Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals

Environmental Health Perspectives

Volumn 107, Issue SUPPL. 1, 1999, Pages 89-108

  Andersen, Helle Raun ^a   Andersson, Anna Maria ^b   Arnold, Steven F ^c   Autrup, Herman ^d   Barfoed, Marianne ^e   Beresford, Nicola A ^f   Bjerregaard, Poul ^a   Christiansen, Lisette B ^a   Gissel, Birgitte ^e   Hummel, René ^b   Jørgensen, Eva Bonefeld ^d   Korsgaard, Bodil ^a   Le Guevel, Remy ^g   Leffers, Henrik ^b   McLachlan, John ^c   Møller, Anette ^a   Nielsen, Jesper Bo ^a   Olea, Nicolas ^h   Oles Karasko, Anita ⁱ   Pakdel, Farzad ^g   Pedersen, Knud L ^a   Perez, Pilar ^h   Skakkebœk, Niels Erik ^b   Sonnenschein, Carlos ⁱ   Soto, Ana M ⁱ   Sumpter, John P ^f   Thorpe, Susan M ^e   Grandjean, Philippe ^a   more..

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b Rigshospitalet   (Denmark)

^c TULANE UNIVERSITY   (United States)

^d AARHUS UNIVERSITY   (Denmark)

^e NOVO NORDISK A S   (Denmark)

^f BRUNEL UNIVERSITY   (United Kingdom)

^g Campus de Beaulieu   (France)

^h UNIVERSITY OF GRANADA   (Spain)

ⁱ TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiestrogens; Binding assay; Estrogenic chemicals; Estrogenicity tests; Estrogens; MCF 7; Vitellogenin; Yeast

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 4,4' ISOPROPYLIDENEDIPHENOL; ALCOHOL; CHLORPHENOTANE; COLCHICINE; ENDOSULFAN; ENVIRONMENTAL CHEMICAL; ESTRADIOL; ESTROGEN DERIVATIVE; ESTROGEN RECEPTOR; METHOXYCHLOR; PHTHALIC ACID DIBUTYL ESTER; TAMOXIFEN; TESTOSTERONE; VITELLOGENIN;

ANIMAL CELL; ARTICLE; ASSAY; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; RAINBOW TROUT; RELIABILITY; REPORTER GENE; REPRODUCIBILITY; STANDARDIZATION; TOXICITY TESTING; YEAST;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS; ONCORHYNCHUS MYKISS; SALMONIDAE;

EID: 0032910218     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.99107s189     Document Type: Article

References (68)

1. Toppari J, Larsen JC, Christiansen P, Christiansen P, Giwercman A, Grandjean P, Guil lette LJ Jr, Jégou B, Jensen TK, Jouannet P, et al. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 104 (Suppl 4):741-803 (1996).
2. Sumpter JP. Feminized responses in fish to environmental estrogens. Toxicol Lett 82-83: 737-742 (1995).
3. Fry DM. Reproductive effects in birds exposed to pesticides and industrial chemicals. Environ Health Perspect 103 (Suppl 7):165-171 (1995).
4. Folmar LC, Denslow ND, Rao V, Chow M, Grain DA, Enblom J, Marcino J, Guilette LJ, Jr. Vitellogenin induction and reduced serum testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant. Environ Health Perspect 104:1096-1101 (1996).
5. Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103 (Suppl 7):113-122 (1995).
6. Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect 103:582-587 (1995).
7. Shelby MD, Newbold RR, Tully DB, Chae K, Davis VL. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays. Environ Health Perspect 104:1296-1300 (1996).
8. Perez P, Pulgar R, Olea Serrano F. Villalobos M. Rivas A, Metzler M, Pedraza V, Olea N. The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups. Environ Health Perspect 106:167-174 (1998).
9. Korach KS, McLachlan JA. Techniques for detection of estrogenicity. Environ Health Perspect 103 (Suppl 7):5-8 (1995).
10. Reel JR, Lamb IVC, Neal BH Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fundam Appl Toxicol 34:288-305 (1996).
11. Ashby J, Lefevre PA, Odum J, Tinwell H, Kennedy SJ, Beresford NA, Sumpter JP. Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents. Regul Toxicol Pharmacol 26:96-101 (1997).
12. Odum J, Lefevre PA, Tittensor S, Paton D, Routledge EJ, Beresford NA, Sumpter JP, Ashby J. The rodent uterotrophic assay: critical protocol features, studies with nonylphenols, and comparison with a yeast estrogenicity assay. Regul Toxicol Pharmacol 25:176-188 (1997).
13. Gradishar WJ, Jordan VC. Clinical potential of new antiestrogens. J Clin Oncol 15:840-852 (1997).
14. Levin W, Welch RM, Conney AH. Effect of carbon tetrachloride and other inhibitors of drug metabolism on the metabolism and action of estradiol-17 beta and estrone in the rat. J Pharmacol Exp Ther 173:247-255 (1970).
15. Arnold SF, Robinson MK, Notides AC, Guillette LJ Jr, McLachlan JA. A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. Environ Health Perspect 104:544-548 (1996).
16. Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 105:70-76 (1997).
17. vom Saal FS, Montano MM, Wang MH. Sexual differentiation in mammals. In: Chemically Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection. Vol XXI (Colborn T, Clement CR, eds). Princeton, NJ:Princeton Scientific Publishing, 1992; 17-83.
18. Nimrod AC, Benson WH. Environmental estrogenic effects of alkylphenol ethoxylates. Crit Rev Toxicol 26:335-364 (1996).
19. Fry DM, Toone CK. DDT-induced feminization of gull embryos Science 213:922-924 (1981).
20. Sumpter JP, Jobling S. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment. Environ Health Perspect 103(Suppl 7):173-178 (1995).
21. Klotz DM, Beckman BS, Hill SM, McLachlan JA, Walters MR, Arnold SF. Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays. Environ Health Perspect 104:1084-1089 (1996).
22. Mellanen P, Petänen T, Lehtimäki J, Mäkelä S, Bylund G, Holmbom B, Mannila E, Oikari A, Santti R. Wood-derived estrogens: studies in vitro with breast cancer cell lines and in vivo in trout. Toxicol Appl Pharmacol 136:381-388 (1996).
23. Coldham NC, Dave M, Sivapathasundaram S, McDonnell DP, Connor C, Sauer MJ. Evaluation of a recombinant yeast cell estrogen screening assay. Environ Health Perspect 105:734-742 (1997).
24. Brotons JA, Olea Serrano MF, Villalobos M, Pedraza V, Olea N. Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect 103:608-612 (1995).
25. Soto AM, Chung KL, Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 102:380-383 (1994).
26. Olea N, Pulgar R, Ferez P, Olea Serrano F, Rivas A, Novillo Fertrell A, Pedraza V, Soto AM, Sonnenschein C. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 104:298-305 (1996).
27. Routledge EJ, Sumpter JP. Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ Toxicol Chem 15:241-248 (1996).
28. Harris CA, Henttu P, Parker MG, Sumpter JP. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 105:802-811 (1997).
29. Bicknell RJ, Herbison AE, Sumpter JP. Oestrogenic activity of an environmentally persistent alkylphenol in the reproductive tract but not the brain of rodents. J Steroid Biochem Mol Biol 54:7-9 (1995).
30. Sharpe RM, Fisher JS, Millar MM, Jobling S, Sumpter JP. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect 103:1136-1143 (1995).
31. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135:175-182 (1994).
32. Lech JJ, Lewis SK, Ren L. In vivo estrogenic activity of nonylphenol in rainbow trout. Fundam Appl Toxicol 30:229-232 (1996).
33. Soto AM, Justicia H, Wray JW, Sonnenschein C. p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene. Environ Health Perspect 92:167-173 (1991).
34. Colerangle JB, Roy D. Exposure of environmental estrogenic compound nonylphenol to Noble rats alters cell-cycle kinetics in the mammary gland. Endocrine 4:115-122 (1996).
35. Routledge EJ, Sumpter JP. Structural features of alkylphenolic chemicals associated with estrogenic activity. J Biol Chem 272:3280-3288 (1997).
36. Bigsby RM, Caperell-Grant A, Madhukar BV. Xenobiotics released from fat during fasting produce estrogenic effects in ovariectomized mice. Cancer Res 57:865-869 (1997).
37. Bitman J, Cecil HC, Harris SJ, Fries GF. Estrogenic activity of o,p′ -DDT in the mammalian uterus and avian oviduct. Science 162:371-372 (1968).
38. Welch RM, Levin W, Conney AH. Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol 4:358-367 (1969).
39. Chen CW, Hurd C, Vorojeikina DP, Arnold SF, Notides AC. Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells. Biochem Pharmacol 53:1161-1172 (1997).
40. Bulger WH, Muccitelli RM, Kupfer D. Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem Pharmacol 27:2417-2423 (1978).
41. Wade MG, Desaulniers D, Leingartner K, Foster WG. Interactions between endosulfan and dieldrin on estrogen-mediated processes in vitro and in vivo. Reprod Toxicol 11:791-798 (1997).
42. Chakravorty S, Lal B, Singh TP. Effect of endosulfane (thiodan) on vitellogenesis and its modulation by different hormones in the vitellogenic catfish Clarias batrachus. Toxicology 75:191 (1992)
43. Kelce WR, Stone CR, Laws SC, Earl Gray L, Kemppainen JA, Wilson EM. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375:581-585 (1995).
44. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Current Protocols in Molecular Biology. New York:John Wiley & Sons, 1995.
45. 32P-labeled protein, applied to HIV-1 Gag and Rev. Gene 162:235-237 (1995).
46. EORTC (European Organization for Research and Treatment of Cancer). Standards for the assessment of estrogen receptors in human breast cancer. Report of a workshop on 29 September, 1972, at the Antoni van Leeuwenhoek-Huis, Amsterdam. Eur J Cancer 9:379-381 (1973).
47. Thorpe SM. Steroid receptors in breast cancer: sources of inter-laboratory variation in dextrancharcoal assays. Breast Cancer Res Treat 9:175-189 (1987).
48. Soto AM, Lin T, Justicia H, Silvia RM, Sonnenschein C. An "in culture" bioassay to assess the estrogenicity of xenobiotics (E-SCREEN). In: Chemically Induced Alterations in Sexual Development: The Wildlife/Human Connection (Colborn T, Clement CR, eds). Princeton, NJ:Princeton Scientific Publishing 1992;295-309.
49. Villalobos M, Olea N, Brotons JA, Olea Serrano MF, Almodovar JMR, Pedraza V. The E-SCREEN assay: a comparison of different MCF-7 cell stocks. Environ Health Perspect 103:844-850 (1995).
50. Jorgensen ECB, Autrup H. Autoregulation of human CYP1A1 gene promoter activity in HepG2 and MCF-7 cells. Carcinogenesis 17:435-441 (1996).
51. Jorgensen ECB, Autrup H. Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells. FEBS Lett 365:101-107 (1995).
52. Jorgensen ECB, Autrup H, Hansen JC. Effect of toxaphene on estrogen receptor function in human breast cancer cells. Carcinogenesis 18:1651-1654 (1997).
53. Petit F, Valotaire Y, Pakdel F. Differential functional activities of rainbow trout and human estrogen receptors expressed in the yeast Saccharomyces cerevisiae. Eur J Biochem 233:584-592 (1995).
54. Wiley SH, Opresko L, Wallace RA. New methods for the purification of vertebrate vitellogenin. Anal Biochem 97:145-152 (1979).
55. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors and α and β. Endocrinology 138:863-870 (1997).
56. Ousterhout J, Struck RF, Nelson JA. Estrogenic activities of methoxychlor metabolites. Biochem Pharmacol 30:2869-2871 (1981).
57. Borräs M, Laios I, Khissiin AE, Seo H-S, Lempereur F, Legros N, Leclercq G. Estrogenic and antiestrogenic regulation of the half-life of covalently labeled estrogen receptor in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol 57:203-213 (1996).
58. Soto AM, Murai JT, Siiteri PK, Sonnenschein C. Control of cell proliferation: evidence for negative control on estrogen-sensitive T47D human breast cancer cells. Cancer Res 46:2271-2275 (1986).
59. Kohno H, Gandini O, Curtis SW, Korach KS. Anti-estrogen activity in the yeast transcription system: estrogen receptor mediated agonist response. Steroids 59:572-578 (1994).
60. Metzger D, Ali S, Bornert J-M, Chambon P. Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells. J Biol Chem 270:9535-9542 (1995).
61. Kudoh M, Susaki Y, Ideyma Y, Nanya T, Mori M, Shikama H, Fujikura T. Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511, on the proliferation of MCF-7 human breast cancer cell. J Steroid Biochem Mol Biol 58:189-194 (1996).
62. Tada A, Sasaki H, Nakamura J, Yoshihama M, Terashima Y. Aromatase activity and the effect of estradiol and testosterone on DNA synthesis in endometrial carcinoma cell lines. J Steroid Biochem Mol Biol 44:661-666 (1993).
63. Jobling S, Sumpter JP. Detergent components in sewage effluent are weakly oestrogenic to fish: an in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 27:361-372 (1993).
64. vom Saal FS, Nagel SC, Palanza P, Boechler M, Parmigiani S, Welshons WV. Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behaviour in male mice. Toxicol Lett 77:343-350 (1995).
65. Tiemann U, Schneider F, Tuchscherer A. Effects of organochlorine pesticides on DNA synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers. Arch Toxicol 70:490-496 (1996).
66. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guilette LJ Jr, McLachlan JA. Synergistic activation of human estrogen receptor by combinations of environmental chemicals. Science 272: 1489-1492 (1996).
67. Donohoe RM, Curtis LR. Estrogenic activity of chlordecone, o,p′-DDT and o,p′-DDE in juvenile rainbow trout: Induction of vitellogenesis and interaction with hepatic estrogen binding sites. Aquatic Toxicol 36:31-52 (1996).
68. Przylipiak A, Rabe T, Hafner J, Przylipiak M, Runnebaum R. Influence of ethanol on in vitro growth of human mammary carcinoma cell line MCF-7. Arch Gynecol Obstet 258:137-140 (1996).