Medical therapy for inflammatory bowel disease

Gastroenterology Clinics of North America

Volumn 28, Issue 2, 1999, Pages 297-321

  Stein, R B ^a   Hanauer, S B ^a  

^a PENN PRESBYTERIAN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOSALICYLIC ACID; ANTIBIOTIC AGENT; AZATHIOPRINE; BALSALAZIDE; CORTICOSTEROID; CYCLOSPORIN; IMMUNOMODULATING AGENT; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; METRONIDAZOLE; OLSALAZINE; PREDNISONE; SALAZOSULFAPYRIDINE;

ADRENAL HEMORRHAGE; AFFECTIVE NEUROSIS; ANOREXIA; BONE MARROW SUPPRESSION; BONE NECROSIS; CATARACT; COLON RESECTION; CROHN DISEASE; DIARRHEA; DIET THERAPY; DYSPEPSIA; ENTERITIS; FEVER; FISTULA; FLUID RETENTION; HEADACHE; HEPATITIS; HUMAN; HYPERGLYCEMIA; IMMUNOMODULATION; INFLAMMATION; LEUKOPENIA; LIVER FIBROSIS; MALAISE; MYOPATHY; NAUSEA; PANCREATITIS; RASH; REVIEW; TERATOGENESIS; ULCERATIVE COLITIS; VOMITING;

EID: 0032980138     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8553(05)70058-3     Document Type: Article

References (252)

1. D.J. Adler B.I. Korelitz The therapeutic efficacy of 6-mercaptourine in refractory ulcerative colitis Am J Gastroenterol 85 1990 712 722
2. S. Arora W.N. Katkov J. Cooley A double-blind, randomized, placebo-controlled trial of methotrexate in Crohn's disease Gastroenterology 102 1993 A591
3. Azad Khan A.K. D.T. Howes J. Piris Optimum dose of sulphasalazine for maintenance treatment in ulcerative colitis Gut 21 1980 232 240
4. S. Bank C. Sninsky M. Robinson Safety and activity evaluation of rhIL-11 in subjects with active Crohn's disease Gastroenterology 112 1997 A927
5. G. Bardazzi Intermittent versus continuous 5-aminosalicylic acid treatment for maintaining remission in ulcerative colitis Ital J Gastroenterol 26 1994 334 337
6. J.H. Baron A.M. Connell T.G. Kanaghinis Outpatient treatment of ulcerative colitis: Comparison between three doses of oral prednisone BMJ 2 1962 441 443
7. J.H. Baron P.M. Connell J.E. Lennard-Jones Sulphasalazine and salicylazosulphadimidine in ulcerative colitis Lancet 1 1962 1094
8. T.H. Baron C.D. Truss C.O. Elson Low-dose oral methotrexate in refractory inflammatory bowel disease Dig Dis Sci 38 1993 1851 1856
9. A. Belluzi C. Brignola M. Campieri Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease N Engl J Med 334 1996 1557 1560
10. A. Belluzi M. Campieri C. Belloli A new enteric coated preparation of omega-3 fatty acids for preventing post-surgical recurrence in Crohn's disease Gastroenterology 112 1997 A930
11. L.H. Bernstein M.S. Frank L.J. Brandt Healing of perineal Crohn's disease with metronidazole Gastroenterology 79 1980 357 365
12. Bianchi Porro G. C. Prantera M. Campieri Comparative trial of budesonide or methylprednisolone enemas in active distal ulcerative colitis Eur J Gastroenterol Hepatol 6 1994 125 130
13. R.C. Bicks K.W. Groshart R.W. Chandler The treatment of severe chronically active Crohn's disease by T8 (suppressor cell) lymphapheresis Gastroenterology 88 1985 A1325
14. S.J. Bickston F. Cominelli Treatment of Crohn's disease at the turn of the century N Engl J Med 339 1998 401 402
15. W.L. Biddle N.J. Greenberger J.T. Swan 5-Aminosalicylic acid enemas: Effective agent in maintaining remission in left-sided colitis Gastroenterology 94 1988 1075 1079
16. I. Bjarnason J. Hayllar A. MacPherson Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans Gastroenterology 104 1993 1832 1847
17. D.T. Boumpas G.P. Chrousos R.L. Wilder Glucocorticoid therapy immune-mediated diseases: Basic and clinical correlates Ann Intern Med 119 1993 1198 1208
18. A. Bousvaros B. Kirschner S. Werlin Oral tacrolimus treatment of severe colitis in children Gastroenterology 112 1997 A941
19. L.J. Brandt L.H. Bernstein S.J. Boley Metronidazole therapy for perineal Crohn's disease: A follow-up study Gastroenterology 83 1982 383 387
20. R. Brattsand Overview of newer glucocorticosteroid preparations for inflammatory bowel disease Can J Gastroenterol 4 1990 407 414
21. R. Brattsand M. Linden Cytokine modulation by glucocorticoids: Mechanisms and actions in cellular studies Aliment Pharmacol Ther 10 1996 81 92
22. R.I. Breuer S.K. Buto M.I. Christ Rectal irrigation with short chain fatty acids for distal ulcerative colitis: Preliminary report Dig Dis Sci 36 1991 185 187
23. C. Brignola M. Cottone A. Pera Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease Gastroenterology 108 1994 345 349
24. J. Brynskov L. Freund S.N. Rasmussen A placebo-controlled, double-blind randomized trial of cyclosporine therapy in active chronic Crohn's disease N Engl J Med 321 1989 845 850
25. J. Brynskov L. Freund S.N. Rasmussen Final report on a placebo-controlled, double-blind, randomized, multicenter trial of cyclosporine treatment in active Crohn's disease Scand J Gastroenterol 26 1991 689 695
26. C. Camma Mesalamine in the maintenance treatment of Crohn's disease: A meta-analysis adjusted for confounding variables Gastroenterology 113 1997 1465 1473
27. M. Campieri R. Defranchis G. Bianchi Mesalazine (5-ASA) suppositories in the treatment of ulcerative proctitis or distal proctosigmoiditis Scand J Gastroenterol 25 1990 663 668
28. S. Candy J. Wright M. Gerber A controlled double blind study of azathioprine in the management of Crohn's disease Gut 37 1995 674 678
29. R. Caprilli A. Anreoli L. Capurso Oral mesalazine (5-aminosalicylic acid; Asacol) for the prevention of post-operative recurrence of Crohn's disease. (GISC) Aliment Pharmacol Ther 8 1994 35 43
30. R. Caprilli R. Carratu M. Babbini A double-blind comparison of the effectiveness of azathioprine and sulfasalazine in idiopathic proctocolitis: A preliminary report Dig Dis 20 1975 115 120
31. R.W. Chapman W.S. Selby D.P. Jewel Controlled trial of metronidazole as an adjunct to corticosteroids in severe ulcerative colitis Gut 27 1986 1210 1212
32. P.M. Choi S.R. Targan Immunomodualatory treatment in inflammatory bowel disease Dig Dis Sci 39 1994 1885 1892
33. R.Y. Chong S.B. Hanauer R.D. Cohen Methotrexate in Crohn's disease: How is it doing? Gastroenterology 113 1998 A3245
34. R.D. Cohen S.B. Hanauer Immunomodulatory agents and other medical therapies in inflammatory bowel disease Curr Opin Gastroenterol 11 1995 321 330
35. J.F. Colombel M. Lemann Y. Bouhnik A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn's disease Gastroenterology 112 1997 A951
36. T. Colonna B.I. Korelitz The role of leukopenia in the 6-mercaptopurine-induced remission of refractory Crohn's disease Am J Gastroenterol 89 1994 362 366
37. J.E. Comptson Review article: Osteoporosis, corticosteroids and inflammatory bowel disease Aliment Pharmacol Ther 9 1995 237 250
38. W.R. Connell M.A. Kamm M. Dickson Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease Lancet 343 1994 1249 1252
39. W.R. Connell M.A. Kamm J.K. Ritchie Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience Gut 34 1993 1081 1085
40. M. Cottone M. Roselli A. Orlando Smoking habits and recurrence in Crohn's disease Gastroenterology 106 1994 643 648
41. C. Cuffari 6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity Gut 39 1996 401 406
42. d'Albaso G. Combined therapy with 5-aminosalicylic acid tablets and enemas for maintaining remission in ulcerative colitis: A randomized double-blind study Am J Gastroenterol 92 1997 1143 1147
43. d'Albaso G. Maintenance treatment of ulcerative proctitis with mesalazine suppositories: A double-blind placebo-controlled trial. The Italian IBD Study Group Am J Gastroenterol 93 1998 799 803
44. A. Danielsson G. Hellers E. Lyrenas A controlled randomized trial of budesonide versus prednisolone retention enemas in active distal ulcerative colitis Scand J Gastroenterol 22 1987 987
45. A. Danielsson R. Lofberg T. Persson A steroid enema, budesonide, lacking systemic effects for the treatment of distal ulcerative colitis or proctitis Scand J Gastroenterol 27 1992 9 12
46. Danish Budesonide Study Group Budesonide enema in distal ulcerative colitis: A randomized dose-response trial with prednisolone enema as a positive control Scand J Gastroenterol 26 1991 1225 1230
47. K.M. Das M.A. Eastwood J.P. McManus Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype N Engl J Med 289 1973 491 495
48. K.M. Das M.A. Eastwood Acetylation polymorphism of sulfapyridine in patients with ulcerative colitis and Crohn's disease Clin Pharmacol Ther 18 1972 514 520
49. G. D'Haens Intravenous cyclosporine monotherapy versus intravenous methylprednisolone monotherapy in severe ulcerative colitis: A randomized, double-blind controlled trial Gastroenterology 114 1998 A963
50. A.P. Dick M.J. Grayson R.G. Carpenter Controlled trial of sulphasalazine in the treatment of ulcerative colitis Gut 5 1964 437
51. F.E. DiPavoda Pharmacology of cyclosporine (Sandimmune) Pharmacol Rev 41 1989 373 397
52. A.S. Dissanayake S.C. Truelove A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine (Salazopyrin) Gut 14 1973 923 926
53. R. Eliakim D. Rachmilewitz Potential mediators of inflammatory bowel disease Gastroenterol Int 5 1992 48 56
54. E. Elton S.B. Hanauer Review article: The medical management of Crohn's disease Aliment Pharmacol Ther 10 1996 1 22
55. R.C. Evans V.S. Wong A.I. Morris Treatment of corticosteroid-resistant ulcerative colitis with heparin—a report of 16 cases Aliment Pharmacol Ther 11 1997 1037
56. K. Ewe C. Herfarth H. Makhow Postoperative recurrence of Crohn's disease in relation to radicality of operation and sulfasalazine prophylaxis: A multicenter trial Digestion 42 1989 224 232
57. K. Ewe A.G. Press C. Singe Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease Gastroenterology 105 1993 367 372
58. B.G. Feagan J.W.D. McDonald Rochon J. for the Canadian Crohn's Prevention Trial Investigators Low dose cyclosporin A for treatment of Crohn's disease N Engl J Med 330 1994 1846 1851
59. B.G. Feagan J. Rochon R.N. Fedorak Methotrexate for the treatment Crohn's disease N Engl J Med 332 1995 292 297
60. K. Fellerman D. Ludwig M. Stahl Tacrolimus in steroid refractory inflammatory bowel disease Gastroenterology 112 1997 A971
61. F. Fernandez-Banares Azathioprine is useful in maintaining long-term remission induced by intravenous cyclosporine in steroid-refractory severe ulcerative colitis Am J Gastroenterol 91 1996 2498 2499
62. R. Fiasse F. Fontaine R. Vanheuverzwyn Prevention of Crohn's disease recurrences after intestinal resection wtih Eudragit-L-coated 5-aminosalicylic acid: Preliminary results of a 1-year double-blind placebo-controlled study Gastroenterology 100 1991 A208
63. C. Fiocchi Inflammatory bowel disease: Etiology and pathogenesis Gastroenterology 115 1998 182 205
64. C. Florent A. Cortot P. Quandale Placebo-controlled trial of Claversal in the prevention of early endoscopic relapse after curative resection for Crohn's disease Gastroenterology 102 1992 A623
65. D. Freeman Pharmacokinetics of a new oral formulation of cyclosporine in liver transplant recipients Ther Drug Monit 17 1995 213 216
66. L.S. Friedman J.M. Richter S.E. Kirkham 5-ASA enemas in refractory distal ulcerative colitis: A randomized controlled trial Am J Gastroenterol 81 1986 412 416
67. P.R. Gaffney C.T. Doyle A. Gaffney Paradoxical response to heparin in10 patients with ulcerative colitis Am J Gastroenterol 90 1995 220 223
68. T.S. Gaginella R.E. Walsh Sulfasalazine: Multiplicity of action Dig Dis Sci 37 1992 801 812
69. J.P. Gendre J.Y. Mary C. Florent Oral mesalamine (Pentasa) as maintenance treatment in Crohn's disease: A multicenter placebo-controlled study (GETAID) Gastroenterology 104 1993 435 439
70. L. Genestier Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells J Clin Invest 102 1998 322 328
71. J. George D.H. Present R. Pou The long-term outcome of ulcerative colitis treated with 6-mercaptopurine Am J Gastroenterol 91 1996 1711 1714
72. M.H. Giaffer C.J. O'Brien C.D. Holdsworth Clinical tolerance to three 5-ASA releasing preparations in patients with inflammatory bowel disease intolerant or allergic to sulfasalazine Aliment Pharmacol Ther 6 1992 51 61
73. P. Gionchetti Comparison of mesalazine suppositories in proctitis and distal proctosigmoiditis Aliment Pharmacol Ther 11 1997 1053 1057
74. J.T. Green Nicotine enemas for active ulcerative colitis—A pilot study Aliment Pharmacol Ther 11 1997 859 863
75. G.R. Greenberg G.B. Feagan the Canadian Inflammatory Bowel Disease Study Group Oral budesonide for active Crohn's disease N Engl J Med 331 1994 836 841
76. S.L. Greenbloom A.H. Steinhart G.R. Greenberg Combination ciprofloxacin and metronidazole for active Crohn's disease Can J Gastroenterol 12 1998 53 56
77. S.M. Greenfield N.A. Punchard J.P. Teare Review article: The mode of action of the aminosalicylates in inflammatory bowel disease Aliment Pharmacol Ther 7 1993 369 383
78. M.B. Grisham Oxidants and free radicals in inflammatory bowel disease Lancet 344 1994 859 861
79. D.J. Haber S.J. Meltzer D.H. Present Nature and course of pancreatitis caused by 6-mercaptopurine in the treatment of inflammatory bowel disease Gastroenterology 91 1986 982 986
80. R. Hamedani R.D. Feldman B.G. Feagan Review article: Drug development in inflammatory bowel disease: Budesonide—a model of targeted therapy Aliment Pharmacol Ther 11 1997 98 108
81. S.J. Hampson M.C. Parker S.H. Saverymuttu Results of quadruple antimycobacterial chemotherapy in 17 Crohn's disease patients completing six months of treatment Gastroenterology 94 1988 A170
82. S. Hanauer B. Powers M. Robinson Maintenance of remission of ulcerative colitis by mesalamine (Asacol) vs. placebo Gastroenterology 106 1994 A696
83. S. Hanauer J. Schwartz M. Robinson Mesalamine capsules for the treatment of active ulcerative colitis: Results of a controlled trial Am J Gastroenterol 88 1993 1188 1197
84. S.B. Hanauer Dose-ranging study of mesalamine (Pentasa) enemas in the treatment of acute ulcerative proctosigmoiditis: Results of a multicentered placebo-controlled trial. The U.S. Pentasa Enema Study Group Inflammatory Bowel Diseases 4 1998 79 83
85. S.B. Hanauer Drug therapy: Inflammatory bowel disease N Engl J Med 334 1996 841 848
86. S.B. Hanauer Medical therapy in ulcerative colitis Kirsner J.B. Shorter R.G. Inflammatory Bowel Disease ed 4 1995 Williams & Wilkins Baltimore 664 694
87. S.B. Hanauer Medical therapy of ulcerative colitis Lancet 342 1993 412 417
88. S.B. Hanauer Nicotine for colitis: The smoke has not yet cleared N Engl J Med 330 1994 856 857
89. S.B. Hanauer Update on mesalazine for inflammatory bowel disease Res Clin Forums 20 1998 203 208
90. S.B. Hanauer Long-term management of Crohn's disease with mesalamine capsules (Pentasa). Pentasa Crohn's Disease Compassionate Use Study Group Am J Gastroenterol 88 1993 1343 1351
91. S.B. Hanauer F. Baert Medical therapy of inflammatory bowel disease Med Clin North Am 78 1994 1413 1426
92. S.B. Hanauer G. D'Haens Medical management of ulcerative colitis Targan S.R. Shanahan F. Inflammatory Bowel Disease: From Bench to Bedside 1994 Williams & Wilkins Baltimore 545 566
93. S.B. Hanauer S. Meyers D.B. Sachar The pharmacology of anti-inflammatory drugs in inflammatory bowel disease Kirsner J.B. Shorter R.G. Inflammatory Bowel Disease ed 4 1995 Williams & Wilkins Baltimore 643 663
94. S.B. Hanauer Meyers S: Management of Crohn's disease in adults Am J Gastroenterol 92 1997 559 566
95. S.B. Hanauer M. Schulman Novel therapies for inflammatory bowel disease Gastroenterol Clin North Am 24 1995 523 540
96. S.B. Hanauer M.B. Smith Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A Am J Gastroenterol 88 1993 646 649
97. S.B. Hanauer G. Stathopoulos Risk-benefit assessment of drugs used in treatment of inflammatory bowel disease Drug Safe 6 1991 192 219
98. J.M. Harig K.H. Soergel C.M. Wood Treatment of diverson colitis with short chain fatty acids N Engl J Med 320 1989 23 28
99. Hawthorne A.B. Daneshmend C.J. Hawkey Treatment of ulcerative colitis with fish oil supplementation: A prospective 12 month randomised controlled trial Gut 33 1992 922 928
100. A.B. Hawthorne C.J. Hawkey Immunosuppressive drugs in inflammatory disease: A review of their mechanisms of efficacy and place in therapy Drugs 38 1989 267 288
101. A.B. Hawthorne R.F.A. Logan C.J. Hawkey Randomized controlled trial of azathioprine withdrawal in ulcerative colitis BMJ 305 1992 20 22
102. A.B. Hawthorne C.O. Record C.D. Holdsworth Double-blind trial of oral fluticasone proprionate versus prednisolone in the treatment of active ulcerative colitis Gut 34 1993 125
103. J.O. Hunter Nutritional factors in inflammatory bowel disease Eur J Gastroenterol Hepatol 10 1998 23507
104. International Mesalazine Study Group Coated oral 5-aminosalicylic acid versus placebo in maintaining remission in inactive Crohn's disease Aliment Pharmacol Ther 4 1990 55 64 428–437, 1990.
105. D.P. Jewell J.E. Lennard-Jones the Cyclosporin Study Group of Great Britain and Ireland Oral cyclosporin for chronic active Crohn's disease: A multicentre controlled trial Eur J Gastroenterol Hepatol 6 1994 499 505
106. D.P. Jewell S.C. Truelove Azathioprine in ulcerative colitis: Final report on a controlled therapeutic trial BMJ 4 1974 627 630
107. L.D. Kennedy Nicotine therapy for ulcerative colitis Ann Pharmacother 30 1996 1022 1023
108. Y.I. Kim Short-chain fatty acids in ulcerative colitis Nutr Rev 56 1998 17 24
109. A.P. Kirk J.E. Lennard-Jones Controlled trial of azathioprine in chronic ulcerative colitis BMJ 284 1982 1291 1292
110. M. Klein H.J. Binder M. Mitchell Treatment of Crohn's disease with azathioprine: A controlled evaluation Gastroenterology 66 1974 916 922
111. S. Klein J. Kinney J. Khursheed Nutrition support in clinical practice: Review of published data and recommendations for future research directions J Parenter Enteral Nutr 21 1997 133
112. U. Klotz K. Maier C. Fischer Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease N Engl J Med 303 1980 1499 1502
113. B. Korelitz S. Hanauer P. Rutgeerts Post-operative prophylaxis with 6-MP, 5-ASA or placebo in Crohn's disease: A 2 year multicenter trial Gastroenterology 114 1998 A991
114. B.I. Korelitz D.J. Adler R.A. Mendelsohn Long-term experience with 6-mercaptopurine in the treatment of Crohn's disease Am J Gastroenterol 88 1993 1198 1205
115. A.A. Kornbluth Meta-analysis of the effectiveness of current drug therapy of ulcerative colitis J Clin Gastroenterol 16 1993 215 218
116. A. Kornbluth S. Lichtiger D.H. Present Long-term results of oral cyclosporin in patients with severe ulcerative colitis: A double-blind, randomized, multicenter trial Gastroenterology 106 1995 A714
117. A. Kornbluth D.H. Present S. Lichtiger Cyclosporin for severe ulcerative colitis: A user's guide Am J Gastroenterol 92 1997 1424 1428
118. A. Kornbluth D.B. Sachar Ulcerative colitis practice guidelines in adults Am J Gastroenterol 92 1997 204 211
119. J. Korzenik IBD: A vascular disorder? The case for heparin therapy Inflammatory Bowel Diseases 3 1997 87 94
120. R.A. Kozorek D.J. Patterson M.D. Gelfand Methotrexate induces clinical and histological remission in patients with refractory inflammatory bowel disease Ann Intern Med 110 1989 353 356
121. K. Lake D. Canafax Important interactions of drugs with immunosuppressive agents used in transplant recipients J Antimicrob Chemother 36 1995 11 22
122. C.A. Langford Use of cytotoxic agents and cyclosporine in the treatment of autoimmune disease Ann Intern Med 129 1998 49 58
123. K. Lauritsen S. Laursen Bukhave K. Inflammatory intermediaries in inflammatory bowel disease Int J Colorectal Dis 4 1989 75 90
124. A. Lavy G. Wwisz Y. Adir Hyperbaric oxygen for perianal Crohn's disease J Clin Gastroenterol 19 1994 202 205
125. J.E. Lennard-Jones Sulphasalazine in asymptomatic Crohn's disease: A multicenter trial Gut 18 1977 69 72
126. J.E. Lennard-Jones Toward optimal use of corticosteroids in ulcerative colitis and Crohn's disease Gut 24 1983 177
127. J.E. Lennard-Jones A.J. Longmore A.C. Newel An assessment of prednisone, salazopyrine and topical hydrocortisone hemisuccinate used a outpatient treatment of ulcerative colitis Gut 1 1960 217 222
128. J.D. Lewis R.L. Fisher Nutrition support in inflammatory bowel disease Med Clin North Am 78 1994 1443 1456
129. S. Lichtiger D.H. Present Preliminary report: Cyclosporin in treatment of severe acute ulcerative colitis Lancet 336 1990 16 19
130. S. Lichtiger D.H. Present A. Kornbluth Cyclosporin in severe ulcerative colitis refractory to steroid therapy N Engl J Med 330 1994 1841 1845
131. R. Lofberg New data on inflammatory bowel disease treatment with topical steroids Res Clin Forums 19 1997
132. R. Lofberg P. Rutgeerts H. Malchow Budesonide CIR for maintenance of remission in ileocecal Crohn's disease: A European multicenter placebo controlled trial for 12 months Gastroenterology 160 1994 A722
133. R.P. MacDermott Alterations in the mucosal immune system in ulcerative colitis and Crohn's disease Med Clin North Am 78 1994 1207 1231
134. A.M. Macleod A.W. Thomson FK506: An immunosuppressant for the 1990's? Lancet 337 1991 25
135. Y.R. Mahida D.P. Jewell Slow-release 5-amino-salicylic acid (Pentasa) for the treatment of active Crohn's disease Digestion 45 1990 88 92
136. H. Malchow K. Ewe J.W. Brandes European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment Gastroenterology 86 1984 249 266
137. M.L. Margolin M.P. Krumholz S.E. Fochios Clinical trials in ulcerative colitis: II. Historical review Am J Gastroenterol 83 1988 227 243
138. J.F. Marion D.H. Present The modern medical management of acute, severe ulcerative colitis Eur J Gastroenterol Hepatol 9 1997 831 835
139. J.K. Marshall E.J. Irvine Rectal aminosalicylate therapy for distal ulcerative colitis: A meta-analysis Aliment Pharmacol Ther 9 1995 293 300
140. J.K. Marshall E.J. Irvine Rectal corticosteroids versus alternative treatments in ulcerative colitis: A meta-analysis Gut 40 1997 775 781
141. J.K. Marshall E.J. Irvine Topical aminosalicylate (ASA) therapy for distal ulcerative colitis: A meta-analysis Gastroenterology 106 1994 A1037
142. R. Mcleod B.G. Wolff H. Steinhart Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease Gastroenterology 109 1995 404 413
143. A. Messori C. Brignila G. Trallori Effectiveness of 5-aminosalicylic acid for maintaining remission in patients with Crohn's disease: A meta-analysis Am J Gastroenterol 89 1994 692 698
144. S. Meyers H.D. Janowitz Systemic corticosteroid therapy of ulcerative colitis Gastroenterology 89 1985 1189 1199
145. S. Meyers H.D. Janowitz The “natural history” of ulcerative colitis: An analysis of the placebo response J Clin Gastroenterol 11 1989 33 37
146. S. Meyers D.B. Sachar J.D. Goldberg Corticotropin versus hydrocortisone in intravenous treatment of ulcerative colitis Gastroenterology 85 1983 351 357
147. S. Meyers D.B. Sachar Medical therapy of Crohn's disease Kirsner J.B. Shorter R.G. Inflammatory Bowel Disease ed 4 1995 Williams & Wilkins Baltimore 695 714
148. P.B. Minor Factors influencing the relapse of patients with inflammatory bowel disease Am J Gastroenterol 92 1997 1S
149. J.J. Misiewicz J.E. Lennard-Jones A.M. Connell Controlled trial of sulphasalazine in maintenance therapy for ulcerative colitis Lancet 1 1965 185 188
150. R. Modigliani Mesalamine in Crohn's disease with steroid-induced remission: Effect on steroid withdrawal and remission maintenance. Group d'Etudes Therapeutiques des Affections Inflammatoires Digestives Gastroenterology 110 1996 688 693
151. S.L. Morgan J.E. Baggott W.H. Vaughn Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis Ann Intern Med 121 1994 833 841
152. L.M. Morrison Results of treatment of ulcerative colitis with salicylazosulfapyridine Gastroenterology 21 1952 133 138
153. P. Munkholm E. Langholz M. Davidsen Frequency of glucocorticoid resistance and dependency in Crohn's disease Gut 35 1994 360 362
154. M.F. Neurath R. Wanitschke M. Peters Randomized trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease Gastroenterology 113 1998 A1958
155. L.J. O'Donnell Double-blind, controlled trial of 4-aminoslicylic acid and prednisolone enemas in distal ulcerative colitis Gut 33 1992 947 949
156. D.P. O'Donoghue A.M. Dawson J. Powell-Tuck Double-blind withdrawal trial of azathioprine as maintenance treatment in Crohn's disease Lancet 2 1978 955 957
157. S.J. O'Keefe B.G. Rooser Nutrition and inflammatory bowel disease Targan S.R. Shanahan F. Inflammatory Bowel Disease: From Bench to Bedside 1994 Williams & Wilkins Baltimore 461 477
158. R. Oren M. Moshkowitz S. Odes Methotrexate in chronic active Crohn's disease: A double-blind, randomized, Israeli multicenter trial Am J Gastroenterol 92 1997 2203 2209
159. J. Patz W.Z. Jacobson S. Gottschalk-Aabag Treatment of distal ulcerative colits with short-chain fatty acid enemas Am J Gastroenterol 91 1996 73 74
160. Pearson D. Azathioprine for maintenance of remission of Crohn's disease (Cochrane Review). The Cochrane Library Vol Issue 3 1998 Update Software Oxford
161. D.C. Pearson G.R. May G.H. Fick Azathioprine and 6-MP in Crohn's disease: A meta-analysis Ann Intern Med 122 1995 132 142
162. M. Peppercorn K. Das C. Elson Zileuton, a 5-lipoxygenase inhibitor, in the treatment of active ulcerative colitis: A double-blind, placebo-controlled trial Gastroenterology 106 1994 A751
163. F. Pigot C. Roux S. Chaussade Low bone mineral density in patients with inflammatory bowel disease Dig Dis Sci 37 1992 1396
164. D.K. Podolsky Inflammatory bowel disease (review article) N Engl J Med 325 1991 928 937
165. C. Prantera A. Kohn R. Mangiarotti Antimycobacterial therapy in Crohn's disease: Results of a controlled, double-blind trial with a multiple antibiotic regimen Am J Gastroenterol 89 1994 513 518
166. C. Prantera F. Pallone G. Brunetti Oral-5-aminosalicylic acid (Asacol) in the maintenance treatment of Crohn's disease Gastroenterology 103 1992 363 368
167. D.H. Present Toxic megacolon Med Clin North Am 77 1993 1129 1148
168. D.H. Present B.I. Korelitz N. Wisch Treatment of Crohn's disease with 6-mercaptopurine: A long-term randomized, double-blind study N Engl J Med 302 1981 981 987
169. D.H. Present S. Lichtiger Efficacy of cyclosporine in treatment of fistula of Crohn's disease Dig Dis Sci 39 1994 374 380
170. D.H. Present S.J. Meltzer M.P. Krumholz 6-Mercaptopurine in the management of inflammatory bowel disease: Short and long term toxicity Ann Intern Med 111 1989 641 649
171. R.D. Pullan S. Ganesh V. Mani Comparison of bismuth citrate and 5-aminosalicylic acid enemas in distal ulcerative colitis: A controlled trial Gut 34 1993 676
172. R.D. Pullan J. Rhodes S. Ganesh Transdermal nicotine for active ulcerative colitis N Engl J Med 330 1994 811 815
173. V.A. Quan Cyclosporin treatment for ulcerative colitis complicated by fatal Pneumocystis carinii pneumonia BMJ 314 1997 363 364
174. J. Ramakrishna Combined use of cyclosporine and azathioprine or 6-mercaptopurine in pediatric inflammatory bowel disease J Pediatr Gastroenterol Nutr 22 1996 296 302
175. J. Rask-Madsen K. Burkhave L.S. Laursen 5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease Agents Actions (special conference) 1992 C37 C46
176. S.N. Rasmussen K. Laurtisen U. Tage-Jensen 5-Aminosalicylic acid in the treatment of Crohn's disease Scand J Gastroenterol 22 1987 877 883
177. J. Rhodes D. Bainton P. Beck Controlled trial of azathioprine in Crohn's disease Lancet 2 1971 1273 1276
178. J.L. Rosenberg B. Levin A.J. Wall A controlled trial of azathioprine in Crohn's disease Dig Dis 20 1975 721 726
179. J.L. Rosenberg A.J. Wall B. Levin A controlled trial of azathioprine in the management of chronic Crohn's disease Gastroenterology 69 1975 96 99
180. J.L. Rosenberg A.J. Wall R.H. Settles A controlled trial of azathioprine in the treatment of chronic ulcerative colitis Gastroenterology 64 1973 793 801
181. P. Rutgeerts M. Hick M. Peeters Prevention of clinical recurrence after ileal resection for Crohn's disease with metronidazole: A placebo controlled study Gastroenterology 106 1994 A764
182. P. Rutgeerts M. Hiele K. Geboes Controlled trial of metronidazole for prevention of Crohn's recurrence after ileal resection Gastroenterology 108 1995 1617 1621
183. P. Rutgeerts R. Lofberg H. Malchow A comparison of budesonide and prednisolone for active Crohn's disease N Engl J Med 331 1994 842 845
184. D.B. Sachar Budesonide for inflammatory bowel disease Is it the magic bullet? N Engl J Med 331 1994 873 874
185. D.B. Sachar Maintenance therapy in ulcerative colitis and Crohn's disease J Clin Gastroenterol 20 1995 117 122
186. P. Saloman A. Kornbluth J. Aisenberg How effective are current drugs for Crohn's disease? A meta-analysis J Clin Gastroenterol 14 1992 211 215
187. W. Sandborn An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease Gastroenterology 109 1995 1808 1817
188. W. Sandborn Azathioprine or 6-mercaptopurine therapy for induction of remission in active Crohn's disease. The Cochrane Library Vol Issue 3 1998 Update Software Oxford
189. W.J. Sandborn A critical review of cyclosporine therapy in inflammatory bowel disease Inflammatory Bowel Diseases 1 1995 48 63
190. W.J. Sandborn Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease Am J Gastroenterol 92 1997 876 879
191. W.J. Sandborn A review of immune modifier therapy for inflammatory bowel disease: Azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate Am J Gastroenterol 91 1996 423 433
192. W.J. Sandborn Are short-chain fatty acid enemas effective for left-sided ulcerative colitis? Gastroenterology 114 1998 218 219
193. W.J. Sandborn Pouchitis following ileal pouch-anal anastomosis: Definition, pathogenesis, and treatment Gastroenterology 107 1994 1856 1860
194. W.J. Sandborn Transdermal nicotine for mildly to moderately active ulcerative colitis: A randomized, double-blind, placebo-controlled trial Ann Intern Med 126 1997 364 371
195. W.J. Sandborn W.J. Tremaine Cyclosporine treatment of inflammatory bowel disease Mayo Clin Proc 67 1992 981 990
196. W.J. Sandborn W. Tremaine R.D. Hurt Open maintenance treatment with transdermal nicotine: Long-term results after a randomized, double-blind, placebo-controlled trial for active ulcerative colitis Gastroenterology 114 1998 A4401
197. W.R. Sandborn R. McLeod D. Jewell Medical therapy for induction and maintenance of remission in pouchitis: A systematic review. The Cochrane Library Vol Issue 3 1998 Update Software Oxford
198. G.I. Sandle J.P. Hayslett H.J. Binder Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis Gut 27 1986 309 316
199. R.B. Sartor Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis, and experimental intestinal inflammation Kirsner J.B. Shorter R.G. Inflammatory Bowel Disease ed 4 1995 Williams & Wilkins Baltimore 96 124
200. W. Scheppach H. Sommer T. Kirchner Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis Gastroenterology 103 1992 51 56
201. Schreiber S. Fedorak R.N. Nielson O.H. the Crohn's Disease IL-10 Cooperative Study Group A safety and efficacy study of recombinant human interleuken-10 (rHuIL-10) treatment in 329 patients with chronic active Crohn's disease Gastroenterology 114 1998 A1083
202. K.W. Schroeder W.J. Tremaine D.M. Ilstrup Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis N Engl J Med 317 1987 1625 1629
203. J.W. Singleton H.B. Hanauer Gitnick G.L. the Pentasa Crohn's Disease Study Group Mesalamine capsules for the treatment of active Crohn's disease: Results of a 16 week trial Gastroenterology 104 1993 1293 1301
204. C.A. Sninsky D.H. Cort F. Shanahan Oral mesalamine (Asacol) for mildly to moderately active ulcerative colitis Ann Intern Med 115 1991 350 355
205. W.A. Stack S.D. Mann A.J. Roy Randomized controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease Lancet 349 1997 521
206. M.E. Stark W.J. Tremaine Maintenance of symptomatic remission in patients with Crohn's disease Mayo Clin Proc 68 1993 1183 1190
207. R. Stein R. Cohen S. Hanauer Complications during cyclosporine therapy for inflammatory bowel disease Gastroenterology 112 1997 A1096
208. R.B. Stein S.B. Hanauer Life-threatening complications of IBD: How to handle fulminant colitis and toxic megacolon J Crit Illness 13 1998 518 525
209. A.H. Steinhart A. Brzezinski J.P. Baker Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas Am J Gastroenterol 89 1994 179 184
210. A.H. Steinhart D. Hemphill G.R. Greenberg Sulfasalazine and mesalazine for the maintenance treatment of Crohn's disease: A meta analysis Am J Gastroenterol 84 1994 2116 2124
211. W.F. Stenson D. Cort J. Rodgers Dietary supplementaton with fish oil in ulcerative colitis Ann Intern Med 116 1992 609 614
212. M. Sternthal J. George A. Kornbluth Toxicity associated with the use of cyclosporin in patients with inflammatory bowel disease Gastroenterology 110 1996 A1019
213. B.R. Stotland G.R. Lichtenstein Newer treatments for inflammatory bowel disease Prim Care Clin North Am 23 1996 577 608
214. A. Stronkhorst S. Radema ten Berge I Phase I multiple-dose pilot study of chimeric monoclonal M-T412 (anti-CD-4) antibodies is Crohn's disease Gastroenterology 104 1993 A784
215. R.W. Summers D.M. Switz Sessions J.T. Jr National Cooperative Crohn's Disease Study (NCCDS): Results of drug treatment Gastroenterology 77 1979 847 869
216. L. Sutherland The use of oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis (Cochrane Review). The Cochrane Library Vol Issue 3 1998 Update Software Oxford
217. L. Sutherland Systematic review of the use of oral 5-aminosalicylic acid in the induction of remission in ulcerative colitis (Cochrane Review). The Cochrane Library Vol Issue 3 1998 Update Software Oxford
218. L. Sutherland D. Roth P. Beck Alternatives to sulfasalazine: A meta-analysis of 5-ASA in the treatment of ulcerative colitis Inflammatory Bowel Diseases 3 1997 665 678
219. L. Sutherland J. Singleton J. Sessions Double blind, placebo controlled trial of metronidazole in Crohn's disease Gut 32 1991 1071 1075
220. L.R. Sutherland Topical treatment of ulcerative colitis Med Clin North Am 74 1990 119 131
221. L.R. Sutherland G.R. May E.A. Shaffer Sulfasalazine revisited: A meta-analysis of 5-aminosalicylic acid in the treatment of ulcerative colitis Ann Intern Med 118 1993 540 549
222. N. Svartz Sulfasalazine: II. Some notes on the discovery and development of salazopyrin Am J Gastroenterol 83 1988 497 503
223. G.L. Swift E.D. Srivastava R. Stone Controlled trial of anti-tuberculous chemotherapy for two years in Crohn's disease Gut 35 1994 363 368
224. S.L. Taffet K.M. Das Sulfasalazine: Adverse effects and desensitization Dig Dis Sci 28 1983 833
225. A.A. Tanis Azathioprine in inflammatory bowel disease, a safe alternative? Mediators Inflamm 7 1998 141 144
226. S.R. Targan S.B. Hanauer van Derventer S.J.H. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease N Engl J Med 337 1997 1029
227. G.A.O. Thomas J. Rhodes J.T. Green Inflammatory bowel disease and smoking—a review Am J Gastroenterol 93 1998 144 149
228. G.A.O. Thomas J. Rhodes V. Mani Transdermal nicotine as therapy for ulcerative colitis N Engl J Med 332 1995 988 992
229. O.O. Thomsen A comparison of budesonide and mesalamine for active Crohn's disease. International Budesonide-Mesalamine Study Group N Engl J Med 339 1998 370 374
230. W.J. Tremaine A randomized, double-blind, placebo-controlled trial of the oral mesalamine (5-ASA) preparation, Asacol, in the treatment of symptomatic Crohn's colitis and ileocolitis J Clin Gastroenterol 19 1994 278 282
231. W.J. Tremaine W.J. Sandborn M.L. Kenan Bismuth subsalicylate tablets for chronic antibiotic-resistant pouchitis Gastroenterology 113 1998 A1956
232. S.C. Truelove L.J. Witts Cortisone and corticotrophin in ulcerative colitis BMJ 1 1959 387 394
233. S.C. Truelove L.J. Witts Cortisone in ulcerative colitis: Final report on a therapeutic trial BMJ 2 1955 1041 1048
234. U. Turunen V. Farkkila K. Hakala A double-blind, placebo controlled six-month trial of ciprofloxacin treatment improved prognosis in ulcerative colitis Gastroenterology 106 1994 A786
235. U. Turunen V. Farkkila V. Valtonen Long-term outcome of ciprofloxacin treatment in severe perianal or fistulous Crohn's disease Gastroenterology 104 1993 A793
236. S. Urayama E.B. Chang Mechanisms and treatment of diarrhea in inflammatory bowel diseases Inflammatory Bowel Diseases 3 1997 114 131
237. B. Ursing T. Alm F. Barany A comparative study of metronidazole and sulfasalazine for active Crohn's disease: The Cooperative Crohn's disease study in Sweden Gastroenterology 83 1982 550 562
238. B. Ursing C. Kamme Metronidazole for Crohn's disease Lancet 1 1975 775 777
239. van Deventer S.J. Tumour necrosis factor and Crohn's disease Gut 40 1997 443 448
240. van Deventer S.J. C.O. Elson R.N. Fedorak Multiple doses of interleukin-10 in steroid refractory Crohn's disease Gastroenterology 113 1997 383
241. van Dulleman H.M. van Derventer S.J.H. D.W. Hommes Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2) Gastroenterology 109 1995 129 135
242. Van Hees P.A.M. Van Lier H.J.J. Van Elteren P.H. Effect of sulphasalazine in patients with active Crohn's disease: A controlled double-blind study Gut 22 1981 404 409
243. C. Wahl Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B J Clin Invest 101 1998 1163 1174
244. G. Watkinson Treatment of ulcerative colitis with topical hydrocortisone hemisuccinate sodium: A controlled trial employed restricted sequential analysis BMJ 2 1958 1077 1082
245. M.E. Weinblatt J.S. Coblyn D.A. Fox Efficacy of low-dose methotrexate in rheumatoid arthritis N Engl J Med 312 1985 818 822
246. A. Wenkert M. Krestensen A.E. Eklund The long-term prophylactic effect of salazosulphapyridine (salazopyrin) in primarily resected patients with Crohn's disease: A controlled double-blind trial Scand J Gastroenterol 13 1978 161 167
247. J.M. Willoughby P.J. Kumar J. Beckett Controlled trial of azathioprine in Crohn's disease Lancet 2 1971 944 947
248. B. Yacyshyn M.B. Woloschuk D. Yacyshyn Efficacy and safety of ISIS 2302 (ICAM antisense oligonucleotide) treatment of steroid dependent Crohn's disease Gastroenterology 112 1997 A1123
249. C.R. Yates Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance Ann Intern Med 126 1997 608 614
250. G.C. Yee Effect of grapefruit juice on blood cyclosporin concentration Lancet 345 1995 955 956
251. M.J. Zimmerman D.P. Jewell Cytokines and mechanisms of action of glucocorticoids and aminosalicylates in the treatment of ulcerative colitis and Crohn's disease Aliment Pharmacol Ther 10 1996 93 99
252. B.J. Zins Pharmacokinetics of nicotine tartrate after single-dose liquid enema, oral, and intravenous administration J Clin Pharmacol 37 1997 426 436