Pharmacokinetics of nicotine tartrate after single-dose liquid enema, oral, and intravenous administration

Journal of Clinical Pharmacology

Volumn 37, Issue 5, 1997, Pages 426-436

  Zins, Bradley J ^a,b   Sandborn, William J ^a   Mays, Dennis C ^a   Lawson, George M ^a   McKinney, Jeffrey A ^a   Tremaine, William J ^a   Mahoney, Douglas W ^a   Zinsmeister, Alan R ^a   Hurt, Richard D ^a   Offord, Kenneth P ^a   Lipsky, James J ^a  

^a MAYO CLINIC   (United States)

^b BILLINGS CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; CARBOXYMETHYLCELLULOSE; CITRATE SODIUM; DRUG VEHICLE; ENEMA; NICOTINE TARTRATE; SODIUM DIHYDROGEN PHOSPHATE; SORBITOL;

ADULT; AREA UNDER THE CURVE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAPHORESIS; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; HEADACHE; HUMAN; HUMAN EXPERIMENT; HYDROPHILICITY; HYDROPHOBICITY; INTRAVENOUS DRUG ADMINISTRATION; NAUSEA; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; REVIEW; SMOKING; TRANSDERMAL DRUG ADMINISTRATION; TREMOR; ULCERATIVE COLITIS; VERTIGO; VOMITING;

EID: 8244247101     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1997.tb04320.x     Document Type: Review

References (20)

1. Harries AD, Baird A, Rhodes J: Non-smoking: a feature of ulcerative colitis. BMJ 1982;284:706.
2. Jick H, Walker AM:Cigarette smoking and ulcerative colitis. N Engl J Med 1983;308:261-263.
3. Boyko EJ, Koepsell TD, Perera DR, Inui TS: Risk of ulcerative colitis among former and current cigarette smokers. N Engl J Med 1987;316:707-710.
4. Motley RJ, Rhodes J, Ford GA, Wilkinson SP, Chesner IM, Asquith P, et al: Time relationships between cessation of smoking and onset of ulcerative colitis. Digestion 1987;37:125-127.
5. Rudra T, Motley R, Rhodes J: Does smoking improve colitis? Scand J Gastroenterol 1989;24(suppl 170):61-63.
6. Roberts CJ, Diggle R: Non-smoking: a feature of ulcerative colitis. BMJ 1982;285:440.
7. Lashner BA, Hanauer SB, Silverstein MD: Testing nicotine gum for ulcerative colitis patients: experience with single-patient trials. Dig Dis Sci 1990;35:827-832.
8. Srivastava ED, Russell MAH, Feyerabend C, Williams GT, Masterson JG, Rhodes J: Transdermal nicotine in active ulcerative colitis. Eur J Gastroenterol Hepatol 1991;3:815-818.
9. Pullan RD, Rhodes J, Ganesh S, Mani V, Morris JS, Williams GT, et al: Transdermal nicotine for active ulcerative colitis. N Engl J Med 1994;330:811-815.
10. Sandborn WJ, Tremaine WJ, Offord KP, Lawson GM, Petersen BT, Batts KP, et al: Transdermal nicotine for mildly to moderately active ulcerative colitis: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1997;126:364-371.
11. Thomas GAO, Rhodes J, Ragunath K, Mani V, Williams GT, et al: Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis. Eur J Gastroenterol Hepatol 1996; 8:769-776.
12. Thomas GAO, Rhodes J, Mani V, Williams GT, Newcombe RG, Russell MAH, Feyerabend C: Transdermal nicotine as maintenance therapy for ulcerative colitis. N Engl J Med 1995;332:988-992.
13. Baskin LB, Charlson JR, Chezick P, Lawson GM: Determination of serum nicotine concentration using solid phase extraction, and GC-MS with selected ion monitoring (abstract). Am J Clin Path 1991;95:272-273.
14. Gibaldi M, Perrier D (eds.): Pharmacokinetics. Second Edition. New York: Marcel Dekker, 1982:409-417.
15. Bannon YB, Corish J, Corrigan OI, Devane JG, Kavanagh M, Mulligan S: Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study. Eur J Clin Pharmacol 1989;37:285-290.
16. Mulligan SC, Masterson JG, Devane JG, Kelly JG: Clinical and pharmacokinetic properties of a transdermal nicotine patch. Clin Phamacol Ther 1990;47:331-337.
17. Armitage AK, Turner DM: Absorption of nicotine in cigarette and cigar smoke through oral mucosa. Nature 1970;226:1231-1232.
18. Compton RF, Sandborn WJ, Lawson GM, Tremaine WJ, Zins BJ, Mays DC, et al: A dose-ranging pharmacokinetic study of nicotine tartrate following delayed-release oral (DRO) and intravenous (IV) administration (abstract). Gastroenterology 1997, in press.
19. Sandborn WJ, Tremaine WJ, Leighton JA, Lawson GM, Zins BJ, Compton RF, et al: Nicotine tartrate liquid enemas for mildly to moderately active left-sided ulcerative colitis unresponsive to first-line therapy: a pilot study. Aliment Pharmacol Ther, in press, 1997.
20. Benowitz NL, Jacob P, Denaro C, Jenkins R: Stable isotope studies of nicotine kinetics and bioavailability. Clin Pharmacol Ther 1991;49:270-277.