High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection

Hepatology

Volumn 24, Issue 1, 1996, Pages 32-37

  Bozkaya, Hakan ^a   Ayola, Brick ^b   Lok, Anna S F ^b,c  

^a ANKARA UNIVERSITY   (Turkey)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; FEMALE; FOLLOW UP; GENE MUTATION; GENE SEQUENCE; HEPATITIS B; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROCONVERSION; VIRUS GENE; VIRUS MUTATION;

EID: 0030000221     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008707278     Document Type: Article

References (28)

1. Ehata T, Omata M, Yokosuka O, Hosoda K, Ohto M. Variations in codon 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J Clin Invest 1992;89:332-338.
2. Wakita T, Kakumu S, Shibata M, Yoshioka K, Ito Y, Shinagawa T, Ishikawa T, et al. Detection of pre-core and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J Clin Invest 1991;88:1793-1801.
3. Chuang WL, Omata M, Ehata T, Yokosuka O, Ito Y, Imazeki F, Lu SN, et al. Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 1993;104:263-271.
4. Akarca US, Lok ASF. Naturally occurring hepatitis B virus core gene mutations. HEPATOLOGY 1995;22:50-60.
5. Chuang WL, Omata M, Ehata T, Yokosuka O, Ohta M. Concentrating missense mutations in core gene of hepatitis B virus. Evidence for adaptive mutation in chronic hepatitis B virus infection. Dig Dis Sci 1993;38:594-600.
6. Ehata T, Omata M, Chuang WL, Yokosuka O, Ito Y, Hosoda K, Ohto M. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J Clin Invest 1993;91:1206-1213.
7. Aye TT, Uchida T, Becker SO, Hirashima M, Shikata T, Komine F, Moriyama M, et al. Variations of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B Dig Dis Sci 1994;39:1281-1287.
8. Uchida T, Aye TT, Shikata T, Yano M, Yatsuhashi H, Koga M, Mima S. Evolution of the hepatitis B virus gene during chronic infection in seven patients. J Med Virol 1994;43:148-154.
9. Santantonio T, Jung MC, Schneider R, Fernholz D, Milella M, Monno L, Pastore G, et al. Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy. Virology 1992;188:948-952.
10. Santantonio T, Jung MC, Schneider R, Pastore G, Pape GR, Will H. Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment. J Hepatol 1991;13:368-371.
11. Naoumov NV, Thomas MG, Mason AL, Chokshi S, Bodicky CJ, Farzaneh F, Williams R, et al. Genomic variations in the hepatitis B virus core gene: a possible factor influencing response to interferon alfa treatment. Gastroenterology 1995;108:505-514.
12. Fattovich G, McIntyre G, Thursz M, Colman K, Giulian G, Alberti A, Thomas HC, et al. Hepatitis B virus precore/core variation and interferon therapy. HEPATOLOGY 1995;22:1355-1362.
13. Bertoletti A, Sette A, Chisari FV, Penna A, Levero M, Carli MD, Fiacadori F, et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cell. Nature 1994;369:407-410.
14. Lok ASF, Lai CL, Wu PC, Leung EKY, Lam TS. Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection. Gastroenterology 1987;92:1839-1843.
15. Lok ASF, Lai CL, Wu PC, Leung EKY. Long-term follow-up in a randomized controlled trial of recombinant alpha-interferon in Chinese patients with chronic hepatitis B infection. Lancet 1988;2:298-302.
16. Lok ASF, Wu PC, Lai CL, Lau JYN, Leung EKY, Wong LSK, Ma OCK, et al. A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology 1992;102:2091-2097.
17. Zaaijer HL, ter Borg F, Cuypers HTM, Hermus MCAH, Lelie PN. Comparison of methods for detection of hepatitis B virus DNA. J Clin Microbiol 1994;32:2088-2091.
18. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 1988;69: 2575-2583.
19. Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. Jpn J Exp Med 1987; 57:231-236.
20. Ferrari C, Bertoletti A, Penna A, Cavalli A, Valli A, Missale G, Pilli M, et al. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J Clin Invest 1991;88:214-222.
21. Salfeld J, Pfaff E, Noah M, Schaller H. Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus. J Virol 1989;63:798-808.
22. Bertoletti A, Chisari FV, Penna A, Guilhot S, Galati L, Missale G, Fowler P, et al. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 1993;67:2376-2380.
23. Hatton T, Zhou S, Standring DN. RNA- and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. J Virol 1992;66:5232-5241.
24. Lok ASF. Natural history and control of perinatally acquired hepatitis B virus infection. Dig Dis 1992;10:46-52.
25. Hagen TM, Huang S, Curnutte J, Fowler P, Martinez V, Mehr CM, Ames BN, et al. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc Natl Acad Sci U S A 1994;91:12808-12812.
26. Rehermann B, Pasquinelli C, Mosier SM, Chisari FV. Hepatitis B virus sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection. J Clin Invest 1995;96:1527-1534.
27. Lok ASF, Akarca US, Greene S. Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance. HEPATOLOGY 1995;21:19-24.
28. Lok ASF, Akarca US, Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pregenome encapsidation signal. Proc Natl Acad Sci U S A 1994;91:4077-4081.