An analysis of herpes simplex virus gene expression during latency establishment and reactivation

Journal of General Virology

Volumn 80, Issue 5, 1999, Pages 1271-1282

  Lachmann, Robin H ^a   Sadarangani, Manish ^a   Atkinson, Helen R ^a   Efstathiou, Stacey ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; GANGLION; GENE EXPRESSION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HISTOCHEMISTRY; INNERVATION; LATENT VIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SENSORY NERVE CELL; VIRUS EXPRESSION; VIRUS GENE; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS RECOMBINANT;

EID: 0032930507     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-80-5-1271     Document Type: Article

References (43)

1. Ace, C. I., McKee, T. A., Ryan, J. M., Cameron, J. M. & Preston, C. M. (1989). Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression. Journal of Virology 63, 2260-2269.
2. Arthur, J., Efstathiou, S. & Simmons, A. (1993). Intranuclear foci containing low abundance herpes simplex virus latency-associated transcripts visualized by non-isotopic in situ hybridization. Journal of General Virology 74, 1363-1370.
3. Balan, P., Davis-Poynter, N., Bell, S., Atkinson, H., Browne, H. & Minson, T. (1994). An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gI or the putative gJ. Journal of General Virology 75, 1245-1258.
4. Bloom, D. C., Hill, J. M., Devi, R. G., Wagner, E. K., Feldman, L. T. & Stevens, J. G. (1996). A 348 base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation. Journal of Virology 70, 2449-2459.
5. Campbell, M. E., Palfreyman, J. W. & Preston, C. M. (1984). Identification of herpes simplex virus DNA sequences which encode a transacting polypeptide responsible for stimulation of immediate early transcription. Journal of Molecular Biology 180, 1-19.
6. Chiocca, E. A., Choi, B. B., Cai, W. Z., DeLuca, N. A., Schaffer, P. A., DiFiglia, M., Breakefield, X. O. & Martuza, R. L. (1990). Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biology 2, 739-746.
7. DeLuca, N. A., McCarthy, A. M. & Schaffer, P. A. (1985). Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. Journal of Virology 56, 558-570.
8. Ecob-Prince, M. S., Preston, C. M., Rixon, F. J., Hassan, K. & Kennedy, P. G. E. (1993). Neurons containing latency-associated transcripts are numerous and widespread in dorsal root ganglia following footpad inoculation of mice with herpes simplex virus type 1 mutant in1814. Journal of General Virology 74, 985-994.
9. Harris, R. A. & Preston, C. M. (1991). Establishment of latency in vitro by the herpes simplex virus type 1 mutant in1814. Journal of General Virology 72, 907-913.
10. Hill, T. J., Field, H. J. & Blyth, W. A. (1975). Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. Journal of General Virology 28, 341-353.
11. Hill, J. M., Garza, H. H., Su, Y.-H., Meegalla, R., Hanna, L. A., Loutsch, J. M., Thompson, H. W., Varnell, E. D., Bloom, D. C. & Block, T. M. (1997). A 437 bp deletion at the beginning of the latency-associated promoter significantly reduced adrenergically induced HSV-1 ocular reactivation in latently infected rabbits. Journal of Virology 71, 6555-6559.
12. Jamieson, D. R. S., Robinson, L. H., Daksis, J. I., Nicholl, M. J. & Preston, C. M. (1995). Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants. Journal of General Virology 76, 1417-1431.
13. Kosz Vnenchak, M., Coen, D. M. & Knipe, D. M. (1990). Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. Journal of Virology 64, 5396-5402.
14. Kosz Vnenchak, M., Jacobson, J., Coen, D. M. & Knipe, D. M. (1993). Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. Journal of Virology 67, 5383-5393.
15. Kristie, T. M. & Sharp, P. A. (1993). Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16). Journal of Biological Chemistry 268, 6525-6534.
16. Lachmann, R. H. & Efstathiou, S. (1997). Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system. Journal of Virology 71, 3197-3207.
17. Leib, D. A., Coen, D. M., Bogard, C. L., Hicks, K. A., Yager, D. R., Knipe, D. M., Tyler, K. L. & Schaffer, P. A. (1989). Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. Journal of Virology 63, 759-768.
18. Margolis, T. P., Sedarati, F., Dobson, A. T., Feldman, L. T. & Stevens, J. G. (1992). Pathways of viral gene expression during acute neuronal infection with HSV-1. Virology 189, 150-160.
19. Nichol, P. F., Chang, J. Y., Johnson, E. M. & Olivo, P. D. (1996). HSV gene expression in neurons: viral DNA synthesis is a critical regulatory event in the branch point between the lytic and the latent pathways. Journal of Virology 70, 5476-5486.
20. O'Hare, P. & Goding, C. R. (1988). Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation. Cell 52, 435-445.
21. O'Hare, P., Goding, C. R. & Haigh, A. (1988). Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression. EMBO Journal 7, 4231-4238.
22. Perng, G. C., Chokephaibulkit, K., Thompson, R. L., Sawtell, N. M., Slanina, S. M., Ghiasi, H., Nesbur, A. B. & Wechsler, S. L. (1996). The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. Journal of Virology 70, 282-291.
23. Preston, C. M. (1979). Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK. Journal of Virology 29, 275-284.
24. Preston, C. M., Mabbs, R. & Nicholl, M. J. (1997). Construction and characterization of herpes simplex virus type 1 mutants with conditional defects in immediate early gene expression. Virology 229, 228-239.
25. Purves, F. C., Ogle, W. O. & Roizman, B. (1993). Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells. Proceedings of the National Academy of Sciences, USA 90, 6701-6705.
26. Sacks, W. R., Greene, C. C., Aschman, D. P. & Schaffer, P. A. (1985). Herpes simplex virus type 1 ICP27 is an essential regulatory protein. Journal of Virology 55, 796-805.
27. Sawtell, N. M. (1997). Comprehensive quantification of herpes simplex virus latency at the single-cell level. Journal of Virology 71, 5423-5431.
28. Sawtell, N. M. (1998). The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia. Journal of Virology 72, 6888-6892.
29. Sawtell, N. M., Poon, D. K., Tansky, C. S. & Thompson, R. L. (1998). The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. Journal of Virology 72, 5343-5350.
30. Sedarati, F., Margolis, T. P. & Stevens, J. G. (1993). Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome. Virology 192, 687-691.
31. Slobedman, B., Efstathiou, S. & Simmons, A. (1994). Quantitative analysis of herpes simplex virus DNA and transcriptional activity in ganglia of mice latently infected with wild-type and thymidine kinase-deficient viral strains. Journal of General Virology 75, 2469-2474.
32. Speck, P. G. & Simmons, A. (1991). Divergent molecular pathways of productive and latent infection with a virulent strain of HSV-1. Journal of Virology 65, 4001-4005.
33. Speck, P. G. & Simmons, A. (1992). Synchronous appearance of antigen-positive and latently infected neurons in spinal ganglia of mice infected with a virulent strain of herpes simplex virus. Journal of General Virology 73, 1281-1285.
34. Stevens, J. G., Wagner, E. K., Devi Rao, G. B., Cook, M. L. & Feldman, L. T. (1987). RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235, 1056-1059.
35. Stow, N. D. & Stow, E. C. (1986). Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110. Journal of General Virology 67, 2571-2585.
36. Stow, N. D. & Wilkie, N. M. (1976). An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. Journal of General Virology 33, 447-458.
37. Thompson, R. L. & Sawtell, N. M. (1997). The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. Journal of Virology 71, 5432-5440.
38. Tullo, A. B., Easty, D. L., Hill, T. J. & Blyth, W. A. (1982). Ocular herpes simplex and the establishment of latent infection. Transactions of the Opthalmological Societies of the United Kingdom 102, 15-18.
39. Valyi Nagy, T., Deshmane, S., Dillner, A. & Fraser, N. W. (1991). Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia. Journal of Virology 65, 4142-4152.
40. Wagner, E. K. & Bloom, D. C. (1997). Experimental investigation of HSV latency. Clinical Microbiology Reviews 10, 419-443.
41. Wagner, E. K., Guzowski, J. F. & Singh, J. (1995). Transcription of the HSV genome during productive and latent infection. Progress in Nucleic Acids Research and Molecular Biology 51, 123-168.
42. Wilcox, C. L., Smith, R. L., Everett, R. D. & Mysofski, D. (1997). The HSV-1 immediate early protein ICPO is necessary for the efficient establishment of latent infection. Journal of Virology 71, 6777-6785.
43. Wu, N., Watkins, S. C., Schaffer, P. A. & DeLuca, N. A. (1996). Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. Journal of Virology 70, 6358-6369.