In vivo IL-1β-induced modulation of G-protein α(O) subunit subclass in the hypothalamic ventromedial nucleus: Implications to IL-1β-associated anorexia

Molecular Brain Research

Volumn 58, Issue 1-2, 1998, Pages 188-194

  Plata Salamán, Carlos R ^a   Wilson, Charlie D ^b   Ffrench Mullen, J M H ^b  

^a UNIVERSITY OF DELAWARE   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Cytokine; Feeding; Food intake; Hypothalamus; Interleukin; Intracerebroventricular; Nervous system; Neuroimmunology; Rat; Ventromedial nucleus

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN SUBUNIT; BORDETELLA VIRULENCE FACTOR; INTERLEUKIN 1; PERTUSSIS TOXIN; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; BRAIN VENTRICLE; CALORIC INTAKE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEEDING BEHAVIOR; GENETICS; HYPOTHALAMUS; INFUSION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; WISTAR RAT;

ANIMALS; ANOREXIA; CEREBRAL VENTRICLES; DNA PRIMERS; ENERGY INTAKE; FEEDING BEHAVIOR; GTP-BINDING PROTEINS; HYPOTHALAMUS; INFUSIONS, PARENTERAL; INTERLEUKIN-1; MALE; PERTUSSIS TOXIN; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER; VENTROMEDIAL HYPOTHALAMIC NUCLEUS; VIRULENCE FACTORS, BORDETELLA;

EID: 0032527256     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00126-0     Document Type: Article

References (35)

1. H. Akalin, A.C. Akdis, R. Mistik, S. Helvaci, K. Kilicturgay, Cerebrospinal fluid interleukin-1β/interleukin-1 receptor antagonist balance and tumor necrosis factor-α concentrations in tuberculous, viral and acute bacterial meningitis, Scand. J. Infect. Dis. 26 (1994) 667-674.
2. W.P. Arend, Interleukin 1 receptor antagonist. A new member of the interleukin 1 family, J. Clin. Invest. 88 (1991) 1445-1451.
3. J.E. Blundell, Pharmacological approaches to appetite suppression, Trends Pharmacol. Sci. 12 (1991) 147-157.
4. G.A. Bray, Peptides affect the intake of specific nutrients and the sympathetic nervous system, Am. J. Clin. Nutr. 55 (1992) 265S-271S.
5. R. Cacabelos, M. Barquero, P. Garcia, X.A. Alvarez, E.V. Deseijas, Cerebrospinal fluid interleukin-1β (IL-1β) in Alzheimer's disease and neurological disorders, Meth. Find. Exp. Clin. Pharmacol. 13 (1991) 455-458.
6. P. Chomczynski, A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples, Biotechniques 15 (1993) 532-537.
7. D. Gayle, S.E. Ilyin, C.R. Plata-Salamán, Central nervous system IL-1β system and neuropeptide Y mRNAs during IL-1β-induced anorexia in rats, Brain Res. Bull. 44 (1997) 311-317.
8. O-protein complexes using specific GTP-binding-protein antisera, Biochem. J. 306 (1995) 71-75.
9. S.L. Hauser, T.H. Doolittle, R. Lincoln, R.H. Brown, C.A. Dinarello, Cytokine accumulations in CSF of multiple sclerosis patients: frequent detection of interleukin-1 and tumor necrosis factor but not interleukin-6, Neurology 40 (1990) 1735-1739.
10. S.E. Ilyin, C.R. Plata-Salamán, Molecular regulation of the brain interleukin-1β system in obese (fa / fa) and lean (Fa / Fa) Zucker rats, Mol. Brain Res. 43 (1996) 209-218.
11. R.F. Jacobs, D.R. Tabor, The immunology of sepsis and meningitis-cytokine biology, Scand. J. Infect. Dis. Suppl. 73 (1990) 7-15.
12. O proteins functionally coupling galanin receptors to voltage-gated calcium channels, EMBO J. 14 (1995) 4728-4737.
13. S. Kent, F. Rodriguez, K.W. Kelley, R. Dantzer, Reduction of food and water intake induced by micro-injection of interleukin-1β in the ventromedial hypothalamus of the rat, Physiol. Behav. 56 (1994) 1031-1036.
14. Y. Kuroda, M. Matsui, H. Takashima, K. Kurohara, Granulocyte-macrophage colony-stimulating factor and interleukin-1 increase in cerebrospinal fluid, but not in serum, of HTLV-I-associated myelopathy, J. Neuroimmunol. 45 (1993) 133-136.
15. A.C.E. Linthorst, C. Flachskamm, P. Müller-Preuss, F. Holsboer, J.M.H.M. Reul, Effect of bacterial endotoxin and interleukin-1β on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study, J. Neurosci. 15 (1995) 2920-2934.
16. L.F. López-Cortés, N. Cruz-Ruiz, J. Gómez-Mateos, D. Jiménez-Hernández, J. Palomino, E. Jiménez, Measurement of levels of tumor necrosis factor-α and interleukin-1β in the CSF of patients with meningitis of different etiologies: Utility in the differential diagnosis, Clin. Infect. Dis. 16 (1993) 534-539.
17. H.D. McCarthy, S. Dryden, G. Williams, Interleukin-1β-induced anorexia and pyrexia in rat: relationship to hypothalamic neuropeptide Y, Am. J. Physiol. 269 (1995) E852-E857.
18. A. Morien, L. McMahon, P.J. Wellman, Effects on food and water intake of the α1-adrenoceptor agonists amidephrine and SK and F-89748, Life Sci. 53 (1993) 169-174.
19. J.E. Morley, Neuropeptide regulation of appetite and weight, Endocrine Rev. 8 (1987) 256-287.
20. Y. Nomura, Y. Kitamura, M. Tohda, Y. Tokumitsu, Drugs acting on the intracellular signalling system, Medicinal Res. Rev. 13 (1993) 1-60.
21. S. Ohga, T. Aoki, K. Okada, H. Akeda, K. Fujioka, A. Ohshima, T. Mori, I. Minamishima, K. Ueda, Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis, Arch. Dis. Child. 70 (1994) 123-125.
22. O. Perrella, P.B. Carrieri, D. Guarnaccia, M. Soscia, Cerebrospinal fluid cytokines in AIDS dementia complex, J. Neurol. 239 (1992) 387-388.
23. C.R. Plata-Salamán, Immunoregulators in the nervous system, Neurosci. Biobehav. Rev. 15 (1991) 185-215.
24. C.R. Plata-Salamán, Meal patterns in response to the intracerebroventricular administration of interleukin-β in rats, Physiol. Behav. 55 (1994) 727-733.
25. C.R. Plata-Salamán, Anorexia during acute and chronic disease, Nutrition 12 (1996) 69-78.
26. C.R. Plata-Salamán, Hypothalamus and the control of feeding: fifteen decades of direct association, Nutrition 14 (1998) 67-70.
27. C.R. Plata-Salamán, J.M.H. ffrench-Mullen, Interleukin-1β inhibits calcium channel currents in isolated hippocampal CA1 neurons through protein kinase C, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 266 (1994) 1-10.
28. C.R. Plata-Salamán, G. Sonti, J.P. Borkoski, C.D. Wilson, J.M.H. ffrench-Mullen, Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations, Physiol. Behav. 60 (1996) 867-875.
29. OA subunit, Mol. Brain Res. 33 (1995) 72-78.
30. B.B. Ruzicka, R.C. Thompson, S.J. Watson, H. Akil, Interleukin-1β-mediated regulation of μ-opioid receptor mRNA in primary astrocyte-enriched cultures, J. Neurochem. 66 (1996) 425-428.
31. G. Sonti, S.E. Ilyin, C.R. Plata-Salamán, Anorexia induced by cytokine interactions at pathophysiological concentrations, Am. J. Physiol. 270 (1996) R1394-R1402.
32. C. Viollet, C. Loudes, C. Kordon, A. Faivre-Bauman, Selective patterns of expression of G protein α subunits during in vitro development of hypothalamic neurons, J. Neurochem. 63 (1994) 2231-2239.
33. S. Watson, S Arkinstall, The G-protein Linked Receptor FactsBook, Academic Press, London, 1994, 427 pp.
34. Oα-subtype G protein in rat primary afferent neurons, J. Neurophysiol. 77 (1997) 1338-1348.
35. S. Zalcman, J.M. Green-Johnson, L. Murray, D.M. Nance, D. Dyck, H. Anisman, A.H. Greenberg, Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6, Brain Res. 643 (1994) 40-49.