Primary HIV infection of infants: The effects of somatic growth on lymphocyte and virus dynamics

Clinical Immunology

Volumn 92, Issue 1, 1999, Pages 25-33

  Krogstad, Paul ^a   Uittenbogaart, Christel H ^a   Dickover, Ruth ^a   Bryson, Yvonne J ^a   Plaeger, Susan ^a   Garfinkel, Alan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute retrovital syndrome; CD4; Pediatric HIV infection; Thymus

Indexed keywords

ARTICLE; CLINICAL ARTICLE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; INFANT; LYMPHOCYTE PROLIFERATION; MATHEMATICAL MODEL; NEWBORN INFECTION; ONTOGENY; PRIORITY JOURNAL; THYMUS; VIREMIA; VIRUS REPLICATION;

EID: 0032977054     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1999.4728     Document Type: Article

References (52)

1. Daar E. S., Moudgil T., Meyer R. D., Ho D. D. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N. Engl. J. Med. 324:1991;961-964.
2. Graziosi C., Pantaleo G., Butini L., Demarest J. F., Saag M. S., Shaw G. M., Fauci A. S. Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. Proc. Natl. Acad. Sci. USA. 90:1993;6405-6409.
3. Kinloch-De Loës S., Hirschel B. J., Hoen B., Cooper D. A., Tindall B., Carr A., Saurat J. H., Clumeck N., Lazzarin A., Mathiesen L. A controlled trial of zidovudine in primary human immunodeficiency virus infection. N. Engl. J. Med. 333:1995;408-413.
4. Mulder J., McKinney N., Christopherson C., Sninsky J., Greenfield L., Kwok S. Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: Application to acute retroviral infection. J. Clin. Microbiol. 32:1994;292-300.
5. Schacker T., Collier A. C., Hughes J., Shea T., Corey L. Clinical and epidemiologic features of primary HIV infection. Ann. Intern. Med. 125:1996;257-264.
6. Dickover R. E., Dillon M., Leung K. M., Krogstad P., Plaeger S., Kwok S., Christopherson C., Deveikis A., Keller M., Stiehm E. R., Bryson Y. J. Early prognostic indicators in primary perinatal human immunodeficiency virus type 1 infection: Importance of viral RNA and the timing of transmission on long-term outcome. J. Infect. Dis. 178:1998;375-387.
7. Shearer W. T., Quinn T. C., LaRussa P., Lew J. F., Mofenson L., Almy S., Rich K., Handelsman E., Diaz C., Pagano M., Smeriglio V., Kalish L. A. Viral load and disease progression in infants infected with human immunodeficiency virus type 1. N. Engl. J. Med. 336:1997;1337-1342.
8. McLean A. R., Emery V. C., Webster A., Griffiths P. D. Population dynamics of HIV within an individual after treatment with zidovudine. AIDS. 5:1991;485-489.
9. Nowak M. A., May R. M., Anderson R. M. The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease. AIDS. 4:1990;1095-10103.
10. Phillips A. N. Reduction of HIV concentration during acute infection: Independence from a specific immune response. Science. 271:1996;497-499.
11. Safrit J. T., Koup R. A. The immunology of primary HIV infection: Which immune responses control HIV replication. Curr. Opin. Immunol. 7:1995;456-461.
12. Luzuriaga K., Holmes D., Hereema A., Wong J., Panicali D. L., Sullivan J. L. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J. Immunol. 154:1995;433-443.
13. Martin N. L., Levy J. A., Legg H., Weintrub P. S., Cowan M. J., Wara D. W. Detection of infection with human immunodeficiency virus (HIV) type 1 in infants by an anti-HIV immunoglobulin A assay using recombinant proteins. J. Pediatr. 118:1991;354-358.
14. Pikora C. A., Sullivan J. L., Panicali D., Luzuriaga K. Early HIV-1 envelope-specific cytotoxic T lymphocyte responses in vertically infected infants. J. Exp. Med. 185:1997;1153-1161.
15. Pugatch D., Sullivan J. L., Pikora C. A., Luzuriaga K. Delayed generation of antibodies mediating human immunodeficiency virus type 1-specific antibody-dependent cellular cytotoxicity in vertically infected infants. J. Infect. Dis. 176:1997;643-648.
16. Haynes B. F., Martin M. E., Kay H. H., Kurtzberg J. Early events in human T-cell ontogeny. J. Exp. Med. 168:1988;1061-1080.
17. Galy A., Verma S., Barcena A., Spits H. Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development. J. Exp. Med. 178:1993;391-401.
18. Hori T., Spits H. Clonal analysis of human CD4-CD8-CD3- thymocytes highly purified from postnatal thymus. J. Immunol. 146:1991;2116-2121.
19. Ho D. D., Moudgil T., Alam M. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N. Engl. J. Med. 321:1989;1621-1625.
20. Wei X., Ghosh S. K., Taylor M. E., Johnson V. A., Emini E. A., Deutsch P., Lifson J. D., Bonhoeffer S., Nowak M. A., Hahn B. H. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 373:1995;117-122.
21. Dickover R. E., Garratty E. M., Herman S. A., Sim M. S., Plaeger S., Boyer P. J., Keller M., Deveikis A., Stiehm E. R., Bryson Y. J. Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission. J. Am. Med. Assoc. 275:1996;599-605.
22. Plaeger-Marshall S., Hultin P., Bertolli J., O'Rourke S., Kobayashi R., Kobayashi A. L., Giorgi J. V., Bryson Y., Stiehm E. R. Activation and differentiation antigens on T cells of healthy, at-risk, and HIV-infected children. J. Acquir. Immune Defic. Syndr. 6:1993;984-993.
23. Uittenbogaart C. H., Higashitani S., Schmid I., Vollger L. W., Boone T., Clement L. T. Interleukin-4 induces expression of the CD45RA antigen on human thymocyte subpopulations. Int. Immunol. 1990;1179-1187.
24. Perelson A. S., Neumann A. U., Markowitz M., Leonard J. M., Ho D. D. HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science. 271:1996;1582-1586.
25. Pakker N. G., Notermans D. W., de Boer R. J., Roos M. T., de Wolf F., Hill A., Leonard J. M., Danner S. A., Miedema F., Schellekens P. T. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat. Med. 4:1998;208-214.
26. Comans-Bitter W. M., de Groot R., van den Beemd R., Neijens H. J., Hop W. C., Groeneveld K., Hooikjaas H., van Dongen J. J. Immunophenotyping of blood lymphocytes in childhood. J. Pediatr. 130:1997;388-393.
27. Cavert W., Notermans D. W., Staskus K., Wietgrefe S. W., Zupancic M., Gebhard K., Henry K., Zhang Z. Q., Mills R., McDade H., Goudsmit J., Danner S. A., Haase A. T. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science. 276:1997;960-964.
28. Chun T. W., Carruth L., Finzi D., Shen X., DiGiuseppe J. A., Taylor J., Hermankova M., Chadwick K., Margolick J., Quinn T. C., Kuo Y. H., Brookmeyer R., Zeiger M. A., Barditch-Crovo P., Siliciano R. F. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 387:1997;183-187.
29. Stevenson M., Stanwick T. L., Dempsey M. P., Lamonica C. A. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9:1990;1551-1560.
30. Zack J. A., Arrigo S. J., Weitsman S. R., Go A. S., Haislip A., Chen I. S. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure. Cell. 61:1990;213-222.
31. Gougeon M. L., Lecoeur H., Dulioust A., Enouf M. G., Crouvoiser M., Goujard C., Debord T., Montagnier L. Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J. Immunol. 156:1996;3509-3520.
32. Sprent J. Fundamental Immunology. 1993;Raven Press, New York. p. 75-109.
33. Kourtis A. P., Ibegbu C., Nahmias A. J., Lee F. K., Clark W. S., Sawyer M. K., Nesheim S. Early progression of disease in HIV-infected infants with thymus dysfunction. N. Engl. J. Med. 335:1996;1431-1436.
34. Kirschner D. E., Mehr R., Perelson A. S. Role of the thymus in pediatric HIV-1 infection. J. Acquire. Immune Defic. Syndr. Hum. Retrovirol. 18:1998;95-109.
35. Pedroza-Martins L., Gurney K. B., Torbett B. E., Uittenbogaart C. H. Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: Coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level. J. Virol. 72:1998;9441-9452.
36. Pediatr. Infect. Dis. 11:1992;1018-1026.
37. Hamill P. V., Drizd T. A., Johnson C. L., Reed R. B., Roche A. F., Moore W. M. Physical growth: National Center for Health Statistics percentiles. Am. J. Clin. Nutr. 32:1979;607-629.
38. McKinney R. E. Jr., Robertson J. W. Effect of human immunodeficiency virus infection on the growth of young children. J. Pediatr. 123:1993;579-582.
39. Lancet. 339:1992;1007-1012.
40. Mofenson L. M. A critical review of studies evaluating the relationship of mode of delivery to perinatal transmission of human immunodeficiency virus. Pediatr. Infect. Dis. J. 14:1995;169-176.
41. Von Seidlein L., Bryson Y. Maternal-fetal transmission of the human immunodeficiency virus. Sem. Infect. Dis. 5:1994;78-86.
42. McIntosh K., Shevitz A., Zaknun D., Kornegay J., Chatis P., Karthas N., Burchett S. K. Age- and time-related changes in extracellular viral load in children vertically infected by human immunodeficiency virus. Pediatr. Infect. Dis. J. 15:1996;1087-1091.
43. Perelson A. S., Essunger P., Cao Y., Vesanen M., Hurley A., Saksela K., Markowitz M., Ho D. D. Decay characteristics of HIV-1 infected compartments during combination therapy. Nature. 387:1997;188-191.
44. Bryson Y. J., Luzuriaga K., Sullivan J. L., Wara D. W. Proposed definitions for in utero versus intrapartum transmission of HIV-1. N. Engl. J. Med. 327:1992;1246-1247.
45. Douek D. C., McFarland R. D., Keiser P. H., Gage E. A., Massey J. M., Haynes B. F., Polis M. A., Haase A. T., Feinberg M. B., Sullivan J. L., Jamieson B. D., Zack J. A., Picker L. J., Koup R. A. Changes in thymic function with age and during the treatment of HIV infection. Nature. 396:1998;690-695.
46. Hellerstein M., M.B. H., Cesar D., Siler S., C. P., Wieder E., Schmidt D., Hoh R., Neese R., Macallan D., Deeks S., McCune J. M. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat. Med. 5:1999;83-89.
47. Krogstad P., Wiznia A., Luzuriaga K., Dankner W., Nielsen K., Kerr B., Hendricks A., Gersten M., Boczany B., Rosenberg M., Jung D., Spector S., Bryson Y. J. Treatment of HIV-1 infected infants and children with the protease inhibitor nelfinavir mesylate. Clin. Infect. Dis. 28:1999;1109-1118.
48. Luzuriaga K., Bryson Y., Krogstad P., Robinson J., Stechenberg B., Lamson M., Cort S., Sullivan J. L. Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection. N. Engl. J. Med. 336:1997;1343-1349.
49. Mueller B. U., Butler K. M., Stocker V. L., Balis F. M., Brouwers P., Jarosinski P., Husson R. N., Lewis L. L., Venzon D., Pizzo P. A. Clinical and pharmacokinetic evaluation of long-term therapy with didanosine in children with HIV infection. Pediatrics. 94:1994;724-731.
50. Mueller B. U., Sleasman J., Nelson R. P. Jr., Smith S., Deutsch P. J., Ju W., Steinberg S. M., Balis F. M., Jarosinski P. F., Brouwers P., Mistry G., Winchell G., Zwerski S., Sei S., Wood L. V., Zeichner S., Pizzo P. A. A phase I/II study of the protease inhibitor indinavir in children with HIV infection. Pediatrics. 102:1998;101-109.
51. Ho D. D., Neumann A. U., Perelson A. S., Chen W., Leonard J. M., Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 373:1995;123-126.
52. Haase A. T., Henry K., Zupanic M., Sedgewick G., Faust R. A., Melroe H., Cavert W., Gebhard K., Staskus K., Zhang Z. Q., Dailey P. J., Balfour H. H. Jr., Erice A., Perelson A. S. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science. 274:1996;985-989.