Do germinal centers have a role in the generation of lymphomas?

Current Topics in Microbiology and Immunology

Volumn 246, Issue , 1999, Pages 53-62

  Yang, K ^a   Davila, M ^a   Kelsoe, G ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN ANTIBODY COMPLEX; B CELL LYMPHOMA; CARCINOGENESIS; CELL LABELING; CELLULAR DISTRIBUTION; CONFERENCE PAPER; DENDRITIC CELL; GENE MUTATION; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNITY; IMMUNIZATION; PRIORITY JOURNAL; TRANSGENE;

EID: 0032931278     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-60162-0_7     Document Type: Conference Paper

References (15)

1. Agrawal, A, Eastman, QM, Schatz, DG (1998) Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 394, 744-751
2. Chen, Y, Wang, LC, Huang, MS, Rosenberg N (1994) An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes & Development 8, 688-697
3. Dal Porto, J, Haberman, AM, Shlomchik, MJ, Kelsoe, G (1998) Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. J Immunol 161, 5373-5381
4. Han, S, Zheng, B, Schatz, DG, Spanopoulou, E, Kelsoe G (1996) Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science, 274, 2094-2097
5. Han, S, Dillon, SR, Zheng, B, Shimoda, M, Schilesse, MS, Kelsoe, G (1997) V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science, 278, 301-305
6. Hertz, M, Kouskoff, V, Nakamura, T, Nemazee, D(1998) V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signaling. Nature 394, 292-295
7. Hiom, K, Melek, M, Gellert, M (1998) DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations. Cell 94, 463-470
8. MacLennan, ICM, (1994)Germinal centers. Annu. Rev. Immunol 12, 117-139
9. McMahan, CJ, Fink, PJ (1998) RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells. Immunity 9, 1-20
10. Meffre, E, Papavasiliou, F, Cohen, P, de Bouteiller, O, Bell, D, Karasuyama, H, Schiff, C, Banchereau, J, Liu, YJ, Nussenzweig, MC (1998) Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J.Exp Med188, 765-772
11. Smith, KG, Weiss, U, Rajewsky, K, Nossal, GJ, Tarlinton, DM (1994) Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. Immunity 1, 803-813
12. Spanopoulou, E, Cortes, P, Shih, C, Huang, CM, Silver, DP, Svec, P, Baltimore, D, (1995) Localization, interaction, and RNA binding properties of the V(D)J recombination activating proteins RAG1 and RAG2. Immunity 3, 715-726
13. Takahashi, Y, Dutta, PR, Cerasoli, DM, Kelsoe, G (1998)In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med 187, 885-895
14. Tuscano, JM, Druet, KM, Riva, A, Pena, J Thompson, CB, Kehrl, JH (1996) Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center. Blood 88, 1359-1364
15. Zheng, B, Han, S, Zhu, Q, Goldsby, R, Kelsoe G (1996) Alternative pathways for the selection of antigen-specific peripheral T cells. Nature 384, 263-266