Brain mechanisms in cytokine-induced anorexia

Psychoneuroendocrinology

Volumn 24, Issue 1, 1999, Pages 25-41

  Plata Salamán, Carlos R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Feeding; Food intake; Interleukin; Leptin; Nervous system; Tumor necrosis factor

Indexed keywords

ALPHA INTERFERON; BETA 2 MICROGLOBULIN; CHEMOKINE; CYTOKINE; DNA; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; ION; LEPTIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MURAMYL DIPEPTIDE; NEUROPEPTIDE; PEPTIDE; PROTEIN; RECEPTOR; RECEPTOR SUBTYPE; RNA; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA; CALCIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NERVE PROTEIN;

ANOREXIA; ARTICLE; BRAIN; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOTHERAPY; ION CONDUCTANCE; LATERAL HYPOTHALAMUS; MEAL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; APPETITE; AWARDS AND PRIZES; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MOLECULAR BIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REVIEW;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ANIMALS; ANOREXIA; APPETITE; AWARDS AND PRIZES; BRAIN; CALCIUM CHANNELS; CYTOKINES; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GTP-BINDING PROTEINS; HUMANS; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MOLECULAR BIOLOGY; NERVE TISSUE PROTEINS; RATS;

EID: 0032928354     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(98)00045-6     Document Type: Article

References (55)

1. S-subunit in rat hypothalamic neurones. Journal of Physiology (London). 487(2):1995;291-303.
2. Flynn M.C., Scott T.R., Pritchard T., Plata-Salamán C.R. Mode of action of OB protein (leptin) on feeding. American Journal of Physiology. 275:1998;R174-R179.
3. Gayle, D., Ilyin, S.E., Flynn, M.C., Plata-Salamán, C.R., 1998a. Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: Characterization of brain cytokine and neuropeptide systems mRNAs. Brain Research 795, 77-86.
4. Gayle, D., Ilyin, S.E., Miele, M.E., Plata-Salamán, C.R., 1998b. Modulation of TNF-α mRNA production in rat C6 glioma cells by TNF-α, IL-1β, IL-6, and IFN-α: in vitro analysis of cytokine-cytokine interactions. Brain Research Bulletin (in press).
5. Gayle D., Ilyin S.E., Plata-Salamán C.R. Central nervous system IL-1β system and neuropeptide Y mRNAs during IL-1β-induced anorexia in rats. Brain Research Bulletin. 44:1997;311-317.
6. Ilyin S.E., Gayle D., Flynn M.C., Plata-Salamán C.R. Interleukin-1β system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-α, TGF-β1 and neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia. Brain Research Bulletin. 45:1998a;507-515.
7. Ilyin S.E., González-Gómez I., Gilles F.H., Plata-Salamán C.R. Interleukin-1α (IL-1α), IL-1β, IL-1 receptor type I, IL-1 receptor antagonist and TGF-β1 mRNAs in pediatric astrocytomas, ependymomas and primitive neuroectodermal tumors. Molecular and Chemical Neuropathology. 33:1998b;125-137.
8. Ilyin S.E., Plata-Salamán C.R. An approach to study molecular mechanisms involved in cytokine-induced anorexia. Journal of Neuroscience Methods. 70:1996a;33-38.
9. Ilyin S.E., Plata-Salamán C.R. Molecular regulation of the brain interleukin-1β system in obese (fa/fa) and lean (Fa/Fa) Zucker rats. Molecular Brain Research. 43:1996b;209-218.
10. Ilyin S.E., Plata-Salamán C.R. In vivo regulation of the IL-1β system (ligand, receptors I and II, receptor accessory protein and receptor antagonist) and TNF-α mRNAs in specific brain regions. Biochemical and Biophysical Research Communications. 227:1996c;861-867.
11. Ilyin S.E., Plata-Salamán C.R. HIV-1 gp120 modulates hypothalamic cytokine mRNAs in vivo: Implications to cytokine feedback systems. Biochemical and Biophysical Research Communications. 231:1997a;514-518.
12. Ilyin S.E., Plata-Salamán C.R. HIV-1 envelope glycoprotein 120 regulates brain IL-1β system and TNF-α mRNAs in vivo. Brain Research Bulletin. 44:1997b;67-73.
13. Ilyin S.E., Sonti G., Gayle D., Plata-Salamán C.R. Regulation of brain interleukin-1β (IL-1β) system mRNAs in response to pathophysiological concentrations of IL-1β in the cerebrospinal fluid. Journal of Molecular Neuroscience. 7:1996;169-181.
14. Plata-Salamán C.R. Food intake suppression by immunomodulators. Neuroscience Research Communications. 3:1988;159-165.
15. Plata-Salamán C.R. Immunomodulators and feeding regulation: A humoral link between the immune and nervous systems. Brain Behavior and Immunity. 3:1989;193-213.
16. Plata-Salamán C.R. Dexamethasone inhibits food intake suppression induced by low doses of interleukin-1β administered intracerebroventricularly. Brain Research Bulletin. 27:1991a;737-738.
17. Plata-Salamán C.R. Immunoregulators in the nervous system. Neuroscience and Biobehavioral Reviews. 15:1991b;185-215.
18. Plata-Salamán C.R. Regulation of hunger and satiety in man. Digestive Diseases. 9:1991c;253-268.
19. Plata-Salamán C.R. Interferons and central regulation of feeding. American Journal of Physiology. 263:1992;R1222-R1227.
20. Plata-Salamán C.R. Cytokines and ingestive behavior: Methods and overview. Methods in Neuroscience. 17:1993;151-168.
21. Plata-Salamán C.R. Meal patterns in response to the intracerebroventricular administration of interleukin-1β in rats. Physiology and Behavior. 55:1994a;727-733.
22. Plata-Salamán C.R. Tumor necrosis factor (TNF) production in response to lipids: Immunomodulatory activity with clinical applicability? Nutrition. 10:1994b;179-180.
23. Plata-Salamán C.R. Cytokines and feeding suppression: An integrative view from neurological to molecular levels. Nutrition. 11:1995a;674-677.
24. Plata-Salamán C.R. Strategies for potential manipulation of anorexia during acute and chronic disease. Nutrition. 11:1995b;702-704.
25. Plata-Salamán C.R. Anorexia during acute and chronic disease. Nutrition. 12:1996a;69-78.
26. Plata-Salamán C.R. Leptin (OB protein), neuropeptide Y, and interleukin-1 interactions as interface mechanisms for the regulation of feeding in health and disease. Nutrition. 12:1996b;718-719.
27. Plata-Salamán C.R. Anorexia induced by activators of the signal transducer gp 130. NeuroReport. 7:1996c;841-844.
28. Plata-Salamán C.R. Cytokine action in the nervous system at pathophysiological versus pharmacological concentrations. Advances in Experimental Medicine and Biology. 402:1996d;191-197.
29. Plata-Salamán C.R. Anorexia during acute and chronic disease: Relevance of neurotransmitter-peptide-cytokine interactions. Nutrition. 13:1997a;159-160.
30. Plata-Salamán C.R. Integrating computerized meal pattern analyses with molecular biology approaches. SSIB Ingestive Behavior Protocols. 1:1997b;15-28.
31. Plata-Salamán C.R. Hypothalamus and the control of feeding: fifteen decades of direct association. Nutrition. 14:1998a;67-70.
32. Plata-Salamán C.R. Cytokines and anorexia: A brief overview. Seminars in Oncology. 25:1998b;64-72.
33. Plata-Salamán C.R. Brain injury and immunosuppression. Nature Medicine. 4:1998c;768-769.
34. Plata-Salamán, C.R., 1998d. Cytokines and feeding. News in Physiological Sciences (in press).
35. Plata-Salamán C.R., Borkoski J.P. Interleukin-8 modulates feeding by direct action in the central nervous system. American Journal of Physiology. 265:1993a;R877-R882.
36. Plata-Salamán C.R., Borkoski J.P. Centrally administered bacterial lipopolysaccharide depresses feeding in rats. Pharmacology Biochemistry and Behavior. 46:1993b;787-791.
37. Plata-Salamán C.R., Borkoski J.P. Chemokines/intercrines and central regulation of feeding. American Journal of Physiology. 266:1994;R1711-R1715.
38. Plata-Salamán C.R., ffrench-Mullen J.M.H. Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1β Physiology and Behavior. 51:1992a;1277-1279.
39. Plata-Salamán C.R., ffrench-Mullen J.M.H. Interleukin-1β depresses calcium currents in hippocampal CA1 neurons at pathophysiological concentrations. Brain Research Bulletin. 29:1992b;221-223.
40. Plata-Salamán C.R., ffrench-Mullen J.M.H. Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons. NeuroReport. 4:1993;579-581.
41. Plata-Salamán C.R., ffrench-Mullen J.M.H. Interleukin-1β inhibits calcium channel currents in isolated hippocampal CA1 neurons through protein kinase C. European Journal of Pharmacology: Molecular Pharmacology Section. 266:1994;1-10.
42. Plata-Salamán C.R., Ilyin S.E. IL-1β-induced modulation of the hypothalamic IL-1β system, TNF-α and TGF-β1 mRNAs in obese (fa/fa) and lean (Fa/Fa) Zucker rats: Implications to IL-1β feedback systems and cytokine-cytokine interactions. Journal of Neuroscience Research. 49:1997;541-550.
43. Plata-Salamán, C.R., Ilyin, S.E., Gayle, D., 1998a. Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells. American Journal of Physiology 275, R566-R573.
44. Plata-Salamán C.R., Ilyin S.E., Gayle D., Flynn M.C. Gram-negative and Gram-positive bacterial products induce differential cytokine profiles in the brain: Analysis using an integrative molecular-behavioral in vivo model. International Journal of Molecular Medicine. 1:1998b;387-397.
45. Plata-Salamán C.R., Oomura Y., Kai Y. Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system. Brain Research. 448:1988;106-114.
46. Plata-Salamán, C.R., Peloso, E., Satinoff, E., 1998c. Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats. American Journal of Physiology (in press).
47. Plata-Salamán C.R., Sonti G., Borkoski J.P. Modulation of feeding by β2-microglobulin, a marker of immune activation. American Journal of Physiology. 268:1995a;R1513-R1519.
48. Plata-Salamán C.R., Sonti G., Borkoski J.P., Wilson C.D., ffrench-Mullen J.M.H. Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiology and Behavior. 60:1996;867-875.
49. Plata-Salamán C.R., Vasselli J.R., Sonti G. Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexia. Obesity Research. 5:1997;36-42.
50. O subunit subclass in the hypothalamic ventromedial nucleus: Implications to IL-1β-associated anorexia. Molecular Brain Research, 58, 188-194.
51. OA subunit. Molecular Brain Research. 33:1995b;72-78.
52. Sonti G., Flynn M.C., Plata-Salamán C.R. Interleukin-1 (IL-1) receptor type I mediates anorexia, but not adipsia induced by centrally administered IL-1β Physiology and Behavior. 62:1997;1179-1183.
53. Sonti G., Ilyin S.E., Plata-Salamán C.R. Anorexia induced by cytokine interactions at pathophysiological concentrations. American Journal of Physiology. 270:1996a;R1394-R1402.
54. Sonti G., Ilyin S.E., Plata-Salamán C.R. Neuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats. Peptides. 17:1996b;517-520.
55. Turrin, N.P., Plata-Salamán, C.R., 1998. Polyunsaturated fatty acids and disease-associated and cytokine-induced neurological manifestations. Nutritional Neuroscience (in press).