Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis: Implications of clustering changes in a small region of the HBV core region

Journal of Medical Virology

Volumn 48, Issue 1, 1996, Pages 38-46

  Hur, Gang Min ^a,b   Lee, Yoon Ik ^a   Suh, Dong Jin ^c   Lee, Jae Heun ^b   Lee, Young Ik ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Chungnam National University   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

Cytotoxic T lymphocytes (CTL); Hepatitis variation; Polymerase chain reaction; Precoreicore region (pre C C); Variation

Indexed keywords

ADULT; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; FEMALE; HEPATITIS B VIRUS; HUMAN; MALE; MUTATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; VIRUS CORE; VIRUS GENOME;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; CODON, TERMINATOR; DISEASE PROGRESSION; DNA, VIRAL; FEMALE; GENES, VIRAL; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS, CHRONIC; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN PRECURSORS;

EID: 0029994613     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199601)48:1<38::AID-JMV6>3.0.CO;2-M     Document Type: Article

References (29)

1. Bertoletti A, Chisari FV, Penna A, Guilhot S, Galati L, Missale G, Fowler P, Schlicht H-J, Vitiello A, Chesnut RC, Fiaccadori F, Ferrari C (1993): Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. Journal of Virology 67:2376-2382.
2. Brechot C (1987): Hepatitis B virus (HBV) and hepatocellular carcinoma. HBV DNA status and its implication. Journal of Hepatology 4:269-279.
3. Brunetto MR, Giarin MM, Oriveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, Saracco G, Verme G, Will H, Bonino F (1991): Wild-type and e antigen-minus hepatitis B virus and course of chronic hepatitis. Proceedings of the National Academy of Sciences USA 88:4186-4190
4. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC (1989): Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 9:588-590.
5. Chu CM, Liaw YF (1987): Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection. Gastroenterology 92:220-225.
6. Edington TS, Chisari FV (1975): Immunological aspects of hepatitis B virus infection. American Journal of Medical Science 270:213-217.
7. Ehata T, Omata M, Yokosuka O, Hosoda K, OhtoM (1992): Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. Journal of Clinical Investigation 89:332-338.
8. Ferrari C, Penna A, Gruberci T, Tong MJ, Ribera E, Fiaccadori F, Chisari FV (1987): Intrahepatic, nucleocapsid antigen-specific T cell in chronic active hepatitis B. Journal of Immunology 139: 2050-2058.
9. Fujiyama A, Miyanohara A, Nozaki C, Yoneyama T, Ohtomo N, Matsubara K (1983): Cloning and structural analysis of hepatitis B virus DNAs, subtype adr. Nucleic Acids Research 11:4601-4610.
10. Gunter S, Meisel H, Reip A, Misaka S, Krüger DH, Will H (1992): Frequent and rapid emergence of mutated pre-c sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatement. Virology 187:271-279.
11. Hasegawa K, Huang J, Wands JR, Obeta H, Liang TJ (1991): Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan. Virology 185:460-463.
12. Hoofnagle JH (1987): Chronic type B hepatitis and the healthy HBs Ag carrier state. Hepatology 7:758-763.
13. Kakumi S, Arao M, Mizokami M, Orido E, Yamamoto M, Sakamoto N (1989): Pre-S proteins in chronic hepatitis B virus infection. Makers of active viral infection. American Journal of Gastroenterology 84:1250-1254.
14. Kaneko S, Miller RH (1989): Heterogeneity of the core gene sequence in a patient chronically infected with hepatitis B virus. Journal of Infectious Diseases 160:903-904.
15. Kaneko S, Miller RH, Feinstone SM, Unoura M, Kobayashi K, Hattori N, Purcell RH (1989): Detection of serum hepatitis B virus DNA in patients with chronic hepatitis using the polymerase chain reaction assay. Proceedings of the National Academy of Sciences, USA 86:312-316.
16. Kojima M, Shimizu M, Tsuchimochi T, Koyasu M, Tanaka S, Izuka H, Tanaka K, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M (1991): Posttransfusion fulminant hepatitis B associated with pre-core defective HBV mutants. Vox Sang 60:34-39.
17. Milich DR, Hughes JR, Hughes R, Houghten R, Mclachlan A, Jones JE (1989): Functional identification of agretopic and epitope residues within an HBc Ag T cell detreminant. Journal of Immunology 143:3141-3147.
18. Naoumov NV, Schneider R, Grotzinger T, Jung MC, Misaka S, Pape GR, Will H (1992): Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 102:538-548.
19. Raimondo G, Stemler M, Schneider R, Wildner G, Squadrito G, Will H (1990): Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patient. Journal of Hepatology 11: 374-380.
20. Rötzschke O, Falk K, Deres K, Shild H, Norda M, Metzger J, Jung G, Rammensee HG (1990): Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252-254.
21. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA (1988): Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239: 487-491.
22. Sambrook J, Fritsch EF, Maniatis T (1989): "Molecular Cloning, A Laboratory Manual." Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
23. Santantonio T, Jung MC, Schneider R, Pastore G, Pape GR, Will H (1991): Selection for a pre-C stop codon mutation in a hepatitis B virus variants with a pre-C initiation codon mutation during interferon treatement. Journal of Hepatology 13:368-371.
24. Standring DN, Ou JH, Masiarz FR, Rutter WJ (1988): A signal peptide encoded within the precore region of hepatitis B virus defects the secretion of a heterogenous population of e antigens in Xenopus oocytes. Proceedings of the National Academy of Sciences USA 85:8405-8409.
25. Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M (1990): Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBe Ag to anti-HBe induced spontaneously or with Interferon therapy. Hepatology 12:1284-1289.
26. Thomas HC, Jacyna M, Waters J, Main J (1988): Virus-host interaction in chronic hepatitis B virus infection. Seminars in Liver Disease 8:342-349.
27. Thomas HC, Karayiannis P, Brook G (1991): Treatment of hepatitis B virus infection with interferon: Factors predicting response to interferon Journal of Hepatology 13:S4-S7.
28. D molecule. Nature 348:213-216.
29. Vento S, Hegarty JE, Alberti A, Obrien CJ, Alexander GJM, Eddleston ALWF, Williams R (1985): T lymphocyte sensitization to HBc Ag and T cell-mediated unresponsiveness to HBs Ag in hepatitis B virus-related chronic liver disease. Hepatology 5:192-197.