DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus

European Journal of Pharmacology

Volumn 322, Issue 2-3, 1997, Pages 173-178

  Breakwell, Nicholas A ^a   Huang, LingQian ^a   Rowan, Michael J ^a   Anwyl, Roger ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

AP5 (D 2 amino 5 phosphonopentanoic acid); DCG IV; Metabotropic glutamate receptor; NMDA receptor

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 2 METHYL 4 PHOSPHONOBUTYRIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; 2 METHYL 2 (CARBOXYCYCLOPROPYL)GLYCINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE RECEPTOR BLOCKING AGENT; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ALPHA METHYL 4 TETRAZOLYLPHENYLGLYCINE; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; CYCLOPROPANES; EVOKED POTENTIALS; GLYCINE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, PURINERGIC P1; SYNAPTIC TRANSMISSION; XANTHINES;

EID: 0030942364     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00015-0     Document Type: Article

References (24)

1. Baskys, A. and R.C. Malenka, 1991, trans-ACPD depresses synaptic transmission in the hippocampus, Eur. J. Pharmacol. 193, 131.
2. 3 does not require NMDA receptor activation but is suppressed by inhibitors of phosphoinositide-mediated signalling pathways, Brain Res. 633, 72.
3. Breakwell, N.A., M.J. Rowan and R. Anwyl, 1996, Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area CA1 of the submerged rat hippocampal slice, J. Neurophysiol. 76, 3126.
4. Bushell, T.J., D.E. Jane, H.W. Tse, J.C. Watkins, C.H. Davies, J. Garthwaite and G.L. Collingridge, 1995, Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4, Neuropharmacology 34, 239.
5. Bushell, T.J., D.E. Jane, H.W. Tse, J.C. Watkins, J. Garthwaite and G.L. Collingridge, 1996, Pharmacological, antagonism of the actions of group II and group III metabotropic glutamate receptor agonists in the lateral perforant path of rat hippocampal slices, Br. J. Pharmacol. 117, 1457.
6. Fitzjohn, S.M., A.J. Irving, M.J. Palmer, J. Harvery, D. Lodge and G.L. Collingridge, 1996, Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices, Neurosci. Lett. 203, 211.
7. Forghani, R. and K. Krnjevic, 1995, Adenosine antagonists have differential effects on induction of long term potentiation in hippocampal slices, Hippocampus 5, 71.
8. Gereau, R.W., D.G. Winder and P.J. Conn, 1995, Pharmacological differentiation of the effects of co-activation of β-adrenergic and metabotropic glutamate receptors in rat hippocampus, Neurosci. Lett. 186, 119.
9. Hayashi, Y., A. Momiyama, T. Takahashi, H. Oshishi, R. Ogawameguro, R. Shigemoto, N. Mizuno and S. Nakanishi, 1993, Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb, Nature 366, 687.
10. Ishida, M., T. Saitoh, K. Shimamoto, Y. Ohfune and H. Shinozaki, 1993, A novel metabotropic glutamate receptor agonist marked depression of monosynaptic excitation in newborn rat isolated spinal cord, Br. J. Pharmacol. 109, 1169.
11. Ishida, M., T. Saitoh and H. Shinozaki, 1993b, A new metabotropic glutamate receptor agonist - developmental change of its sensitivity to receptors in the newborn rat spinal cord, Neurosci. Lett. 160, 156.
12. Jane, D.E., P.L. Jones, P. Pook, H. Tse and J.C. Watkins, 1994, Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptors in the neonatal rat spinal cord, Br. J. Pharmacol. 112, 809.
13. Jane, D.E., K. Pittaway, D.C. Sunter, N.K. Thomas and J.C. Watkins, 1995, New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord, Neuropharmacology 34, 851.
14. Kamiya, H., H. Shinozaki and C. Yamamoto, 1996, Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses, J. Physiol. 493.2, 447.
15. Kauer, J.A., R.C. Malenka and R.A. Nicoll, 1988, NMDA application potentiates synaptic transmission in the hippocampus, Nature 334, 250.
16. Lovinger, D. and B. McCool, 1995, Metabotropic glutamate receptor mediated presynaptic depression at corticostriatal synapses involves metabotropic glutamate receptor 2 or 3, J. Neurophysiol. 73, 1076.
17. Manzoni, O.J., T. Manabe and R.A. Nicoll, 1994, Release of adenosine by activation of NMDA receptors in the hippocampus, Science 265, 2098.
18. Neki, A., H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi and N. Mizuno, 1996, Pre- and postsynaptic localization of a metabotropic glutamate receptor, metabotropic glutamate receptor2, in the rat brain: an immunohistochemical study with a monoclonal antibody, Neurosci. Lett. 202, 197.
19. Petralia, R.S., Y.X. Wang, A.S. Niedzielski and R.J. Wenthold, 1996, The metabotropic glutamate receptors, metabotropic glutamate receptor 2 and metabotropic glutamate receptor 3, show unique post-synaptic, presynaptic and glial localisations, Neuroscience 71, 949.
20. Pin, J.P. and R. Duvoisin, 1995, The metabotropic glutamate receptors: structure and functions, Neuropharmacology 34, 1.
21. Poncer, J.C., H. Shinozaki and R. Miles, 1995, Dual modulation of synaptic inhibition by distinct metabotropic glutamate receptors in rat hippocampus, J. Physiol. 485, 121.
22. Pook, P.C., D.E. Sunter, P.M. Udvarhelyi and J.C. Watkins, 1992, Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurons by (1S,3S)- and (1S,3R)-ACPD, Exp. Physiol. 77, 529.
23. Ugolini, A. and F. Bordi, 1995, Metabotropic glutamate group II receptors are responsible for the depression of synaptic transmission induced by ACPD in the dentate gyrus, Eur. J. Pharmacol. 294, 403.
24. Wilsch, V.W., V.I. Pidoplichko, T. Opitz, H. Shinozaki and K.G. Reymann, 1994, Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons, Eur. J. Pharmacol. 262, 287.