Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation

Journal of Virology

Volumn 72, Issue 3, 1998, Pages 2168-2176

  Yuan, Thomas Ta Tung ^a   Lin, Min Hui ^a   Qiu, Sui Min ^a   Shih, Chiaho ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATITIS B(E) ANTIGEN;

ARTICLE; DELETION MUTANT; HEPATITIS B VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS MUTANT; VIRUS REPLICATION;

EID: 0031886046     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.3.2168-2176.1998     Document Type: Article

References (70)

1. Ackrill, A. M., N. V. Naoumov, A. L. W. F. Eddleston, and R. Williams. 1992. Comparison of pre-core/core hepatitis B virus region in liver tissue and serum from patients with chronic hepatitis B infection. J. Hepatol. 16:224-227.
2. Ackrill, A. M., N. V. Naoumov, A. L. W. F. Eddleston, and R. Williams. 1993. Specific deletions in the hepatitis B virus core open reading frame in patients with chronic active hepatitis. Br. J. Med. Virol. 41:165-169.
3. Akarca, U. S., and A. S. F. Lok. 1995. Naturally occurring core-gene-defective hepatitis B viruses. J. Gen. Virol. 76:1821-1826.
4. Aye, T. T., T. Uchida, S. O. Becker, M. Hirashima, T. Shikata, F. Komine, M. Moriyama, Y. Arakawa, S. Mima, M. Mizokami, and J. Y. N. Lau. 1994. Variations of hepatitis B virus precore/core gene sequence in acute and fulminant hepatitis B. Dig. Dis. Sci. 39:1281-1287.
5. Bartenschlager, R., M. Junker-Niepmann, and H. Schaller. 1990. The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation. J. Virol. 64:5324-5332.
6. Bartenschlager, R., and H. Schaller. 1992. Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome. EMBO J. 11:3413-3420.
7. Bartenschlager, R., C. Kuhn, and H. Schaller. 1992. Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabeling at newly introduced phosphorylation. sites. Nucleic Acids Res. 20:195-202.
8. Beames, B., and R. E. Lanford. 1993. Carboxy-terminal truncations of the HBV core protein affect capsid formation and the apparent size of the encapsidated HBV RNA. Virology 194:597-607.
9. Birnbaum, F., and M. Nassal. 1990. Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein. J. Virol. 64:3319-3330.
10. Bottcher, B., S. A. Wynne, and R. A. Crowther. 1997. Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386:88-91.
11. Buckwold, V. E., Z. Xu, M. Chen, T. S. B. Yen, and J. H. Ou. 1996. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J. Virol. 70:5845-5851.
12. Carman, W. F., M. R. Jacyna, S. Hadziyannis, P. Karayiannis, M. J. McGarvey, A. Makris, and H. C. Thomas. 1989. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet ii:588-591.
13. Chang, L. J., R. C. Hirsch, D. Ganem, and H. E. Varmus. 1990. Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. J. Virol. 64:5553-5558.
14. Chen, P.-J., C.-R. Chen, J.-L. Sung, and D.-S. Chen. 1989. Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus. J. Virol. 63:4165-4171.
15. Chiang, P. W., K. S. Jeng, C. P. Hu, and C. M. Chang. 1992. Characterization of a cis element required for packaging and replication of the human hepatitis B virus. Virology 186:701-711.
16. Conway, J. F., N. Cheng, A. Zlotnick, P. T. Wingfield, S. J. Stahi, and A. C. Steven. 1997. Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature 386:91-94.
17. Dimmock, N. J. 1996. Antiviral activity of defective interfering influenza virus in vivo, p. 421-445. In S. Myint and D. Taylor-Robinson (ed.), Viral and other infections of the human respiratory tract. Chapman & Hall, Inc., London, England.
18. Ehata, T., M. Omata, W.-L. Chuang, O. Yokosuka, Y. Ito, K. Hosoda, and M. Ohto. 1993. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J. Clin. Invest. 91:1206-1213.
19. Faruqi, A., S. Roychoudbury, and C. Shih. Unpublished data.
20. Ferrari, C., A. Bertoletti, A. Pena, A. Cavalli, A. Valli, G. Missale, M. Pilli, P. Fowler, T. Giuberti, F. V. Chisari, and F. Fieccadori. 1991. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J. Clin. Invest. 88:214-222.
21. Fiordalisi, C., D. Primi, E. Tanzi, E. Magni, C. Incarbone, A. R. Zanetti, and E. Cariani. 1994. Hepatitis B virus C gene heterogeneity in a familial cluster of anti-HBc negative chronic carriers. J. Med. Virol. 42:109-114.
22. Gallina, A., F. Bonelli, L. Zentilin, G. Rindi, M. Muttini, and G. Milanesi. 1989. A recombinant hepatitis B core antigen polypeptide with the protamine-like domain deleted self-assembles into capsid particles but fails to bind nucleic acids. J. Virol. 63:4645-4652.
23. Gunther, S., B. C. Li, S. Miska, D. H. Kruger, H. Meisel, and H. Will. 1995. A novel method of efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients. J. Virol. 69:5437-5444.
24. Gunther, S., S. Baginski, H. Kissel, P. Reinke, D. H. Kruger, H. Will, and H. Meisel. 1996. Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease. Hepatology 24:751-758.
25. Haton, T., S. Zhon, and D. N. Standring. 1992. RNA-and DNA-binding activities in hepatitis B virus capsid protein: a model for their roles in viral replication. J. Virol. 66:5232-5241.
26. Hirsch, R. C., J. E. Lavine, L. J. Chang, H. E. Varmus, and D. Ganem. 1990. Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription. Nature 344:552-555.
27. Holland, J. J. 1987. Defective interfering rhabdoviruses. p. 297. In R. Wagner, (ed.), The rhabdoviruses. Plenum Publishing Co., New York, N.Y.
28. Hosono, S., P.-C. Tai, W. Wang, M. Ambrose, D. G.-Y. Hwang, T.-T. Yuan, B.-H. Peng, C.-S. Yang, C.-S. Lee, and C, Shih. 1995. Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes. Virology 212:151-162.
29. Hu, J., and C. Seeger. 1996. Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase. Proc. Natl. Acad. Sci. USA 93:1060-1064.
30. Hu, J., D. O. Toft, and C. Seeger. 1997. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids. EMBO J. 16:59-68.
31. Huang, A. S., and D. Baltimore. 1970. Defective viral particles and viral disease processes. Nature (London) 226:325-327.
32. Huang, M., and J. Summers. 1991. Infection initiated by the RNA pregenome of a DNA virus. J. Virol. 65:5435-5439.
33. + T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection. J. Virol. 69:3358-3368.
34. Junker-Niepmann, M. R. Bartenschlager, and H. Schaller. 1990. A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA. EMBO J. 9:3389-3396.
35. Kirkegaard, K., and D. Baltimore. 1986. The mechanism of RNA recombination in poliovirus. Cell 47:433-443.
36. Lai, M. M. C. 1990. Coronavirus: organization, replication and expression of genome. Annu. Rev. Microbiol. 44:303-333.
37. Lai, M. Y., D. S. Chen, P. J. Chen, S. C. Lee, J. C. Sheu, G. T. Huang, T. C. Wei, C. S. Lee, S. C. Yu, H. C. Hsu, and J. L. Sung. 1988. Status of hepatitis B virus DNA in hepatocellular carcinoma: a study based on paired tumor and nontumor liver tissues. J. Med. Virol. 25:249-258.
38. Li, J.-S., S.-P. Tong, Y.-M. Wen, L. Vitvitski, Q. Zhang, and C. Trépo. 1993. Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J. Virol. 67:5402-5410.
39. Marinos, G., F. Torre, S. Gunther, M. G. Thomas, H. Will, G. Williams, and N. V. Naoumov. 1996. Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection. Gastroenterology 111:183-192.
40. Menne, S., J. Maschke, T. K. Tolle, M. Lu, and M. Roggendorf. 1997. Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope. J. Virol. 71:65-74.
41. Milich, D. R., A. McLachlan, A. Moriarty, and G. B. Thornton. 1987. Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg. J. Immunol. 139:1223-1231.
42. Milich, D. R., J. E. Jones, J. L. Hughes, J. Price, A. K. Raney, and A. McLachlan. 1990. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc. Natl. Acad. Sci. USA 87:6599-6603.
43. Mondelli, M., G. M. Vergani, A. Alberti, D. Vergani, B. Portmann, A. L. W. F. Eddleston, and R. Williams. 1982. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection; evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J. Immunol. 129:2773-2778.
44. Nassal, M. 1992. Conserved cysteines of the hepatitis B virus core protein are not required for assembly of replication-competent core particles nor for their envelopment. Virology 190:499-505.
45. Nassal, M., and A. Rieger. 1996. A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesis. J. Virol. 70:2764-2773.
46. Okamoto, H., F. Tsuda, and M. Mayumi. 1987. Defective mutants of hepatitis B virus in the circulation of symptom-free carriers. Jpn. J. Exp. Med. 57:217-221.
47. Okamoto, H., F. Tsuda, T. Akahane, Y. Sugai, M. Yoshiba, K. Moriyama, T. Tanaka, Y. Miyakawa, and M. Mayumi. 1994. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J. Virol. 68:8102-8110.
48. Ou, J.-H., H. Bao, C. Shih, and S. M. Tahara. 1990. Preferred translation of human hepatitis B virus polymerase from core protein-but not from precore protein-specific transcript. J. Virol. 64:4578-4581.
49. Pei, D., and C. Shih. 1991. An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP. Mol. Cell. Biol. 11:1480-1487.
50. Perri, S., and D. Ganem. 1996. A host factor that binds near the termini of hepatitis B virus pregenomic RNA. J. Virol. 70:6803-6809.
51. Pollack, J. R., and D. Ganem. 1993. An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsulation. J. Virol. 67:3254-3263.
52. Radziwill, G., W. Tucker, and H. Schaller. 1990. Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity. J. Virol. 64:613-620.
53. Roychoudhury, S., A. Faruqi, and C. Shih. 1991. Pregenomic RNA encapsidation analysis of eleven missense and nonsense polymerase mutants of human hepatitis B virus. J. Virol. 65:3617-3624.
54. Salfeld, J., E. Pfaff, M. Noah, and H. Schaller. 1989. Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus. J. Virol. 63:798-808.
55. Shih, C., K. Burke, M.-J. Chou, J. Zeldis, C.-S. Yang, C.-S. Lee, K. J. Isselbacher, J. Wands, and H. M. Goodman. 1987. Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J. Virol. 61:3491-3498.
56. Shih, C., L. S. Li, S. Roychoudhury, and M. H. Ho. 1989. In vitro propagation of human hepatitis B virus in a rat hepatoma cell line. Proc. Natl. Acad. Sci. USA 86:6223-6327.
57. Shih, C., P.-C. Tai, W. Whitehead, S. Hosono, C.-S. Lee, and C.-S. Yang. 1996. Hepatitis B and C viruses and liver cancer, p. 824-834. In J. R. Bertino (ed.), Encyclopedia of cancer, vol. II. Academic Press, Inc., New York, N. Y.
58. Su, T.-S., C.-J. Lai, J.-L. Huang, L.-H. Lin, Y.-K. Yauk, C. Chang, S. J. Lo, and S.-H. Han. 1989. Hepatitis B virus transcript produced by RNA splicing. J. Virol. 63:4011-4018.
59. Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
60. Tai, P.-C., D. Banik, G.-I. Lin, S. Pai, K. Pai, M.-H. Lin, G. Yuoh, S. Che, S. H. Hsu, T.-C. Chen, T.-T. Kuo, C.-S. Lee, C.-S. Yang, and C. Shih. 1997. Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen. J. Virol. 71:4852-4856.
61. Takayanagi, M., S. Kakumu, T. Ishikawa, Y. Higashi, K. Yoshioka, and T. Wakita. 1993. Comparison of envelope and precore/core variants of hepatitis B virus (HBV) during chronic HBV infection. Virology 196:138-145.
62. Terre, S., M. A. Petit, and C. Brechet 1991. Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced RNA in vivo. J. Virol. 65:5539-5543.
63. Tiollais, P., C. Pourcel, and A. Dejean. 1985. The hepatitis B virus. Nature 317:489-495.
64. + cytotoric T lymphocytes. J. Clin. Invest. 97:577-584.
65. Uchida, T., T. T. Aye, T. Shihata, M. Yano, H. Yatsuhashi, M. Koga, and S. Mima. 1994. Evolution of the hepatitis B virus gene during chronic infection in seven patients. J. Med. Virol. 43:148-154.
66. Wakita, T., S. Kakumu, M. Shibata, K. Yoshioka, Y. Ito, T. Shinagawa, T. Ishikawa, M. Takayanagi, and T. Morishima. 1991. Detection of pre-C and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J. Clin. Invest. 88:1793-1801.
67. Wang, G. H., and C. Seeger. 1992. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis. Cell 71:663-670.
68. Xu, Z., and T. S. B. Yen. 1996. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J. Virol. 70:133-140.
69. Yuan, T.-T., A. Faruqi, J. W. K. Shin, and C. Shih. 1995. The mechanism of natural occurrence of two closely-linked HBV precore predominant mutations. Virology 211:144-156.
70. Yuan, T.-T., M.-H. Lin, D.-S. Chen, and C. Shih. 1998. A defective interference-like phenomenon of human hepatitis B virus in chronic carriers. J. Virol. 72:578-584.