Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1339, Issue 1, 1997, Pages 1-3

  Craig III, Sydney P ^a,b   Focia, Pamela J ^c   Fletterick, Robert J ^c  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mutagenesis; Phosphoribosyltransferase; Structure

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

CHEMICAL MODIFICATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MUTATION; PRIORITY JOURNAL; SHORT SURVEY; THREE DIMENSIONAL IMAGING;

EID: 0030950479     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(97)00037-X     Document Type: Article

References (6)

1. S.P. Craig III, F.E. Cohen, L. Yuan, J.H. McKerrow, C.C. Wang, in: C.C. Wang (Ed.), Molecular and Immunological Aspects of Parasitism, AAAS Press, Washington, DC, 1991, pp. 123-138.
2. J.C. Eads, G. Scapin, Y. Xu, C. Grubmeyer, J.C. Sacchettini, Cell 78 (1994) 325-334.
3. L. Yuan, S.P. Craig III, J.H. McKerrow, C.C. Wang, Biochemistry 31 (1992) 806-810.
4. K.L. Nakamaye, F. Eckstein, Nucleic Acids Res. 14 (1986) 9679-9698.
5. S.P. Craig III, L. Yuan, D.A. Kuntz, J.H. McKerrow, C.C. Wang, Proc. Natl. Acad. Sci. USA 88 (1991) 2500-2504.
6. A.E. Eakin, R. Nieves, R. Tosado-Acevedo, M.S. Chin, C.C. Wang, S.P. Craig III, Antimicrob. Agents Chemother. 39 (1995) 620-625.