Variations of hepatitis B virus core gene sequence in Western patients with chronic hepatitis B virus infection

Journal of Viral Hepatitis

Volumn 4, Issue 6, 1997, Pages 371-378

  Gray, A H ^a   Fang, J W S ^a   Davis, G L ^a   Mizokami, M ^b   Wu, P C ^c   Williams, R ^d,e   Schuster, S M ^a   Lau, J Y N ^a,f  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d KING S COLLEGE HOSPITAL   (United Kingdom)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

Core gene; Deletion; HBV; HBV antigens; Interferon ; Liver disease; Mutation; Nucleotide sequence; Precore

Indexed keywords

HEPATITIS B CORE ANTIGEN; VIRUS DNA;

ADULT; AMINO ACID SEQUENCE; ARTICLE; FEMALE; GENETIC VARIABILITY; GENETICS; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; ISOLATION AND PURIFICATION; MALE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; UNITED KINGDOM; UNITED STATES; VIROLOGY; VIRUS GENE;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; DNA, VIRAL; FEMALE; GENES, VIRAL; GREAT BRITAIN; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; UNITED STATES; VARIATION (GENETICS);

EID: 0031297068     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1997.00075.x     Document Type: Article

References (26)

1. Chisari FV, Milich DR, Tiollais P. Hepatitis B virus infection: a model for immunologically mediated hepatocellular injury. In: Keppler D et al., eds. Mechanism of Hepatocyte Injury and Death. Lancaster: MTP Press, 1984: 293-297.
2. Ferrari C, Penna P, Delgi Antoni A, Fiaccadori F. Cellular immune response to hepatitis B virus antigens. An overview. J Hepatol 1988; 7: 21-33.
3. Hsu HC, Su IJ, Lai MY et al. Biologic and prognostic significance of hepatocyte hepatitis B core antigen expression in the natural course of chronic hepatitis B virus infection. J Hepatol 1987; 5: 45-50.
4. Chu CM, Liaw YF. Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection. Gastroenterology 1987; 92: 220-225.
5. Naoumov NV, Portmann BS, Tedder RS et al. Detection of hepatitis B virus antigens in liver tissue. Gastroenterology 1990; 99: 1248-1253.
6. Wu PC, Lau JYN, Lau TK, Lau SK, Lai CL. Relationship between intrahepatic expression of hepatitis B viral antigens and histology in Chinese patients with chronic hepatitis B virus infection. Am J Clin Pathol 1993; 100: 648-653.
7. Ferrari C, Penna A, Giuberti T et al. Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B. J Immunol 1987; 139: 2050-2058.
8. Penna A, Chisari FV, Bertoletti A et al. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. J Exp Med 1991; 174: 1565-1570.
9. Lau JYN, Wright TL. Molecular virology and pathogenesis of hepatitis B. Lancet 1993; 342: 1335-1340.
10. Carman WF, Jacyna MR, Hadziyannis S et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989; ii: 588-591.
11. Brunetto MR, Stemler M, Bonino F et al. A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol 1990; 10: 258-261.
12. Naoumov NV, Schneider R, Grotzinger T et al. Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 1992; 102: 538-543.
13. Wakita T, Kakumu S, Shibata M et al. Detection of pre-c and core region mutants of hepatitis B virus in chronic hepatitis B virus carriers. J Clin Invest 1991; 88: 1793-1801.
14. Ehata T, Omata M, Yokosuka O, Hosoda K, Ohto M. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J Clin Invest 1992; 89: 332-338.
15. Chuang WL, Omata M, Ehata T et al. Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 1993; 104: 263-271.
16. Fagan EA, Guarner P, Perera SDK et al. Quantitation of hepatitis B virus DNA in serum using the spot hybridisation technique and scintillation counting. J Virol Methods 1985; 12: 251-262.
17. Lau JYN, Davies SE, Bain VG et al. High level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis. Gastroenterology 1992; 102: 956-962.
18. Lau JYN, Bain VG, Davies SE, Alexander GJM, Williams R. Export of intracellular HBsAg in chronic hepatitis B virus infection is related to viral replication. Hepatology 1991; 14: 416-421.
19. Berninger M, Hammer M, Hoyer B, Gerin JL. An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol 1982; 9: 57-68.
20. Ono Y, Onda H, Sasada R, Igarishi K, Sugino Y, Nishioka K. The complete nucleotide sequence of the cloned hepatitis B virus subtype adr and adw. Nucl Acids Res 1983; 11: 1747-1757.
21. Raimondo G, Stemler M, Schneider R, Wildner G, Squadrito G, Will H. Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patient. J Hepatol 1990; 11: 374-380.
22. Lau JYN, Alexander GJM, Alberti A. Viral hepatitis. Gut 1991; 5: S47-S62.
23. Chuang WL, Omata M, Ehata T, Yokosuka O, Ohto M. Concentrating missense mutations in core gene of hepatitis B virus. Dig Dis Sci 1993; 38: 594-600.
24. Naoumov NV, Thomas M, Mason AL et al. Genomic variations in the hepatitis B core gene: a possible factor influencing response to interferon alfa treatment. Gastroenterology 1995; 108: 505-514.
25. Bozkaya H, Ayola B, Lok ASF. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 1996; 24: 32-37.
26. Lander IJ, Lin HJ, Lau JYN, Siu TS, Lai CL. The variability of the hepatitis B virus genome - statistical analysis and biological implications. Mol Biol Evol 1993; 10: 457-470.