Health risks of heterocyclic amines

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 376, Issue 1-2, 1997, Pages 37-41

  Felton, James S ^a   Malfatti, Michael A ^a   Knize, Mark G ^a   Salmon, Cynthia P ^a   Hopmans, Ellen C ^a   Wu, Rebekah W ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC AMINE;

ARTICLE; CANCER RISK; CARCINOGENICITY; COOKING; DOSIMETRY; EPIDEMIOLOGY; FOOD; HEALTH HAZARD; HUMAN; MUTAGENICITY; PRIORITY JOURNAL; RISK ASSESSMENT; XENOBIOTIC METABOLISM;

AMINES; ANIMALS; CARCINOGENS; COOKERY; DIET; HETEROCYCLIC COMPOUNDS; HUMANS; MEAT; MICE; MUTAGENS; RATS; RISK FACTORS;

PRIMATES;

EID: 0030914470     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00023-7     Document Type: Article

References (25)

1. Adamson, R.H., U.P. Thorgeirsson, E.G. Snyderwine, S.S. Thorgeirsson, J. Reeves, D.W. Dalgard, S. Takayama and T. Sugimura (1990) Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques, Jpn. J. Cancer Res. (Gann), 81, 10-14.
2. Alexander, J., H. Wallin, J.A. Holme and G. Becher (1989) 4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate-A major metabolite of the food mutagen 2-amino-1-methyl-6-imidazo[4,5-b]pyridine (PhIP) in the rat, Carcinogenesis, 10, 1543-1547.
3. Buonarati, M.H., K.W. Turteltaub, N.H. Shen and J.S. Felton (1990) Role of sulfation and acetylation in the activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine to intermediates which bind to DNA, Mutat. Res., 245, 185-190.
4. Davis, C.D., H.A. Schut, R.H. Adamson, U.P. Thorgeirsson, S.S. Thorgeirsson and E.G. Snyderwine (1993) Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo, Carcinogenesis, 14, 61-65.
5. Gerhardsson De Verdier, M., Hagman, U., Peters, R.K., Steineck, G. and Overvik, E. (1991) Meat, cooking methods and colorectal cancer: A case-referent study in Stockholm, Int. J. Cancer, 49, 520-525.
6. Hatch, F.T., Knize, M.G., Moore, D.H. and Felton, J.S. (1992) Quantitative correlation of mutagenic and carcinogenic potencies for heterocyclic amine from cooked foods and additional aromatic amines, Mutat. Res., 271, 269-287.
7. Holme, J.A., H. Wallin, G. Bronborg, E.J. Soderlund, J.K. Hongslo and J. Alexander (1989) Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxy-amino-PhIP, a directly acting genotoxic metabolite, Carcinogenesis, 10, 1389-1396.
8. Ito, N. et al. (1991) Carcinogenesis, 12, 1503-1506.
9. Josephy, P.D., L.S. Debruin, H.L. Lord, J.N. Oak, D.H. Evans, Z. Guo, M-S. Dong and F.P. Guengerich (1995) Bioactivation of aromatic amines by recombinant human cytochrome P-4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations, Cancer Res., 55, 799-802.
10. Kato, R. and Y. Yamazoe (1987) Metabolic activation and covalent binding to nucleic acids of carciongenic heterocyclic amines from cooked foods and amino acids pyrolysates, Jpn. J. Cancer Res. (Gann), 78, 297-311.
11. Knekt, P. Steineck, G., Jarvinen, R. Hakulinen, T. and Aromaa, A., (1994) Intake of fried meat and risk of cancer: a follow-up study in Finland, Int. J. Cancer, 59, 756-760.
12. Lang, N.P., M.A. Butler, J. Massengill, M. Lawson, R.C. Stotts, M. Hauer-Jenmsen and F.F. Kadlubar (1994) Rapid metabolic phenotypes for acetyltransferases and cytochrome P-4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps, Cancer Epid. Biomarkers Prev., 3, 675-682.
13. Layton, D.W., K.T. Bogen, M.G. Knize, F.T. Hatch, V.M. Johnson and J.S. Felton (1995) Cancer risk of heterocyclic amines in cooked foods: An analysis and implications for research, Carcinogenesis, 16, 39-52.
14. Lin, D.-X., N.P. Lang and F.F. Kadlubar (1995) Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice, Drug Metab Disposit., 23, 518.
15. Lynch, A.M., Knize, M.G., Boobis, A.R., Gooderham, N.J., Davies, D.S. and Murray, S. (1992) Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef, Cancer Res., 52, 6216-6223.
16. Malfatti, M.A., N.H. Shen, R.W. Wu, K.W. Turteltaub and J.S. Felton (1995) A correlation of Salmonella mutagenicity with DNA adducts induced by the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, Mutagenesis, 10, 425-431.
17. McManus, M.E., W.M. Burgess, M.E. Veronese, A. Huggett, L.C. Quattrochi and R.H. Tukey (1990) Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450, Cancer Res., 50, 3367-3376.
18. Minchin et al. (1992) Biochem. Biophys. Res. Commun., 185, 839-844.
19. Murray, S., N.J. Gooderham, A.R. Boobis and D.S. Davies (1989) Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal, Carcinogenesis, 10, 763-765.
20. Salmon, C.P., M.G. Knize and J.S. Felton (1997) Effects of marinating on heterocyclic amine carcinogen production in grilled chicken, Fd. Chem. Toxic., submitted.
21. Sinha, R., N. Rothman, E. Brown, O. Levander, C.P. Salmon, M.G. Knize and J.S. Felton (1995) High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) occur in chicken but are dependent on the cooking method, Cancer Res., 55, 4516-4519.
22. Steineck, G., M. Gerhardsson de Verdier and E. Övervik (1993) The epidemiological evidence concerning intake of mutagenic activity from the fried surface and risk of cancer cannot justify preventive measures, Eur. J. Cancer Prevent., 2, 293-300.
23. Trinidad, A.C., R.W. Wu, L.H. Thompson and J.S. Felton (1991) Expression of mouse cytochrome P-4501A1 cDNA in repair-deficient and repair proficient CHO cells, Mol. Carcinogen., 4, 510-518.
24. Weisburger, J.H., Horn, C.L. and Wynder, E.L. (1992) Mechanism of nutritional elements in prevention of cancer and other chronic diseases, in G. Schlidrf (Ed.), Recent Advances in Clinical Nutrition, Smith-Gordon, UK, pp. 83-96.
25. Willet, W.C, M.J. Stampfer, G.A. Colditz, B.A. Rosner and F.E. Speizer (1990) Relation of meat, fat and fiber intake to the risk of colon cancer in a prospective study among women, New. Engl. J. Med., 323, 1664-1672.