Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-β in liver stellate cells

Hepatology

Volumn 26, Issue 4, 1997, Pages 913-921

  Okuno, Masataka ^a   Moriwaki, Hisataka ^a   Imai, Shoko ^a   Muto, Yasutoshi ^a   Kawada, Norifumi ^b   Suzuki, Yasuhiro ^c   Kojima, Soichi ^c  

^a GIFU UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c RIKEN TSUKUBA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; COLLAGENASE; DRUG ANALOG; HYDROXYPROLINE; MESSENGER RNA; PLASMIN; PLASMINOGEN ACTIVATOR; PROCOLLAGEN; RETINOIC ACID; RETINOID; RETINOL; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER FIBROSIS; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; STELLATE CELL;

EID: 0030755313     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260417     Document Type: Article

References (52)

1. Gressner AM. Liver fibrosis: perspectives in pathobiochemical research and clinical outlook. Eur J Clin Chem Clin Biochem 1991;29:293-311.
2. Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med 1993; 328:1828-1835.
3. Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 1994;331:1286-1292.
4. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, et al. Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A 1995;92:2572-2576.
5. Blomhoff R, Wake K. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 1991;5:271-277.
6. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, Casini A, et al. Differential expression of matrix metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994; 144:528-537.
7. Ramadori G, Neubauer K, Odenthal M, Nakamura T, Knittel T, Schwögler S, Meyer zum Büschenfelde K-H. The gene of hepatocyte growth factor is expressed in fat-storing cells of rat liver and is down-regulated during cell growth and by transforming growth factor-β. Biochem Biophys Res Commun 1992;183:739-742.
8. Roberts AB, Sporn MB. The transforming growth factor-βs. In: Sporn MB, Roberts AB, eds. Peptide growth factors and their receptors I. Handbook of Experimental Pharmacology. Vol 95/I. Berlin: Springer-Verlag, 1990:419-472.
9. Flaumenhaft R, Kojima S, Abe M, Rifkin DB. Activation of latent transforming growth factor β. In: August JT, Anders MW, Murad F, eds. Advances in Pharmacology. Vol 24. San Diego: Academic Press, 1993: 51-76.
10. Lyons RM, Gentry LE, Purchio AF, Moses HL. Mechanism of activation of latent recombinant transforming growth factor β1 by plasmin. J Cell Biol 1990;110:1361-1367.
11. Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-β1-like molecule by plasmin during co-culture. J Cell Biol 1989; 109:309-315.
12. Sato Y, Tsuboi R, Lyons R, Moses H, Rifkin DB. Characterization of the activation of latent TGF-β by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J Cell Biol 1990; 111:757-763.
13. Kojima S, Harpel PC, Rifkin DB. Lipoprotein (a) inhibits the generation of transforming growth factor β: an endogenous inhibitor of smooth muscle cell migration. J Cell Biol 1991;113:1439-1445.
14. Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A 1991;88:580-584.
15. Flaumenhaft R, Abe M, Sato Y, Miyazono K, Harpel J, Heldin C-H, Rifkin DB. Role of the latent TGF-β binding protein in the activation of latent TGF-β by co-cultures of endothelial and smooth muscle cells. J Cell Biol 1993;120:995-1002.
16. Kojima S, Nara K, Rifkin DB. Requirement for transglutaminase in the activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Biol 1993;121:439-448.
17. Gudas LJ, Sporn MB, Roberts AB. Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS, eds. The Retinoids. Biology, Chemistry, and Medicine. Ed 2. New York: Raven, 1994: 443-520.
18. Mangelsdorf DJ, Umesono K, Evans RM. The retinoid receptors. In: Sporn MB, Roberts AB, Goodman DS, eds. The Reitnoids. Biology, Chemistry, and Medicine. Ed 2. New York: Raven, 1994:319-349.
19. Yamada Y, Shidoji Y, Fukutomi Y, Ishikawa T, Kaneko T, Nakagama H, Imawari M, et al. Positive and negative regulations of albumin gene expression by retinoids in human hepatoma cell lines. Mol Carcinogenesis 1994;10:151-158.
20. Krätzschmar J, Haendler B, Kojima S, Rifkin DB, Schleuning W-D. Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid. Gene 1993;125:177-183.
21. Nara K, Nakanishi K, Hagiwara H, Wakita K, Kojima S, Hirose S. Retinol-induced morphological changes of cultured bovine endothelial cells are accompanied by a marked increase in transglutaminase. J Biol Chem 1989;264:19308-19312.
22. Kojima S, Rifkin DB. Mechanism of retinoid-induced activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Physiol 1993;155:323-332.
23. Kawada N, Klein H, Decker K. Eicosanoid-mediated contractility of hepatic stellate cells. Biochem J 1992;285:367-371.
24. Kawada N, Tran-Thi T-A, Klein H, Decker K. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances: possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur J Biochem 1993;213:815-823.
25. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
26. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Ed 2. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
27. Derynck R, Jarrett JA, Chen EY, Goeddel DV. The murine transforming growth factor-b precursor. J Biol Chem 1986;261:4377-4379.
28. Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R. Murine transforming growth factor-β 2 cDNA sequence and expression in adult tissues and embryos. Mol Endocrinol 1989;3:1108-1114.
29. Miller DA, Lee A, Matsui Y, Chen EY, Moses HL, Derynck, R. Complementary DNA cloning of the murine transforming growth factor-beta3 (TGF-beta3) precursor and the comparative expression of TGF-beta3 and TGF-beta1 messenger RNA in murine embryos and adult tissues. Mol Endocrinol 1989;3:1926-1934.
30. Kojima S, Muramatsu H, Amanuma H, Muramatsu T. Midkine enhances fibrinolytic activity of bovine endothelial cells. J Biol Chem 1995;270: 9590-9596.
31. Muto Y, Moriwaki H. Antitumor activity of vitamin A and its derivatives. J Natl Cancer Inst 1984;73:1389-1393.
32. Khalil N, Bereznay O, Sporn M, Greenberg AH. Macrophage production of transforming growth factor β and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med 1989;170:727-737.
33. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. HEPATOLOGY 1981;1:431-435.
34. Okuno M, Muto Y, Moriwaki H, Kato M, Noma A, Tagaya O, Nozaki Y, et al. Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats. J Gastroenterol 1990;25:223-229.
35. Weiner FR, Giambrone M-A, Czaja MJ, Shah A, Annoni G, Takahashi S, Eghbali M, et al. Ito-cell gene expression and collagen regulation. HEPATOLOGY 1990;11:111-117.
36. Koda H, Okuno M, Imai S, Moriwaki H, Muto Y, Kawada N, Kojima S. Retinoic acid-stimulated liver stellate cells suppress the production of albumin from parenchymal cells via TGF-β. Biochem Biophys Res Commun 1996;221:565-569.
37. Senoo H, Wake K. Suppression of experimental hepatic fibrosis by administration of vitamin A. Lab Invest 1985;52:182-194.
38. Seifert WF, Bosma A, Brouwer A, Hendriks H, Roholl PJM, van Leeuwen REW, van Thiel-de Ruiter GCF, et al. Vitamin A deficiency promotes CCl4 liver fibrosis. HEPATOLOGY 1994;19:193-201.
39. Leo MA, Lieber CS. Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat. HEPATOLOGY 1983;3:1-11.
40. Geubel AP, De Galocsy C, Alves N, Rahier J, Dive C. Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology 1991;100:1701-1709.
41. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambom P. Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J 1990;9: 4443-4454.
42. Pan L, Eckhoff C, Brinckerhoff CE. Suppression of collagenase gene expression by all-trans and 9-cis retinoic acid is ligand dependent and requires both RARs and RXRs. J Cell Biochem 1995;57:575-589.
43. Hanazawa S, Takeshita A, Kitano S. Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-α-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells. J Biol Chem 1994;269:21379-21384.
44. Muto Y, Nouri-Aria KT, Meager A, Alexander GJM, Eddleston ALWF, Williams R. Enhanced tumor necrosis factor and interleukin-1 in fluminant hepatic failure. Lancet 1988;2:72-74.
45. Davis BH, Pratt BM, Madri JA. Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels. J Biol Chem 1987;262:10280-10286.
46. Davis BH, Kramer RT, Davidson NO. Retinoic acid modulates rat Ito cell proliferation, collagen and transforming growth factor β production. J Clin Invest 1990;86:2062-2070.
47. Davis BH, Vucic A. The effect of retinol on Ito cell proliferation in vitro. HEPATOLOGY 1988;8:788-793.
48. Pinzani M, Gentilini P, Abboud HE. Phenotypical modulation of liver fat-storing cells by retinoids. Influence on unstimulated and growth factor-induced cell proliferation. J Hepatol 1992;14:211-220.
49. Davis BH. Transforming growth factor β responsiveness is modulated by the extracellular collagen matrix during hepatic Ito cell culture. J Cell Physiol 1988;136:547-553.
50. Imai S, Okuno M, Moriwaki H, Muto Y, Murakami K, Shudo K, Suzuki Y, et al. 9, 13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-β via RAR α in a human stellate cell line, LI90. FEBS Lett 1997; in press.
51. Mavier P, Mallat A. Perspectives in the treatment of liver fibrosis. J Hepatol 1995;22 (suppl 2):111-115.
52. Strobel D, Wittekind Ch, Ruoslahti E, Hahn EG. In vivo application of a neutralizing TGF-beta antibody in experimental liver fibrosis. J Hepatol 1993;18 (suppl 1):S63.