Tyrosine kinases in neutrophils

Current Opinion in Hematology

Volumn 6, Issue 1, 1999, Pages 51-58

  Berton, Giorgio ^a  

^a Istituto di Patologia Generale   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CYTOKINE; PROTEIN TYROSINE KINASE;

CELL ADHESION; HUMAN; LEUKOCYTE ACTIVATION; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

CELL ADHESION; ENZYME ACTIVATION; HUMANS; MONOCYTE CHEMOATTRACTANT PROTEINS; NEUTROPHILS; PHAGOCYTOSIS; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0032907349     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199901000-00009     Document Type: Review

References (68)

1. 1 Welch H, Mauran C, Maridonneau-Parini I: Nonreceptor protein-tyrosine kinases in neutrophil activation. Methods 1996, 9:607-618.
2. 2 Weil D, Power MA, Smith SI, Li CL: Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage. Blood 1997, 90:4332-4340.
3. 3 Indik ZK, Park JG, Hunter S, Schreiber AD: The molecular dissection of Fcγ receptor mediated phagocytosis. Blood 1995, 86:4389-4399.
4. 4 Santana C, Noris G, Espinoza B, Ortega E: Protein tyrosine phosphorylation in leukocyte activation through receptors for IgG. J Leukoc Biol 1996, 60:433-440.
5. 5 Sánchez-Mejorada G, Rosales C: Signal transduction by immunoglobulin Fc receptors. J Leukoc Biol 1998, 63:521-533.
6. 6 Greenberg S, Chang P, Wang DC, Xavier R, Seed B: Clustered syk tyrosine kinase domains trigger phagocytosis. Proc Natl Acad Sci U S A 1996, 93:1103-1107.
7. 7 Cox D, Chang P, Kurosaki T, Greenberg S: Syk tyrosine kinase is required for immunoreceptor tyrosine activation motif-dependent actin assembly. J Biol Chem 1996, 271:16597-16602.
8. 8 Matsuda M, Park JG, Wang DC, Hunter S, Chien P, Schreiber AD: Abrogation of the Fcγ receptor IIA-mediated phagocytic signal by stemloop Syk antisense oligonucleotides. Mol Biol Cell 1996, 7:1095-1106.
9. 9 Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, et al: A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J Exp Med 1997, 186:1027-1039. This important study demonstrates defective FcγRs-dependent phagocytosis and signaling in liver macrophages obtained from Syk-deficient mice, but not in bone marrow-derived macrophages obtained from mice deficient for the three Src-family kinases Hck, Fgr, and Lyn.
10. 10 Kiefer F, Brumell J, Al-Alawi N, Latour S, Cheng A, Veillette A, et al: The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils. Mol Cell Biol 1998, 18:4209-4220. This is another important study on defective FcγRs-dependent phagocytosis and signaling in Syk-deficient phagocytic cells.
11. c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol 1996, 133:895-910.
12. 12 Lowell CA, Soriano P: Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev 1996, 10:1845-1857.
13. src expression in human macrophages and myelomonocytic cell lines. FEBS Lett 1993, 327:315-320.
14. 14 Ibarrola I, Vossebeld PJ, Homburg CH, Thelen M, Roos D, Verhoeven AJ: Influence of tyrosine phosphorylation on protein interaction with FcγRIIa. Biochem Biophys Acta 1997, 1357:348-358.
15. 15 Allen LA, Aderem A: Molecular definition of distinct cytoskeletal structures involved in complement-and Fc receptor-mediated phagocytosis in macrophages. J Exp Med 1996, 184:627-637.
16. 16 Hauck CR, Meyer TF, Lanf F, Gulbins E: CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase-and Rac1-dependent signalling pathway. EMBO J 1998, 17:443-454. This article characterizes a signaling pathway triggered by CD66 and involved in phagocytosis of Neisseria gonorrhoeae that appears to be Src-family kinase dependent but Syk independent, and that impinges on Rac-1.
17. 17 Virji M, Makepeace K, Ferguson DJ, Watt SM: Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae. Mol Microbiol 1996, 22:941-950.
18. 18 Chen T, Grunert F, Medina-Marino A, Gotschlich EC: Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. J Exp Med 1997, 185:1557-1564.
19. 19 Skubitz KM, Campbell KD, Ahmed K, Skubitz AP: CD66 family members are associated with tyrosine kinase activity in human neutrophils. J Immunol 1995, 155:5382-5390.
20. 20 Hackam DJ, Rotstein OD, Schreiber A, Zhang WJ, Grinstein S: Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ receptors in macrophages. J Exp Med 1997, 186:955-966. This article demonstrates that Rho is implicated in FcγRs signaling in a macrophage cell line and COS cells transfected with FcγRIIA. It also shows that Rho is required for the formation of F-actin-rich phagocytic cups and clustering of FcγRs.
21. 21 Cox D, Chang P, Zhang Q, Reddy PG, Bokoch GM, Greenberg S: Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med 1997, 186:1487-1494. This is an important study on the role of Rac1 and Cdc42 in membrane ruffling induced by chemoattractant and Fcγ receptors in a macrophage cell line.
22. 22 Toker A, Cantley LC: Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997, 387:673-676.
23. 23 Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR: Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 1997, 385:169-172.
24. 24 Araki N, Johnson MT, Swanson JA: A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J Cell Biol 1996, 135:1249-1260.
25. 25 Corey S, Eguinoa A, Puyana-Theall K, Bolen JB, Cantley L, Mollinedo F, et al: Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 1993, 12:2681-2690.
26. 26 Al-Shami A, Bourgoin SG, Naccache PH: Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils: I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters. Blood 1997, 89:1035-1044.
27. 27 Wei S, Liu JH, Epling-Burnette PK, Gamero AM, Ussery D, Pearson EW, et al: Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J Immunol 1996, 157:5155-5162.
28. 28 Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ: Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A 1994, 91:4683-4687.
29. 29 Brizzi MF, Aronica MG, Rosso A, Bagnara GP, Yarden Y, Pegoraro L: Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes. J Biol Chem 1996, 271:3562-3567.
30. 30 Al-Shami A, Mahanna W, Naccache PH: Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils: selective activation of JAK2, STAT3, and STAT5b. J Biol Chem 1998, 273:1058-1063. This is a detailed study on expression and activation of Jaks and STATs in human neutrophils.
31. 31 Bovolenta C, Gasperini S, Cassatella MA: Granulocyte colony-stimulating factor induces the binding of STAT1 and STAT3 to the IFNγ response region within the promoter of the FcγRI/CD64 gene in human neutrophils. FEBS Lett 1996, 386:239-242.
32. 32 Bovolenta C, Gasperini S, McDonald PP, Cassatella MA: High affinity receptors for IgG (FcγRI/CD64) gene and STAT protein binding to the IFN-γ response region (GRR) are regulated differentially in human neutrophils and monocytes by IL-10. J Immunol 1998, 160:911-919. This article demonstrates that STATs are involved in interferon - induced gene transcription in neutrophils, and failure of IL-10 to induce FcγRI transcription is due to its inability to activate STATs.
33. 33 Heydemann A, Juang G, Hennessy K, Parmacek MS, Simon MC: The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor. Mol Cell Biol 1996, 16:1676-1686.
34. 34 Heydemann A, Boehmler JH, Simon MC: Expression of two myeloid cell-specific genes requires the novel transcription factor, c-fes expression factor. J Biol Chem 1997, 272:29527-29537. This article reports on a further advancement in the characterization of a novel, myeloid-specific transcription factor that regulates Fes transcription.
35. 35 Li J, Smithgall TE: Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation. J Biol Chem 1998, 273:13828-13834. This important study demonstrates that Fes impinges on Ras, Rac, and Cdc42 to activate extracellular signal-regulated and c-Jun N-terminal kinases.
36. 36 Bokoch GM: Chemoattractant signaling and leukocyte activation. Blood 1995, 86:1649-1660.
37. 37 Stephens L, Eguinoa A, Corey S, Jackson T, Hawkins PT: Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J 1993, 12:2265-2273.
38. 38 Ptasznik A, Traynor-Kaptan A, Bokoch GM: G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase. She adapter protein signaling complexes. J Biol Chem 1995, 270:19969-19973.
39. 39 Gaudry M, Gilbert C, Barabé F, Poubelle PE, Naccache PH: Activation of Lyn is a common element of the stimulation of human neutrophils by soluble and particulate agonists. Blood 1995, 86:3567-3574.
40. 40 Welch H, Maridonneau-Parini I: Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells. Oncogene 1997, 15:2021-2029.
41. 41 Ptasznik A, Prossnitz ER, Yoshikawa D, Smrcka A, Traynor-Kaplan AE, Bokoch GM: A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils. J Biol Chem 1996, 271:25204-25207.
42. 42 Bokoch GM: Interplay between Ras-related and heterotrimeric GTP binding proteins: lifestyles of the BIG and little. FASEB J 1996, 10:1290-1295.
43. 43 Zheng L, Eckerdal J, Dimitrijevic I, Andersson T: Chemotactic peptide-induced activation of Ras in human neutrophils is associated with inhibition of p120-GAP activity. J Biol Chem 1997, 272:23448-23454.
44. 44 Laudanna C, Campbell JJ, Butcher EC: Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 1996, 271:981-983.
45. 45 Dorseuil O, Quinn MT, Bokoch GM: Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors. J Leukoc Biol 1995, 58:108-113.
46. 46 Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A: Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity 1996, 5:591-604.
47. 47 Torres M, Coates TD: Pyk2/RAFTK is activated by chemoattractants in neutrophils [abstract]. Eur J Haematol 1998, 60:350.
48. 48 Laudanna C, Constantin G, Baron P, Scarpini E, Scarlato G, Cabrini G, et al: Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-α and interleukin-B mRNA in human neutrophils: evidence for a role of L-selectin as a signaling molecule. J Biol Chem 1994, 269:4021-4026.
49. 49 Waddell TK, Fialkow L, Chan CK, Kishimoto TK, Downey GP: Signaling functions of L-selectin: enhancement of tyrosine phosphorylation and activation of MAP kinase. J Biol Chem 1995, 270:15403-15411.
50. 50 Hidari KI, Weyrich AS, Zimmerman GA, McEver RP: Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem 1997, 272:28750-28756. This is the first report of the signaling role of a selectin ligand in neutrophils.
51. 51 Berton G, Lowell CA: Integrin signaling in neutrophils and macrophages. Cell Signal 1999, in press. This article is a timely review of mechanisms of signal transduction by integrins in phagocytic cells with special reference to the role of tyrosine kinases.
52. 52 Berton G, Fumagalli L, Laudanna C, Sorio C: β2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils. J Cell Biol 1994, 126:1111-1121.
53. 53 Yan SR, Fumagalli L, Berton G: Activation of p58c-fgr and p53/56lyn in adherent human neutrophils: evidence for a role of divalent cations in regulating neutrophil adhesion and protein tyrosine kinase activities. J Inflamm 1995, 45:297-311.
54. 54 Yan SR, Huang M, Berton G: Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen. J Immunol 1997, 158:1902-1910.
55. 2 release in adherent human neutrophils. J Immunol 1998, 160:5154-5162. This interesting study shows that a selective inhibitor of Syk blocks neutrophil from spreading over fibrinogen and spreading-dependent generation of hydrogen peroxide, as well as phosphorylation of the cytoskeletal protein paxillin.
56. 2 integrin-dependent tyrosine phosphorylation of FAK in human neutrophils.
57. 57 Lowell CA, Berton G: Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc Natl Acad Sci U S A 1998, 95:7580-7584. This article provides the first evidence that defective integrin signaling, resulting from deficiency of Hck and Fgr, results in impaired neutrophil-dependent tissue injury.
58. 58 Zheng L, Sjölander A, Eckerdal J, Andersson T: Antibody-induced engagement of β2 integrins on adherent human neutrophils triggers activation of p21 ras through tyrosine phosphorylation of the protooncogene product Vav. Proc Natl Acad Sci U S A 1996, 93:8431-8436.
59. -/- triple-knockout macrophages, integrin-dependent Cbl phosphorylation, membrane translocation of Cbl, and activity of Cbl-associated, membrane-localized Pl3-kinase are defective. This article also shows that integrin signaling leading to MAP kinases activation is normal in triple-knockout macrophages.
60. 60 Möhn H, Le Cabec V, Fischer S, Maridonneau-Parini I: The Src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation. Biochem J 1995, 309:657-665.
61. 61 Welch H, Maridonneau-Parini I: Hck is activated by opsonized zymosan and A23187 in distinct subcellular fractions of human granulocytes. J Biol Chem 1997, 272:102-109.
62. 62 Brumell JH, Burkhardt AL, Bolen JB, Grinstein S: Endogenous reactive oxygen intermediates activate tyrosine kinases in human neutrophils. J Biol Chem 1996, 271:1455-1461.
63. lyn tyrosine kinases. J Biol Chem 1996, 271:23464-23471.
64. + exchanger in neutrophils.
65. 65 Roach T, Slater S, Koval M, White L, McFarland EC, Okumura M, et al: CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol 1997, 7:408-417.
66. 66 Fialkow L, Chan CK, Downey GP: Inhibition of CD45 during neutrophil activation. J Immunol 1997, 158:5409-541 7.
67. 67 Berton G: Degranulation. In Inflammation: Basic Principles and Clinical Correlates, edn 3. Edited by Gallin J, Snyderman R, Fearon D, Haynes B, Nathan C. Philadelphia: Lippincott-Raven; 1999, in press.
68. 3 and phosphoinositidase Cγ.