Evaluation of a recombinant yeast cell estrogen screening assay

Environmental Health Perspectives

Volumn 105, Issue 7, 1997, Pages 734-742

  Coldham, Nick G ^a   Dave, Mehul ^a   Sivapathasundaram, Susila ^a   McDonnell, Donald P ^b   Connor, Caroline ^b   Sauer, Maurice J ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antiestrogens; Environmental contaminants; Estrogen; Metabolism; Phytoestrogens; Potency; Receptor; Recombinant yeast cell bioassay; Uterotrophic

Indexed keywords

ALPHA ZEARALENOL; DIETHYLSTILBESTROL; EQUOL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTRONE; PHENOL DERIVATIVE; PHTHALIC ACID; PHYTOESTROGEN; STEROID; TAMOXIFEN;

ARTICLE; BIOASSAY; BREAST CANCER; CALIBRATION; CANCER CELL; CELL TRANSFORMATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ESTROGEN METABOLISM; HORMONE ACTION; NONHUMAN; PLASMID; POLLUTANT; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RISK ASSESSMENT; SCREENING; YEAST CELL;

EID: 0030881559     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.97105734     Document Type: Article

References (47)

1. Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392-1395 (1993).
2. McLachlan JA. Functional toxicology: a new approach to detect biologically active xenobiotics. Environ Health Perspect 101:386-387 (1993).
3. Wild SR, Harrad SJ, Jones KC. The influence of sewage sludge applications to agricultural land on human exposure to polychlorinated dibenzo-p-dioxins (PCDDs) and -furans (PCDFs). Environ Pollut 83:357-369 (1994).
4. Litchfield M, Peakall D. Assessment on Environmental Oestrogens: Consequences to Human Health and Wildlife. Leicester, UK:Institute for Environment and Health, 1995.
5. Nimrod AC, Benson WH. Environmental estrogenic effects of alkylphenol ethoxylates. Crit Rev Toxicol 26:335-364 (1996).
6. Kupfer DL. Critical evaluation of methods for detection and assessment of estrogenic compounds in mammals: strengths and limitations for application to risk assessment. Reprod Toxicol 1:147-153 (1988).
7. Nelson JA, Struck RF, James R. Estrogenic activities of chlorinated hydrocarbons. J Toxicol Environ Health 4:325-339 (1978).
8. Korach KS, Sarver P, Chae K, McLachlan JA, McKinney JD. Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: conformationally restricted structural probes. Mol Pharmacol 33:120-126 (1988).
9. Soto AM, Chung KL, Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 102:380-383 (1994).
10. Welshons WV, Rottinghaus GE, Nonneman DJ, Dolan-Timpe M, Ross PF. A sensitive bioassay for detection of dietary estrogens in animal feeds. J Vet Diagn Invest 2:268-273 (1990).
11. Rubin BL, Dorfman AS, Black L, Dorfman RI. Bioassay of estrogens using the mouse uterine response. Endocrinology 49:429-439 (1951).
12. Galey FD, Mendez LE, Whitehead WE, Holstege DM, Plumlee KH, Johnson B. Estrogenic activity of forages: diagnostic use of the classical mouse uterine bioassay. J Vet Diagn Invest 5:603-608 (1993).
13. Day BW, Magarian RA, Jain PT, Pent JT, Mousissian GK, Meyer KL. Synthesis and biological evaluation of a series of 1,1-dichloro-2,2,3-triarylcyclopropanes as pure anti-oestrogens. J Med Chem 34:842-851 (1991).
14. Klein KO, Baron J, Colli MJ, McDonnell D, Cutler GB. Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J Clin Invest 94:2475-2480 (1994).
15. Routledge EJ, Sumpter JP. Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ Toxicol Chem 15:241-248 (1996).
16. Arnold SF, Robinson MK, Notides AC, Guillette LJ Jr, McLachlan JA. A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. Environ Health Perspect 104:544-548 (1996).
17. McDonnell DP, Nawaz Z, Densmore C, Weigel NL, Pham TA, Clark JH, O'Malley BW. High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae. J Steroid Biochem Mol Biol 39:291-297 (1991).
18. Lyttle CR, Damian-Matsumura P, Juul H, Butt TR. Human estrogen receptor regulation in a yeast model system and studies on receptor agonists and antagonists. J Steroid Biochem Mol Biol 42:677-685 (1992).
19. Katzenellenbogen BS, Bhardwaj B, Fang H, Ince BA, Pakdel F, Reese JC, Schodin D, Wrenn CK. Hormone binding and transcription activation by estrogen receptors: analyses using mammalian and yeast systems. J Steroid Biochem Mol Biol 47:39-48 (1993).
20. Miksicek RJ. Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 49:153-160 (1994).
21. Korenman SG. Comparative binding affinity of estrogens and its relation to estrogenic potency. Steroids 13:163-177 (1969).
22. Arts CJM, Van Den Berg H. Multi-residue screening of bovine urine on xenobiotic oestrogens with an oestrogen radioreceptor assay. J Chromatogr 489:225-234 (1989).
23. Gyling M, Leclercq G. Estrogen and antiestrogen interaction with estrogen receptor of MCF-7 cells-relationship between processing and estrogenicity. J Steroid Biochem 29:1-8 (1988).
24. Sonnenschein C, Soto AM, Fernandez M, Olea N, Olea-Serrano MF, Ruiz-Lopez MD. Development of a marker of estrogenic exposure in human serum. Clin Chem 41/12:1888-1895 (1995).
25. Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132:2279-2286 (1993).
26. Coldham NG, James VHT. A possible mechanism fot increased breast cell proliferation by progestins through increased reductive 17β-hydroxysteroid dehydrogenase activity. Int J Cancer 45:174-178 (1990).
27. 3H]estradiol-17β metabolites in calf perirenal fat. Analyst 119:2623-2626 (1994).
28. 1. Cancer Res 54:3140-3144 (1994).
29. Soto AM, Justicia H, Wray JW, Sonnenschein C. P-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene. Environ Health Perspect 92:167-173 (1991).
30. McDonnell DP, Nawaz Z, O'Malley BW. In situ distinction berween steroid receptor binding and transactivation at a target gene. Mol Cell Biol 11:4350-4355 (1991).
31. Pham TA, Hwung Y-P, McDonnell DP, O'Malley BW. Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. J Biol Chem 266:18179-18187 (1991).
32. Allen E, Doisy E. An ovarian hormone. Preliminary report on its localization, extraction, and partial purification, and action in test animals. JAMA 10:819-821 (1923).
33. Braunsberg H, Coldham NG, Leake RE, Cowan SK, Wong W. Actions of a progestagen on human breast cancer cells: mechanisms of growth stimulation and inhibition. Eur J Cancer Clin Oncol 23:563-571 (1987).
34. Moore MR. Correspondence on 'Difference between R5020 and the anti-progestin RU486 in antiproliferative effects on human breast cancer cells'. Breast Cancer Res Treat 12:81-82 (1988).
35. Martin L, Claringbold PJ. The mitogenic action of oestrogens in the vaginal epithelium of the ovariectomized mouse. J Endocrin 20:173-186 (1960).
36. Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect 103:582-587 (1995).
37. Birnbaum LS. Developmental effects of dioxins. Environ Health Perspect 103(suppl 7):89-94.
38. Harris M, Zacharewski T, Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Res 50:3579-3584 (1990).
39. Katzenellenbogen BS, Katzenellenbogen JA, Mordecai D. Zearalenones: Characterization of the estrogenic potencies and receptor interactions of a series of fungal β-resorcyclic acid lactones. Endocrinology 105:33-40 (1979).
40. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135:175-182 (1994).
41. Magarian RA, Avor KS, Overacre LB, Kunchandy J, Paxton TR. Synthesis and biological evaluation of basic side chain derivatives of Analog II as pure anti-oestrogens and antitumor agents. Anticancer Drug Des 10:311-331 (1995).
42. Sutherland RL, Watts CK, Hall RE, Ruenitz PCJ. Mechanisms of growth inhibibition by non-steroidal anti-oestrogens in human breast cancer cells. J Steroid Biochem 27:891-897 (1987).
43. Imhof M, McDonnell DP. Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol 16:2594-2605 (1996).
44. Herman C, Adlercreutz T, Goldin BR, Gorbach SL, Hockerstedt KAV, Watanabe S, Hamalainen EK, Markkanen MH, Marela TH, Wahala KT. Soybean phytoestrogen intake and cancer risk. J Nutr 125(suppl):757-770 (1995).
45. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ, McLachlan JA. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272:1489-1492 (1996).
46. Ashby J, Lefevre PA, Odum J, Harris CA, Routledge EJ, Sumpter JP. Synergy between synthetic oestrogens? Nature 385:494 (1997).
47. Bulger WH, Feil VJ, Kupfer D. Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants. Mol Pharmacol 27:115-124 (1985).