메뉴 건너뛰기




Volumn 67, Issue 6, 1999, Pages 2957-2963

Disruption of anthrax toxin binding with the use of human antibodies and competitive inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BACTERIAL ANTIGEN; CELL SURFACE RECEPTOR; GREEN FLUORESCENT PROTEIN;

EID: 0033055641     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.2957-2963.1999     Document Type: Article
Times cited : (39)

References (54)
  • 1
    • 0032539990 scopus 로고    scopus 로고
    • Identification of residues lining the anthrax protective antigen channel
    • Benson, E. L., P. D. Huynh, A. Finkelstein, and R. J. Collier. 1998. Identification of residues lining the anthrax protective antigen channel. Biochemistry 37:3941-3948.
    • (1998) Biochemistry , vol.37 , pp. 3941-3948
    • Benson, E.L.1    Huynh, P.D.2    Finkelstein, A.3    Collier, R.J.4
  • 2
    • 0024523836 scopus 로고
    • Anthrax toxin: Channel-forming activity of protective antigen in planar phospholipid-bilayers
    • Blaustein, R. O., T. M. Koehler, R. J. Collier, and A. Finkelstein. 1989. Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid-bilayers. Proc. Natl. Acad. Sci. USA 86:2209-2213.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2209-2213
    • Blaustein, R.O.1    Koehler, T.M.2    Collier, R.J.3    Finkelstein, A.4
  • 3
    • 0032193039 scopus 로고    scopus 로고
    • Strain-specific recombinant antibodies to potato-virus-Y potyvirus
    • Boonham, N., and I. Barker. 1998. Strain-specific recombinant antibodies to potato-virus-Y potyvirus. J. Virol. Methods 74:193-199.
    • (1998) J. Virol. Methods , vol.74 , pp. 193-199
    • Boonham, N.1    Barker, I.2
  • 5
    • 0027443091 scopus 로고
    • Use of living columns to select specific phage antibodies
    • Bradbury, A., L. Persic, T. Werge, and A. Cattaneo. 1993. Use of living columns to select specific phage antibodies. Bio/Technology 11:1565-1569.
    • (1993) Bio/Technology , vol.11 , pp. 1565-1569
    • Bradbury, A.1    Persic, L.2    Werge, T.3    Cattaneo, A.4
  • 8
    • 0026044658 scopus 로고
    • Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells
    • Escuyer, V., and R. J. Collier. 1991. Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells. Infect. Immun. 59:3381-3386.
    • (1991) Infect. Immun. , vol.59 , pp. 3381-3386
    • Escuyer, V.1    Collier, R.J.2
  • 9
    • 0031910883 scopus 로고    scopus 로고
    • Fermentation, purification, and characterization of protective antigen from a recombinant, avirulent strain of Bacillus anthracis
    • Farchaus, J. W., W. J. Ribot, S. Jendrek, and S. F. Little. 1998. Fermentation, purification, and characterization of protective antigen from a recombinant, avirulent strain of Bacillus anthracis. Appl. Environ. Microbiol. 64: 982-991.
    • (1998) Appl. Environ. Microbiol. , vol.64 , pp. 982-991
    • Farchaus, J.W.1    Ribot, W.J.2    Jendrek, S.3    Little, S.F.4
  • 10
    • 0022891493 scopus 로고
    • Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process
    • Friedlander, A. M. 1986. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261:7123-7126.
    • (1986) J. Biol. Chem. , vol.261 , pp. 7123-7126
    • Friedlander, A.M.1
  • 11
    • 0028872463 scopus 로고
    • Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases
    • Gordon, V. M., K. R. Klimpel, N. Arora, M. A. Henderson, and S. H. Leppla. 1995. Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect. Immun. 63:82-87.
    • (1995) Infect. Immun. , vol.63 , pp. 82-87
    • Gordon, V.M.1    Klimpel, K.R.2    Arora, N.3    Henderson, M.A.4    Leppla, S.H.5
  • 12
    • 0030807070 scopus 로고    scopus 로고
    • A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen
    • Gordon, V. M., A. Rehemtulla, and S. H. Leppla. 1997. A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen. Infect. Immun. 65:3370-3375.
    • (1997) Infect. Immun. , vol.65 , pp. 3370-3375
    • Gordon, V.M.1    Rehemtulla, A.2    Leppla, S.H.3
  • 14
    • 0031946979 scopus 로고    scopus 로고
    • Lethal factor active-site mutations affect catalytic activity in vitro
    • Hammond, S. E., and P. C. Hanna. 1998. Lethal factor active-site mutations affect catalytic activity in vitro. Infect. Immun. 66:2374-2378.
    • (1998) Infect. Immun. , vol.66 , pp. 2374-2378
    • Hammond, S.E.1    Hanna, P.C.2
  • 16
  • 17
    • 0026498189 scopus 로고
    • Anthrax toxin protective antigen is activated by a cell-surface protease with the sequence specificity and catalytic properties of furin
    • Klimpel, K. R., S. S. Molloy, G. Thomas, and S. H. Leppla. 1992. Anthrax toxin protective antigen is activated by a cell-surface protease with the sequence specificity and catalytic properties of furin. Proc. Natl. Acad. Sci. USA 89:10277-10281.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10277-10281
    • Klimpel, K.R.1    Molloy, S.S.2    Thomas, G.3    Leppla, S.H.4
  • 18
    • 0025771545 scopus 로고
    • Anthrax toxin protective antigen: Low-pH-induced hydrophobicity and channel formation in liposomes
    • Koehler, T. M., and R. J. Collier. 1991. Anthrax toxin protective antigen: low-pH-induced hydrophobicity and channel formation in liposomes. Mol. Microbiol. 5:1501-1506.
    • (1991) Mol. Microbiol. , vol.5 , pp. 1501-1506
    • Koehler, T.M.1    Collier, R.J.2
  • 19
    • 0032579510 scopus 로고    scopus 로고
    • Recombinant human single-chain Fv antibodies recognizing human interleukin-6: Specific targeting of cytokine-secreting cells
    • Krebs, B., H. Griffin, G. Winter, and S. Rosejohn. 1998. Recombinant human single-chain Fv antibodies recognizing human interleukin-6: specific targeting of cytokine-secreting cells. J. Biol. Chem. 273:2858-2865.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2858-2865
    • Krebs, B.1    Griffin, H.2    Winter, G.3    Rosejohn, S.4
  • 20
    • 0002661972 scopus 로고
    • The anthrax toxin complex
    • J. H. F. J. E. Alouf (ed.), Academic Press, London, England
    • Leppla, S. H. 1991. The anthrax toxin complex, p. 277-302. In J. H. F. J. E. Alouf (ed.), Sourcebook of bacterial protein toxins. Academic Press, London, England.
    • (1991) Sourcebook of Bacterial Protein Toxins , pp. 277-302
    • Leppla, S.H.1
  • 21
    • 0000947082 scopus 로고
    • Anthrax toxin edema factor: A bacterial adenylate-cyclase that increases cyclic-AMP concentrations in eukaryotic cells
    • Leppla, S. H. 1982. Anthrax toxin edema factor: a bacterial adenylate-cyclase that increases cyclic-AMP concentrations in eukaryotic cells. Proc. Natl. Acad. Sci. USA 79:3162-3156.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3162-13156
    • Leppla, S.H.1
  • 22
    • 0024214705 scopus 로고
    • Production and purification of anthrax toxin
    • Leppla, S. H. 1988. Production and purification of anthrax toxin. Methods Enzymol. 165:103-116.
    • (1988) Methods Enzymol. , vol.165 , pp. 103-116
    • Leppla, S.H.1
  • 23
    • 0001825875 scopus 로고
    • Proteolytic activation of anthrax toxin bound to cellular receptors
    • F. Fehrenbach, J. E. Alouf, P. Falmagne, W. Goebel, J. Jelaszewics, D. Jurgens, and R. Rappuoli (ed.), Gustav Fischer Verlag, Stuttgart, Germany
    • Leppla, S. H., A. M. Friedlander, and E. M. Cora. 1988. Proteolytic activation of anthrax toxin bound to cellular receptors, p. 111-112. In F. Fehrenbach, J. E. Alouf, P. Falmagne, W. Goebel, J. Jelaszewics, D. Jurgens, and R. Rappuoli (ed.), Bacterial protein toxins. Gustav Fischer Verlag, Stuttgart, Germany.
    • (1988) Bacterial Protein Toxins , pp. 111-112
    • Leppla, S.H.1    Friedlander, A.M.2    Cora, E.M.3
  • 24
    • 0030785493 scopus 로고    scopus 로고
    • Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs
    • Little, S. F., B. E. Ivins, P. F. Fellows, and A. M. Friedlander. 1997. Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs. Infect. Immun. 65:5171-5175.
    • (1997) Infect. Immun. , vol.65 , pp. 5171-5175
    • Little, S.F.1    Ivins, B.E.2    Fellows, P.F.3    Friedlander, A.M.4
  • 25
    • 0028223589 scopus 로고
    • Structure-function analysis of Bacillus anthracis edema factor by using monoclonal-antibodies
    • Little, S. F., S. H. Leppla, J. W. Burnett, and A. M. Friedlander. 1994. Structure-function analysis of Bacillus anthracis edema factor by using monoclonal-antibodies. Biochem. Biophys. Res. Commun. 199:676-682.
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , pp. 676-682
    • Little, S.F.1    Leppla, S.H.2    Burnett, J.W.3    Friedlander, A.M.4
  • 26
    • 0029958827 scopus 로고    scopus 로고
    • Characterization of lethal factor-binding and cell-receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodies
    • Little, S. F., J. M. Novak, J. R. Lowe, S. H. Leppla, Y. Singh, K. R. Klimpel, B. C. Lidgerding, and A. M. Friedlander. 1996. Characterization of lethal factor-binding and cell-receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodies. Microbiology 142:707-715.
    • (1996) Microbiology , vol.142 , pp. 707-715
    • Little, S.F.1    Novak, J.M.2    Lowe, J.R.3    Leppla, S.H.4    Singh, Y.5    Klimpel, K.R.6    Lidgerding, B.C.7    Friedlander, A.M.8
  • 27
    • 0029914097 scopus 로고    scopus 로고
    • Selection of binders from phage displayed antibody libraries using the BIAcore biosensor
    • Malmborg, A. C., M. Duenas, M. Ohlin, E. Soderlind, and C. Borrehaeck. 1996. Selection of binders from phage displayed antibody libraries using the BIAcore biosensor. J. Immunol. Methods 198:51-57.
    • (1996) J. Immunol. Methods , vol.198 , pp. 51-57
    • Malmborg, A.C.1    Duenas, M.2    Ohlin, M.3    Soderlind, E.4    Borrehaeck, C.5
  • 29
    • 0344434275 scopus 로고    scopus 로고
    • Antibodies from phage display as genomics tools and therapeutic agents
    • Coronado, Calif.
    • McCafferty, J. 1998. Antibodies from phage display as genomics tools and therapeutic agents. IBC Antibody Engineering Conference, Coronado, Calif.
    • (1998) IBC Antibody Engineering Conference
    • McCafferty, J.1
  • 30
    • 4243732447 scopus 로고
    • Anthrax protective antigen forms ring-shaped oligomers during intoxication of mammalian cells
    • Milne, J. C., D. Furlong, P. C. Hanna, J. Wall, and R. J. Collier. 1994. Anthrax protective antigen forms ring-shaped oligomers during intoxication of mammalian cells. FASEB J. 8:A1464.
    • (1994) FASEB J. , vol.8
    • Milne, J.C.1    Furlong, D.2    Hanna, P.C.3    Wall, J.4    Collier, R.J.5
  • 31
    • 0028018856 scopus 로고
    • Anthrax protective antigen forms oligomers during intoxication of mammalian cells
    • Milne, J. C., D. Furlong, P. C. Hanna, J. S. Wall, and R. J. Collier. 1994. Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J. Biol. Chem. 269:20607-20612.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20607-20612
    • Milne, J.C.1    Furlong, D.2    Hanna, P.C.3    Wall, J.S.4    Collier, R.J.5
  • 33
    • 0026794750 scopus 로고
    • Functional characterization of protease-treated Bacillus anthracis protective antigen
    • Novak, J. M., M. P. Stein, S. F. Little, S. H. Leppla, and A. M. Friedlander. 1992. Functional characterization of protease-treated Bacillus anthracis protective antigen. J. Biol. Chem. 267:17186-17193.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17186-17193
    • Novak, J.M.1    Stein, M.P.2    Little, S.F.3    Leppla, S.H.4    Friedlander, A.M.5
  • 35
    • 0018567632 scopus 로고
    • Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination
    • Perelson, A. S., and G. F. Oster. 1979. Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. J. Theor. Biol. 81:645-670.
    • (1979) J. Theor. Biol. , vol.81 , pp. 645-670
    • Perelson, A.S.1    Oster, G.F.2
  • 37
    • 0026050285 scopus 로고
    • Contribution of individual toxin components to virulence of Bacillus anthracis
    • Pezard, C., P. Berche, and M. Mock. 1991. Contribution of individual toxin components to virulence of Bacillus anthracis. Infect. Immun. 59:3472-3477.
    • (1991) Infect. Immun. , vol.59 , pp. 3472-3477
    • Pezard, C.1    Berche, P.2    Mock, M.3
  • 38
    • 0000941241 scopus 로고
    • Large-scale production of protective antigen of Bacillus anthracis anaerobic cultures
    • Puziss, M., L. C. Manning, L. W. Lynch, E. Barclay, I. Abelow, and G. G. Wright. 1963. Large-scale production of protective antigen of Bacillus anthracis anaerobic cultures. Appl. Microbiol. 11:330-334.
    • (1963) Appl. Microbiol. , vol.11 , pp. 330-334
    • Puziss, M.1    Manning, L.C.2    Lynch, L.W.3    Barclay, E.4    Abelow, I.5    Wright, G.G.6
  • 39
    • 0023911589 scopus 로고
    • Purification of anthrax-toxin components by high-performance anion-exchange, gel-filtration and hydrophobic-interaction chromatography
    • Quinn, C. P., C. C. Shone, P. C. B. Turnbull, and J. Melling. 1988. Purification of anthrax-toxin components by high-performance anion-exchange, gel-filtration and hydrophobic-interaction chromatography. Biochem. J. 252: 753-758.
    • (1988) Biochem. J. , vol.252 , pp. 753-758
    • Quinn, C.P.1    Shone, C.C.2    Turnbull, P.C.B.3    Melling, J.4
  • 40
    • 0002890184 scopus 로고
    • Mapping and characterization of the Bacillus anthracis plasmids pXO1 and pXO2
    • Robertson, D., T. Bragg, S. Simpson, R. Kaspar, W. Xie, and M. Tippetts. 1990. Mapping and characterization of the Bacillus anthracis plasmids pXO1 and pXO2. Salisbury Med. Bull. 68(Special Suppl.):55-58.
    • (1990) Salisbury Med. Bull. , vol.68 , Issue.SPECIAL SUPPL. , pp. 55-58
    • Robertson, D.1    Bragg, T.2    Simpson, S.3    Kaspar, R.4    Xie, W.5    Tippetts, M.6
  • 41
    • 0029989324 scopus 로고    scopus 로고
    • Isolation of high-affinity monomeric human anti-c-erbB-2 single-chain Fv using affinity-driven selection
    • Schier, R., J. Bye, G. Apell, A. McCall, G. P. Adams, M. Malmqvist, L. M. Weiner, and J. D. Marks. 1996. Isolation of high-affinity monomeric human anti-c-erbB-2 single-chain Fv using affinity-driven selection. J. Mol. Biol. 255:28-43.
    • (1996) J. Mol. Biol. , vol.255 , pp. 28-43
    • Schier, R.1    Bye, J.2    Apell, G.3    McCall, A.4    Adams, G.P.5    Malmqvist, M.6    Weiner, L.M.7    Marks, J.D.8
  • 44
    • 0024837128 scopus 로고
    • A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo
    • Singh, Y., V. K. Chaudhary, and S. H. Leppla. 1989. A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo. J. Biol. Chem. 264:19103-19107.
    • (1989) J. Biol. Chem. , vol.264 , pp. 19103-19107
    • Singh, Y.1    Chaudhary, V.K.2    Leppla, S.H.3
  • 45
    • 0031842407 scopus 로고    scopus 로고
    • Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracis
    • Singh, Y., B. E. Ivins, and S. H. Leppla. 1998. Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracis. Infect. Immun. 64:3447-3448.
    • (1998) Infect. Immun. , vol.64 , pp. 3447-3448
    • Singh, Y.1    Ivins, B.E.2    Leppla, S.H.3
  • 46
    • 0025858389 scopus 로고
    • The carboxyl-terminal end of protective antigen is required for receptor-binding and anthrax toxin activity
    • Singh, Y., K. R. Klimpel, C. P. Quinn, V. K. Chaudhary, and S. H. Leppla. 1991. The carboxyl-terminal end of protective antigen is required for receptor-binding and anthrax toxin activity. J. Biol. Chem. 264:15493-15497.
    • (1991) J. Biol. Chem. , vol.264 , pp. 15493-15497
    • Singh, Y.1    Klimpel, K.R.2    Quinn, C.P.3    Chaudhary, V.K.4    Leppla, S.H.5
  • 48
    • 0031573631 scopus 로고    scopus 로고
    • Efficient selection of scFv antibody phage by adsorption to in situ expressed antigens in tissue-sections
    • Tordsson, J., L. Abrahmsen, T. Kalland, C. Ljung, C. Ingvar, and T. Brodin. 1997. Efficient selection of scFv antibody phage by adsorption to in situ expressed antigens in tissue-sections. J. Immunol. Methods 210:11-23.
    • (1997) J. Immunol. Methods , vol.210 , pp. 11-23
    • Tordsson, J.1    Abrahmsen, L.2    Kalland, T.3    Ljung, C.4    Ingvar, C.5    Brodin, T.6
  • 51
    • 0032581369 scopus 로고    scopus 로고
    • Anthrax lethal factor cleaves the N-terminus of MAP-K-Ks and induces tyrosine/threonine phosphorylation of MAP-Ks in cultured macrophages
    • Vitale, G., R. Pellizzari, C. Recchi, G. Napolitani, M. Mock, and C. Montecucco. 1998. Anthrax lethal factor cleaves the N-terminus of MAP-K-Ks and induces tyrosine/threonine phosphorylation of MAP-Ks in cultured macrophages. Biochem. Biophys. Res. Commun. 248:706-711.
    • (1998) Biochem. Biophys. Res. Commun. , vol.248 , pp. 706-711
    • Vitale, G.1    Pellizzari, R.2    Recchi, C.3    Napolitani, G.4    Mock, M.5    Montecucco, C.6
  • 52
    • 0030734272 scopus 로고    scopus 로고
    • Structure and interaction of PA63 and EF (edema toxin) of Bacillus anthracis with lipid-membrane
    • Wang, X. M., R. Wattiez, M. Mock, P. Falmagne, J. M. Ruysschaert, and V. Cabiaux. 1997. Structure and interaction of PA63 and EF (edema toxin) of Bacillus anthracis with lipid-membrane. Biochemistry 36:14906-14913.
    • (1997) Biochemistry , vol.36 , pp. 14906-14913
    • Wang, X.M.1    Wattiez, R.2    Mock, M.3    Falmagne, P.4    Ruysschaert, J.M.5    Cabiaux, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.