Evidence that Par-4 participates in the pathogenesis of HIV encephalitis

American Journal of Pathology

Volumn 155, Issue 1, 1999, Pages 39-46

  Kruman, Inna I ^a   Nath, Avindra ^b   Maragos, William F ^b   Chan, Sic L ^a   Jones, Melina ^c   Rangnekar, Vivek M ^a   Jakel, Rebekah J ^b   Mattson, Mark P ^a,b,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; LEUCINE ZIPPER PROTEIN; PROTEIN PAR 4; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; DEMENTIA; ENZYME ACTIVATION; HIPPOCAMPUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LEARNING; MEMORY; MITOCHONDRIAL RESPIRATION; MONKEY; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS ENCEPHALITIS; VIRUS PATHOGENESIS;

EID: 0033022928     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65096-1     Document Type: Article

References (35)

1. Lipton SA: Neuropathogenesis of acquired immunodeficiency syndrome dementia. Curr Opin Neurol 1997, 10:247-253
2. Ketzler S, Weiss S, Haung H, Budka H: Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol 1990, 80:92-94
3. Masliah E, Ge N, Morey M, DeTeresa R, Terry RD, Wiley CA: Cortical dendritic pathology in human deficincy virus encephalitis. Lab Invest 1992, 66:285-291
4. Wiley C, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R: Neocortical damage during HIV infection. Ann Neurol 1991, 29:651-657
5. Conant K, Garzino-Demo A, Nath A, McArthur JC, Halliday W, Power C, Gallo RC, Major EO: Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci USA 1998, 95:3117-3121
6. Epstein LG, Gendelman HE: HIV-1 infection of the nervous system: pathogenic mechanisms. Ann Neurol 1993, 33:429-436
7. Nath A, Geiger J: Neurobiological aspects of human immunodeficiency virus infection: neurotoxic mechanisms. Prog Neurobiol 1998, 54:19-33
8. Brenneman DE, Westbrook GL, Fitzgerald SP, Ennist DL, Elkins KL, Ruff MR, Pert CB: Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal polypeptide. Nature 1988, 335:639-642
9. Dawson VI, Dawson TM, Uhl GR, Snyder SH: Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical neurons. Proc Natl Acad Sci USA 1993, 90:3256-3259
10. Lipton SA, Sucher NJ, Kaiser PK, Dreyer EB: Synergistic effects of HIV coat protein and NMDA receptor mediated neurotoxicity. Neuron 1991, 7:111-118
11. Adamson DC, Wildemann B, Sasaki M, Glass JD, McArthur JC, Chritov VI, Dawson TM, Dawson VL: Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 1996, 274:1917-1921
12. Wesselingh SL, Power C, Glass JD, Tyor WR, McArthur JC, Farber JM, Griffin JW, Griffin DE: Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993, 33:576-582
13. Wiley CA, Baldwin M, Achim CL: Expression of regulatory and structural mRNA in the central nervous system. AIDS 1996, 10:843-847
14. Nath A, Geiger JD, Mattson MP, Magnuson DSK, Jones M, Berger JR: Role of viral proteins in neurapathogenesis of HIV infection with emphasis on Tat. NeuroAIDS 1998, 1: (www.sciencemag.org/NAIDS)
15. Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B: HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. AIDS 1997, 11:1421-1431
16. Tardieu M, Hery C, Peudenier S, Boespflug O, Montagnier L: Human immunodeficiency virus type 1-infected cells can destroy human neural cells after cell-to-cell adhesion. Ann Neurol 1992, 32:11-17
17. Everall IP, Hudson L, Liu J, Nath A, Male D, Narayan O: Detection of the human immunodeficiency virus regulatory gene Tat protein and mRNA in CNS tissues. J Neurovirol 1988, 4:349-355
18. Magnuson DKS, Brownstone RM, Nath A: HIV-1 Tat activates non-NMDA excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 1995, 37:373-380
19. Haughey N, Nath A, Geiger JD: HIV-1 regulatory protein Tat and Tat fragments induce calcium in human brain cells. Can J Inf Dis 1995, 6:14-20
20. New DR, Ma M Epstein LG, Nath A, Gelbard HA: Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. J Neurovirol 1997, 3:168-173
21. Kruman I, Nath A, Mattson MP: HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation and mitochondrial calcium overload Exp Neural 1998, 154:276-288
22. D'Mello SR: Molecular regulation of neuronal apoptosis. Curr Top Dev Biol 1998, 39:187-213
23. Mattson MP, Guo Q, Furukawa K, Pedersen WA: Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J Neurochem 1998; 70:1-14
24. Sells SF, Han S-S, Muthukkumar S, Maddiwar N, Johnstone R, Boghaert E, Gillis D, Liu G, Nair P, Monnig S, Collins P, Mattson MP, Sukhatme VP, Zimmer SG, Wood DP, McRoberts JW, Shi Y, Rangnekar VM: Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol Cell Biol 1997, 17:3823-3832
25. Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, Bondada V, Rangnekar VM, Mattson MP: Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Nat Med 1998, 4:957-962
26. Raghaven R, Stephens EB, Koag SV, Adany I, Pinson DM, Li Z, Jai F, Shani M, Wang C, Leung K, Foresman L, Narayan O: Neuropathogenesis of chimeric simian/human imunodeficiency virus infection in pig-tailed and rhesus macaques. Brain Pathol 1997, 7:851-861
27. Mattson MP, Zhang Y, Bose S: Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose. Exp Neurol 1993, 121:1-13
28. Nath A, Psooy K, Martin C, Knudsen B, Magnuson DSK, Haughey N, Geiger JD: Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996, 70:1475-1480
29. Kooy NW, Royall JA, Ischoropoulos H, Beckman JS: Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic Biol Med 1994, 16:149-156
30. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K: Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of Mn-SOD and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 1997, 49:681-697
31. Mattson MP, Keller JN, Begley JG: Evidence for synaptic apoptosis, Exp Neurol 1998, 153:35-48
32. An SF, Giometto B, Scaravilli T, Tavolato B, Gray F, Scaravilli F: Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patients, Acta Neuropathol 1996, 91:169-173
33. Krajewski S, James HJ, Ross J, Blumberg BM, Epstein LG, Gendelman HE, Gummuluru S, Dewhurst S, Sharer LR, Reed JC, Gelbard HA: Expression of pro-and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis. Neuropathol Appl Neurobiol 1997, 23:242-253
34. Shi B, DeGirolami U, He J, Wang S, Lorenzo A, Busciglio J, Gabuzda D: Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest 1996, 98:1979-1990
35. Mattson MP: Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 1997, 77:1081-1132