A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits

Journal of Virology

Volumn 71, Issue 9, 1997, Pages 6555-6559

  Hill, James M ^a   Garza Jr , Hildegardo H ^a   Su, Ying Hsiu ^b   Meegalla, Rupalie ^b   Hanna, Lily A ^a   Loutsch, Jeannette M ^a   Thompson, Hilary W ^a   Varnell, Emily D ^a   Bloom, David C ^c   Block, Timothy M ^b  

^a LSU EYE CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ARTICLE; EYE INFECTION; GENE DELETION; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RABBIT; VIRUS GENE; VIRUS INFECTION; VIRUS MUTATION; VIRUS REACTIVATION; VIRUS TITRATION; VIRUS TYPING;

EID: 0030808931     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.9.6555-6559.1997     Document Type: Article

References (30)

1. Agresti, A., C. R. Mehta, and N. R. Patel. 1990. Exact inference for contin gency tables with ordered categories. J. Am. Statistical Assn. 85:453-458.
2. Block, T. M., S. Deshmane, J. Masonis, J. Maggioncalda, N. T. Valyi, and N.W. Fraser. 1493. An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers. Virology 192:618-630.
3. Block, T. M., J. G. Spivack, I. Steiner, S. Deshmane, M. T. Mclntosh, R. P. Lirette, and N. W. Fraser. 1990. A herpes simplex virus type 1 latencyassociated transcript mutant reactivates with normal kinetics from latent infection. J. Virol. 64:3417-3426.
4. Bloom, D. C., G. B. Devi-Rao, J. M. Hill, J. G. Stevens, and E. K. Wagner. 1994. Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo. J. Virol. 68:1283-1292.
5. Bloom, D. C., J. M. Hill, G. B. Devi-Rao, E. K. Wagner, L. T. Feldman, and J. G. Stevens. 1996. A 348-base-pair region in the latency-associated transript facilitates herpes simplex virus type 1 reactivation. J. Virol. 70:2449-2459.
6. Bloom, D. C., J. G. Stevens, J. M. Hill, and R. K. Tran. Mutagenesis of a cAMP response element within the latency-associated transcript promoter of HSV-1 reduces adrenergic reactivation. Virology, in press.
7. Coen, D. M. 1990, Quuntitation of rare DNAs by the polymerase chain reaction, p. 15.3.1-15.38. In F. M. Ausuhel. R. Brent. R. E. Kingston. D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl (ed.). Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
8. Coen, D. M. 1994. Quantification of DNAs by the polymerase chain reaction using an internal control, p. 89-96. In K. B. Mullis, F. Ferre, and R. A. Gibbs (ed.), The polymerase chain reaction. Birkhauser, Boston. Mass.
9. Furrell, M. J., J. M. Hill, T. P. Murgolis, J. G. Stevens, E. K. Wagner, and L. T. Feldman. 1993. The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORK-2. J. Virol. 67:3653-3655.
10. Hill, J. M., J. B. Dudley, Y. Shimomura, and H. E. Kaufman. 1986. Quantitation and kinetics of induced HSV-1 ocular shedding. Curr. Eye Res. 5:241-246.
11. Hill, J. M., B. M. Gebhardt, R. Wen, A. M. Bouterie, H. W. Thompson, R. J. O'Callaghan, W. F. Halford, and H. E. Kaufman. 1996. Quantitaten of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency. J. Virol. 70:3137-3141.
12. Hill, J. M., W. P. Haiford, R. Wen, L. S. Engel, L. C. Green, and B. M. Gebhardt. 1996. Quantitative analysis of polymerase chain reaction products by dot blot. Anal. Biochem. 235:44-48.
13. Hill, J. M., Y. Huruta, and D. S. Rootman. 1987. Adrenergically induced recurrent HSV-1 corneal epithelial lesion. Curr. Eye Res. 6:1065-1071.
14. Hill. J. M., J. B. Maggioncalda, H. H. Garza, Jr., Y-H Su, N. W. Fraser, and T. M. Block. 1996. In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-hase-pair region located between the promoter and the 5′ end of the 2.0-kilohase latency-associated transcript. J. Virol. 70:7270-7274.
15. Hill, J. M., M. A. Rayfleld, and Y. Haruta. 1987. Strain specificity of spontaneous and adrenergically induced HSV-1 ocular reactivation in latently infected rabbits. Curr. Eye Res. 6:91-97.
16. Hill, J. M., R. J. O'Callaghan, J. A. Hobden, and H. E. Kaufman. 1993. Ocular iontophoresis, p. 331-354. In A. K. Mitra (ed.), Ophthalmic drug delivery systems. Marcel Dekker. Inc., New York. N.Y.
17. Hill, J. M., F. Sedarati, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174:117-125.
18. Hill, J. M., R. Wen, and W. P. Halford. Pathogenesis and molecular biology of ocular HSV in the rabbit. Methods Mol. Biol., in press.
19. Karlin, S., W. Doerfier, and L. R. Cardon. 1994, Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? J. Virol. 68:2889-2897.
20. Maggioncalda, J., A. Mehta. O. Bagasra, N. W. Fraser, and T. M. Block. 1996. A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics. J. Neurovirol. 2:268-278.
21. Maggioncalda, J., A. Mehta, N. W. Fraser, and T. M. Block. 1994. Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5′ end of the 2.0-kilobase transcript. J. Virol. 68:7816-7824.
22. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
23. Perng, G.-C., E. C. Dunkel, P. A. Geary, S. M. Slanina, H. Ghiasi, R. Kaiwar, A. B. Nesburn, and S. L. Wechsler. 1994. The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J. Virol. 68:8045-8055.
24. Perns, G.-C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, and S. L. Wechsler. 1996. The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene residues completely within the first 1.5 kilobascs of the 8.3-kilobase primary transcript. J. Virol. 70:976-984.
25. Perng, G.-C., S. M. Slanina, H. Ghiasi, A. B. Nesburn, and S. L Wechsler. 1996. A 371-nucleotidc region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1. J. Virol. 70:2014-2018.
26. L. junction. Virology 196: 220-231.
27. Treco, D. A. 1990. Preparation and analysis of DNA, p. 2.0.3-2.2.3. In F. M. Ausubel, M. R. Brent, R. E. Kingston. D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl (ed.). Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
28. Trousdale, M. D., I. Steiner, J. G. Spivack, S. Deshmane, S. M. Brown, A. R. MacLean, J. H. Subak-Sharpe, and N. W. Fraser. 1991. In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model. J. Virol. 65:6989-6993.
29. Wasseneggur, M., S. Heimes, L. Riedel, and H. Sanger. 1994. RNA-directed de novo methylation of genomic sequences in plants. Cell 76:567-576.
30. Wu, T. T., Y. H. Su, T. M. Block, and J. M. Taylor. 1996. Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear. J. Virol. 70:5962-5967.