Evaluation of genetic tests: APOE genotyping for the diagnosis of Alzheimer disease

Genetic Testing

Volumn 3, Issue 1, 1999, Pages 47-53

  McConnell, Laura M ^a   Sanders, Gillian D ^b   Owens, Douglas K ^b   Koenig, Barbara ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E;

ALZHEIMER DISEASE; DIAGNOSTIC VALUE; GENOTYPE; HUMAN; MEDICAL RESEARCH; REVIEW; SOCIAL PSYCHOLOGY;

EID: 0032966315     PISSN: 10906576     EISSN: None     Source Type: Journal    
DOI: 10.1089/gte.1999.3.47     Document Type: Review

References (35)

1. AMERICAN COLLEGE OF MEDICAL GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, AND WORKING GROUP ON APOE AND ALZHEIMER DISEASE. (1995). Statement on use of apolipoprotein E testing for Alzheimer disease. J. Am. Med. Assn. 274, 1627-1629.
2. BLACKER, D., HAINES, J.L., RODES, L., et al. (1997). ApoE-4 and age at onset of Alzheimer's disease: The NIMH Genetics Initiative. Neurology 48, 1139-147.
3. BOURKE, G.J., DALEY, L.E., and McGILVRAY, J. (1985). Interpretation and Uses of Medical Statistics. (Blackwell Scientific Publications, Palo Alto).
4. COMBARROS, O., LENO, C., OTERINO, A., et al. (1998). Gender effect on apolipoprotein E epsiolon4 allele-associated risk for sporadic Alzheimer's disease. Acta Neurol. Scand. 97, 68-71.
5. CORDER, E.H., SAUNDERS, A.M., STRITTMATTER, W.J., et al. (1995). The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease [letter]. J. Am. Med. Assn. 273, 373-374.
6. DUARA, R., BARKER, W. W., LOPEZ-ALBEROLA, R., et al. (1996). Alzheimer's disease: interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset. Neurology 46, 1575-1579.
7. FARLOW, M.R. (1997). Alzheimer's disease: Clinical implications of the apolipoprotein E genotype. Neurology 48 (Suppl. 6), S30-S34.
8. FARLOW, M.R., LAHIRI, D.K., POIRIER, J., et al. (1998). Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease. Neurology 50, 669-677.
9. FARRER, L.A., CUPPLES, L.A., HAINES, J.L., et al. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. J. Am. Med. Assn. 278, 1349-1356.
10. GOMEZ-ISLA, T., WEST, H.L., REBECK, G.W., et al. (1996). Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann. Neurol. 39, 62-70.
11. GREELY, H.T. (1999). Special problems in genetic testing for Alzheimer disease. Genet. Testing. 3, 115-119
12. GROWDON, J.H., LOCASCIO, J.J., CORKIN, S., et al. (1996). Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology 47, 444-448.
13. HIXSON, J.E., and VERNIER, D.T. (1990). Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J. Lipid Res. 31, 545-548.
14. HOLTZMAN, N.A., and WATSON, M.S. (1997). Promoting Safe and Effective Genetic Testing in the United States: Final Report of the Tax Force on Genetic Testing. (National Institutes of Health, Washington, DC).
15. HYMAN, B.T., GOMEZ-ISLA, T., BRIGGS, M., et al. (1997). Apolipoprotein E and cognitive change in an elderly population. Ann. Neurol. 40, 55-66.
16. KAPP, M.B. (1996). Medicolegal, employment, and insurance issues in APOE genotyping and Alzheimer's disease. Ann. N.Y. Acad. Sci. 802, 139-148.
17. MAYEUX, R. (1998). Evaluation and use of diagnostic tests in Alzheimer's disease. Neurobiol. Aging 19, 139-143.
18. MAYEUX, R., SAUNDERS, A.M., SHEA, S., et al. (1998). Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. N. Engl. J. Med. 338, 506-511.
19. MEDICAL AND SCIENTIFIC ADVISORY COMMITTEE, AND ALZHEIMER'S DISEASE INTERNATIONAL. (1995). Consensus statement on predictive testing for Alzheimer disease. Alzheimer Dis. Assoc. Disord. 9, 182-187.
20. NATIONAL INSTITUTE ON AGING, AND ALZHEIMER'S ASSOCIATION WORKING GROUP. (1996). Apolipoprotein E genotyping in Alzheimer's disease. Lancet 347, 1091-1095.
21. PAUKER, S.G., and KASSIRER, J.P. (1980). The threshold approach to clinical decision making. N. Engl. J. Med. 302, 1109-1117.
22. PAYAMI, H., ZAREPARSI, S., MONTEE, K.R., et al. (1996). Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: A possible clue to the higher incidence of Alzheimer disease in women. Am. J. Hum. Genet. 58, 803-811.
23. POIRIER, J., DELISLE, M.C., QUIRION, R., et al. (1995). Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proc. Natl. Acad. Sci. USA 92, 12260-12264.
24. POST, S.G., WHITEHOUSE, P.J., BINSTOCK, R.H., et al. (1997). The clinical introduction of genetic testing for Alzheimer disease: An ethical perspective. J. Am. Med. Assn. 227, 832-836.
25. ROSES, A.D. (1996). Apolipoprotein E and Alzheimer's disease: A rapidly expanding field with medical and epidemiological consequences. Ann. N.Y. Acad. Sci. 802, 50-57.
26. SAUNDERS, A.M., HULETTE, C., WELSH-BOHMER, K.A., et al. (1996). Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet 348, 90-93.
27. SMALL, G.W., RABINS, P.V., BARRY, P.P., et al. (1997). Diagnosis and treatment of Alzheimer disease and related disorders: consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. J. Am. Med. Assn. 278, 1363-1371.
28. SOX, H.C., BLATT, M.A., HIGGINS, M.C., and MARTON, K.I. (1988a). Medical Decision Making. (Butterworths, Boston).
29. SOX, H.C., BLATT, M.A., HIGGINS, M.C., and MARTON, K.I. (1988b). Selection and interpretation of diagnostic tests. In Medical Decision Making. (Butterworths, Boston, MA) pp. 239-290.
30. SOX, H.C., BLATT, M.A., HIGGINS, M.C., and MARTON, K.I. (1988c). Understanding new information: Bayes' theorem. In Medical Decision Making. (Butterworths, Boston, MA) pp. 67-101.
31. STRITTMATTER, W.J., SAUNDERS, A.M., SCHMECHEL, D., et al. (1993). Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90, 1977-1981.
32. TANG, M.-X., STERN, Y., MARDER, K., et al. (1998). The APOE-e4 allele and the risk of Alzheimer disease among African Americans, Whites, and Hispanics. J. Am. Med. Assn. 279, 751-755.
33. VAN GOOL, W.A. (1996). The use of apolipoprotein E genotyping as a diagnostic test in suspected Alzheimer's disease. Ann. N.Y. Acad. Sci. 802, 79-91.
34. WEISGRABER, K.H., RALL, S.C., and MAHLEY, R.W. (1981). Human E apoprotein heterogeneity: Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J. Biol. Chem. 256, 9077-9083.
35. WELSH-BOHMER, K.A., GEARING, M., SAUNDERS, A.M., et al. (1997). Apolipoprotein E genotypes in a neuropathological series from the Consortium to Establish a Registry of Alzheimer's disease. Ann. Neurol. 42, 319-325.