Are immunological mechanisms relevant for the development of atherosclerosis?

Clinical Immunology

Volumn 90, Issue 2, 1999, Pages 153-156

  Witztum, J L ^a   Palinski, W ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROGENESIS; ATHEROSCLEROSIS; EDITORIAL; HUMAN; IMMUNIZATION; IMMUNOGENICITY; IMMUNOPATHOGENESIS; INFLAMMATORY DISEASE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0032951534     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1998.4682     Document Type: Editorial

References (38)

1. C. Napoli F.P. D'Armiento F.P. Mancini A. Postiglione J.L. Witztum G. Palumbo W. Palinski Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of LDL and its oxidation precede monocyte recruitment into early atherosclerotic lesions J. Clin. Invest. 110 1997 2680 2690
2. R.T. Lee P. Libby The unstable atheroma Arterioscler. Thromb. Vasc. Biol. 17 1997 1859 1867
3. R. Ross The pathogenesis of atherosclerosis: A perspective for the 1990s Nature 362 1993 801 809
4. P. Libby G.K. Hansson J.S. Pober Atherogenesis and inflammation Molecular Basis of Cardiovascular Disease 1999 Saunders Philadelphia p. 349–366
5. J.L. Witztum W. Palinski Autoimmunity to oxidized lipoproteins G.K. Hansson P. Libby Immune Functions of the Vessel Wall 1996 Harwood Academic Amsterdam 159 172
6. G.K. Hansson Cell-mediated immunity in atherosclerosis Curr. Opin. Lipidol. 8 1997 301 311
7. J.D. Smith E. Trogan M. Ginsberg C. Grigaux J. Tian M. Miyata Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E Proc. Natl. Acad. Sci. USA 92 1995 8264 8268
8. L. Gu Y. Okada S.K. Clinton C. Gerard G.K. Sukhova P. Libby B.J. Rollins Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice Mol. Cell 2 1998 275 281
9. L. Boring J. Gosling M. Cleary I.F. Charo Decreased lesion formation in CCR2(−/−) mice reveals a role for chemokines in the initiation of atherosclerosis Nature 394 1998 894 897
10. W.A. Boisvert R. Santiago L.K. Curtiss R.A. Terkeltaub A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice J. Clin. Invest. 101 1998 353 363
11. R. Terkeltaub V.A. Boisvert L.K. Curtiss Chemokines and atherosclerosis Curr. Opin. Lipidol. 9 1998 397 405
12. Steinberg, D. Witztum, J. L. Lipoproteins, lipoprotein oxidation, and atherogenesis, In , Molecular Basis of Cardiovascular Disease, K. R. Chien, 458, 475, Saunders, Philadelphia, 1999
13. R. Abraham A. Choudhury S.K. Basu V. Bal S. Rath Disruption of T cell tolerance by directing a self antigen to macrophage-specific scavenger receptors J. Immunol. 158 1997 4029 4035
14. F. Mach U. Schonbeck G.K. Sukhova E. Atkinson P. Libby Reduction of atherosclerosis in mice by inhibition of CD40 signalling Nature 394 1998 200 203
15. S. Ylä-Herttuala W. Palinski S. Butler S. Picard D. Steinberg J.L. Witztum Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized low density lipoprotein Arterioscler. Thromb. 14 1994 32 40
16. Y. Sohma H. Sasano R. Shiga S. Saeki T. Suzuki H. Nagura M. Nose T. Yamamoto Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits Proc. Natl. Acad. Sci. USA 92 1995 4937 4941
17. G.K. Hansson J. Holm S. Holm Z. Fotev H.J. Hedric J. Fingerle T lymphocytes inhibit the vascular response to injury Proc. Natl. Acad. Sci. USA 88 1991 10530 10534
18. S.E. Roselaar G. Schonfeld A. Daugherty Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity J. Clin. Invest. 96 1995 1389 1394
19. A.I. Fyfe J.H. Qiao A.J. Lusis Immune deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet J. Clin. Invest. 94 1994 2516 2520
20. H. Nagano R.N. Mitchell M.K. Taylor S. Hasegawa N.L. Tilney P. Libby Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts J. Clin. Invest. 100 1997 550 557
21. S. Gupta A.M. Pablo X. Jiang N. Wang A.R. Tall C. Schindler IFN-gamma potentiates atherosclerosis in ApoE knock-out mice J. Clin. Invest. 99 1997 2752 2761
22. S.A. Schreyer J.J. Peschon R.C. LeBoeuf Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55 J. Biol. Chem. 271 1996 26174 26178
23. A. Nicoletti S. Kaveri G. Caligiuri J. Bariety G.K. Hansson Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice J. Clin. Invest. 102 1998 910 918
24. H.M. Dansky S.A. Charlton M.M. Harper J.D. Smith T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse Proc. Natl. Acad. Sci. USA 94 1997 4642 4646
25. A. Daugherty E. Puré D. Delfel-Butteiger S. Chen J. Leferovich S.E. Roselaar D. Rader The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E−/− mice J. Clin. Invest. 100 1997 1575 1580
26. Q. Xu H. Dietrich H.J. Steiner A.M. Gown G. Mikuz S.H.E. Kaufmann G. Wick Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65 Arterioscler. Thromb. 12 1992 789 799
27. W. Palinski S. Hörkkö E. Miller U.P. Steinbrecher H.C. Powell L.K. Curtiss J.L. Witztum Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice J. Clin. Invest. 98 1996 800 814
28. S. Hörkkö E. Miller E. Dudl P.D. Reaven N.J. Zvaifler R. Terkeltaub S.S. Pierangeli L.K. Curtiss W. Branch W. Palinski J.L. Witztum Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids: Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein J. Clin. Invest. 98 1996 815 825
29. S. Hörkkö E. Miller H. Itabe G. Subbanagounder N. Leitinger J.A. Berliner H. Itabe P. Friedman E. Dennis L.K. Curtiss W. Palinski J.L. Witztum Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins J. Clin. Invest. 103 1999
30. S. Freigang S. Hörkkö E. Miller J.L. Witztum W. Palinski Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes Arterioscler. Thromb. Vasc. Biol. 18 1998 1972 1982
31. S. Stemme B. Faber J. Holm G. Bondjers J.L. Witztum G.K. Hansson T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein Proc. Natl. Acad. Sci. USA 92 1995 3893 3897
32. X. Zhou G. Paulsson S.D. Stemme G.K. Hansson Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apoE-knockout mice J. Clin. Invest. 101 1998 1717 1725
33. J.T. Salonen S. Ylä-Herttuala R. Yamamoto S. Butler H. Korpela R. Salonen K. Nyyssönen W. Palinski J.L. Witztum Autoantibody against oxidised LDL and progression of carotid atherosclerosis Lancet 339 1992 883 887
34. S. Ylä-Herttuala Is oxidized low-density lipoprotein present in vivo Curr. Opin. Lipidol. 9 1998 337 344
35. W. Palinski E. Miller J.L. Witztum Immunization of LDL receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis Proc. Natl. Acad. Sci. USA 92 1995 821 825
36. S. Ameli A. Hultgårdth-Nilsson J. Regnström F. Calara J. Yano B. Cerek P.K. Shah J. Nilsson Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits Arterioscler. Thromb. Vasc. Biol. 16 1996 1074 1079
37. J. Nilsson F. Calara J. Regnström A. Hultgårdth-Nilsson S. Ameli B. Cercek P.K. Shah Immunization with homologous oxidized low density lipoprotein reduces neointimal formation after balloon injury in hypercholesterolemic rabbits J. Am. Coll. Cardiol. 30 1997 1886 1891
38. J. George A. Afek B. Gilburd H. Levkovitz A. Shaish I. Goldberg Y. Kopolovic G. Wick Y. Shoenfeld D. Harats Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis Atherosclerosis 138 1998 147 152