Regulation of the IL-12 receptor β2 subunit by soluble antigen and IL-12 in vivo

European Journal of Immunology

Volumn 28, Issue 1, 1998, Pages 209-220

  Galbiati, Francesca ^a   Rogge, Lars ^a   Guéry, Jean Charles ^a,b   Smiroldo, Simona ^a   Adorini, Luciano ^a  

^a ROCHE MILANO RICERCHE   (Italy)

^b CHU PURPAN   (France)

Author keywords

IL 12 receptor; Immune deviation; Th1; Th2

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 2; RECEPTOR SUBUNIT; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HELPER CELL; IMMUNIZATION; INTERFERON PRODUCTION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION; IMMUNIZATION; INFUSION PUMPS, IMPLANTABLE; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MURAMIDASE; OVALBUMIN; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; RNA, MESSENGER; SOLUBILITY; TH1 CELLS; TH2 CELLS;

EID: 0031974684     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199801)28:01<209::AID-IMMU209>3.0.CO;2-S     Document Type: Article

References (56)

1. Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A. and Coffmann, R. L., Two types of murine helper T cell clone. I. Definition according to profile of lymphokine activities and secreted proteins. J. Immunol. 1986. 136: 2348-2357.
2. Trinchieri, G., Interleukin 12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol, 1995. 13: 251-276.
3. Paul, W. E. and Seder, R. A., Lymphocytes responses and cytokines. Cell 1994. 76: 241-251.
4. Scott, B., Liblau, R., Degermann, S., Marconi, L. A., Ogata, L., Caton, A. J., McDevitt, H. O. and Lo, D., A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1994. 1: 1-20.
5. Hsieh, C., Macatonia, S. E., O'Garra, A. and Murphy, K. M., T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 1995. 181: 713-731
6. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995. 13: 151-177.
7. Pfeiffer, C., Stein, J., Southwood, S., Ketelaar, H., Sette, A. and Bottomly, K., Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 1995. 181: 1569-1574.
8. Nicholson, L. B., Greer, J. M., Sobel, R. A., Lees, M. B. and Kuchroo, V. K., An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995. 3: 397-405.
9. + helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 1995. 182: 1579-1584.
10. + T cells. J. Exp. Med. 1995. 182: 1591-1596.
11. Quéry, J.-C., Galbiati, F., Smiroldo, S. and Adorini, L., Non MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection. J. Immunol. 1997. 159: 2147-2153.
12. Burstein, H. J., Shea, C. M. and Abbas, A. K., Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-γ-producing (Th1) cells. J. Immunol. 1992. 148: 3687-3691.
13. De Wit, D., Van Mechelen, M., Ryelandt, M., Figueiredo, A. C., Abramowicz, D., Goldman, M., Bazin, H., Urbain, J. and Leo, O., The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes. J. Exp. Med. 1992. 175: 9-14.
14. Quéry, J.-C., Galbiati, F., Smiroldo, S. and Adorini, L., Selective development of Th2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice. J. Exp. Med. 1996. 183: 485-497.
15. Wolf, S. F., Temple, P. A., Kobayashi, M., Young, D., Dicig, M., Lowe, L., Dzialo, R., Fitz, L., Ferenz, D., Hewick, R. M., Kelleher, H., Herrmann, S. H., Clark, S. C., Azzoni, L., Chan, S. H., Trinchieri, G. and Perussia, B., Cloning of cDNA for natural killer stimulatory factor, a heterodimeric cytokine with multiple biological effects on T and natural killer cells. J. Immunol. 1991. 146: 3074-3081.
16. Gubler, U., Chua, A. O., Schoenhaut, D. S., Dwyer, C. M., McComas, W., Motyka, R., Nabavi, N., Wolitzky, A. G., Quinn, P. M., Familletti, P. C. and Gately, M. K., Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 1991. 88: 4143-4147.
17. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A. and Murphy, K. M., Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
18. Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G. and Scott, P., The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994. 263: 235-237.
19. Szabo, S. J., Jacobson, A. G., Gubler, U. and Murphy, K. M., Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 1995. 2: 665-675.
20. Szabo, S. J., Dighe, A. S., Gubler, U. and Murphy, K. M., Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997. 185: 817-824.
21. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U. and Sinigaglia, F., Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 1997. 185: 825-831.
22. + T cell population to the T helper 2 pathway. J. Immunol. 1996. 157: 3260-3269.
23. Gaur, A., Wiers, B., Liu, A., Rothbard, J. and Fathman, C. G., Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 1992. 258: 1491-1494.
24. Beverly, B., Kang, S. M., Lenardo, M. J. and Schwartz, R. H., Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 1992. 4: 661-671.
25. Chua, A. O., Chizzonite, R., Desai, B. B., Truitt, T. P., Nunes, P., Minetti, L. J., Warrier, R. R., Presky, D. H., Levine, J. F., Gately, M. K. and Gubler, U., Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 1994. 153: 128-136.
26. Chua, A. O., Wilkinson, V. L., Presky, D. H. and Gubler, U., Cloning and characterization of a mouse IL-12 receptor β component. J. Immunol. 1995. 155: 4286-4294.
27. Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C.-Y., Gately, M. K. and Gubler, U., A functional interleukin-12 receptor complex is composed of two β type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 1996. 93: 14002-14007.
28. Bretscher, P. and Cohn, M., A theory of self-nonself discrimination. Paralysis and induction involve the recognition of one and two determinants on the antigen, respectively. Science 1970. 169: 1042-1048.
29. Linsley, P. S., Brady, W., Grosmarie, A., Aruffo, A., Damle, N. K. and Ledbetter, J. A., Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 1991. 173: 721-730.
30. Freeman, G. J., Gribben, J. G., Boussiotis, V. A., Ng, J. W., Restivo, V. A. J., Lombard, L. A., Gray, G. S. and Nadler, L. M., Cloning of B7-2: a CTLA-4 counter receptor that costimulates T cell proliferation. Science 1993. 262: 909-911.
31. Kubin, M., Kamoun, M. and Trinchieri, G., Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 1994. 180: 211-222.
32. Murphy, E. E., Terres, G., Macatonia, S. E., Hsieh, C. S., Mattson, J., Lanier, L., Wysocka, M., Trinchieri, G., Murphy, K. and O'Garra, A., B7 and interleukin 12 cooperate for proliferation and Interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 1994. 180: 223-231.
33. Yanagida, T., Kato, T., Igarashi, O., Inoue, T. and Nariuchi, H., Second signal activity of IL-12 on the proliferation and IL-12R expression of T helper cell-1 clone. J. Immunol. 1994. 152: 4919-4928.
34. Van Parijs, L., Perez, V. L., Biuckians, A., Maki, R. G., London, C. A. and Abbas, A. K., Role of interleukin 12 and costimulators in T cells anergy in vivo. J. Exp. Med. 1997. 186: 1119-1128.
35. Lehmann, P., Sercarz, E., Forsthuber, T., Dayan, C. and Gammon, G., Determinant spreading and the dynamics of the autoimmune T cell repertoire, Immunol. Today 1993. 14: 203-208.
36. Mueller, D. L., Jenkins, M. K. and Schwarte, R. H., Clonal expansion versus functional inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 1989. 7: 445-480.
37. + T cells. J. Exp. Med. 1996. 184: 19-29.
38. Mocci, S. and Coffman, R. L., Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 1995. 154: 3779-3787.
39. Murphy, E., Shibuya, K., Hosken, N., Openshaw, P., Maino, V., Davis, K., Murphy, K. and O'Garra, A., Reversibility of T helper 1 and 2 population is lost after long term stimulation. J. Exp. Med. 1996. 183: 901-913.
40. Mocci, S. and Coffman, R. L., The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations. J. Immunol. 1997. 158: 1559-1564.
41. Nabors, G. S., Afonso, L. C. C., Farrell, J. P. and Scott, P., Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA 1995. 92: 3142-3146.
42. Perez, V. L., Lederer, J. A., Lichtman, A. H. and Abbas, A. K., Stability of Th1 and Th2 populations. Int. Immunol. 1995. 7: 869-875.
43. Manetti, R., Gerosa, F., Giudici, M. G., Biagiotti, R., Parronchi, P., Piccinni, M.-P., Sampognaro, S., Maggi, E., Romagnani, S. and Trinchieri, G., Interleukin 12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 1994. 179: 1273-1283.
44. + T cells, analyzed at the single-cell level. J. Exp. Med. 1996. 184: 473-483.
45. + T cells. J. Immunol. 1995. 154: 4915-4923.
46. Quéry, J.-C., Ria, F., Galbiati, F., Smiroldo, S. and Adorini, L., The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells. Int. Immunol. 1997. 9: 9-15.
47. Saoudi, A., Simmonds, S., Huitinga, I. and Mason, D. W., Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of autoantigen-specific T cells. J. Exp. Med. 1995. 182: 335-344.
48. Quéry, J. C., Ria, F., Galbiati, F. and Adorini, L., Normal B cells fail to secrete IL-12. Eur. J. Immunol. 1997. 27: 1632-1639.
49. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kaempgen, E., Romani, N. and Schuler, G., High level IL-12 production by murine dendritic cells: up-regulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 1996. 184: 741-746.
50. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
51. Sypek, J. P., Chung, D. L., Mayor, S. E. H., Subramanyam, J. M., Goldman, S. J., Sieburth, D. S., Wolf, S. F. and Schaub, R. G., Resolution of Cutaneous Leishmaniasis: Interleukin 12 Initiates a Protective T Helper Type 1 Immune Response. J. Exp. Med. 1993. 177: 1797-1802.
52. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E. and Gately, M. K., Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 1993. 177: 1505-1509.
53. Wynn, T. A. and Sher, A., IL-12 as an adjuvant for vaccines designed to prevent infection and immunopathology by schistosomes. Res. Immunol. 1995. 146: 583-590.
54. Gately, M. K., Warrier, R. R., Honasoge, S., Carvajal, D. M., Faherty, D. A., Connaughton, S. E., Anderson, T. D., Sarmiento, U., Hubbard, B. R. and Murphy, M., Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 1994. 6: 157-167.
55. Prat, M., Gribaudo, G., Comoglio, P. M., Cavallo, G. and Landolfo, S., Monoclonal antibodies against murine γ interferon. Proc. Natl. Acad. Sci. USA 1984. 81: 4515-4519.
56. Openshaw, P., Murphy, E. E., Hosken, N. A., Maino, V., Davis, K., Murphy, K. and O'Garra, A., Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 1995. 182: 1357-1367.