Transforming growth factor-β receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas

American Journal of Pathology

Volumn 151, Issue 1, 1997, Pages 33-35

  Samowitz, Wade S ^a,b   Slattery, Martha L ^a  

^a Department of Pathology ^*  (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2;

ADENOMA; ARTICLE; CARCINOGENESIS; COLORECTAL CARCINOMA; COLORECTAL TUMOR; FRAMESHIFT MUTATION; GENE SEQUENCE; GENETIC LINKAGE; HUMAN; HUMAN TISSUE; MOLECULAR STABILITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADENOMA; ADULT; AGED; CARCINOMA; COLORECTAL NEOPLASMS; DNA, SATELLITE; FRAMESHIFT MUTATION; HUMANS; MICROSATELLITE REPEATS; MIDDLE AGED; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 0030738435     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Parsons R, Myeroff LL, Liu B, Willson JKV, Markowitz SD, Kinzler KW, Vogelstein B: Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res 1995, 55:5548-5550
2. Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mpri T, Koike M, Ushio K, Chiba M, Nomizu S, Konishi F, Utsunomiya J, Miyaki M: Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996,111:307-317
3. Akiyama Y, Iwanaga R, Ishikawa T, Sakamoto K, Nishi N, Nihei Z, Iwama T, Saitoh K, Yuasa Y: Mutations of the transforming growth factor-β type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer 1996,78:2478-2484
4. Akiyama Y, Iwanaga R, Saitoh K, Shiba K, Ushio K, Ikeda E, Iwama T, Nomizu T, Yuasa Y: Transforming growth factor β receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer. Gastroenterology 1997, 112:33-39
5. Myeroff LL, Parsons R, Kim S, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW. Lutterbaugh J, Park K, Bang Y, Lee H, Park J, Lynch H, Roberts A, Vogelstein B, Markowitz S: A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 1995, 55:5545-5547
6. Aaltonen LA, Peltomaki P, Mecklin JP, Jarvinen H, Jass JR, Green JS, Lynch HT, Watson P, Tallqvist G, Juhola M, Sistonen P, Hamilton SR, Kinzler KW, Vogelstein B, de la Chapelle A: Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994, 54:1645-1648
7. Young J, Leggett B, Gustafson C, Ward M, Searle J, Thomas L, Buttenshaw R, Chenevix-Trench G: Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum Mutat 1993, 2:351-354
8. Lothe RA, Andersen SN, Hofstad B, Meling Gl, Peltomaki P, Heim S, Brogger A, Vatn M, Rognum TO, Borresen A-L: Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chromosomes & Cancer 1995, 14:182-188
9. Samowitz WS, Slattery ML: Microsatellite instability in colorectal adenomas. Gastroenterology 1997, 112: 1515-1519
10. Samowitz WS, Slattery ML, Kerber RA: Microsatellite instability in human colonie cancer is not a useful clinical indicator of familial colorectal cancer. Gastroenterology 1995, 109:1765-1771
11. Lothe RA, Peltomaki P, Meling Gl, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, Heimdal K, Andersen Tl, Moller P, Rognum TO, Fossa SD, Haldorsen T, Langmark F, Brogger A, de la Chapelle A, Borresen A-L: Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993, 53:5849-5852
12. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A: Clues to the pathogenesis of familial colorectal cancer. Science 1993, 260:812-816
13. Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DMA replication errors in microsatellite sequences. Am J Pathol 1994, 145:148-156
14. Fynan TM, Reiss M: Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis. Crit Rev Oncogen 1993, 4:493-540