A genetic screen for modifiers of E2F in Drosophila melanogaster

Genetics

Volumn 153, Issue 1, 1999, Pages 275-287

  Staehling Hampton, Karen ^a   Ciampa, Phillip J ^a   Brook, Adam ^a   Dyson, Nicholas ^a  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELISM; ARTICLE; CARCINOGENESIS; CELL CYCLE S PHASE; DROSOPHILA MELANOGASTER; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC SCREENING; NONHUMAN; PRIORITY JOURNAL; RETINOBLASTOMA; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE;

ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DEATH; DIMERIZATION; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; E2F TRANSCRIPTION FACTORS; EYE; GENES, CDC; GENES, DOMINANT; GENES, INSECT; GENETIC COMPLEMENTATION TEST; INSECT PROTEINS; MICROSCOPY, ELECTRON, SCANNING; MUTATION; PHENOTYPE; RETINOBLASTOMA PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; SUPPRESSION, GENETIC; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0032883929     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. ASANO, M., J. R. NEVINS and R. P. WHARTON, 1996 Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 10: 1422-1432.
2. BREHM, A., E. A. MISKA, D. J. MCCANCE, J. L. REID, A. J. BANNISTER et al., 1998 Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391: 597-601.
3. BRIZUELA, B. J., and J. A. KENNISON, 1997 The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginai tissues. Mech. Dev. 65: 209-220.
4. BRIZUELA, B. J., L. ELFRING, J. BALLARD, J. W. TAMKUN and J. A. KENNISON, 1994 Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72AB. Genetics 137: 803-813.
5. BROOK, A., J.-E. XIE, W. DU and N. DYSON, 1996 Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J. 15: 3676-3683.
6. BRUNNER, D., K. DUCKER, N. OELLERS, E. HAFEN, H. SCHOLZ et al., 1994 The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370: 386-389.
7. CARLSON, M., and B. C. LAURENT, 1994 The SNF/SWI family of global transcriptional activators. Curr. Opin. Cell Biol. 6: 396-402.
8. CROSBY, M., C. MILLER, T. ALON, K. L. WATSON, C. P. VERRIJZER et al., 1999 The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster. Mol. Cell. Biol. 19: 1159-1170.
9. DEGREGORI, J., T. KOWALIK and J. NEVINS, 1995 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol. Cell. Biol. 15: 4215-1224.
10. DE NOOIJ, J. C., and I. K. HARIHARAN, 1995 Uncoupling cell fate determination from patterned cell division in the Drosophila eye. Science 270: 983-985.
11. DE NOOIJ, J. C., M. A. LETENDRE and I. K. HARIHARAN, 1996 Acyclin-dependent kinase inhibitor, dacapo, is necessary for timely exit from the cell cycle during drosophila embryogenesis. Cell 87: 1237-1247.
12. DICKSON, B. J., A. VAN DER STRATEN, M. DOMINGUEZ and E. HAFEN, 1996 Mutations modulating Raf signaling in Drosophila eye development. Genetics 142: 163-171.
13. DINGWALL, A. K., S. J. BEEK, C. M. MCCALLUM, J. W. TAMKUN, G. V. KALPANA et al., 1995 The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex. Mol. Biol. Cell 6: 777-791.
14. DU, W., and N. DYSON, 1999 The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 18: 916-925.
15. DU, W., M. VIDAL, J.-E. XIE and N. DYSON, 1996a RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 10: 1206-1218.
16. DU, W., J.-E. XIE and N. DYSON, 1996b Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15: 3684-3692.
17. DUNAIEF, J. L., B. E. STROBER, S. GUHA, P. A. KHAVARI, K. ALIN et al., 1994 The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79: 119-130.
18. DURONIO, R. J., and P. H. O'FARRELL, 1994 Developmental control of a G1-S transcriptional program in Drosophila. Development 120: 1503-1515.
19. DURONIO, R. J., P. H. O'FARRELL, J.-E. XIE, A. BROOK and N. DYSON, 1995 The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9: 1445-1455.
20. DURONIO, R. J., P. C. BONNETTE and P. H. O'FARRELL, 1998 Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the S-phase transition. Mol. Cell. Biol. 18: 141-151.
21. DYNLACHT, B. D., A. BROOK, M. S. DEMBSKI, L. YENUSH and N. DYSON, 1994 DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc. Natl. Acad. Sci. USA 91: 6359-6363.
22. DYSON, N., 1998 The regulation of E2F by pRB-family proteins. Genes Dev. 12: 2245-2262.
23. ELFRING, L. K., C. DANIEL, O. PAPOULAS, R. DEURING, M. SARTE et al., 1998 Genetic analysis of brahma (brm): the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2. Genetics 148: 251-265.
24. ELLIS, M. C., E. M. O'NEILL and G. M. RUBIN, 1993 Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein. Development 119: 855-865.
25. FARNHAM, P. J. (Editor), 1995 Transcriptional Control of Cell Growth: The E2F Gene Family. Springer-Verlag, New York.
26. FIELD, S. J., F.-Y. TSAI, F. KUO, A. M. ZUBIAGA, J. KAELIN et al., 1996 E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85: 549-561.
27. GABAY, L., H. SCHOLZ, M. GOLEMBO, A. KLAES, B. Z. SHILO et al., 1996 EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122: 3355-3362.
28. GELLON, G., K. W. HARDING, N. MCGINNIS, M. M. MARTIN and W. MCGINNIS, 1997 A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. Development 124: 3321-3331.
29. GIRLING, R., J. F. PARTRIDGE, L. R. BANDARA, N. BURDEN, N. F. TOTTY et al., 1993 A new component of the transcription factor DRTF1/E2F. Nature 362: 83-87.
30. GOLDMAN-LEVI, R., C. MILLER, J. BOGOCH and N. B. ZAK, 1996 Expanding the Mot1 superfamily: 89B helicase encodes a new Drosophila melanogaster SNF-2-related protein which binds to multiple sites on polytene chromosomes. Nucleic Acids Res. 24: 3121-3128.
31. HAMEL, P. A., R. M. GILL, R. A. PHILLIPS and B. L. GALLIE, 1992 Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol. Cell. Biol. 12: 3431-3438.
32. HAO, X. F., L. ALPHEY, L. R. BANDARA, E. W. LAM, D. GLOVER et al., 1995 Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. J. Cell Sci. 108: 2945-2954.
33. HELIN, K., 1998 Regulation of cell proliferation by the E2F transcription factors. Curr. Opin. Genet. Dev. 8: 28-35.
34. HOLSTEGE, F. C. P., E. G. JENNINGS, J. J. WYRICK, T. I. LEE, C. J. HENGARTNER et al., 1998 Dissecting the regulatory circuit of a eukaryotic genome. Cell 95: 717-728.
35. KENNISON, J. A., 1993 Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet. 9: 75-79.
36. KENNISON, J. A., 1995 The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu. Rev. Genet. 29: 289-303.
37. KENNISON, J. A., and J. W. TAMKUN, 1988 Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. USA 85: 8136-8140.
38. KIMMEL, B. E., U. HEBERLEIN and G. M. RUBIN, 1990 The homeodomain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev. 4: 712-729.
39. KLAMBT, C., 1993 The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117: 163-176.
40. LANE, M. E., K. SAUER, K. WALLACE, Y. N. JAN, C. F. LEHNER et al., 1996 Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87: 1225-1235.
41. LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, San Diego.
42. LUO, R. X., A. A. POSTIGO and D. C. DEAN, 1998 Rb interacts with histone deacetylase to repress transcription. Cell 92: 463-473.
43. MAGNAGHI-JAULIN, L., R. GROISMAN, I. NAGUIBNEVA, P. ROBIN, S. LORAIN et al., 1998 Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391: 601-605.
44. MUCHARDT, C., B. BOURACHOT, J.-C. REYES and M. YANIV, 1998 ras transformation is associated with decreased expression of the brm/SNF2α ATPase from the mammalian SWI-SNF complex. EMBO J. 17: 223-231.
45. MURRAY, A., and T. HUNT, 1993 The Cell Cycle: An Introduction. Freeman, New York.
46. NASMYTH, K., 1996 Viewpoint: putting the cell cycle in order. Science 274: 1643-1645.
47. OHTANI, K., and J. R. NEVINS, 1994 Functional properties of a Drosophila homolog of the E2F1 gene. Mol. Cell. Biol. 14: 1603-1612.
48. O'NEILL, E. M., I. REBAY, R. TIJAN and G. M. RUBIN, 1994 The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78: 137-147.
49. PAN, H., C. YIN, N. DYSON, E. HARLOW, L. YAMASAKI et al., 1998 Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2: 283-292.
50. PAPOULAS, O., S. J. BEEK, S. L. MOSELEY, C. M. MCCALLUM, M. SARTE et al., 1998 The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes. Development 125: 3955-3966.
51. PETERSON, C. L., and J. W. TAMKUN, 1995 The SWI-SNF complex: a chromatin remodeling machine? Trends Biochem. Sci. 20: 143-146.
52. REYES, J. C., J. BARRA, C. MULCHARDT, A. CAMUS, C. BABINET et al., 1998 Altered control of cellular proliferation in the absence of mammalian brahma (SNF2α). EMBO J. 17: 6979-6991.
53. ROYZMAN, I., A. J. WHITTAKER and T. L. ORR-WEAVER, 1997 Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev. 11: 1999-2011.
54. SCHNITZLER, G., S. SIF and R. E. KINGSTON, 1998 Human SWI/SNF interconverts a nucleosome between its base state and a stable remodeled state. Cell 94: 17-27.
55. SHANAHAN, F., W. SEGHEZZI, D. PARRY, D. MAHONY and E. LEES, 1999 Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol. Cell. Biol. 19: 1460-1469.
56. SHERR, C. J., 1994 G1 phase progression: cycling on cue. Cell 79: 551-556.
57. SIF, S., P. T. STUKENBERG, M. W. KIRSCHNER and R. E. KINGSTON, 1998 Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev. 12: 2842-2851.
58. SINGH, P., S. H. WONG and W. HONG, 1994 Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J. 13: 3329-3338.
59. SINGH, P., J. COE and W. HONG, 1995 A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature 374: 562-565.
60. TAMKUN, J. W., R. DEURING, M. P. SCOTT, M. KISSINGER, A. M. PATTATUCCI et al., 1992 brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF/SWI2. Cell 68: 561-572.
61. TAUTZ, D., and C. PFEIFLE, 1989 A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81-85.
62. THOMAS, B. J., D. A. GUNNING, J. CHO and S. L. ZIPURSKY, 1994 Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1. Cell 77: 1003-1014.
63. TROUCHE, D., and T. KOUZARIDES, 1996 E2F1 and EIA 12S have a homologous activation domain regulated by RB and CBP. Proc. Natl. Acad. Sci. 93: 1439-1442.
64. TROUCHE, D., C. LE CHALONY, C. MUCHARDT, M. YANIV and T. KOUZARIDES, 1997 RB and hBRM cooperate to repress the activation functions of E2F-1. Proc. Natl. Acad. Sci. USA 94: 11268-11273.
65. TSAI, K. Y., Y. HY, K. F. MACLEOD, D. CROWLEY, L. YAMASAKI et al., 1998 Mutation of E2F1 suppresses apoptosis and inappropriate S-phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2: 293-304.
66. VÁZQUEZ, M., L. MOORE and J. A. KENNISON, 1999 The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the Brahma chromatin remodeling factor to regulate transcription. Development 126: 733-742.
67. WEINTRAUB, S. J., C. A. PRATER and D. C. DEAN, 1992 Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259-261.
68. WEINTRAUB, S. J., K. N. B. CHOW, R. X. LUO, S. H. ZHANG, S. HE et al., 1995 Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375: 812-815.
69. WOLFF, T., and D. F. READY, 1993 Pattern formation in the Drosophila retina, pp. 1277-1326 in The Development of Drosophila melanogaster, edited by M. BATE and A. MARTINEZ ARIAS. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
70. WU, X., and A. J. LEVINE, 1994 p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91: 3602-3606.
71. WU, C.-L., L. R. ZUKERBERG, C. NGWU, E. HARLOW and J. A. LEES, 1995 In vivo association of E2F and DP family proteins. Mol. Cell. Biol. 15: 2536-2546.
72. YAMASAKI, L., T. JACKS, R. BRONSON, E. GOILLOT, E. HARLOW et al., 1996 Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85: 537-548.
73. YAMASAKI, L., R. T. BRONSON, B. O. WILLIAMS, N. DYSON, E. HARLOW et al., 1998 Loss of E2F-1 reduces tumorigenesis and extends lifespan of Rb(+/-) mice. Nat. Genet. 18: 360-364.