Programmed cell death in brains of HIV-1-positive AIDS and pre-AIDS patients

Acta Neuropathologica

Volumn 91, Issue 2, 1996, Pages 169-173

  An, S F ^a   Giometto, B ^b   Scaravilli, T ^b   Tavolato, B ^b   Gray, F ^c   Scaravilli, F ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PADOVA   (Italy)

^c HENRI MONDOR HOSPITAL   (France)

Author keywords

Asymptomatic; HIV; In situ end labelling (ISEL); Neuronal cell loss; Programmed cell death (apoptosis)

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; BRAIN; CELL DEATH; CELL LOSS; CONTROLLED STUDY; ENCEPHALITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; NERVE CELL; NEUROPATHOLOGY; PRIORITY JOURNAL; WHITE MATTER;

EID: 0030070528     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050409     Document Type: Article

References (44)

1. Adle-Biassette H, Levy Y, Colombel M, Poron F, Natchey S, Keohane C, Gray F (1995) Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neurobiol 21:218-227
2. An SF, Franklin D, Fleming KA (1992) Generation of digoxigenin-labelled double-stranded and single-stranded probes using the polymerase chain reaction. Mol Cell Probes 6:193-200
3. Ansari B, Coates PJ, Greenstein BD. Hall PA (1993) In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 170: 1-8
4. Boehringer Mannheim (1989) DNA labelling and detection nonradioactive. Applications Manual. Boehringer Mannheim, Mannheim
5. + T cells during an immune response to HIV-1-pulsed dendritic cells. AIDS Res Hum Retroviruses 10:61-71
6. Carbonari M, Cibati M, Cherchi M, Sbarigia D, Pesce AM. Dell'Anna L, Modica A, Fiorilli M (1994) Detection and characterisation of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immuocytometric method. Blood 83 : 1268-1277
7. Chen SC, Curran T, Morgan JI (1995) Apoptosis in the nervous system: new revelations. J Clin Pathol 48:7-12
8. Everall IP, Luthert PJ, Lantos PL (1993) Neuronal number and volume alterations in the neocortex of HIV infected individuals, J Neurol Neurosurg Psychiatry 56:481-486
9. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119:493-501
10. Gelbard HA, James HJ, Sharer LR, Perry SW, Saito Y, Kazee AM. Blumberg BM, Epstein LG (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 21 : 208-217
11. Gold R, Schmied M, Giegerich G, Breitschopf H, Harfung HP. Toyka KV, Lassmann H (1994) Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 71:219-225
12. Gougeon ML, Olivier R, Garcia S, Guetard D, Dragic T. Dauguet C, Montagnier L (1991) Demonstration of an engagement process towards cell death by apoptosis in lymphocytes of HIV infected patients. C R Acad Sci III 312:529-537
13. Gougeon ML, Garcia S, Heeney J, Tschopp R, Lecoeur H, Guetard D, Rame V, Dauguet C, Montagnier L (1993) Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses 9:553-563
14. Greenspan HC, Arouma O (1994) Could oxidative stress initiate programmed cell death in HIV infection? A role for plant derived metabolites having synergistic antioxidant activity. Chem Biol Interact 91: 187-197
15. + T-lymphocytes in asymptomatic HIV infected patients induce the program action of lymphocyte death by apoptosis. C R Acad Sci III 312:599-606
16. + T cells from human immunideficiency virus-infected asymptomatic individuals. J Exp Med 175:331-340
17. - and 'activating' memory T cells. Clin Exp Immunol 95 : 195-200
18. Jaleco AC, Covas MJ, Victorino RM (1994) Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients. Clin Exp Immunol 98,185-189
19. Ketzler S, Weis S, Haug H, Budka H (1990) Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol 80:92-94
20. Kizaki H, Nakada S, Ohnishi Y, Azuma Y, Mizuno Y, Tadakuma T (1993) Tumour necrosis factor-alpha enhances cAMP-induced programmed cell death in mouse thymocytes. Cytokine 5:342-347
21. Laurent-Crawford AC, Krust B, Riviere Y, Desgranges C, Muller S, Kieny MP, Dauguet C, Hovanessian AG (1993) Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res Hum Retroviruses 9:761-773
22. + T cells from HIV-infected persons. J Immunol 153 :412-420
23. Louis JC, Magel E, Takayama S, Varon S (1993) CNTF protection of oligodendrocytes against natural and tumour necrosis factor-induced death. Science 259:689-692
24. + cells expressing gp160 of human immunodeficiency virus type 1. J Virol 68:390-399
25. Mangan DF, Wahl SM (1991) Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines. J Immunol 147:3408-3412
26. + T cells in vitro. Differential induction of apoptosis in these cells. J Immunol 152 :330-342
27. Mastino A, Grelli S, Piacentini M, Oliverio S, Favalli C, Perno CF, Garci E (1993) Correlation between induction of lymphocyte apoptosis and prostaglandin E2 production by macrophages infected with HIV. Cell Immunol 152: 120-130
28. Meyaard L, Otoo SA, Jonker RR, Mijinster MJ, Keet RP, Miedema F (1992) Programmed death of T cells in HIV-1 infection. Science 257:217-219
29. Meyaard L, Otto SA, Keet IP, Roos MT, Miedema F (1994) Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease. J Clin Invest 93:982-988
30. Michel D, Chabot JG, Moyse E, Danik M, Quirion R (1992) Possible functions of a new genetic marker in central nervous system: the sulfated glycoprotein-2 (SGP-2). Synapse 11:105-111
31. Muller WE, Schroder HC, Ushijima H, Dapper J, Bormann J (1992) gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine. Eur J Pharmacol 226:209-214
32. Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993) Programmed cell death induced by ceramide. Science 259: 1769-1771
33. Ohno K, Nakano T, Matsumoto Y, Watari T, Goitsuka R, Nakayama H, Tsujimoto H, Hasegawa A (1993) Apoptosis induced by tumour necrosis factor in cells chronically infected with feline immunodeficiency virus. J Virol 67 :2429-2433
34. Petito CK, Roberts B (1995) Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 146: 1121-1130
35. Sandstrom PA, Roberts B, Folks TM, Buttke TM (1993) HIV gene expression enhances T cell susceptibility to hydrogen peroxide-induced apoptosis. AIDS Res Hum Retroviruses 9:1107-1113
36. Sandstrom PA, Tebbey PW, Van-Cleave S, Buttke TM (1994) Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione perioxidase deficiency. J Biol Chem 269:798-801
37. Schnittman SM, Fauci AS (1994) Human immunodeficiency virus and acquired immunodeficiency syndrome: an update. Adv Intern Med 39:305-355
38. Shearer WT, Rosenblatt HM, Schuluchter MD, Mofenson LM, Denny TN (1993) Immunologic targets of HIV infection: T cells. Ann NY Acad Sci 693 :35-51
39. Sinclair E, Gray F, Scaravilli F (1992) PCR detection of HIV proviral DNA in the brain of an asymptomatic HIV-positive patient. J Neurol 239:469-471
40. Sinclair E, Gray F, Ciardi A. Scaravilli F (1994) Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients. J Neuropathol Exp Neurol 53:43-50
41. Tyor WR, Glass JD, Griffin JW, Becker PS, McArthur JC, Bezman L, Griffin DE (1992) Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol 31:349-360
42. Umehara F, Nakamura A, Izumo S, Kubota R, Ijichi S, Kashio N. Hashimoto KI, Usuku K, Sato E, Osame M (1994) Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-1-associated myelopathy: a possible mechanism to control viral infection in the central nervous system. J Neuropathol Exp Neurol 53:617-624
43. Wijsman JH, Jonker RR, Keijzer R, Van de Velde CJH, Cornelisse CJ, Dierendonck JHV (1993) A new method to detect apoptosis in paraffin sections: in situ end-labelling of fragmented DNA. J Histochem Cytochem 41:7-12
44. Wiley CA, Masliah E, Morey M, Lemere C, DeTeresa R, Grafe M, Hansen L, Terry R (1991) Neocortical damage during HIV infection. Ann Neurol 29:651-657