Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 376, Issue 1-2, 1997, Pages 107-114

  Ito, Nobuyuki ^a   Hasegawa, Ryohei ^b   Imaida, Katsumi ^b   Tamano, Seiko ^b,c   Hagiwara, Akihiro ^b,c   Hirose, Masao ^b   Shirai, Tomoyuki ^b  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c Daiyukai Research Institute for Medical Science   (Japan)

Author keywords

2 Amino 1 methyl 6 phenylimidazo 4,5 6 pyridine (PhIP); Breast cancer; Carcinogenicity; Chemoprevention; Colon cancer; Rat

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; CHLOROPHYLL; HYDROQUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST ADENOCARCINOMA; BREAST CANCER; CARCINOGENICITY; CHEMOPROPHYLAXIS; COLON CANCER; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HISTOPATHOLOGY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PREGNANCY; PRIORITY JOURNAL; RAT;

ADENOCARCINOMA; ANIMALS; CARCINOGENS; CHLOROPHYLLIDES; COLONIC NEOPLASMS; DISEASE TRANSMISSION, VERTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROQUINONES; IMIDAZOLES; LACTATION; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, EXPERIMENTAL; RATS; RATS, INBRED F344;

ANIMALIA; RODENTIA;

EID: 0031008969     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00032-8     Document Type: Article

References (34)

1. Brittebo, E.B., A.Å. Karlsson, K.I. Skog and I.M. Jägerstad (1994) Transfer of the food mutagen PhIP to foetuses and newborn mice following maternal exposure. Food Chem. Toxicol., 32, 717-726.
2. Dooley, K.L., L.S. von Tungeln, T. Bucci, P.P. Fu and F.F. Kadlubar (1992) Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mice. Cancer Lett., 62, 205-209.
3. 1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn. J. Cancer Res., 80, 1176-1178.
4. Felton, J.S. and M.G. Knize (1991) Occurrence, identification, and potential mutagenicity of heterocyclic amines in cooked food. Mutat. Res., 259, 205-217.
5. Freedman, L.S., C. Clifford and M. Messina (1990) Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review. Cancer Res., 50, 5710-5719.
6. Gerhardsson de Verdier, M., U. Hagman, R.K. Peters, G. Steineck and E. Overvik (1991) Meat, cooking methods and colorectal cancer: a case-referent study in Stockholm. Int. J. Cancer, 49, 520-525.
7. Ghoshal, A. and E.G. Snyderwine (1993) Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn. Carcinogenesis, 14, 2199-2203.
8. Ghoshal, A., K.-H. Preisegger, S. Takayama, S.S. Thorgeirsson and E.G. Snyderwine (1994) Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat. Carcinogenesis, 15, 2429-2433.
9. Giovannucci, M., M.J. Stampfer, G.A. Colditz, Manson J.E. and B.A. Rosner (1993) A comparison of prospective and retrospective assessments of diet in the study of breast cancer. Am. J. Epidemiol., 137, 502-511.
10. Imaida, K. et al. (1996) Jpn. J. Cancer Res., 87, 1116-1120.
11. Hasegawa, R., M. Hirose, T. Kato, A. Hagiwara, P. Boonyaphiphat, M. Nagao, N. Ito and T. Shirai (1995a) Inhibitory effect of chlorophyllin on PhIP-induced mammary Carcinogenesis in female F344 rats. Carcinogenesis, 14, 2553-2557.
12. Hasegawa, R., J. Kimura, M. Yaono, S. Takahashi, T. Kato, M. Futakuchi, M. Fukutake, K. Fukutome, K. Wakabayashi, T. Sugimura, N. Ito and T. Shirai (1995b) Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats. Cancer Res., 55, 4333-4338.
13. Hasegawa, R., E. Miyata, M. Futakuchi, A. Hagiwara, M. Nagao, T. Sugimura and N. Ito (1994a) Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. Carcinogenesis, 15, 1037-1041.
14. Hasegawa, R., M. Sano, S. Tamano, K. Imaida, T. Shirai, M. Nagao, T. Sugimura and N. Ito (1993) Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis in rats. Carcinogenesis, 14, 2553-2557.
15. Hasegawa, R., T. Shirai, K. Hakoi, K. Takaba, S. Iwasaki, T. Hoshiya, N. Ito, M. Nagao and T. Sugimura (1991) Synergistic enhancement of glutathione S-transferase placental form-positive hepatic cell foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses. Jpn. J. Cancer Res., 82, 1378-1384.
16. Hasegawa, R., S. Takahashi, T. Shirai, S. Iwasaki, Kim, D.-J., M. Ochiai, M. Nagao, T. Sugimura and N. Ito (1992) Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA αC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 13, 1427-1431.
17. Hasegawa, R., H. Tanaka, S. Tamano, T. Shirai, M. Nagao, T. Sugimura and I. Ito (1994b) Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. Carcinogenesis, 15, 2567-2573.
18. Hirose, M., K. Akagi, R. Hasegawa, M. Yaono, T. Satoh, Y. Hara, K. Wakabayashi and N. Ito (1995a) Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats. Carcinogenesis, 16, 217-221.
19. Hirose, M., S. Iwata, E. Ito, Y. Nihro, S. Takahashi, Y. Mizoguchi, T. Miki, T. Satoh, N. Ito and T. Shirai (1995b) Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipirido[1,2-a;3′,2′-d]imidazole (Glu-P-1). Carcinogenesis, 16, 2227-2232.
20. Ito, N., R. Hasegawa, T. Shirai, S. Fukushima, K. Hakoi, K. Takaba, S. Iwasaki, K. Wakabayashi, M. Nagao and T. Sugimura (1991a) Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses. Carcinogenesis, 12, 767-772.
21. Ito, N., R. Hasegawa, S. Sano, S. Tamano, H. Esumi, S. Takayama and T. Sugimura (1991b) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP). Carcinogenesis, 12, 1503-1506.
22. Kimura, J., R. Hasegawa, M. Yaono, T. Kato, K. Wakabayashi, T. Sugimura, N. Ito and T. Shirai (1996) Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, PhIP, in Sprague-Dawley rats. Cancer Lett., in press.
23. Klurfeld, D.M., M.M. Weber and D. Kritchevsky (1987) Inhibition of chemically-induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat. Cancer Res., 47, 2759-2762.
24. Layton, D.W., K.T. Bogen, M.K. Knize, F.T. Hatch, V.M. Johnson and J.S. Felton (1995) Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis, 16, 39-52.
25. Ochiai, M., K. Ogawa, K. Wakabayashi, T. Sugimura, S. Nagase, H. Esumi and M. Nagao (1991) Induction of intestinal adenocarcinomas by 2-amino-1methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn. J. Cancer Res., 82, 363-366.
26. Rose, D.P. (1993) Diet hormones, and cancer. Ann. Rev. Public Health, 14, 1-17.
27. Russo, J. and I.H. Russo (1987) Biological and molecular bases of mammary carcinogenesis. Lab. Invest., 57, 112-137.
28. Schiffman, M.H. and J.S. Felton (1990) Fried foods and the risk of colon cancer. Am. J. Epidemiol., 131, 376-378.
29. Sinha, D.K., J.E. Pazik and T.L. Dao (1988) Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy. Br. J. Cancer, 57, 390-394.
30. Sugimura, T. (1992) Multistep carcinogenesis: a 1992 perspective. Science, 258, 603-607.
31. Takayama, K., K. Yamashita, K. Wakabayashi, T. Sugimura and M. Nagao (1989) DNA modification by 2-amino-1-methyl-6-s-phenylimidazo[4,5-b]pyridine in rats. Jpn. J. Cancer Res., 80, 1145-1148.
32. Wakabayashi, K., M. Nagao, H. Esumi and T. Sugimura (1992) Food-derived mutagens and carcinogens. Cancer Res., 52, 2092s-2098s.
33. Weisburger, J.H. (1993) Heterocyclic amines in cooked foods: Possible human carcinogens. Cancer Res., 53, 2422-2424.
34. Ziegler, R.G., R.N. Hoover, M.C. Pike, A. Hildesheim, A.M.Y. Nomura, D.W. West, A.H. Wu-Williams, L.N. Kolonel, P.L. Horn-Ross, J.F. Rosenthal and M.B. Hyer (1993) Migration patterns and breast cancer risk in Asian-American women. J. Natl. Cancer Inst., 85, 1819-1827.