699-705.
    • (1996) J Clin Invest , vol.97 , pp. 699-705
    • Stratakis, C.A.1    Carney, J.A.2    Lin, J.P.3
  • 84
    • 0029838757 scopus 로고    scopus 로고
    • Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex)
    • Stratakis CA, Jenkins RB, Pras E, et al. cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation and endocrine overactivity (Carney complex). J Clin Endocrinol Metab 1996;81:3607-3614.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3607-3614
    • Stratakis, C.A.1    Jenkins, R.B.2    Pras, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.